GO:0004221

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Name ubiquitin thiolesterase activity
Categary Function
Go Slim No
Go Link GO:0004221
Unique Molecular Interactions 29
Total Molecular Interactions 38
Total Single Events 331
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ubiquitin thiolesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for ubiquitin thiolesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
2 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
3 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
4 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
5 INT180246 Binding of Tbca and Uchl1 1 0.00 0.47 0.27
6 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27
7 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
8 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
9 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
10 INT320402 Binding of Usp14 and Psmb10 1 0.00 0 0.05
11 INT65410 Penk Positive_regulation of Uchl1 1 0.05 0.19 0.05
12 INT65415 Penk Positive_regulation of Binding of Uchl1 1 0.05 0.19 0.05
13 INT65413 Tac1 Positive_regulation of Uchl1 1 0.02 0.19 0.05
14 INT320439 Binding of Uchl5 and Psmb10 1 0.00 0 0.04
15 INT247856 Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 1 0.03
16 INT247853 Positive_regulation of Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 0.54 0
17 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
18 INT307225 CYLD Regulation of TNFRSF11A 1 0.14 0.81 0
19 INT247848 Narfl Negative_regulation of Uchl1 1 0.03 0.74 0
20 INT22675 Binding of USP6 and PNMA1 1 0.02 0 0
21 INT271282 Stat1 Regulation of Usp18 1 0.30 1.37 0
22 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
23 INT139619 Binding of Usp14 and Gm16381 1 0.04 1.01 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ubiquitin thiolesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in ubiquitin thiolesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
2 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
3 INT26787 Localization of Uchl1 10 0.60 5.9 4.48
4 INT36115 Transcription of Uchl1 7 0.60 3.24 3.25
5 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11
6 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14
7 INT101148 Gene_expression of UCHL1 20 0.70 9.61 1.8
8 INT214123 Negative_regulation of Gene_expression of Uchl1 3 0.06 4.52 1.52
9 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4
10 INT26786 Positive_regulation of Uchl1 7 0.34 1.37 1.32
11 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
12 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
13 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
14 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
15 INT123124 Positive_regulation of Gene_expression of Uchl1 1 0.49 0.54 0.84
16 INT101149 Positive_regulation of Gene_expression of UCHL1 1 0.02 1.22 0.84
17 INT123125 Positive_regulation of Positive_regulation of Uchl1 1 0.49 0.54 0.84
18 INT101146 Positive_regulation of Transcription of Uchl1 1 0.13 1.22 0.84
19 INT101145 Transcription of Uchl1 1 0.18 1.17 0.82
20 INT159728 Localization of Uchl1 2 0.73 0.54 0.8
21 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
22 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
23 INT243712 Positive_regulation of Gene_expression of Uchl1 4 0.21 2.68 0.61
24 INT293504 Regulation of Gene_expression of Uchl1 1 0.03 0.31 0.46
25 INT271483 Regulation of Regulation of Uchl1 1 0.01 0.58 0.41
26 INT202908 Binding of Uchl1 1 0.08 0.27 0.4
27 INT181179 Binding of CYLD 4 0.43 7.06 0.39
28 INT34999 Regulation of UCHL1 1 0.04 0 0.38
29 INT185432 Negative_regulation of CYLD 4 0.52 3.19 0.35
30 INT123126 Protein_catabolism of Uchl1 1 0.64 0.2 0.27
31 INT113433 Binding of UCHL1 3 0.47 1.84 0.22
32 INT185452 Regulation of CYLD 6 0.40 6.09 0.21
33 INT97050 Negative_regulation of Uchl1 2 0.22 2.28 0.14
34 INT180233 Negative_regulation of Negative_regulation of Uchl1 1 0.14 0.6 0.14
35 INT307231 Positive_regulation of Gene_expression of CYLD 1 0.45 2.37 0.14
36 INT185449 Regulation of Regulation of CYLD 1 0.21 2.03 0.13
37 INT345349 Protein_catabolism of Uchl1 1 0.54 0.94 0.13
38 INT113434 Negative_regulation of Gene_expression of UCHL1 4 0.53 1.34 0.12
39 INT307240 Localization of CYLD 3 0.72 3.09 0.1
40 INT113431 Negative_regulation of UCHL1 2 0.39 0.62 0.08
41 INT65408 Binding of Uchl1 2 0.30 0.95 0.08
42 INT185440 Negative_regulation of Negative_regulation of CYLD 1 0.20 1.02 0.08
43 INT139614 Gene_expression of Usp14 1 0.78 2.29 0.06
44 INT113432 Regulation of Gene_expression of UCHL1 1 0.24 0.6 0.06
45 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05
46 INT307229 Phosphorylation of CYLD 1 0.73 1.02 0.05
47 INT320416 Binding of Usp14 1 0.23 0 0.05
48 INT320365 Binding of Uchl5 1 0.02 0 0.04
49 INT176155 Gene_expression of USP6 7 0.65 1.84 0
50 INT217333 Positive_regulation of TNFAIP3 3 0.23 2.65 0
51 INT196297 Localization of USP6 2 0.73 0.33 0
52 INT300048 Binding of USP6 2 0.47 0.51 0
53 INT307235 Positive_regulation of Binding of CYLD 1 0.45 1.1 0
54 INT348456 Protein_catabolism of TNFAIP3 1 0.22 1.13 0
55 INT348453 Positive_regulation of Positive_regulation of TNFAIP3 1 0.17 1.06 0
56 INT307244 Regulation of Gene_expression of CYLD 1 0.24 1.84 0
57 INT247884 Negative_regulation of Gene_expression of Uchl1 1 0.21 1.22 0
58 INT247860 Regulation of Uchl1 1 0.14 1.46 0
59 INT327507 Negative_regulation of Localization of CYLD 1 0.05 0.58 0
60 INT139615 Binding of Usp14 1 0.48 0.99 0
61 INT307230 Regulation of Localization of CYLD 1 0.40 0.11 0
62 INT271253 Gene_expression of Usp18 1 0.57 1.37 0
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