GO:0004180

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Name carboxypeptidase activity
Categary Function
Go Slim No
Go Link GO:0004180
Unique Molecular Interactions 276
Total Molecular Interactions 390
Total Single Events 3245
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for carboxypeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for carboxypeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
2 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
3 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
4 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
5 INT231968 Binding of Cpn1 and Rvm 1 0.11 1.57 2.45
6 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
7 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
8 INT231971 Binding of Cpn1 and Shbdp1 1 0.04 1.39 2.26
9 INT231967 Binding of Psmd1 and Cpn1 1 0.06 1.39 2.25
10 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25
11 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
12 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
13 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
14 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
15 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
16 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
17 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
18 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
19 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
20 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
21 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
22 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
23 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
24 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
25 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
26 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
27 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
28 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
29 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
30 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
31 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
32 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
33 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
34 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
35 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
36 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
37 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
38 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
39 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
40 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1 0.02 1.29 0.9
41 INT59482 Cpe Positive_regulation of Rbm39 1 0.02 0 0.89
42 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
43 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
44 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
45 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
46 INT41864 Nts Regulation of Cpe 1 0.01 0 0.84
47 INT41867 GRP Regulation of Cpe 1 0.00 0 0.84
48 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
49 INT97056 Cpz Regulation of Gene_expression of Bcl2l1 1 0.22 0.57 0.83
50 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
51 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
52 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
53 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75
54 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
55 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73
56 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
57 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
58 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
59 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
60 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
61 INT2700 Binding of App and Cpe 1 0.00 0 0.63
62 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62
63 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
64 INT63525 Cpe Positive_regulation of Gpi1 1 0.03 0 0.59
65 INT1211 Binding of Kitl and Cpz 1 0.27 0 0.58
66 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
67 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
68 INT1210 Negative_regulation of Binding of Kitl and Cpz 1 0.33 0 0.58
69 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
70 INT84489 Cpe Negative_regulation of Binding of Mif-ps1 1 0.06 0 0.56
71 INT28925 Cpe Regulation of Sh2b3 1 0.04 0.14 0.55
72 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
73 INT130469 Tubgcp2 Negative_regulation of Naalad2 1 0.05 0.44 0.5
74 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
75 INT47225 Asap1 Regulation of Cpe 1 0.04 0.18 0.49
76 INT65007 DAK Negative_regulation of CTSA 1 0.03 0.35 0.48
77 INT323905 Positive_regulation of CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
78 INT323904 CNDP1 Positive_regulation of IL4 1 0.00 0.9 0.46
79 INT6280 Cpe Regulation of Gene_expression of Mc2r 1 0.09 0 0.46
80 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
81 INT323903 CNDP1 Positive_regulation of IL10 1 0.00 0.9 0.46
82 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
83 INT6279 Cpe Regulation of Gene_expression of Pomc 1 0.27 0 0.46
84 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
85 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
86 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
87 INT22524 Binding of CPB1 and CPA6 1 0.05 0 0.39
88 INT42847 Binding of Cpe and SLTM 1 0.00 0 0.38
89 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
90 INT80694 Cpe Negative_regulation of Positive_regulation of Fos 1 0.08 0 0.37
91 INT161004 Binding of Cpe and Cpb2 1 0.03 0.53 0.37
92 INT161006 Itgam Regulation of Cpb2 1 0.07 0.52 0.37
93 INT161003 Binding of Itgam and Cpb2 1 0.10 0.52 0.37
94 INT161000 Binding of Cpe and Gfap 1 0.05 0.53 0.37
95 INT161007 Gfap Regulation of Cpb2 1 0.04 0.52 0.37
96 INT160999 Binding of Gfap and Cpb2 1 0.14 0.52 0.37
97 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
98 INT270939 Gene_expression of Cpe Positive_regulation of Slc6a3 1 0.20 0 0.36
99 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
100 INT75941 Negative_regulation of Binding of Cpe and Frk 1 0.01 1.28 0.34
101 INT75946 Binding of Cpe and Frk 1 0.01 1.28 0.34
102 INT92444 Cpe Negative_regulation of Phosphorylation of Cd3eap 1 0.01 0 0.34
103 INT75942 Positive_regulation of Binding of Cpe and Frk 1 0.02 1.28 0.34
104 INT75949 Negative_regulation of Binding of Cpe and Ptafr 1 0.03 1.27 0.33
105 INT75953 Binding of Cpe and Ptafr 1 0.03 1.27 0.33
106 INT33581 Thop1 Positive_regulation of Cpe 1 0.01 0 0.33
107 INT75940 Positive_regulation of Binding of Cpe and Ptafr 1 0.04 1.27 0.33
108 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
109 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
110 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32
111 INT110462 Cpe Regulation of Phosphorylation of Gtf3a 1 0.00 0 0.32
112 INT138469 Cpb2 Negative_regulation of Gene_expression of Ryr2 1 0.04 0.25 0.32
113 INT239079 D0H4S114 Positive_regulation of Gene_expression of Cpa1 1 0.11 0.3 0.32
114 INT31276 Oxt Negative_regulation of Cpe 1 0.01 0 0.31
115 INT31275 Avp Negative_regulation of Cpe 1 0.00 0 0.31
116 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
117 INT31277 Penk Negative_regulation of Cpe 1 0.12 0 0.29
118 INT230745 Negative_regulation of Ace Negative_regulation of Icam1 1 0.05 1.22 0.29
119 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
120 INT270954 Gene_expression of Cpe Positive_regulation of Gene_expression of Slc6a3 1 0.23 0 0.28
121 INT231025 Cpb2 Positive_regulation of Gene_expression of Fos 1 0.20 0.19 0.27
122 INT33584 Enpep Positive_regulation of Cpe 1 0.03 0 0.27
123 INT231030 Cpb2 Regulation of Gene_expression of Fos 1 0.11 0.31 0.27
124 INT118928 Csf2 Regulation of Cpe 1 0.04 0.27 0.27
125 INT33583 Enpep Regulation of Positive_regulation of Cpe 1 0.03 0 0.27
126 INT220317 Binding of CPB1 and PLEKHM1 1 0.00 0.93 0.26
127 INT33582 Thop1 Regulation of Positive_regulation of Cpe 1 0.01 0 0.26
128 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25
129 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
130 INT270955 Cpe Regulation of Gene_expression of Slc6a3 1 0.14 0 0.25
131 INT270951 Regulation of Binding of Slc6a3 and Cpe 1 0.23 0 0.25
132 INT64726 Ace Negative_regulation of KNG1 1 0.01 0.26 0.25
133 INT64727 Ace Positive_regulation of KNG1 1 0.01 0.26 0.25
134 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24
135 INT239238 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.01 0.46 0.24
136 INT124078 Binding of Ace and Cpox 1 0.09 0.14 0.24
137 INT270940 Negative_regulation of Binding of Slc6a3 and Cpe 1 0.25 0 0.23
138 INT270948 Cpe Regulation of Regulation of Slc6a3 1 0.14 0.28 0.23
139 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22
140 INT200637 Binding of Abpa and Ace 1 0.01 4.62 0.22
141 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
142 INT115006 Binding of Serpine1 and Cpb2 1 0.09 1.53 0.2
143 INT74431 Negative_regulation of Cpe Positive_regulation of Localization of PENK 1 0.44 0 0.2
144 INT74439 Negative_regulation of Cpe Positive_regulation of INS 1 0.06 0 0.2
145 INT74436 Negative_regulation of Cpe Positive_regulation of CHGA 1 0.44 0 0.2
146 INT74434 Negative_regulation of Cpe Positive_regulation of PENK 1 0.44 0 0.2
147 INT270947 Cpe Negative_regulation of Phosphorylation of Slc6a3 1 0.25 0 0.2
148 INT338391 Thim Positive_regulation of Cpb2 1 0.08 0.37 0.19
149 INT88698 Binding of Max and Cpm 1 0.00 0.27 0.18
150 INT88702 Binding of CPM and Max 1 0.01 0.27 0.18
151 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
152 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17
153 INT265827 ACE Negative_regulation of ANGPT2 1 0.09 0.59 0.17
154 INT8164 Ace Positive_regulation of Gene_expression of Fos 1 0.24 0.32 0.16
155 INT258812 Sugt1 Positive_regulation of Ace 1 0.05 1.26 0.16
156 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
157 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15
158 INT307807 Ace Positive_regulation of ras 1 0.38 3 0.15
159 INT195770 Binding of CPB1 and MIF 1 0.01 0.47 0.15
160 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
161 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
162 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
163 INT256021 Ace Negative_regulation of Gene_expression of Agtrap 1 0.05 0.37 0.13
164 INT220318 Binding of CPB1 and CCL2 1 0.01 0.46 0.13
165 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12
166 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
167 INT221989 Cpn1 Positive_regulation of Localization of Ccl2 1 0.07 1.6 0.12
168 INT43095 Binding of Ace and Mme 1 0.26 0 0.12
169 INT345159 Binding of Cpa1 and Dmbx1 1 0.01 0 0.12
170 INT229364 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.02 0.86 0.11
171 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 0.02 1.18 0.1
172 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1
173 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09
174 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09
175 INT265829 ACE Positive_regulation of Protein_catabolism of KNG1 1 0.33 0.73 0.09
176 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09
177 INT302529 Hal Regulation of Cpz 1 0.26 0.43 0.08
178 INT26310 IL1B Positive_regulation of ACE2 1 0.18 0.46 0.07
179 INT307805 Ace Positive_regulation of Ang 1 0.32 1.52 0.07
180 INT102886 Binding of GBE1 and CTSA 1 0.00 0 0.07
181 INT302530 Cpz Regulation of Negative_regulation of Mbp 1 0.22 0.1 0.07
182 INT229539 Cpz Negative_regulation of Localization of Prnp 1 0.05 0.58 0.07
183 INT307806 Ace Positive_regulation of Agt 1 0.28 1.51 0.07
184 INT229538 Cpz Negative_regulation of Positive_regulation of Prnp 1 0.05 0.58 0.07
185 INT270983 Binding of Cpe and GSTK1 1 0.01 0.12 0.07
186 INT200634 Binding of Agtr2 and Ace2 1 0.00 0.91 0.06
187 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06
188 INT249958 Cpa1 Positive_regulation of NOS1 1 0.00 0.32 0.06
189 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
190 INT249955 Cpa1 Positive_regulation of Nos2 1 0.02 0.33 0.06
191 INT332269 Cndp2 Negative_regulation of Tenc1 1 0.41 0.8 0.05
192 INT200635 Binding of Ace and Spink1 1 0.37 1.4 0.05
193 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05
194 INT249954 Cpa1 Positive_regulation of Nos3 1 0.04 0.36 0.05
195 INT29521 Ace Positive_regulation of ACE 1 0.19 0 0.04
196 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04
197 INT249959 Cpa1 Regulation of NOS1 1 0.00 0.08 0.04
198 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04
199 INT221991 Cpn1 Regulation of Gene_expression of Crp 1 0.05 1.14 0.03
200 INT270956 Slc6a3 Positive_regulation of Cpe 1 0.29 0 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for carboxypeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in carboxypeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
2 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
3 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
4 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
5 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
6 INT5214 Localization of Cpe 49 0.73 13.3 44.36
7 INT2699 Binding of Cpe 40 0.48 7.07 33.64
8 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
9 INT1728 Negative_regulation of Cndp2 36 0.57 3.76 25.39
10 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
11 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
12 INT17938 Binding of Cpe 28 0.48 11.17 13.62
13 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
14 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
15 INT13287 Gene_expression of Cpb2 27 0.56 7.84 11.95
16 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
17 INT18334 Positive_regulation of Cpb2 24 0.69 2.98 11.22
18 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
19 INT119777 Negative_regulation of Naalad2 9 0.40 5.93 10.11
20 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47
21 INT20664 Binding of ACE 60 0.48 35.27 9.16
22 INT20425 Localization of Cpe 23 0.81 5.18 9.14
23 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
24 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
25 INT14033 Negative_regulation of Gene_expression of Cpe 10 0.33 3.47 8.2
26 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
27 INT25958 Regulation of Ace 26 0.59 11.88 7.87
28 INT9389 Regulation of Cpe 14 0.61 2.23 7.79
29 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
30 INT524 Positive_regulation of Cpa1 12 0.39 4.74 7.38
31 INT38466 Positive_regulation of Localization of Cpe 7 0.29 1.36 7.2
32 INT50990 Regulation of Cpb2 12 0.37 2.71 7.07
33 INT42038 Localization of ACE 26 0.80 8.88 7.06
34 INT62691 Transcription of Cpe 11 0.40 3.5 6.66
35 INT231964 Binding of Cpn1 1 0.25 5.28 6.63
36 INT16687 Regulation of Cndp2 6 0.44 0.23 6.11
37 INT141558 Positive_regulation of Naalad2 2 0.45 2.41 6.04
38 INT25822 Negative_regulation of Positive_regulation of Cpe 7 0.29 2.43 6.02
39 INT16688 Positive_regulation of Cndp2 11 0.49 1.12 5.86
40 INT20064 Regulation of Gene_expression of Cpe 9 0.47 2.05 5.16
41 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05
42 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34
43 INT26477 Regulation of ACE 26 0.45 16.31 4.33
44 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
45 INT387 Regulation of Ace 18 0.45 5.24 4.24
46 INT99059 Positive_regulation of Cpb1 16 0.45 3.12 4.09
47 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06
48 INT93339 Gene_expression of Naalad2 4 0.10 1.73 4.03
49 INT78737 Positive_regulation of Gene_expression of Cpb2 5 0.38 1.77 3.84
50 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
51 INT50380 Gene_expression of Cpm 7 0.73 4.43 3.38
52 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34
53 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24
54 INT93343 Gene_expression of Cpb2 10 0.58 4.63 3.24
55 INT45199 Protein_catabolism of Cndp2 7 0.86 0.31 3.15
56 INT54364 Negative_regulation of Protein_catabolism of Cpe 4 0.53 0.15 3.14
57 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08
58 INT138016 Regulation of Naalad2 3 0.43 1.28 2.96
59 INT21343 Regulation of Localization of Cpe 3 0.21 1.38 2.83
60 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
61 INT56382 Negative_regulation of Cpa1 5 0.34 2.06 2.73
62 INT141559 Localization of Naalad2 2 0.55 1.14 2.65
63 INT68444 Gene_expression of CPE 9 0.76 4.6 2.59
64 INT1488 Negative_regulation of Negative_regulation of Cpe 3 0.42 0.86 2.42
65 INT104041 Positive_regulation of Cpb2 7 0.59 2.88 2.39
66 INT5958 Positive_regulation of Positive_regulation of Cpe 3 0.38 0.58 2.39
67 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33
68 INT9386 Transcription of Cpe 7 0.72 0.53 2.31
69 INT111922 Binding of Cpb2 3 0.41 3.12 2.3
70 INT9354 Negative_regulation of Binding of Cpe 3 0.21 0.09 2.3
71 INT388 Positive_regulation of Gene_expression of Ace 4 0.42 1.04 2.13
72 INT39134 Positive_regulation of Ace2 3 0.14 0.57 2.13
73 INT39837 Positive_regulation of Cpn1 6 0.69 6.2 2.06
74 INT50896 Negative_regulation of Cpb2 6 0.37 0.6 2.01
75 INT14586 Gene_expression of Cpb1 23 0.58 6.18 1.99
76 INT45646 Protein_catabolism of Ace 5 0.98 3.14 1.95
77 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94
78 INT43084 Binding of Ace 10 0.46 4.7 1.93
79 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93
80 INT14182 Gene_expression of CPB1 26 0.67 10.06 1.9
81 INT39133 Binding of Ace2 3 0.30 0.8 1.89
82 INT55606 Binding of Ace 14 0.37 10.73 1.82
83 INT87315 Negative_regulation of Transcription of Cpe 3 0.13 1.76 1.81
84 INT64737 Regulation of Regulation of Cpe 1 0.05 0 1.8
85 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77
86 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73
87 INT91560 Positive_regulation of Negative_regulation of Cpe 2 0.40 0.62 1.67
88 INT165347 Localization of CPE 2 0.55 0.59 1.56
89 INT157067 Regulation of Regulation of Cpb2 2 0.22 1.29 1.39
90 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37
91 INT111755 Regulation of Positive_regulation of Cpe 1 0.03 0.27 1.37
92 INT41521 Binding of Cndp2 4 0.36 0.74 1.34
93 INT44145 Negative_regulation of Gene_expression of Ace 5 0.40 4.5 1.33
94 INT11207 Positive_regulation of Gene_expression of Cpe 3 0.46 0.17 1.33
95 INT32039 Positive_regulation of CPE 3 0.37 1.92 1.32
96 INT20424 Protein_catabolism of Cpe 3 0.52 0 1.28
97 INT231960 Regulation of Binding of Cpn1 1 0.21 0.75 1.25
98 INT122783 Regulation of Transcription of Cpe 2 0.20 0.21 1.21
99 INT127363 Binding of Cpb1 8 0.32 2.5 1.14
100 INT16669 Gene_expression of CNDP2 8 0.26 1.7 1.12
101 INT88948 Localization of Ace 9 0.69 9.18 1.11
102 INT264244 Gene_expression of Cpz 10 0.58 3.24 1.09
103 INT111923 Regulation of Cpb2 1 0.33 1.3 1.08
104 INT281919 Localization of ACE2 4 0.75 2.69 1.02
105 INT28784 Positive_regulation of Gene_expression of CNDP1 3 0.22 3.87 1
106 INT182516 Negative_regulation of Negative_regulation of ACE 9 0.42 6.84 0.99
107 INT107288 Positive_regulation of ACE2 4 0.66 5.48 0.99
108 INT119776 Positive_regulation of Negative_regulation of Naalad2 1 0.02 0.73 0.99
109 INT97054 Regulation of Cpz 2 0.37 1.07 0.97
110 INT3957 Gene_expression of CNDP1 6 0.52 3.7 0.96
111 INT12888 Positive_regulation of Protein_catabolism of Cpe 1 0.55 0.21 0.94
112 INT14185 Regulation of CPB1 9 0.35 5.88 0.93
113 INT39226 Positive_regulation of Negative_regulation of Cpe 2 0.45 0.17 0.93
114 INT335443 Negative_regulation of Cpm 1 0.17 1.3 0.92
115 INT41480 Positive_regulation of Binding of Cpe 1 0.15 0.42 0.92
116 INT239075 Negative_regulation of Positive_regulation of Cpa1 1 0.09 0.75 0.89
117 INT11028 Binding of CNDP2 6 0.24 3.47 0.87
118 INT242750 Positive_regulation of Positive_regulation of Naalad2 1 0.08 0.34 0.86
119 INT34811 Localization of Cpb1 3 0.65 0 0.84
120 INT160993 Negative_regulation of Cpb2 2 0.18 1.68 0.83
121 INT165383 Positive_regulation of Positive_regulation of Cpb1 1 0.15 0.66 0.83
122 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82
123 INT230803 Regulation of Negative_regulation of Ace 2 0.39 1.89 0.81
124 INT83577 Negative_regulation of Gene_expression of Cpb2 1 0.35 0 0.81
125 INT3958 Regulation of CNDP1 5 0.35 0.86 0.78
126 INT39835 Gene_expression of Cpn1 2 0.75 8.81 0.77
127 INT118669 Binding of Cpb2 4 0.31 0.97 0.76
128 INT171772 Binding of CPB1 13 0.32 9.92 0.75
129 INT342130 Negative_regulation of Localization of ACE2 1 0.01 1.16 0.74
130 INT242751 Negative_regulation of Localization of Naalad2 1 0.07 0.32 0.74
131 INT38830 Protein_catabolism of Cpb1 2 0.74 0.48 0.72
132 INT335440 Regulation of Cpm 1 0.18 1.02 0.72
133 INT259902 Regulation of Gene_expression of ACE 3 0.45 1.87 0.7
134 INT18794 Negative_regulation of Regulation of Cndp2 1 0.37 0 0.7
135 INT212265 Positive_regulation of Gene_expression of CPE 1 0.44 1.26 0.7
136 INT2384 Regulation of CTSA 4 0.44 2.22 0.69
137 INT135376 Negative_regulation of Regulation of Cpe 1 0.32 0.13 0.66
138 INT48903 Protein_catabolism of ACE2 1 0.08 1.13 0.66
139 INT335441 Positive_regulation of Cpm 1 0.20 0.91 0.65
140 INT157066 Regulation of Gene_expression of Cpb2 1 0.22 0.47 0.64
141 INT335442 Localization of Cpm 1 0.30 0.85 0.63
142 INT72446 Negative_regulation of Binding of ACE 4 0.42 2.48 0.62
143 INT56045 Positive_regulation of Localization of ACE 3 0.69 1.38 0.6
144 INT200636 Regulation of Gene_expression of Ace 1 0.26 1.64 0.6
145 INT23039 Positive_regulation of Transcription of Cpe 1 0.46 0.06 0.6
146 INT33926 Negative_regulation of Gene_expression of Cpe 2 0.31 0 0.59
147 INT37610 Negative_regulation of Positive_regulation of CNDP1 1 0.01 0.22 0.59
148 INT37609 Positive_regulation of Positive_regulation of CNDP1 1 0.01 0.22 0.59
149 INT69252 Positive_regulation of Transcription of Cpe 2 0.09 0 0.58
150 INT59012 Negative_regulation of Positive_regulation of Cpb2 1 0.37 0 0.58
151 INT215180 Positive_regulation of CNDP2 1 0.15 0.69 0.58
152 INT88700 Gene_expression of CPM 8 0.76 2.55 0.56
153 INT242749 Negative_regulation of Binding of Naalad2 1 0.07 0.34 0.56
154 INT242752 Binding of Naalad2 1 0.06 0.33 0.55
155 INT270969 Regulation of Gene_expression of Cpe 1 0.27 0 0.55
156 INT97860 Gene_expression of CTSA 8 0.43 2.22 0.54
157 INT14183 Negative_regulation of CPB1 5 0.41 3.53 0.53
158 INT45200 Positive_regulation of Protein_catabolism of Cndp2 1 0.40 0 0.53
159 INT22333 Regulation of Negative_regulation of Ace 3 0.45 0.72 0.52
160 INT189241 Localization of CNDP1 2 0.51 0.67 0.52
161 INT72790 Regulation of Gene_expression of Cpa1 1 0.22 0 0.52
162 INT36764 Localization of Ace 7 0.80 1.53 0.51
163 INT16133 Positive_regulation of Cpn1 1 0.28 0.09 0.49
164 INT43091 Positive_regulation of Negative_regulation of Ace 3 0.30 1.51 0.48
165 INT30936 Regulation of Protein_catabolism of Cpe 1 0.35 0.16 0.48
166 INT3907 Gene_expression of Ace2 5 0.54 2.35 0.46
167 INT23152 Regulation of Localization of Cpe 1 0.45 0.1 0.46
168 INT180739 Binding of ACE2 5 0.37 7.88 0.45
169 INT117796 Binding of CPM 5 0.48 2.79 0.45
170 INT22525 Localization of CPB1 3 0.61 0.98 0.45
171 INT49244 Localization of Cndp2 2 0.35 0.1 0.45
172 INT105987 Negative_regulation of Protein_catabolism of Cpe 1 0.04 0 0.45
173 INT171150 Negative_regulation of Binding of Ace 2 0.17 2.67 0.44
174 INT44032 Regulation of Positive_regulation of Ace 1 0.38 0.1 0.43
175 INT14186 Positive_regulation of Gene_expression of CPB1 2 0.39 3.46 0.42
176 INT39840 Negative_regulation of Cpn1 2 0.58 1.86 0.42
177 INT39839 Positive_regulation of Gene_expression of Cpn1 2 0.48 1.57 0.41
178 INT165384 Transcription of Cpb1 1 0.20 0.32 0.41
179 INT40182 Regulation of Binding of Cpe 1 0.01 0 0.41
180 INT165382 Positive_regulation of Transcription of Cpb1 1 0.15 0.32 0.41
181 INT94173 Positive_regulation of CTSA 3 0.53 3.22 0.4
182 INT18335 Positive_regulation of Positive_regulation of Cpb2 1 0.28 0 0.4
183 INT114063 Negative_regulation of Localization of Ace 1 0.29 0.31 0.39
184 INT60040 Negative_regulation of Negative_regulation of Ace 6 0.43 3.64 0.38
185 INT235276 Regulation of Cpa1 3 0.18 0.8 0.38
186 INT181635 Positive_regulation of Protein_catabolism of ACE 1 0.15 0.41 0.38
187 INT42846 Regulation of Binding of Cpe 1 0.01 0 0.38
188 INT77686 Transcription of Ace 2 0.65 2.65 0.37
189 INT229626 Negative_regulation of Localization of ACE 3 0.41 2 0.36
190 INT23153 Positive_regulation of Positive_regulation of Cpe 1 0.50 0 0.36
191 INT267844 Positive_regulation of Gene_expression of Ace 10 0.57 15.35 0.35
192 INT270972 Phosphorylation of Cpe 1 0.33 0 0.33
193 INT312038 Positive_regulation of Gene_expression of CTSA 1 0.04 0.72 0.32
194 INT312033 Transcription of CTSA 1 0.05 0.72 0.32
195 INT39836 Regulation of Cpn1 1 0.27 0.55 0.32
196 INT59998 Regulation of CNDP2 2 0.21 0.05 0.31
197 INT33578 Regulation of Negative_regulation of Cpe 1 0.04 0 0.3
198 INT264243 Binding of Cpz 4 0.32 1.26 0.29
199 INT96863 Transcription of ACE 3 0.69 0.38 0.29
200 INT230864 Regulation of Binding of ACE 1 0.22 0.79 0.29
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