GO:0004175

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Name endopeptidase activity
Categary Function
Go Slim No
Go Link GO:0004175
Unique Molecular Interactions 541
Total Molecular Interactions 738
Total Single Events 9515
Pain Genes Associated 48

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
2 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
3 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
4 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
5 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
6 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92
7 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92
8 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
9 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
10 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
11 INT237286 Dlat Regulation of Prep 1 0.01 0 1.57
12 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
13 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
14 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
15 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
16 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
17 INT62019 CSF2 Regulation of ELANE 1 0.03 0.47 1.21
18 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16
19 INT60134 MME Negative_regulation of GRP 1 0.20 0 1.12
20 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
21 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
22 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
23 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
24 INT45665 Fpr1 Negative_regulation of Mme 1 0.13 0 1
25 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
26 INT227545 Hspa9 Positive_regulation of Prep 1 0.18 0.59 0.96
27 INT103933 Cps1 Negative_regulation of Gene_expression of Cd69 1 0.03 0.25 0.93
28 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 0.02 0.25 0.93
29 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92
30 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92
31 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
32 INT193291 Binding of CAP1 and Cfd 1 0.02 0.13 0.91
33 INT193277 Binding of Cfd and Brs3 1 0.01 0.13 0.91
34 INT159995 Prkcg Regulation of Gene_expression of Bace1 1 0.39 0.32 0.91
35 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1 0.02 1.29 0.9
36 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
37 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85
38 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
39 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 0.07 0 0.8
40 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 0.43 0 0.8
41 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
42 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
43 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 0.07 0 0.8
44 INT110578 PENK Positive_regulation of Gene_expression of MME 1 0.35 0.1 0.76
45 INT219685 Binding of MMP12 and COPD 1 0.27 5.59 0.74
46 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
47 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
48 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
49 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
50 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
51 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
52 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
53 INT36219 Mme Positive_regulation of Protein_catabolism of Penk 1 0.39 0 0.72
54 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
55 INT29380 Binding of gp and Mme 1 0.01 0 0.71
56 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
57 INT111747 Pcsk2 Regulation of Gene_expression of Npy 1 0.29 0 0.71
58 INT190172 Gene_expression of IL13 Regulation of MMP12 1 0.12 0.05 0.68
59 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68
60 INT293010 ELANE Regulation of Localization of LTF 1 0.00 0.54 0.67
61 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
62 INT29381 gp Regulation of Mme 1 0.01 0 0.65
63 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
64 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65
65 INT29382 Positive_regulation of gp Regulation of Mme 1 0.02 0 0.65
66 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
67 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64
68 INT252772 ELANE Regulation of Gene_expression of CCL2 1 0.05 2.16 0.62
69 INT237285 Dlat Negative_regulation of Prep 1 0.01 0 0.62
70 INT79210 Hps4 Negative_regulation of Mme 1 0.00 0 0.62
71 INT32782 Binding of Vip and Elane 1 0.17 0 0.61
72 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
73 INT227544 Hspa9 Regulation of Gene_expression of Prep 1 0.15 0.57 0.61
74 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6
75 INT190166 IL13 Regulation of MMP12 1 0.12 0 0.59
76 INT47284 Binding of Mme and Ctsa 1 0.21 0 0.57
77 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
78 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
79 INT54239 Binding of Mme and Nts 1 0.21 0 0.54
80 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
81 INT55445 Positive_regulation of Ahr Regulation of Mme 1 0.23 0 0.53
82 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
83 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
84 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
85 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 0.03 0.19 0.51
86 INT103932 Cps1 Negative_regulation of Gene_expression of Trav6-3 1 0.01 0.19 0.5
87 INT103934 Cps1 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.2 0.49
88 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49
89 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
90 INT88696 Tac1 Regulation of Regulation of Mme 1 0.00 0.39 0.48
91 INT65006 DAK Negative_regulation of ELANE 1 0.05 0.35 0.47
92 INT145954 Binding of BSG and MME 1 0.00 0.81 0.47
93 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 0.01 0.13 0.47
94 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
95 INT103936 Cps1 Negative_regulation of Il2ra 1 0.02 0.07 0.46
96 INT88080 Binding of Chrna4 and Psmb6 1 0.03 0.56 0.46
97 INT103931 Cps1 Negative_regulation of Icam1 1 0.01 0.07 0.46
98 INT103935 Cps1 Negative_regulation of Cd69 1 0.03 0.07 0.46
99 INT41039 Thop1 Positive_regulation of Mme 1 0.01 0 0.45
100 INT221026 ELANE Positive_regulation of Gene_expression of CCL18 1 0.01 0.57 0.45
101 INT56631 Negative_regulation of FPR1 Positive_regulation of ELANE 1 0.38 0.54 0.44
102 INT353331 Elane Positive_regulation of F2r 1 0.08 0.78 0.44
103 INT189309 Binding of MME and PENK 1 0.15 1.16 0.42
104 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
105 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
106 INT221027 ELANE Positive_regulation of IL8 2 0.14 1.3 0.4
107 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4
108 INT23664 Cd2 Negative_regulation of Fap 1 0.33 0 0.4
109 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
110 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
111 INT90765 Pcsk2 Positive_regulation of Gene_expression of Pdyn 1 0.41 0 0.39
112 INT312086 ELANE Positive_regulation of MMP13 1 0.13 0.64 0.39
113 INT219684 Binding of MMP12 and GOPC 1 0.09 3.11 0.38
114 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
115 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
116 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
117 INT4876 Regulation of TNF Regulation of MME 1 0.37 0.36 0.37
118 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
119 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
120 INT37328 Binding of PDYN and Mme 1 0.02 0 0.34
121 INT312750 Elane Positive_regulation of Positive_regulation of Ltp 1 0.01 0.38 0.34
122 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
123 INT24127 Cast Positive_regulation of Mme 1 0.15 0 0.33
124 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33
125 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
126 INT312099 ELANE Positive_regulation of Gene_expression of PTGER2 1 0.02 0.64 0.32
127 INT15141 MME Negative_regulation of IL1B 1 0.39 0.19 0.32
128 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32
129 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32
130 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32
131 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
132 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
133 INT80304 Nrd1 Negative_regulation of Furin 1 0.01 0 0.3
134 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
135 INT150351 Binding of EXT1 and MMP12 1 0.04 3.68 0.29
136 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29
137 INT116358 Binding of C3 and ELANE 1 0.12 0 0.29
138 INT116356 Positive_regulation of Binding of C3 and ELANE 1 0.16 0 0.29
139 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
140 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
141 INT327366 Binding of Fap and Ttr 1 0.33 2.9 0.28
142 INT15142 MME Regulation of IL1B 1 0.40 0.16 0.28
143 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
144 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
145 INT141545 Binding of Bace1 and Rtn4 1 0.00 0.45 0.27
146 INT141552 Binding of RTN3 and Bace1 1 0.00 0.45 0.27
147 INT141546 Binding of Bace1 and Rtn4r 1 0.00 0.46 0.27
148 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
149 INT76081 Plg Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.26
150 INT76082 Plg Regulation of Gene_expression of IL6 1 0.01 0.19 0.26
151 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
152 INT312115 ELANE Positive_regulation of Transcription of PTGES 1 0.25 0.53 0.25
153 INT312569 IL6 Positive_regulation of Localization of ELANE 1 0.11 1.05 0.24
154 INT31097 Binding of Penk and Plg 1 0.29 0.07 0.24
155 INT15829 Ambp Regulation of Positive_regulation of ELANE 1 0.00 0 0.24
156 INT160464 Binding of Mme and Lnpep 1 0.31 0.37 0.24
157 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24
158 INT77046 Binding of Pcsk2 and Olfr714 1 0.09 0.07 0.23
159 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
160 INT222178 SERPINB1 Regulation of ELANE 1 0.00 1.04 0.23
161 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23
162 INT124383 ACOT1 Positive_regulation of MME 1 0.01 0.17 0.22
163 INT133166 ELANE Regulation of Tnf 1 0.01 0.98 0.22
164 INT60909 TPP1 Positive_regulation of Gh1 1 0.00 0 0.22
165 INT57250 ELANE Positive_regulation of Localization of CGA 1 0.08 0 0.21
166 INT310939 Binding of ELANE and COPD 1 0.08 1.51 0.2
167 INT255259 Binding of Plg and Tsp1 1 0.05 0.84 0.2
168 INT252814 ELANE Positive_regulation of Positive_regulation of CCL2 1 0.05 0.8 0.2
169 INT27675 Plg Positive_regulation of Protein_catabolism of F13A1 1 0.00 0.75 0.2
170 INT310938 Binding of ELANE and HRCT1 1 0.02 1.5 0.2
171 INT236338 Negative_regulation of Binding of PCSK1 and GOPC 1 0.06 0.19 0.2
172 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
173 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
174 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
175 INT46306 Asrgl1 Positive_regulation of Negative_regulation of Plg 1 0.01 1.07 0.19
176 INT55809 Binding of Ttr and Fap 1 0.12 2.56 0.19
177 INT139848 Binding of Bace1 and Bace2 2 0.28 0.31 0.18
178 INT259634 Elane Positive_regulation of Gene_expression of COPD 1 0.01 0.92 0.17
179 INT221025 TNF Positive_regulation of ELANE 1 0.01 0.13 0.17
180 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
181 INT236339 Binding of PCSK1 and GOPC 1 0.05 0.14 0.17
182 INT34717 Positive_regulation of Vip Positive_regulation of Localization of Ren 1 0.46 0 0.17
183 INT312109 ELANE Positive_regulation of EGR1 1 0.15 0.23 0.16
184 INT312100 ELANE Positive_regulation of Binding of EGR1 1 0.16 0.23 0.16
185 INT141322 Binding of PAPPA and TNNI3 1 0.09 0.98 0.16
186 INT312111 ELANE Regulation of Transcription of PTGES 1 0.22 0.23 0.16
187 INT72116 Binding of PCSK1 and POMC 1 0.32 0 0.15
188 INT116359 Positive_regulation of Binding of C4A and ELANE 1 0.14 0 0.15
189 INT199128 Ctsb Positive_regulation of Prss1 1 0.02 0.9 0.15
190 INT221030 ELANE Positive_regulation of CXCL10 1 0.01 0.24 0.15
191 INT312126 ELANE Positive_regulation of ALOX5AP 1 0.20 0.25 0.15
192 INT22820 ADRA1D Regulation of ELANE 1 0.21 0 0.15
193 INT199129 Ctsb Positive_regulation of PRSS1 1 0.01 0.9 0.15
194 INT312092 ELANE Positive_regulation of Gene_expression of EGR1 1 0.19 0.21 0.15
195 INT221035 ELANE Positive_regulation of CCL18 1 0.01 0.24 0.15
196 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
197 INT21453 Ambp Regulation of ELANE 1 0.00 0 0.15
198 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15
199 INT221019 ELANE Positive_regulation of CCL3 1 0.00 0.24 0.15
200 INT161797 Binding of ECE1 and ING1 1 0.01 0.68 0.14

Single Events

The table below shows the top 100 pain related interactions that have been reported for endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
2 INT46 Localization of Ren 233 0.81 46.15 62.44
3 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
4 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12
5 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
6 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
7 INT1116 Regulation of Ren 103 0.62 27.66 33.26
8 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
9 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
10 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
11 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
12 INT2609 Localization of ELANE 111 0.81 50.22 26.63
13 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
14 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
15 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
16 INT9490 Regulation of Mme 44 0.56 6.69 19.21
17 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
18 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95
19 INT49379 Localization of MMP12 26 0.77 13.07 16.93
20 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69
21 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24
22 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
23 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79
24 INT14453 Localization of Mme 44 0.80 2.46 14.75
25 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69
26 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
27 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
28 INT11205 Gene_expression of Prep 65 0.77 8.11 10.12
29 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
30 INT4880 Regulation of MME 17 0.61 7.78 8.2
31 INT8603 Binding of Mme 28 0.48 1.42 7.64
32 INT7168 Positive_regulation of Ctsb 9 0.70 0.3 7.58
33 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46
34 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44
35 INT2605 Regulation of ELANE 39 0.61 18.22 7.11
36 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02
37 INT14865 Regulation of Prep 20 0.55 4.21 6.75
38 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74
39 INT10610 Negative_regulation of Plg 22 0.40 11.81 6.74
40 INT24907 Gene_expression of PAPPA 42 0.75 28.32 6.63
41 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
42 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
43 INT116420 Localization of Elane 16 0.14 7.8 6
44 INT168446 Gene_expression of Prep 25 0.64 15.17 5.94
45 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
46 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
47 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
48 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54
49 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26
50 INT10100 Binding of ELANE 22 0.47 15.32 5.19
51 INT34358 Binding of MME 13 0.37 7.25 5.14
52 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
53 INT14027 Positive_regulation of Prep 29 0.69 3.63 4.99
54 INT28145 Binding of PAPPA 26 0.48 7.4 4.96
55 INT17582 Negative_regulation of Localization of ELANE 17 0.53 6.11 4.89
56 INT7170 Positive_regulation of Positive_regulation of Ctsb 1 0.40 0 4.76
57 INT81761 Negative_regulation of Prep 12 0.55 8.48 4.73
58 INT17103 Negative_regulation of Prep 15 0.38 4.95 4.71
59 INT3097 Binding of Ren 12 0.48 3.15 4.4
60 INT111066 Regulation of Bace1 40 0.61 31.47 4.28
61 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
62 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
63 INT220594 Localization of Bace1 48 0.79 20.22 4.16
64 INT51986 Negative_regulation of Pcsk2 8 0.50 1.4 4.1
65 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07
66 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05
67 INT126197 Transcription of Bace1 13 0.72 7.34 3.87
68 INT117614 Positive_regulation of PAPPA 18 0.67 11.9 3.76
69 INT20493 Regulation of MMP12 3 0.52 0.89 3.65
70 INT16644 Positive_regulation of Plg 16 0.60 6.38 3.62
71 INT179656 Gene_expression of Elane 12 0.32 9.44 3.53
72 INT20265 Gene_expression of Ctsb 3 0.47 1.01 3.52
73 INT51985 Gene_expression of Pcsk2 10 0.76 1.34 3.44
74 INT22891 Positive_regulation of Localization of ELANE 16 0.69 11.52 3.42
75 INT42581 Regulation of Gene_expression of ELANE 11 0.38 9.25 3.38
76 INT61341 Positive_regulation of Prep 12 0.63 6.08 3.37
77 INT22823 Positive_regulation of Positive_regulation of ELANE 12 0.45 6.89 3.35
78 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
79 INT146890 Gene_expression of Cfd 15 0.66 4.42 3.28
80 INT227524 Positive_regulation of Gene_expression of Prep 13 0.48 7.69 3.28
81 INT217389 Negative_regulation of Gene_expression of Bace1 43 0.59 18.57 3.27
82 INT25344 Localization of Plg 10 0.57 5 3.27
83 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
84 INT16390 Regulation of Plg 13 0.48 6.72 3.2
85 INT58532 Negative_regulation of MMP12 4 0.37 2.61 3.2
86 INT190189 Positive_regulation of Localization of MMP12 4 0.58 2.87 3.18
87 INT37111 Regulation of Negative_regulation of Mme 7 0.44 2.61 3.13
88 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12
89 INT190202 Negative_regulation of Localization of MMP12 1 0.36 1.29 3.12
90 INT156488 Binding of Bace1 46 0.48 15.64 3.04
91 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
92 INT28731 Negative_regulation of Elane 14 0.14 8.97 3.01
93 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
94 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
95 INT11291 Positive_regulation of Gene_expression of Mme 6 0.61 5.93 2.81
96 INT190188 Regulation of Localization of MMP12 1 0.44 0.39 2.8
97 INT133674 Gene_expression of Bace1 3 0.61 1.11 2.78
98 INT24904 Negative_regulation of PAPPA 13 0.57 9.93 2.74
99 INT7148 Negative_regulation of Negative_regulation of Mme 6 0.42 2.19 2.74
100 INT70380 Transcription of Prep 7 0.62 0.43 2.54
101 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
102 INT73028 Positive_regulation of Transcription of Ctsb 1 0.55 1.53 2.54
103 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
104 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46
105 INT163544 Binding of Psen1 40 0.36 15.28 2.42
106 INT111072 Protein_catabolism of Bace1 26 0.98 14.07 2.41
107 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
108 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
109 INT28698 Positive_regulation of F7 13 0.64 9.5 2.38
110 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
111 INT37427 Positive_regulation of Gene_expression of Ctsb 2 0.37 1.02 2.33
112 INT61340 Regulation of Prep 7 0.50 6.13 2.31
113 INT26434 Localization of MME 17 0.81 8.67 2.3
114 INT7173 Regulation of Positive_regulation of Ctsb 1 0.49 0 2.29
115 INT26514 Regulation of Gene_expression of Mme 2 0.41 1.18 2.27
116 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26
117 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
118 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
119 INT30137 Negative_regulation of TPP1 5 0.37 0.96 2.2
120 INT190186 Negative_regulation of Gene_expression of MMP12 5 0.38 5.37 2.17
121 INT124583 Negative_regulation of Elane 8 0.29 5.26 2.14
122 INT42583 Protein_catabolism of ELANE 8 0.89 4.33 2.11
123 INT53668 Regulation of Pcsk1 6 0.53 2.52 2.07
124 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
125 INT60723 Localization of Psen2 5 0.68 2.11 2.02
126 INT59283 Positive_regulation of Gene_expression of Plg 6 0.25 2.36 1.97
127 INT17326 Binding of Plg 14 0.43 11.72 1.94
128 INT51502 Positive_regulation of Elane 5 0.22 2.3 1.94
129 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
130 INT36245 Negative_regulation of Gene_expression of ELANE 11 0.40 5.32 1.88
131 INT187789 Positive_regulation of Positive_regulation of Bace1 18 0.50 16.18 1.87
132 INT83358 Positive_regulation of Elane 8 0.21 8.14 1.83
133 INT110579 Negative_regulation of Gene_expression of MME 15 0.58 12.8 1.81
134 INT190210 Regulation of Positive_regulation of MMP12 1 0.38 1.4 1.79
135 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
136 INT217382 Regulation of Gene_expression of Bace1 26 0.61 17 1.76
137 INT37294 Negative_regulation of Ece1 6 0.54 1.27 1.74
138 INT98497 Regulation of PAPPA 5 0.44 3.18 1.74
139 INT58210 Gene_expression of Pcsk1 11 0.70 5.63 1.71
140 INT30138 Binding of TPP1 1 0.16 0.74 1.69
141 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
142 INT99258 Regulation of Aph1a 3 0.25 2.79 1.68
143 INT73027 Transcription of Ctsb 1 0.56 1.01 1.68
144 INT51984 Localization of Pcsk2 3 0.66 0.37 1.62
145 INT53673 Gene_expression of Furin 6 0.40 1.99 1.54
146 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
147 INT44164 Localization of Ren1 18 0.49 10.53 1.49
148 INT116836 Binding of FAP 6 0.37 6.76 1.47
149 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46
150 INT38043 Gene_expression of Cps1 6 0.56 0.82 1.46
151 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
152 INT190184 Regulation of Gene_expression of MMP12 2 0.44 4.41 1.42
153 INT16388 Protein_catabolism of Plg 6 0.79 3.46 1.4
154 INT227424 Binding of Prep 6 0.35 2.61 1.39
155 INT125762 Negative_regulation of Pcsk1 4 0.42 3.62 1.37
156 INT17325 Negative_regulation of Protein_catabolism of Plg 1 0.32 0 1.37
157 INT92955 Gene_expression of Ece1 5 0.74 2.2 1.36
158 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
159 INT133672 Regulation of Bace1 2 0.25 0.56 1.33
160 INT92954 Positive_regulation of Gene_expression of Ece1 2 0.48 2.16 1.32
161 INT41381 Positive_regulation of Gene_expression of Plg 8 0.44 3.29 1.3
162 INT95270 Regulation of Ece1 1 0.43 2.08 1.3
163 INT126198 Negative_regulation of Transcription of Bace1 3 0.43 1.95 1.27
164 INT43941 Transcription of Mme 6 0.68 0.78 1.26
165 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
166 INT53666 Regulation of Furin 4 0.37 0.3 1.24
167 INT53674 Transcription of Pcsk1 4 0.45 1.48 1.23
168 INT53672 Positive_regulation of Pcsk1 4 0.42 0.61 1.23
169 INT18422 Regulation of Plg 6 0.45 1.71 1.22
170 INT43940 Regulation of Transcription of Mme 1 0.44 0 1.22
171 INT5652 Negative_regulation of Positive_regulation of ELANE 7 0.37 2.46 1.21
172 INT59711 Negative_regulation of Positive_regulation of PSENEN 1 0.17 0.07 1.21
173 INT64948 Positive_regulation of Negative_regulation of MME 1 0.43 0 1.21
174 INT59712 Positive_regulation of PSENEN 3 0.21 0.23 1.19
175 INT34704 Positive_regulation of Negative_regulation of Mme 6 0.47 0.17 1.17
176 INT39818 Positive_regulation of Cfd 8 0.45 3.36 1.15
177 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14
178 INT22353 Positive_regulation of Cps1 6 0.17 0.98 1.14
179 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12
180 INT11204 Regulation of Gene_expression of Prep 11 0.60 1.01 1.12
181 INT85941 Binding of MMP12 3 0.31 4.91 1.12
182 INT20317 Localization of Ctsb 3 0.81 0.68 1.12
183 INT59889 Regulation of Cfd 3 0.39 0.21 1.1
184 INT146891 Positive_regulation of Gene_expression of Cfd 2 0.39 0.75 1.1
185 INT25401 Negative_regulation of Gene_expression of Mme 2 0.43 0.08 1.1
186 INT209099 Binding of Cfd 14 0.15 3.75 1.08
187 INT17805 Regulation of Localization of ELANE 7 0.59 1.88 1.08
188 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
189 INT23636 Protein_catabolism of MMP12 3 0.84 0.58 1.05
190 INT190203 Negative_regulation of Positive_regulation of MMP12 1 0.36 1.5 1.02
191 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
192 INT7149 Phosphorylation of Mme 3 0.60 0.34 0.97
193 INT21842 Regulation of Protein_catabolism of Mme 1 0.19 0.58 0.97
194 INT77856 Binding of Cps1 6 0.30 2.32 0.95
195 INT23660 Negative_regulation of Fap 5 0.35 8.93 0.95
196 INT43648 Positive_regulation of Binding of Mme 3 0.50 0.24 0.94
197 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
198 INT88032 Negative_regulation of PCSK1 4 0.32 1.27 0.92
199 INT72944 Positive_regulation of PCSK1 3 0.49 0 0.89
200 INT32443 Negative_regulation of Binding of ELANE 2 0.11 0.54 0.89
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