GO:0004222

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Name metalloendopeptidase activity
Categary Function
Go Slim No
Go Link GO:0004222
Unique Molecular Interactions 993
Total Molecular Interactions 1236
Total Single Events 12738
Pain Genes Associated 73

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for metalloendopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for metalloendopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
2 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
3 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
4 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
5 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
6 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
7 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
8 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
9 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
10 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
11 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 1 0.00 2.84 1.58
12 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
13 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
14 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
15 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
16 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
17 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
18 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
19 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
20 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
21 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
22 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
23 INT202039 CAMK2N2 Negative_regulation of MMP1 1 0.00 0.73 1.24
24 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24
25 INT202040 CAMK2N2 Negative_regulation of MMP7 1 0.00 0.73 1.24
26 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
27 INT187174 RPS3AP9 Negative_regulation of MMP2 1 0.00 0.9 1.22
28 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2
29 INT264333 IL-17 Positive_regulation of Gene_expression of Mmp1a 1 0.05 2.88 1.18
30 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
31 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16
32 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
33 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
34 INT60134 MME Negative_regulation of GRP 1 0.20 0 1.12
35 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
36 INT187176 Binding of BSG and MMP1 1 0.09 1.18 1.08
37 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
38 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
39 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
40 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
41 INT144069 Positive_regulation of TRPV1 Positive_regulation of Gene_expression of MMP1 1 0.43 1.35 1.03
42 INT45665 Fpr1 Negative_regulation of Mme 1 0.13 0 1
43 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99
44 INT344973 Negative_regulation of Mmp23 Regulation of Negative_regulation of Mag 1 0.01 1.14 0.99
45 INT238091 Binding of GRIP1 and Mmp24 1 0.00 0 0.98
46 INT238092 Binding of SHBG and Mmp24 1 0.04 0 0.98
47 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
48 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
49 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95
50 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94
51 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
52 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92
53 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
54 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91
55 INT121700 IL12RB1 Positive_regulation of Gene_expression of MMP1 1 0.06 0.22 0.9
56 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
57 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
58 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
59 INT56500 Ide Regulation of Maoa 1 0.21 0 0.89
60 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
61 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
62 INT92423 EC3 Negative_regulation of Mme 1 0.02 0.28 0.86
63 INT196523 Binding of MMP2 and TIMP1 3 0.43 1.94 0.85
64 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
65 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85
66 INT105282 Thop1 Positive_regulation of Protein_catabolism of Pnoc 1 0.17 0.1 0.85
67 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85
68 INT105281 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Pnoc 1 0.16 0.09 0.84
69 INT105280 Negative_regulation of Thop1 Negative_regulation of Positive_regulation of Pnoc 1 0.14 0.09 0.83
70 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83
71 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83
72 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83
73 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
74 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
75 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78
76 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
77 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
78 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
79 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
80 INT110578 PENK Positive_regulation of Gene_expression of MME 1 0.35 0.1 0.76
81 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75
82 INT150268 MMP8 Regulation of Transcription of SFTPA1 1 0.05 0.43 0.75
83 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
84 INT46916 Binding of Thop1 and Positive_regulation of Penk 1 0.14 0 0.74
85 INT260895 CRH Regulation of MMP1 1 0.11 0.31 0.74
86 INT219685 Binding of MMP12 and COPD 1 0.27 5.59 0.74
87 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
88 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
89 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
90 INT46920 Thop1 Regulation of Vom1r1 1 0.03 0 0.74
91 INT46918 Binding of Thop1 and Positive_regulation of Vom1r1 1 0.03 0 0.74
92 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
93 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
94 INT162240 Binding of COL7A1 and MMP1 1 0.03 0.86 0.73
95 INT162239 Binding of COL7A1 and MMP8 1 0.04 0.86 0.73
96 INT36219 Mme Positive_regulation of Protein_catabolism of Penk 1 0.39 0 0.72
97 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
98 INT29380 Binding of gp and Mme 1 0.01 0 0.71
99 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
100 INT121697 IL4I1 Positive_regulation of Gene_expression of MMP3 1 0.06 0.27 0.7
101 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7
102 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
103 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69
104 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
105 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68
106 INT190172 Gene_expression of IL13 Regulation of MMP12 1 0.12 0.05 0.68
107 INT157935 Negative_regulation of TRPV1 Negative_regulation of Gene_expression of MMP1 1 0.42 0.1 0.68
108 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68
109 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66
110 INT152299 Mmp2 Negative_regulation of Tsc22d1 1 0.16 0.16 0.66
111 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66
112 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
113 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
114 INT29381 gp Regulation of Mme 1 0.01 0 0.65
115 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
116 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
117 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65
118 INT29382 Positive_regulation of gp Regulation of Mme 1 0.02 0 0.65
119 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
120 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
121 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
122 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64
123 INT113473 RETNLB Positive_regulation of MMP14 1 0.01 0.37 0.64
124 INT99602 ZNF398 Negative_regulation of MMP2 1 0.14 0.85 0.63
125 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
126 INT314051 THL Negative_regulation of Localization of Mmp2 1 0.14 1.1 0.62
127 INT79210 Hps4 Negative_regulation of Mme 1 0.00 0 0.62
128 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62
129 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
130 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
131 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
132 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
133 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
134 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6
135 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
136 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
137 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6
138 INT295721 CSF2 Positive_regulation of MMP9 1 0.06 0.32 0.6
139 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
140 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
141 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59
142 INT190166 IL13 Regulation of MMP12 1 0.12 0 0.59
143 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58
144 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
145 INT144071 TRPV1 Positive_regulation of Gene_expression of MMP14 1 0.21 0.5 0.58
146 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57
147 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
148 INT157934 TRPV1 Positive_regulation of Positive_regulation of MMP1 1 0.45 0.07 0.57
149 INT47284 Binding of Mme and Ctsa 1 0.21 0 0.57
150 INT345302 MMP15 Positive_regulation of MMP2 1 0.06 1.17 0.57
151 INT108387 IL1B Positive_regulation of Localization of MMP1 1 0.27 0.3 0.57
152 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57
153 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
154 INT203105 MMP3 Negative_regulation of Gene_expression of IL10 1 0.06 0.69 0.56
155 INT175627 TIMP1 Positive_regulation of MMP2 1 0.03 0.71 0.56
156 INT173555 TIMP1 Negative_regulation of MMP7 1 0.01 0 0.56
157 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56
158 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56
159 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56
160 INT173554 TIMP1 Negative_regulation of MMP1 1 0.03 0 0.55
161 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55
162 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55
163 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55
164 INT263756 Binding of Bmp1 and Neto1 1 0.30 0.11 0.54
165 INT54239 Binding of Mme and Nts 1 0.21 0 0.54
166 INT316737 Il1 Positive_regulation of Mmp1a 1 0.01 0.64 0.54
167 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54
168 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
169 INT316738 Il1 Positive_regulation of Mmp3 1 0.02 0.63 0.54
170 INT55445 Positive_regulation of Ahr Regulation of Mme 1 0.23 0 0.53
171 INT196522 Binding of MMP1 and TIMP1 1 0.39 0.29 0.53
172 INT314043 THL Negative_regulation of Mmp2 1 0.22 2.11 0.53
173 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
174 INT150790 ZNF398 Positive_regulation of Localization of MMP2 1 0.04 0.51 0.53
175 INT194915 Csf2 Positive_regulation of Gene_expression of Mmp1a 1 0.01 0.85 0.52
176 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
177 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52
178 INT196521 Binding of MMP2 and TIMP2 1 0.30 0.68 0.52
179 INT194916 Kitl Positive_regulation of Gene_expression of Mmp1a 1 0.00 0.85 0.52
180 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52
181 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52
182 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
183 INT144070 Gene_expression of TRPV1 Positive_regulation of Positive_regulation of MMP1 1 0.43 0.68 0.52
184 INT144072 Gene_expression of TRPV1 Positive_regulation of MMP1 1 0.43 0.68 0.52
185 INT150792 THBS3 Negative_regulation of MMP2 1 0.11 0.49 0.51
186 INT196527 Positive_regulation of Binding of MMP1 and MMP2 1 0.44 0.74 0.51
187 INT207466 LGALS3 Positive_regulation of Gene_expression of ADAMTS5 1 0.15 0.88 0.51
188 INT196524 Binding of MMP1 and MMP9 1 0.31 0.74 0.51
189 INT196519 Positive_regulation of Binding of MMP1 and MMP9 1 0.42 0.74 0.51
190 INT196520 Binding of MMP1 and MMP2 1 0.33 0.74 0.51
191 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
192 INT132443 Binding of MEP1A and EFHC1 1 0.44 1.19 0.5
193 INT150921 ZNF398 Negative_regulation of Gene_expression of Mmp2 1 0.00 0.46 0.5
194 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5
195 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
196 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49
197 INT224675 S100a4 Positive_regulation of Mmp3 1 0.04 0.94 0.48
198 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48
199 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
200 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48

Single Events

The table below shows the top 100 pain related interactions that have been reported for metalloendopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in metalloendopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
2 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
3 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72
4 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
5 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9
6 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12
7 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
8 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
9 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78
10 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
11 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
12 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
13 INT99610 Localization of MMP9 126 0.79 48.46 32.67
14 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
15 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
16 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71
17 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
18 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
19 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
20 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
21 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
22 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
23 INT34487 Localization of MMP2 56 0.81 31.41 23.61
24 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73
25 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72
26 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36
27 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
28 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
29 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86
30 INT9490 Regulation of Mme 44 0.56 6.69 19.21
31 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95
32 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
33 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
34 INT49379 Localization of MMP12 26 0.77 13.07 16.93
35 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69
36 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
37 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24
38 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17
39 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
40 INT81486 Localization of MMP3 31 0.81 12.94 15.21
41 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16
42 INT103210 Localization of MMP1 43 0.78 12.15 15.13
43 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
44 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06
45 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91
46 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
47 INT14453 Localization of Mme 44 0.80 2.46 14.75
48 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31
49 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69
50 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
51 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
52 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
53 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
54 INT56494 Localization of Ide 73 0.68 22.9 11.26
55 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
56 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74
57 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63
58 INT34485 Negative_regulation of Localization of MMP2 17 0.50 9.96 10.49
59 INT89282 Regulation of MMP9 39 0.60 25.45 10.34
60 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01
61 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98
62 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96
63 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79
64 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
65 INT102987 Regulation of MMP3 23 0.60 9.35 9.54
66 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42
67 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
68 INT48233 Negative_regulation of Gene_expression of MMP1 34 0.58 12.94 9.08
69 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93
70 INT18258 Negative_regulation of Thop1 20 0.56 1.6 8.61
71 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
72 INT4880 Regulation of MME 17 0.61 7.78 8.2
73 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03
74 INT111903 Regulation of Mmp2 9 0.61 3.95 7.98
75 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88
76 INT8603 Binding of Mme 28 0.48 1.42 7.64
77 INT74629 Gene_expression of Mmp7 17 0.55 12.78 7.58
78 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18
79 INT111398 Localization of Mmp2 37 0.76 23.78 7.17
80 INT168381 Positive_regulation of Mmp3 24 0.58 19.12 7.03
81 INT168600 Binding of Mmp9 14 0.44 12.79 6.92
82 INT67568 Positive_regulation of Localization of MMP2 14 0.31 8.58 6.79
83 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58
84 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
85 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33
86 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
87 INT95607 Regulation of MMP1 19 0.60 7.86 6.18
88 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08
89 INT108628 Regulation of MMP2 27 0.60 14.85 6.06
90 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
91 INT123551 Regulation of Mmp2 17 0.57 11.6 6
92 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96
93 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55
94 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54
95 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54
96 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47
97 INT90202 Protein_catabolism of MMP2 15 0.94 7.47 5.41
98 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36
99 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34
100 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26
101 INT8653 Protein_catabolism of Thop1 13 0.92 0.73 5.16
102 INT34358 Binding of MME 13 0.37 7.25 5.14
103 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12
104 INT107242 Binding of MMP3 14 0.47 12.06 5.11
105 INT90374 Positive_regulation of Positive_regulation of MMP2 14 0.50 10.12 5.08
106 INT71841 Negative_regulation of Thop1 7 0.48 0.41 5.08
107 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
108 INT56495 Positive_regulation of Localization of Ide 20 0.53 3.53 4.92
109 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8
110 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73
111 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71
112 INT29502 Localization of Mmp2 18 0.79 3.49 4.64
113 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64
114 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6
115 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52
116 INT24619 Regulation of Thop1 11 0.44 1.24 4.5
117 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49
118 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47
119 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
120 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21
121 INT113485 Localization of MMP14 11 0.77 3.44 4.19
122 INT21817 Binding of Thop1 9 0.48 0.88 4.19
123 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18
124 INT99608 Transcription of MMP9 18 0.65 9.67 4.11
125 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09
126 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07
127 INT144302 Protein_catabolism of MMP3 7 0.86 7.43 3.98
128 INT220047 Negative_regulation of Gene_expression of Mmp3 4 0.29 5.93 3.95
129 INT133312 Binding of MMP9 25 0.42 16.79 3.83
130 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82
131 INT140186 Positive_regulation of Gene_expression of Mmp3 7 0.55 6.04 3.82
132 INT86293 Positive_regulation of Gene_expression of Mmp2 21 0.64 11.69 3.79
133 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75
134 INT123883 Positive_regulation of Gene_expression of Mmp3 16 0.60 4.42 3.74
135 INT180922 Negative_regulation of Mmp8 4 0.43 8.35 3.72
136 INT74684 Gene_expression of Mmp12 8 0.31 5.69 3.68
137 INT94431 Transcription of MMP1 14 0.56 4.1 3.66
138 INT149614 Localization of MMP13 13 0.81 6.12 3.65
139 INT173849 Positive_regulation of Localization of MMP3 7 0.49 4.6 3.65
140 INT20493 Regulation of MMP12 3 0.52 0.89 3.65
141 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61
142 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59
143 INT129960 Negative_regulation of Gene_expression of MMP13 19 0.53 7.17 3.55
144 INT57439 Regulation of MMP8 6 0.62 2.2 3.54
145 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45
146 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41
147 INT68974 Localization of Mmp9 10 0.80 4.84 3.35
148 INT11616 Gene_expression of Thop1 10 0.74 0.32 3.34
149 INT172689 Localization of Mmp3 15 0.68 5.52 3.32
150 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
151 INT192298 Negative_regulation of MMP7 7 0.27 3.71 3.29
152 INT179456 Negative_regulation of Mmp3 8 0.39 5.95 3.26
153 INT307634 Binding of BMP1 1 0.36 3.12 3.26
154 INT155039 Gene_expression of ADAMTS5 23 0.67 7.85 3.22
155 INT58532 Negative_regulation of MMP12 4 0.37 2.61 3.2
156 INT190189 Positive_regulation of Localization of MMP12 4 0.58 2.87 3.18
157 INT35910 Binding of Mme 8 0.37 4.79 3.16
158 INT215926 Regulation of Gene_expression of Mmp14 1 0.45 5.33 3.15
159 INT37111 Regulation of Negative_regulation of Mme 7 0.44 2.61 3.13
160 INT190202 Negative_regulation of Localization of MMP12 1 0.36 1.29 3.12
161 INT105985 Transcription of Mmp9 11 0.66 8.55 3.02
162 INT21758 Negative_regulation of Nrd1 6 0.36 1.15 3.01
163 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99
164 INT35548 Regulation of Mme 9 0.45 10.62 2.97
165 INT170324 Negative_regulation of Gene_expression of Mmp1a 8 0.13 6.28 2.94
166 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93
167 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93
168 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
169 INT178108 Positive_regulation of MMP7 11 0.56 7.31 2.85
170 INT123139 Binding of Mmp3 7 0.37 1.98 2.84
171 INT11291 Positive_regulation of Gene_expression of Mme 6 0.61 5.93 2.81
172 INT170305 Regulation of Gene_expression of Mmp9 11 0.33 5.7 2.8
173 INT190188 Regulation of Localization of MMP12 1 0.44 0.39 2.8
174 INT220858 Positive_regulation of Mmp1a 15 0.38 9.11 2.77
175 INT106468 Regulation of Gene_expression of MMP2 11 0.50 3.53 2.77
176 INT104474 Gene_expression of Mmp8 15 0.71 3.1 2.76
177 INT172797 Negative_regulation of Mmp1a 8 0.24 6.47 2.74
178 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74
179 INT7148 Negative_regulation of Negative_regulation of Mme 6 0.42 2.19 2.74
180 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73
181 INT99895 Positive_regulation of Mmp14 10 0.58 6.64 2.72
182 INT185898 Gene_expression of MMP10 8 0.49 5.36 2.68
183 INT194892 Regulation of Mmp1a 5 0.22 4.93 2.67
184 INT191974 Regulation of Ide 16 0.38 9.54 2.52
185 INT243033 Localization of Mmp8 8 0.65 5.59 2.52
186 INT129961 Regulation of Gene_expression of MMP1 15 0.46 4.88 2.51
187 INT99897 Positive_regulation of Gene_expression of Mmp14 7 0.36 6.33 2.51
188 INT151309 Positive_regulation of Positive_regulation of MMP3 5 0.60 2.62 2.5
189 INT103603 Negative_regulation of Gene_expression of Mmp2 16 0.51 12.29 2.47
190 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46
191 INT183810 Positive_regulation of Positive_regulation of MMP9 9 0.52 4.15 2.46
192 INT168603 Negative_regulation of Positive_regulation of Mmp9 3 0.37 2.32 2.42
193 INT338117 Negative_regulation of Transcription of Mmp3 1 0.09 1.01 2.4
194 INT173511 Localization of Mmp1a 4 0.21 2.73 2.39
195 INT120124 Transcription of MMP3 9 0.69 2.15 2.38
196 INT6404 Gene_expression of Thop1 3 0.64 0.18 2.36
197 INT26434 Localization of MME 17 0.81 8.67 2.3
198 INT55736 Transcription of MMP2 11 0.68 5.78 2.28
199 INT74628 Positive_regulation of Mmp7 8 0.25 4.19 2.27
200 INT26514 Regulation of Gene_expression of Mme 2 0.41 1.18 2.27
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