GO:0004197

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Name cysteine-type endopeptidase activity
Categary Function
Go Slim No
Go Link GO:0004197
Unique Molecular Interactions 549
Total Molecular Interactions 677
Total Single Events 7887
Pain Genes Associated 38

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cysteine-type endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for cysteine-type endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
2 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
3 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
4 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
5 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
6 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
7 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
8 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
9 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
10 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
11 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
12 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
13 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
14 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
15 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
16 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
17 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
18 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
19 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
20 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
21 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
22 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
23 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
24 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
25 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
26 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
27 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
28 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14
29 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
30 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
31 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
32 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
33 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
34 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
35 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
36 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
37 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
38 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
39 INT90385 EXTL3 Regulation of Ctsl 1 0.00 1.1 0.98
40 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
41 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96
42 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
43 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96
44 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
45 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
46 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
47 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
48 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
49 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
50 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83
51 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
52 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
53 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
54 INT296829 USE1 Regulation of CASP4 1 0.01 0.17 0.81
55 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8
56 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8
57 INT91655 SLC8A1 Negative_regulation of CASP1 1 0.02 0.43 0.75
58 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
59 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
60 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
61 INT278812 PYCARD Positive_regulation of VTA1 1 0.09 0.11 0.71
62 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
63 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
64 INT70161 Casp1 Regulation of Oprd1 1 0.03 0 0.65
65 INT70162 Casp1 Regulation of Penk 1 0.03 0 0.64
66 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
67 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
68 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
69 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
70 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
71 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
72 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
73 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
74 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
75 INT66766 Casp1 Positive_regulation of Transcription of Pla2g10 1 0.06 0.19 0.6
76 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
77 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
78 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
79 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
80 INT128604 Casp1 Positive_regulation of Gene_expression of Fos 1 0.10 0.55 0.59
81 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
82 INT350716 Binding of CD58 and Casp8 1 0.03 1.81 0.58
83 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55
84 INT297311 Casp1 Positive_regulation of Il18 1 0.09 1.02 0.55
85 INT76200 CASP1 Positive_regulation of Gene_expression of PTGS1 1 0.05 0.16 0.54
86 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
87 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
88 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
89 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
90 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
91 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
92 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
93 INT150391 Binding of MEFV and PYCARD 4 0.14 3 0.48
94 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
95 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
96 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
97 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
98 INT338086 PYCARD Positive_regulation of TCEA1 1 0.10 0 0.47
99 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
100 INT338083 Binding of LEFTY1 and PYCARD 1 0.02 0 0.46
101 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46
102 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
103 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45
104 INT155086 CASP1 Negative_regulation of DAXX 1 0.21 1.26 0.45
105 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
106 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
107 INT112800 CASP1 Positive_regulation of Gene_expression of CCL2 1 0.04 0.48 0.43
108 INT90079 Ass1 Positive_regulation of Casp1 1 0.02 0.99 0.43
109 INT296831 Binding of CASP4 and USE1 1 0.01 0 0.43
110 INT228323 PYCARD Positive_regulation of FIG4 1 0.17 0 0.42
111 INT244421 Binding of DST and Ctss 1 0.02 0.42 0.41
112 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
113 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
114 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
115 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41
116 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
117 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
118 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
119 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
120 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
121 INT338085 Binding of PYCARD and GOPC 1 0.05 0 0.39
122 INT91656 SLC8A1 Negative_regulation of Positive_regulation of CASP1 1 0.01 0.2 0.38
123 INT278813 Binding of NOVA2 and PYCARD 1 0.13 0 0.38
124 INT91652 Negative_regulation of SLC8A1 Negative_regulation of CASP1 1 0.02 0.21 0.37
125 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
126 INT296826 USE1 Regulation of Gene_expression of CASP4 1 0.02 0.17 0.37
127 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
128 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36
129 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
130 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32
131 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32
132 INT289178 Regulation of PYCARD Regulation of MFGE8 1 0.05 0 0.32
133 INT28688 Binding of Kng1 and Ctsl1 1 0.15 0 0.31
134 INT289175 PYCARD Regulation of behavior 1 0.03 0 0.31
135 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
136 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31
137 INT112797 Positive_regulation of CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.3
138 INT219151 IL18 Positive_regulation of CASP1 1 0.01 1.05 0.3
139 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
140 INT289179 PYCARD Regulation of TW 1 0.02 0 0.3
141 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
142 INT112799 Positive_regulation of CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.3
143 INT50107 Ei24 Positive_regulation of Localization of CTSB 3 0.00 0.6 0.29
144 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
145 INT112805 CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.29
146 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
147 INT116595 CASP1 Positive_regulation of IL6 1 0.07 0.46 0.28
148 INT116591 CASP1 Positive_regulation of PTGER2 1 0.01 0.46 0.28
149 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28
150 INT180246 Binding of Tbca and Uchl1 1 0.00 0.47 0.27
151 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27
152 INT181998 TNFRSF11B Negative_regulation of Gene_expression of CTSK 1 0.07 1.98 0.27
153 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
154 INT322021 Negative_regulation of CASP1 Positive_regulation of IL1B 1 0.04 0.13 0.26
155 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
156 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
157 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
158 INT149713 Binding of Casp3 and Fas 1 0.40 1.09 0.25
159 INT159991 Ctsk Positive_regulation of POMC 1 0.01 0.35 0.25
160 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
161 INT296464 Binding of Cacng2 and Tinagl1 1 0.06 0.25 0.23
162 INT296449 Binding of Gria1 and Tinagl1 1 0.08 0.25 0.23
163 INT112794 CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.23
164 INT69042 Negative_regulation of Casp1 Negative_regulation of Positive_regulation of IL1B 1 0.21 0.17 0.22
165 INT69041 Casp1 Negative_regulation of Gene_expression of IL1B 1 0.21 0.17 0.22
166 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
167 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
168 INT329530 Malt1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.48 0.22
169 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
170 INT69040 Casp1 Negative_regulation of Gene_expression of IFNA1 1 0.07 0.17 0.22
171 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
172 INT274584 Binding of PSTPIP1 and PYCARD 1 0.13 1.34 0.22
173 INT69039 Negative_regulation of Casp1 Negative_regulation of Gene_expression of IFNA1 1 0.07 0.17 0.22
174 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22
175 INT289174 PYCARD Positive_regulation of MFGE8 1 0.05 0 0.21
176 INT112798 CASP1 Positive_regulation of CCL2 1 0.02 0.19 0.21
177 INT258456 PYCARD Negative_regulation of Localization of Tms 1 0.02 0.05 0.21
178 INT258455 Tms Negative_regulation of Localization of PYCARD 1 0.02 0.05 0.21
179 INT349668 Binding of HRH1 and PYCARD 1 0.00 0.37 0.21
180 INT91654 Negative_regulation of CASP1 Negative_regulation of IL1B 1 0.46 0.15 0.2
181 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
182 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
183 INT91653 Negative_regulation of CASP1 Negative_regulation of IL18 1 0.39 0.15 0.2
184 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
185 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
186 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
187 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
188 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19
189 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
190 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
191 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
192 INT289176 PYCARD Regulation of Localization of MFGE8 1 0.05 0 0.18
193 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18
194 INT289177 PYCARD Regulation of Gene_expression of TW 1 0.03 0 0.18
195 INT69038 Casp1 Regulation of Gene_expression of IFNA1 1 0.07 0.16 0.18
196 INT349539 Smcp Positive_regulation of Positive_regulation of Casp8 1 0.04 0.68 0.18
197 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
198 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
199 INT10291 Trh Regulation of CTSC 1 0.01 0 0.16
200 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15

Single Events

The table below shows the top 100 pain related interactions that have been reported for cysteine-type endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in cysteine-type endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
5 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
6 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
7 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
8 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
9 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
10 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
11 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
12 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
13 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
14 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
15 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
16 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
17 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
18 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
19 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
20 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
21 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
22 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
23 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
24 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
25 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
26 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
27 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37
28 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
29 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
30 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
31 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
32 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
33 INT97516 Binding of PYCARD 46 0.36 7.06 7.85
34 INT98178 Localization of Casp3 32 0.65 21.01 7.77
35 INT7168 Positive_regulation of Ctsb 9 0.70 0.3 7.58
36 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
37 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42
38 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28
39 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
40 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
41 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76
42 INT16344 Gene_expression of CASP4 11 0.74 4.64 6.75
43 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
44 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
45 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36
46 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26
47 INT57232 Binding of Casp3 22 0.36 9.42 6.2
48 INT181017 Gene_expression of Ctss 6 0.65 9.82 6.19
49 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17
50 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
51 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84
52 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69
53 INT18832 Positive_regulation of CASP4 11 0.44 7.12 5.68
54 INT166765 Localization of PYCARD 21 0.70 3.89 5.66
55 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
56 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
57 INT50105 Localization of CTSB 29 0.78 10.98 5.21
58 INT7170 Positive_regulation of Positive_regulation of Ctsb 1 0.40 0 4.76
59 INT26787 Localization of Uchl1 10 0.60 5.9 4.48
60 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44
61 INT47298 Localization of Ctsl 13 0.79 3.77 4.08
62 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78
63 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
64 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
65 INT20265 Gene_expression of Ctsb 3 0.47 1.01 3.52
66 INT36115 Transcription of Uchl1 7 0.60 3.24 3.25
67 INT143297 Negative_regulation of CASP4 2 0.31 1.74 3.19
68 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11
69 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
70 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9
71 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
72 INT110980 Gene_expression of CTSB 17 0.45 8.02 2.69
73 INT107433 Localization of Casp1 6 0.56 2.44 2.64
74 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
75 INT156876 Positive_regulation of Gene_expression of Casp1 10 0.50 10.25 2.58
76 INT73028 Positive_regulation of Transcription of Ctsb 1 0.55 1.53 2.54
77 INT59135 Positive_regulation of CTSB 15 0.67 7.53 2.53
78 INT53505 Regulation of CASP4 3 0.33 1.33 2.53
79 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
80 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44
81 INT37427 Positive_regulation of Gene_expression of Ctsb 2 0.37 1.02 2.33
82 INT31118 Localization of Casp3 17 0.73 11.55 2.3
83 INT7173 Regulation of Positive_regulation of Ctsb 1 0.49 0 2.29
84 INT159989 Positive_regulation of Ctsk 17 0.69 10.51 2.25
85 INT224620 Positive_regulation of Gene_expression of Ctsk 13 0.68 8.35 2.21
86 INT109970 Negative_regulation of Casp8 5 0.52 9.34 2.19
87 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
88 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14
89 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13
90 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
91 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1
92 INT146660 Negative_regulation of Ctsk 9 0.43 6.01 2.07
93 INT151983 Negative_regulation of CFLAR 13 0.57 13.51 2.05
94 INT47303 Regulation of Ctsl 10 0.56 2.64 2.04
95 INT151467 Localization of CASP9 9 0.73 7.62 2.04
96 INT18835 Localization of CASP4 1 0.04 0.15 2.02
97 INT58208 Negative_regulation of Ctsl 8 0.53 3.49 1.91
98 INT153775 Positive_regulation of CTSK 9 0.52 5.44 1.9
99 INT71173 Negative_regulation of Gene_expression of CASP1 5 0.36 3.17 1.84
100 INT101148 Gene_expression of UCHL1 20 0.70 9.61 1.8
101 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8
102 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79
103 INT47302 Regulation of Gene_expression of Ctsl 2 0.53 0.54 1.77
104 INT50106 Positive_regulation of Localization of CTSB 9 0.33 3.15 1.69
105 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69
106 INT73027 Transcription of Ctsb 1 0.56 1.01 1.68
107 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
108 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
109 INT214123 Negative_regulation of Gene_expression of Uchl1 3 0.06 4.52 1.52
110 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
111 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
112 INT95338 Positive_regulation of Positive_regulation of CASP1 9 0.49 4.61 1.43
113 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4
114 INT42335 Binding of CTSB 11 0.34 5.98 1.37
115 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
116 INT69034 Regulation of Casp1 3 0.27 3.56 1.36
117 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
118 INT181055 Positive_regulation of Ctss 5 0.67 2.84 1.35
119 INT26786 Positive_regulation of Uchl1 7 0.34 1.37 1.32
120 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
121 INT96073 Localization of Casp1 11 0.78 4.91 1.29
122 INT73590 Positive_regulation of Positive_regulation of Casp1 2 0.19 1.94 1.28
123 INT228328 Positive_regulation of Gene_expression of PYCARD 7 0.34 0.27 1.23
124 INT267652 Negative_regulation of Gene_expression of PYCARD 6 0.37 2.35 1.22
125 INT244415 Regulation of Ctss 1 0.26 1.57 1.17
126 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15
127 INT153928 Regulation of Cts8 2 0.33 0.35 1.14
128 INT7817 Binding of CASP1 7 0.19 1.26 1.13
129 INT122485 Negative_regulation of CASP9 18 0.46 15.78 1.12
130 INT47305 Positive_regulation of Gene_expression of Ctsl 5 0.59 2.06 1.12
131 INT20317 Localization of Ctsb 3 0.81 0.68 1.12
132 INT59136 Negative_regulation of Positive_regulation of CTSB 3 0.41 2.02 1.11
133 INT128496 Regulation of CASP1 5 0.38 3.4 1.09
134 INT182005 Positive_regulation of Gene_expression of CTSK 7 0.52 4.01 1.08
135 INT16345 Regulation of Gene_expression of CASP4 3 0.26 0.42 1.08
136 INT102845 Localization of CASP3 7 0.81 2.81 1.06
137 INT18829 Positive_regulation of Localization of CASP4 1 0.02 0.07 1.06
138 INT91658 Localization of CASP1 5 0.77 0.89 1.04
139 INT267750 Binding of Casp1 4 0.35 1.53 1.02
140 INT307280 Regulation of Gene_expression of PYCARD 2 0.39 0.27 1.02
141 INT114379 Negative_regulation of Gene_expression of CFLAR 7 0.57 7.31 0.97
142 INT129878 Positive_regulation of CTSS 6 0.70 7.86 0.97
143 INT209423 Negative_regulation of Gene_expression of Ctsk 4 0.41 2.4 0.96
144 INT18831 Negative_regulation of Localization of CASP4 1 0.02 0.07 0.96
145 INT16346 Negative_regulation of Gene_expression of CASP4 1 0.56 0.15 0.95
146 INT6534 Negative_regulation of Ctsl1 3 0.54 0.11 0.94
147 INT35192 Binding of CASP4 2 0.27 0.09 0.94
148 INT31117 Binding of Casp3 14 0.23 5.27 0.93
149 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
150 INT142495 Regulation of LGMN 2 0.14 0.13 0.91
151 INT116197 Positive_regulation of Gene_expression of CFLAR 6 0.67 7.11 0.9
152 INT155093 Positive_regulation of CFLAR 6 0.67 5.02 0.88
153 INT115238 Positive_regulation of Gene_expression of Casp1 5 0.68 1.78 0.88
154 INT96074 Negative_regulation of Gene_expression of Casp1 4 0.57 2.77 0.87
155 INT7175 Negative_regulation of Positive_regulation of Ctsb 1 0.34 0 0.86
156 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
157 INT123124 Positive_regulation of Gene_expression of Uchl1 1 0.49 0.54 0.84
158 INT101149 Positive_regulation of Gene_expression of UCHL1 1 0.02 1.22 0.84
159 INT123125 Positive_regulation of Positive_regulation of Uchl1 1 0.49 0.54 0.84
160 INT101146 Positive_regulation of Transcription of Uchl1 1 0.13 1.22 0.84
161 INT101145 Transcription of Uchl1 1 0.18 1.17 0.82
162 INT129877 Gene_expression of CTSS 4 0.75 4.65 0.81
163 INT228326 Positive_regulation of Localization of PYCARD 3 0.41 0 0.8
164 INT159728 Localization of Uchl1 2 0.73 0.54 0.8
165 INT120046 Negative_regulation of Localization of Ctsl 2 0.40 0.31 0.8
166 INT162466 Positive_regulation of Gene_expression of CASP4 1 0.24 1.24 0.8
167 INT205685 Regulation of Positive_regulation of Casp1 3 0.11 1.62 0.78
168 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
169 INT237965 Protein_catabolism of CFLAR 1 0.23 2.3 0.76
170 INT181040 Positive_regulation of Gene_expression of Ctss 2 0.45 1.51 0.75
171 INT159988 Localization of Ctsk 5 0.70 2.9 0.74
172 INT182049 Protein_catabolism of Casp1 3 0.20 1.64 0.73
173 INT79243 Negative_regulation of Localization of CTSB 2 0.57 1.35 0.73
174 INT163783 Transcription of Casp1 1 0.58 0.88 0.73
175 INT163785 Positive_regulation of Transcription of Casp1 1 0.42 0.89 0.73
176 INT128497 Regulation of Gene_expression of CASP1 4 0.38 2.02 0.72
177 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
178 INT244413 Regulation of Transcription of Ctss 1 0.26 0.89 0.71
179 INT129879 Positive_regulation of Gene_expression of CTSS 3 0.47 3.25 0.7
180 INT156875 Positive_regulation of Gene_expression of Casp8 2 0.49 2.49 0.7
181 INT70156 Regulation of Casp1 2 0.15 0.79 0.7
182 INT167414 Positive_regulation of Positive_regulation of CASP4 1 0.22 0.48 0.7
183 INT20318 Regulation of Ctsb 1 0.54 0.19 0.69
184 INT138237 Negative_regulation of Negative_regulation of Casp1 1 0.30 0.56 0.69
185 INT99510 Regulation of Gene_expression of CFLAR 2 0.08 2.8 0.68
186 INT244416 Transcription of Ctss 1 0.52 0.88 0.68
187 INT235746 Positive_regulation of Casp2 2 0.04 2.67 0.67
188 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
189 INT285006 Positive_regulation of Casp7 4 0.25 4.11 0.66
190 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
191 INT126164 Positive_regulation of Ctsb 15 0.49 3.34 0.63
192 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
193 INT59137 Protein_catabolism of CTSB 5 0.96 3.92 0.62
194 INT153773 Regulation of Gene_expression of CTSK 2 0.34 1.36 0.62
195 INT243712 Positive_regulation of Gene_expression of Uchl1 4 0.21 2.68 0.61
196 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
197 INT71172 Negative_regulation of Gene_expression of Casp1 2 0.58 1.3 0.58
198 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
199 INT28687 Gene_expression of Ctsl1 4 0.61 0.48 0.57
200 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
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