GO:0004190

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Name aspartic-type endopeptidase activity
Categary Function
Go Slim No
Go Link GO:0004190
Unique Molecular Interactions 361
Total Molecular Interactions 457
Total Single Events 9336
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for aspartic-type endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for aspartic-type endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
2 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
3 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
4 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
5 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
6 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
7 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
8 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
9 INT82867 Cck Regulation of Localization of Pgc 1 0.05 0 1.83
10 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
11 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
12 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
13 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 0.21 0 1.43
14 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
15 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
16 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
17 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
18 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
19 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
20 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
21 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
22 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
23 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
24 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
25 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
26 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
27 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
28 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
29 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
30 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
31 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
32 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
33 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
34 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
35 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
36 INT159995 Prkcg Regulation of Gene_expression of Bace1 1 0.39 0.32 0.91
37 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
38 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
39 INT218062 Abat Negative_regulation of Ctse 1 0.03 0.25 0.89
40 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
41 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
42 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
43 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
44 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
45 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
46 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
47 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
48 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
49 INT355815 BACE1 Regulation of Positive_regulation of NAV1 1 0.32 0.26 0.72
50 INT355814 BACE1 Regulation of Gene_expression of NAV1 1 0.37 0.24 0.72
51 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
52 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
53 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
54 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
55 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
56 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
57 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
58 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
59 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
60 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
61 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
62 INT156557 TRPV6 Positive_regulation of BACE2 1 0.00 0.23 0.58
63 INT156558 TRPV6 Negative_regulation of BACE2 1 0.00 0.23 0.58
64 INT82868 Cck Regulation of Pgc 1 0.05 0 0.55
65 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
66 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
67 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
68 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
69 INT17610 Binding of Ctse and Trh 1 0.27 0.89 0.49
70 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
71 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
72 INT39142 ras Positive_regulation of REN 1 0.01 1.34 0.45
73 INT355817 BACE1 Regulation of NAV1 1 0.37 0.7 0.45
74 INT39143 ras Positive_regulation of Gene_expression of REN 1 0.01 1.35 0.45
75 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
76 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
77 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
78 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
79 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
80 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37
81 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
82 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
83 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
84 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
85 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
86 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
87 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
88 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
89 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
90 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
91 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
92 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
93 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
94 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29
95 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29
96 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
97 INT141545 Binding of Bace1 and Rtn4 1 0.00 0.45 0.27
98 INT141552 Binding of RTN3 and Bace1 1 0.00 0.45 0.27
99 INT141546 Binding of Bace1 and Rtn4r 1 0.00 0.46 0.27
100 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
101 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
102 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
103 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
104 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
105 INT51045 Adarb1 Regulation of Localization of Pgc 1 0.01 0 0.25
106 INT149713 Binding of Casp3 and Fas 1 0.40 1.09 0.25
107 INT13538 ASPRV1 Negative_regulation of Gene_expression of LTA 1 0.46 0.56 0.25
108 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
109 INT14642 PENK Positive_regulation of REN 1 0.72 0.19 0.23
110 INT14643 PENK Positive_regulation of Positive_regulation of REN 1 0.48 0.19 0.23
111 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
112 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
113 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
114 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
115 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
116 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
117 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
118 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
119 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
120 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
121 INT139848 Binding of Bace1 and Bace2 2 0.28 0.31 0.18
122 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
123 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
124 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
125 INT34717 Positive_regulation of Vip Positive_regulation of Localization of Ren 1 0.46 0 0.17
126 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
127 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
128 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
129 INT347071 Negative_regulation of REN Negative_regulation of Positive_regulation of AGT 1 0.35 0.44 0.14
130 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
131 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
132 INT37560 Pgc Positive_regulation of F9 1 0.03 0.45 0.14
133 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
134 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
135 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
136 INT275389 Binding of Casp3 and Htatsf1 1 0.00 0.64 0.13
137 INT177714 Binding of GALNT3 and REN 1 0.01 2.36 0.12
138 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
139 INT345289 CRS Regulation of REN 1 0.03 1.02 0.12
140 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
141 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
142 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12
143 INT315391 IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
144 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
145 INT315390 Positive_regulation of IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
146 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11
147 INT316372 Positive_regulation of Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
148 INT316374 Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
149 INT234062 Nes Positive_regulation of Casp3 1 0.18 0.08 0.11
150 INT316377 Gopc Positive_regulation of Positive_regulation of Ren1 1 0.06 0.13 0.11
151 INT139851 Binding of MBTPS1 and Bace2 1 0.00 0.16 0.1
152 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
153 INT285023 Casp3 Negative_regulation of Casp7 1 0.07 0.44 0.1
154 INT2194 HIST2H2BD Regulation of REN 1 0.00 0.07 0.09
155 INT262702 Bace1 Positive_regulation of Aplp2 1 0.14 0.25 0.09
156 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09
157 INT88137 Ren Regulation of Gene_expression of Spp1 1 0.04 0.24 0.09
158 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09
159 INT262704 Bace1 Positive_regulation of Aplp1 1 0.15 0.25 0.09
160 INT311811 Binding of REN and RASGRP1 1 0.16 0.68 0.08
161 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
162 INT354753 Ren Regulation of Agt 1 0.14 0.98 0.08
163 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
164 INT254640 CGA Positive_regulation of REN 1 0.07 1.51 0.08
165 INT354754 Regulation of Ren Regulation of Agt 1 0.14 0.98 0.08
166 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
167 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
168 INT220629 Gene_expression of Bace1 Positive_regulation of Localization of Il1r2 1 0.17 0.19 0.07
169 INT203849 Ass1 Positive_regulation of Casp3 1 0.00 0.71 0.07
170 INT220638 Gene_expression of Bace2 Positive_regulation of Localization of Il1r2 1 0.13 0.19 0.07
171 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
172 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
173 INT175966 Kctd1 Negative_regulation of Positive_regulation of CASP3 1 0.09 0.82 0.06
174 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
175 INT302129 BAX Regulation of Positive_regulation of CASP3 1 0.02 0.69 0.06
176 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
177 INT211347 Binding of Sigmar1 and Positive_regulation of Casp3 1 0.12 0.92 0.06
178 INT344963 Phc1 Regulation of REN 1 0.15 0.66 0.06
179 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05
180 INT316371 Ang Negative_regulation of Ren1 1 0.16 0.64 0.05
181 INT228610 Binding of DNMT3B and ASPRV1 1 0.02 0 0.05
182 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
183 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
184 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
185 INT242411 Mch Positive_regulation of Casp3 1 0.09 0.15 0.04
186 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04
187 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04
188 INT242413 Regulation of Mch Positive_regulation of Casp3 1 0.05 0.16 0.04
189 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04
190 INT267217 Gene_expression of Hspb8 Negative_regulation of Positive_regulation of Casp3 1 0.14 2.8 0.04
191 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
192 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04
193 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
194 INT230816 Binding of ras and Ren1 1 0.11 0.77 0.04
195 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03
196 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
197 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
198 INT175946 RSF1 Positive_regulation of Positive_regulation of CASP3 1 0.01 0.41 0.03
199 INT172897 Negative_regulation of Lox Positive_regulation of Positive_regulation of Casp3 1 0.04 1.19 0.03
200 INT172910 Lox Positive_regulation of Positive_regulation of Casp3 1 0.03 1.19 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for aspartic-type endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in aspartic-type endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT46 Localization of Ren 233 0.81 46.15 62.44
5 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
6 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
7 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
8 INT654 Localization of REN 250 0.81 75.12 47.86
9 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
10 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
11 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
12 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
13 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
14 INT1116 Regulation of Ren 103 0.62 27.66 33.26
15 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
16 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
17 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
18 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
19 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
20 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
21 INT2140 Regulation of REN 104 0.62 28.24 24.49
22 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
23 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
24 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
25 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
26 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
27 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
28 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
29 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
30 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
31 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79
32 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
33 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
34 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
35 INT661 Gene_expression of REN 100 0.78 48.21 11.36
36 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
37 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
38 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
39 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
40 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
41 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
42 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
43 INT98178 Localization of Casp3 32 0.65 21.01 7.77
44 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44
45 INT18463 Localization of Pgc 31 0.78 3.74 7.3
46 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02
47 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
48 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
49 INT73642 Positive_regulation of Ctse 12 0.44 5.57 6.79
50 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
51 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
52 INT57232 Binding of Casp3 22 0.36 9.42 6.2
53 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
54 INT107070 Gene_expression of BACE1 11 0.68 8.63 6.16
55 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
56 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
57 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
58 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
59 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
60 INT20676 Gene_expression of Ctse 16 0.77 10.59 4.68
61 INT3097 Binding of Ren 12 0.48 3.15 4.4
62 INT137795 Positive_regulation of BACE1 3 0.68 4.74 4.31
63 INT111066 Regulation of Bace1 40 0.61 31.47 4.28
64 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
65 INT220594 Localization of Bace1 48 0.79 20.22 4.16
66 INT18461 Positive_regulation of Localization of Pgc 17 0.65 4.41 3.99
67 INT126197 Transcription of Bace1 13 0.72 7.34 3.87
68 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
69 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
70 INT103489 Positive_regulation of Bace2 5 0.03 3.3 3.47
71 INT115232 Negative_regulation of Ctse 2 0.36 1.29 3.37
72 INT217389 Negative_regulation of Gene_expression of Bace1 43 0.59 18.57 3.27
73 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27
74 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
75 INT18462 Positive_regulation of Pgc 29 0.57 22.55 3.24
76 INT76838 Binding of Asprv1 7 0.36 1.42 3.13
77 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
78 INT625 Localization of PGC 35 0.80 11.33 3.05
79 INT156488 Binding of Bace1 46 0.48 15.64 3.04
80 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
81 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
82 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
83 INT133674 Gene_expression of Bace1 3 0.61 1.11 2.78
84 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
85 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
86 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
87 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
88 INT163544 Binding of Psen1 40 0.36 15.28 2.42
89 INT111072 Protein_catabolism of Bace1 26 0.98 14.07 2.41
90 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
91 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
92 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
93 INT31118 Localization of Casp3 17 0.73 11.55 2.3
94 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
95 INT107068 Negative_regulation of BACE1 5 0.42 1.81 2.2
96 INT3533 Binding of REN 24 0.37 10.84 2.16
97 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
98 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
99 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11
100 INT20098 Positive_regulation of PGC 11 0.64 4.78 2.07
101 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
102 INT60723 Localization of Psen2 5 0.68 2.11 2.02
103 INT137797 Positive_regulation of Gene_expression of BACE1 2 0.59 2.15 1.99
104 INT51038 Regulation of Localization of Pgc 5 0.58 0 1.94
105 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
106 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9
107 INT187789 Positive_regulation of Positive_regulation of Bace1 18 0.50 16.18 1.87
108 INT113215 Negative_regulation of Asprv1 1 0.00 0 1.83
109 INT37754 Negative_regulation of Pgc 4 0.48 1.54 1.82
110 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
111 INT217382 Regulation of Gene_expression of Bace1 26 0.61 17 1.76
112 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
113 INT3084 Negative_regulation of Negative_regulation of REN 6 0.42 2.2 1.68
114 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
115 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
116 INT44164 Localization of Ren1 18 0.49 10.53 1.49
117 INT139982 Positive_regulation of BACE2 6 0.42 4.33 1.48
118 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
119 INT114203 Positive_regulation of Bace2 6 0.52 4.89 1.46
120 INT35654 Gene_expression of Pgc 6 0.65 7.97 1.44
121 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
122 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43
123 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
124 INT220578 Gene_expression of Bace2 12 0.60 4.32 1.36
125 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
126 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
127 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
128 INT629 Negative_regulation of Localization of PGC 8 0.45 5.79 1.33
129 INT133672 Regulation of Bace1 2 0.25 0.56 1.33
130 INT156564 Negative_regulation of Gene_expression of BACE1 2 0.36 0.36 1.32
131 INT126198 Negative_regulation of Transcription of Bace1 3 0.43 1.95 1.27
132 INT31804 Positive_regulation of Asprv1 5 0.40 1.92 1.26
133 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
134 INT32704 Negative_regulation of PGC 11 0.54 5.75 1.23
135 INT105122 Regulation of Ctse 4 0.27 0.57 1.23
136 INT59711 Negative_regulation of Positive_regulation of PSENEN 1 0.17 0.07 1.21
137 INT59712 Positive_regulation of PSENEN 3 0.21 0.23 1.19
138 INT142957 Binding of BACE1 3 0.37 0.83 1.17
139 INT107071 Localization of BACE1 3 0.64 0.19 1.16
140 INT136005 Positive_regulation of Gene_expression of Ctse 1 0.47 0.07 1.07
141 INT102845 Localization of CASP3 7 0.81 2.81 1.06
142 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
143 INT156891 Positive_regulation of Transcription of Ctse 1 0.28 0 1.03
144 INT25172 Positive_regulation of Localization of PGC 9 0.68 3.01 1.02
145 INT156890 Transcription of Ctse 1 0.39 0 1.02
146 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
147 INT91767 Gene_expression of BACE2 5 0.69 2.48 0.96
148 INT31117 Binding of Casp3 14 0.23 5.27 0.93
149 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
150 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91
151 INT23756 Regulation of Negative_regulation of REN 5 0.44 0.77 0.87
152 INT29981 Binding of PSENEN 2 0.17 0.24 0.86
153 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
154 INT44300 Negative_regulation of Regulation of Ren 1 0.42 0.1 0.84
155 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
156 INT99723 Binding of Ren1 7 0.27 3.98 0.82
157 INT133673 Transcription of Bace1 1 0.53 0.52 0.82
158 INT114086 Regulation of Bace2 1 0.02 0.94 0.82
159 INT133671 Positive_regulation of Bace1 1 0.46 0.53 0.82
160 INT40053 Positive_regulation of Positive_regulation of Ren1 4 0.54 4.41 0.81
161 INT220600 Regulation of Transcription of Bace1 2 0.42 0.95 0.81
162 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
163 INT220615 Positive_regulation of Negative_regulation of Bace1 2 0.49 1.65 0.79
164 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
165 INT111071 Positive_regulation of Protein_catabolism of Bace1 6 0.50 2.52 0.77
166 INT58215 Regulation of Asprv1 2 0.40 0.41 0.77
167 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
168 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
169 INT220614 Regulation of Positive_regulation of Bace1 5 0.45 5.32 0.76
170 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
171 INT5312 Regulation of Gene_expression of REN 4 0.41 0.73 0.76
172 INT8146 Gene_expression of PSENEN 2 0.14 0.89 0.75
173 INT355827 Protein_catabolism of BACE1 1 0.76 0.24 0.74
174 INT78649 Binding of Psen2 7 0.36 5.9 0.73
175 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
176 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
177 INT99822 Negative_regulation of Gene_expression of BACE2 1 0.01 0.59 0.7
178 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
179 INT220580 Regulation of Localization of Bace1 6 0.61 3.12 0.66
180 INT285006 Positive_regulation of Casp7 4 0.25 4.11 0.66
181 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
182 INT2592 Positive_regulation of Negative_regulation of REN 3 0.24 0.34 0.64
183 INT355820 Positive_regulation of Positive_regulation of BACE1 1 0.49 0.26 0.64
184 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
185 INT355826 Positive_regulation of Localization of BACE1 1 0.43 0 0.62
186 INT3552 Regulation of Gene_expression of Ren 3 0.41 1.39 0.6
187 INT94734 Negative_regulation of Binding of Asprv1 1 0.17 0 0.6
188 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
189 INT64454 Positive_regulation of Ctsd 2 0.44 1.14 0.57
190 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
191 INT161505 Negative_regulation of Bace2 2 0.01 1.93 0.55
192 INT156568 Regulation of Positive_regulation of Bace2 1 0.00 0.22 0.55
193 INT156567 Negative_regulation of Gene_expression of Bace1 1 0.32 0.22 0.54
194 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
195 INT167612 Binding of Bace2 1 0.17 0.86 0.51
196 INT237410 Positive_regulation of Transcription of Bace1 3 0.69 1.53 0.5
197 INT218059 Localization of Ctse 1 0.49 0.22 0.5
198 INT167609 Localization of Bace2 1 0.34 0.85 0.5
199 INT35653 Regulation of Pgc 1 0.03 1.06 0.49
200 INT39246 Gene_expression of PGC 6 0.62 2.5 0.48
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