GO:0004252

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Name serine-type endopeptidase activity
Categary Function
Go Slim No
Go Link GO:0004252
Unique Molecular Interactions 1438
Total Molecular Interactions 2032
Total Single Events 13629
Pain Genes Associated 132

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for serine-type endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for serine-type endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
2 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 0.11 0 3.28
3 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
4 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
5 INT69057 H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
6 INT150455 Binding of Prss12 and Nts 3 0.24 1.42 2.66
7 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
8 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
9 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
10 INT17299 Prss12 Regulation of Localization of Acot1 3 0.05 0 2.07
11 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92
12 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92
13 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
14 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
15 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
16 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
17 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
18 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
19 INT237286 Dlat Regulation of Prep 1 0.01 0 1.57
20 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53
21 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
22 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
23 INT104975 MITF Regulation of Transcription of PRSS1 1 0.68 0.35 1.46
24 INT140314 PCSK7 Positive_regulation of LDHA 1 0.07 1.6 1.4
25 INT777 Prss12 Positive_regulation of Prl 1 0.19 0 1.33
26 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
27 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
28 INT139722 PROC Positive_regulation of CDCP1 1 0.00 1.61 1.29
29 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29
30 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
31 INT20530 Nts Regulation of Prss12 5 0.24 0.74 1.23
32 INT62019 CSF2 Regulation of ELANE 1 0.03 0.47 1.21
33 INT182159 Binding of HGF and DCPS 1 0.01 2.5 1.17
34 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
35 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14
36 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
37 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
38 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
39 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
40 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05
41 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
42 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
43 INT335401 Hgf Positive_regulation of Ngf 1 0.30 1.13 1.04
44 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
45 INT314037 THL Negative_regulation of Localization of Plau 1 0.17 1.64 0.99
46 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98
47 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
48 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
49 INT227545 Hspa9 Positive_regulation of Prep 1 0.18 0.59 0.96
50 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
51 INT118204 ST14 Regulation of YY1 1 0.04 0 0.93
52 INT143323 Binding of HLA-B and HP 1 0.04 0.95 0.93
53 INT107001 F2 Positive_regulation of PAR1 4 0.05 2.15 0.92
54 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92
55 INT138602 Negative_regulation of BCL2L2 Positive_regulation of F2 1 0.00 0.67 0.92
56 INT156989 LPA Positive_regulation of Gene_expression of EFNB1 1 0.00 0.91 0.92
57 INT193291 Binding of CAP1 and Cfd 1 0.02 0.13 0.91
58 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91
59 INT138601 BCL2L2 Positive_regulation of F2 1 0.00 0.66 0.91
60 INT193277 Binding of Cfd and Brs3 1 0.01 0.13 0.91
61 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1 0.02 1.29 0.9
62 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
63 INT154258 Binding of Abat and Prss12 1 0.03 0 0.87
64 INT154257 Binding of Prss12 and Cfp 1 0.02 0 0.87
65 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
66 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
67 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
68 INT153516 PLG Positive_regulation of Pas5a 1 0.57 0.05 0.83
69 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81
70 INT110726 Binding of ALB and LTF 1 0.01 0 0.81
71 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 0.07 0 0.8
72 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 0.43 0 0.8
73 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
74 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 0.07 0 0.8
75 INT16507 Binding of LPA and Crp 1 0.00 0.78 0.78
76 INT16494 Binding of LPA and Serpinf2 1 0.00 0.78 0.78
77 INT351364 LPA Positive_regulation of Trpv1 1 0.02 1.15 0.78
78 INT16492 Positive_regulation of Binding of LPA and Serpinf2 1 0.00 0.78 0.78
79 INT16506 Positive_regulation of Binding of LPA and Crp 1 0.00 0.78 0.78
80 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
81 INT16498 Binding of ADRA1D and LPA 1 0.10 0.78 0.78
82 INT16497 Positive_regulation of Binding of ADRA1D and LPA 1 0.10 0.78 0.78
83 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
84 INT168507 Binding of SPINK1 and Ctrc 1 0.03 0.93 0.76
85 INT125523 PLAT Positive_regulation of GDF15 1 0.13 1.33 0.75
86 INT150268 MMP8 Regulation of Transcription of SFTPA1 1 0.05 0.43 0.75
87 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74
88 INT298730 PROC Positive_regulation of Gene_expression of Ngf 1 0.00 0.6 0.74
89 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
90 INT182044 Binding of Proc and IgG 1 0.00 2.38 0.74
91 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
92 INT162239 Binding of COL7A1 and MMP8 1 0.04 0.86 0.73
93 INT113552 Binding of PLAU and PLAUR 4 0.31 3.09 0.72
94 INT106999 F2 Positive_regulation of PAR4 3 0.06 1.83 0.72
95 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72
96 INT8367 Tacr1 Positive_regulation of Localization of Prss12 1 0.05 0 0.72
97 INT82767 Binding of HP and MLRG 1 0.00 0 0.71
98 INT111747 Pcsk2 Regulation of Gene_expression of Npy 1 0.29 0 0.71
99 INT784 Prss12 Positive_regulation of Gh1 1 0.06 0 0.7
100 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
101 INT783 Prss12 Positive_regulation of Positive_regulation of Oprl1 1 0.05 0 0.7
102 INT126779 Binding of Serpinc1 and F8 1 0.00 1.52 0.69
103 INT24393 Regulation of NPVF Regulation of CLPP 1 0.00 0.13 0.69
104 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
105 INT346225 Binding of PRTN3 and Flg 1 0.01 1.74 0.69
106 INT126781 Binding of F10 and Serpinc1 1 0.00 1.51 0.69
107 INT351367 LPA Regulation of Trpv1 1 0.01 0.83 0.69
108 INT24394 NPVF Regulation of CLPP 1 0.00 0.13 0.68
109 INT124257 Plat Positive_regulation of Jun 5 0.12 3.33 0.67
110 INT168295 PROC Regulation of Gene_expression of VEGFA 2 0.00 1.6 0.67
111 INT70819 Binding of GBE1 and CTRC 1 0.01 0.63 0.67
112 INT13595 Penk Positive_regulation of Localization of Prss12 1 0.12 0 0.67
113 INT180961 Binding of MOCS1 and PLAU 1 0.00 0.61 0.67
114 INT293010 ELANE Regulation of Localization of LTF 1 0.00 0.54 0.67
115 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
116 INT780 Prss12 Positive_regulation of Gene_expression of Prl 1 0.14 0 0.65
117 INT781 Prss12 Positive_regulation of Gene_expression of Gnrhr 1 0.10 0 0.65
118 INT40762 Trh Negative_regulation of Prss12 1 0.06 0 0.65
119 INT24396 CALCB Regulation of CLPP 1 0.00 0.13 0.65
120 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64
121 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
122 INT18231 Binding of ADRA1D and HP 2 0.14 0.17 0.64
123 INT773 Prss12 Positive_regulation of Gnrhr 1 0.04 0 0.64
124 INT167795 Negative_regulation of LPA Negative_regulation of Mag 1 0.01 0.84 0.64
125 INT99728 Binding of F13A1 and PLG 4 0.02 2.51 0.63
126 INT167794 LPA Negative_regulation of Mag 1 0.01 0.77 0.63
127 INT252772 ELANE Regulation of Gene_expression of CCL2 1 0.05 2.16 0.62
128 INT237285 Dlat Negative_regulation of Prep 1 0.01 0 0.62
129 INT182156 Binding of HGF and IL3RA 1 0.03 1.31 0.62
130 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62
131 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61
132 INT32782 Binding of Vip and Elane 1 0.17 0 0.61
133 INT227544 Hspa9 Regulation of Gene_expression of Prep 1 0.15 0.57 0.61
134 INT101718 PLAT Positive_regulation of Transcription of OPRM1 1 0.22 0.06 0.61
135 INT101719 PLAT Positive_regulation of NFYC 1 0.13 0.1 0.6
136 INT101717 PLAT Positive_regulation of JUND 1 0.17 0.1 0.59
137 INT35862 PRSS1 Regulation of Localization of GBE1 1 0.00 0.35 0.59
138 INT207504 Binding of ap and Klkb1 1 0.13 0 0.58
139 INT37034 PLAT Positive_regulation of PLDN 1 0.08 0.15 0.58
140 INT37035 PLAT Negative_regulation of ODC1 1 0.45 0.15 0.58
141 INT145491 PROC Positive_regulation of Cpox 1 0.00 1.08 0.58
142 INT26648 Binding of CEL and HP 1 0.04 0 0.58
143 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57
144 INT195666 Binding of PROC and THBD 2 0.40 2.42 0.56
145 INT313223 Binding of Cx3cr1 and Mcpt1 1 0.06 0.99 0.56
146 INT298271 Proc Negative_regulation of Gene_expression of Ntrk2 1 0.01 0.79 0.56
147 INT139429 LPA Positive_regulation of Negative_regulation of MBP 1 0.00 0.78 0.56
148 INT313224 Negative_regulation of Binding of Cx3cr1 and Mcpt1 1 0.07 0.99 0.56
149 INT145718 Positive_regulation of Plat Positive_regulation of Bdnf 1 0.20 0 0.56
150 INT96089 Binding of F2 and Pf4 1 0.00 1.31 0.56
151 INT96098 Binding of PPBP and F2 1 0.00 1.31 0.56
152 INT298729 PROC Positive_regulation of Set 1 0.00 0.76 0.55
153 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
154 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55
155 INT99736 Binding of PLG and Serpinf2 1 0.01 0.73 0.55
156 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
157 INT46434 Prss12 Negative_regulation of Prl 1 0.16 0 0.54
158 INT125086 LPA Positive_regulation of Rtn4 1 0.00 0.36 0.54
159 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
160 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
161 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
162 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
163 INT59945 Binding of C2 and Srms 1 0.00 0 0.53
164 INT263738 Binding of C1ra and Neto1 1 0.42 0.11 0.53
165 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
166 INT117309 HP Positive_regulation of Gast 1 0.00 0.9 0.51
167 INT167583 ENPP2 Positive_regulation of Gene_expression of LPA 1 0.08 0.93 0.51
168 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5
169 INT297152 Binding of PRTN3 and SNRNP70 1 0.40 1.27 0.5
170 INT135378 Binding of Cfb and Oprk1 1 0.01 0.31 0.49
171 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
172 INT327332 VEGFA Positive_regulation of Gene_expression of Hgfac 1 0.00 2.02 0.49
173 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49
174 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
175 INT84515 IRF6 Positive_regulation of Gene_expression of F2 1 0.02 0.15 0.49
176 INT84520 Gene_expression of F2 Positive_regulation of F13A1 1 0.03 0.16 0.49
177 INT160445 Tpsab1 Positive_regulation of Gene_expression of SPG21 1 0.48 0.96 0.48
178 INT160444 Tpsab1 Positive_regulation of Gene_expression of CEL 1 0.48 0.96 0.48
179 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
180 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
181 INT229127 SPINK1 Positive_regulation of PRSS1 1 0.53 1.59 0.48
182 INT144110 PRSS1 Positive_regulation of Gene_expression of IL8 1 0.21 1.38 0.48
183 INT180958 Binding of F13A1 and PLAT 2 0.03 2.16 0.47
184 INT229128 Binding of CP and PRSS1 1 0.14 0.77 0.47
185 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
186 INT65006 DAK Negative_regulation of ELANE 1 0.05 0.35 0.47
187 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
188 INT173293 LPA Positive_regulation of OR1S1 1 0.03 0.15 0.47
189 INT102556 HGF Positive_regulation of Phosphorylation of ELK1 1 0.10 0.46 0.47
190 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
191 INT300544 Il22 Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.15 0.47
192 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
193 INT102213 Binding of ENG and HP 1 0.01 0 0.47
194 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
195 INT341622 Binding of F2 and CTRC 1 0.06 1.22 0.46
196 INT173295 F2 Positive_regulation of OR1S1 1 0.01 0.15 0.46
197 INT39076 Prss12 Regulation of Penk 1 0.04 0.44 0.46
198 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
199 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
200 INT341625 Binding of SPINK1 and CTRC 1 0.41 1.22 0.46

Single Events

The table below shows the top 100 pain related interactions that have been reported for serine-type endopeptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in serine-type endopeptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15
2 INT117598 Regulation of ACR 118 0.26 41.25 48.01
3 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48
4 INT9650 Gene_expression of LPA 141 0.75 104.57 29
5 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
6 INT8362 Localization of Prss12 53 0.78 5.09 27
7 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75
8 INT2609 Localization of ELANE 111 0.81 50.22 26.63
9 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14
10 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57
11 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
12 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
13 INT4535 Localization of PROC 106 0.73 76.24 21.1
14 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4
15 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48
16 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
17 INT1767 Positive_regulation of PROC 83 0.67 54.14 17
18 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89
19 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74
20 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33
21 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91
22 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89
23 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85
24 INT24684 Localization of PLAT 30 0.78 26.21 13.56
25 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79
26 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63
27 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62
28 INT11359 Gene_expression of PLAU 84 0.76 49.54 12.31
29 INT61946 Positive_regulation of HGF 57 0.69 38.93 11.99
30 INT8548 Gene_expression of HP 86 0.77 47.62 11.94
31 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64
32 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06
33 INT192967 Gene_expression of Hp 14 0.43 8.06 11.01
34 INT273123 Binding of Hp 1 0.25 3.56 10.9
35 INT4498 Gene_expression of F2 83 0.65 57.4 10.8
36 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77
37 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52
38 INT11205 Gene_expression of Prep 65 0.77 8.11 10.12
39 INT112969 Negative_regulation of Mcpt1 30 0.45 20.17 10.11
40 INT32344 Localization of LTF 30 0.80 15.28 10.09
41 INT27937 Gene_expression of Klkb1 35 0.55 1.86 10.08
42 INT10546 Positive_regulation of Prss12 12 0.44 4.57 10.05
43 INT64054 Positive_regulation of Tmprss11d 19 0.67 9.33 9.99
44 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96
45 INT113603 Negative_regulation of Gene_expression of Mcpt1 26 0.41 22.82 9.91
46 INT15449 Positive_regulation of Plat 32 0.69 12.76 9.71
47 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
48 INT8360 Positive_regulation of Localization of Prss12 14 0.26 1.72 9.38
49 INT13593 Binding of Prss12 13 0.36 4.35 9.37
50 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31
51 INT1168 Binding of PROC 62 0.38 44.15 9.04
52 INT4534 Regulation of PROC 38 0.33 19.81 8.99
53 INT13432 Positive_regulation of Klkb1 23 0.57 5.36 8.65
54 INT112967 Regulation of Mcpt1 15 0.54 13.03 8.58
55 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56
56 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49
57 INT4159 Gene_expression of Hp 33 0.72 12.49 8.39
58 INT8160 Gene_expression of Prss12 20 0.67 4.83 8.17
59 INT2271 Gene_expression of F2 51 0.76 30.21 7.97
60 INT3401 Positive_regulation of Hp 22 0.69 16.33 7.97
61 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88
62 INT14043 Binding of HP 52 0.30 26.56 7.76
63 INT14600 Positive_regulation of Tpsab1 51 0.68 22.1 7.7
64 INT153814 Localization of LPA 19 0.65 18.25 7.68
65 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51
66 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46
67 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
68 INT22782 Localization of PRSS1 25 0.81 14.44 7.34
69 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25
70 INT14599 Localization of Tpsab1 36 0.79 14.58 7.18
71 INT10513 Gene_expression of Plat 44 0.76 19.49 7.17
72 INT2605 Regulation of ELANE 39 0.61 18.22 7.11
73 INT717 Regulation of F2 29 0.61 17.46 6.99
74 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84
75 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75
76 INT14865 Regulation of Prep 20 0.55 4.21 6.75
77 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74
78 INT10610 Negative_regulation of Plg 22 0.40 11.81 6.74
79 INT74944 Positive_regulation of Gene_expression of HGF 31 0.70 17.69 6.68
80 INT124488 Positive_regulation of Gene_expression of Plat 14 0.70 5.46 6.52
81 INT1926 Positive_regulation of PLAT 54 0.66 31.42 6.49
82 INT16997 Binding of PRTN3 34 0.48 33.44 6.45
83 INT71116 Gene_expression of Plau 29 0.77 4.94 6.45
84 INT24946 Binding of PRSS1 23 0.47 16.75 6.41
85 INT17262 Negative_regulation of Plat 17 0.59 15.14 6.36
86 INT86805 Localization of HGF 49 0.71 28.48 6.35
87 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33
88 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21
89 INT116420 Localization of Elane 16 0.14 7.8 6
90 INT168446 Gene_expression of Prep 25 0.64 15.17 5.94
91 INT63177 Regulation of HP 71 0.44 39.48 5.86
92 INT52904 Positive_regulation of LTF 21 0.67 15.58 5.78
93 INT10547 Regulation of Prss12 11 0.41 3.11 5.74
94 INT124825 Transcription of Plat 8 0.70 3.15 5.68
95 INT22839 Gene_expression of F2 31 0.74 15.53 5.56
96 INT14598 Gene_expression of Tpsab1 40 0.73 14.55 5.4
97 INT4805 Positive_regulation of Localization of TPSAB1 9 0.55 0.32 5.38
98 INT266746 Binding of ACR 8 0.23 3.44 5.26
99 INT10100 Binding of ELANE 22 0.47 15.32 5.19
100 INT107247 Regulation of Plat 10 0.44 7.21 5.14
101 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12
102 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1
103 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08
104 INT10889 Gene_expression of F8 60 0.78 41.36 5.06
105 INT44608 Gene_expression of C2 45 0.75 15.84 5.05
106 INT51983 Negative_regulation of Prtn3 23 0.34 12.54 5
107 INT11493 Positive_regulation of KLK1 21 0.67 9.22 5
108 INT14027 Positive_regulation of Prep 29 0.69 3.63 4.99
109 INT51839 Positive_regulation of Localization of PLAT 5 0.49 7.09 4.92
110 INT17582 Negative_regulation of Localization of ELANE 17 0.53 6.11 4.89
111 INT13594 Regulation of Localization of Prss12 5 0.30 1.55 4.88
112 INT104668 Negative_regulation of Plat 27 0.49 17.18 4.83
113 INT11030 Binding of LPA 70 0.48 40.35 4.81
114 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81
115 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75
116 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74
117 INT81761 Negative_regulation of Prep 12 0.55 8.48 4.73
118 INT17103 Negative_regulation of Prep 15 0.38 4.95 4.71
119 INT110768 Transcription of Mcpt1 12 0.52 7.66 4.71
120 INT140350 Binding of C2 17 0.36 3.97 4.69
121 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6
122 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55
123 INT21990 Negative_regulation of Ctrc 17 0.42 8.45 4.47
124 INT9842 Binding of F2 36 0.47 22.79 4.42
125 INT35609 Negative_regulation of F10 37 0.57 17.15 4.41
126 INT53787 Transcription of Prss12 7 0.21 3.29 4.4
127 INT67279 Localization of PRTN3 11 0.50 14.18 4.3
128 INT3327 Protein_catabolism of PRSS1 22 1.00 6.96 4.29
129 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
130 INT7725 Positive_regulation of Hgf 9 0.67 3.62 4.25
131 INT11661 Negative_regulation of Prss12 7 0.37 0.78 4.16
132 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12
133 INT51986 Negative_regulation of Pcsk2 8 0.50 1.4 4.1
134 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07
135 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06
136 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05
137 INT38033 Regulation of HGF 26 0.45 14.96 3.81
138 INT180922 Negative_regulation of Mmp8 4 0.43 8.35 3.72
139 INT35864 Regulation of PRSS1 19 0.61 8.14 3.63
140 INT13451 Positive_regulation of DPP4 23 0.68 9.33 3.62
141 INT16644 Positive_regulation of Plg 16 0.60 6.38 3.62
142 INT57439 Regulation of MMP8 6 0.62 2.2 3.54
143 INT179656 Gene_expression of Elane 12 0.32 9.44 3.53
144 INT105222 Positive_regulation of Plau 18 0.54 8.52 3.5
145 INT28802 Binding of F2 15 0.47 8.8 3.47
146 INT51985 Gene_expression of Pcsk2 10 0.76 1.34 3.44
147 INT22891 Positive_regulation of Localization of ELANE 16 0.69 11.52 3.42
148 INT63506 Localization of F2 21 0.77 7.53 3.41
149 INT201959 Positive_regulation of Gene_expression of DPP4 13 0.53 6.24 3.4
150 INT74946 Negative_regulation of Gene_expression of HGF 14 0.58 6.29 3.39
151 INT181001 Regulation of PRTN3 5 0.18 6.07 3.39
152 INT42581 Regulation of Gene_expression of ELANE 11 0.38 9.25 3.38
153 INT61341 Positive_regulation of Prep 12 0.63 6.08 3.37
154 INT22823 Positive_regulation of Positive_regulation of ELANE 12 0.45 6.89 3.35
155 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3
156 INT43985 Regulation of LPA 29 0.62 20.79 3.29
157 INT146890 Gene_expression of Cfd 15 0.66 4.42 3.28
158 INT227524 Positive_regulation of Gene_expression of Prep 13 0.48 7.69 3.28
159 INT25344 Localization of Plg 10 0.57 5 3.27
160 INT12241 Negative_regulation of Positive_regulation of PRSS1 6 0.43 5.39 3.22
161 INT16390 Regulation of Plg 13 0.48 6.72 3.2
162 INT1924 Regulation of PLAT 11 0.60 6.3 3.16
163 INT132149 Positive_regulation of Gene_expression of LTF 10 0.70 11.5 3.14
164 INT129208 Regulation of Gene_expression of Mcpt1 8 0.29 5.94 3.13
165 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12
166 INT10517 Localization of Plat 16 0.47 8.44 3.11
167 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06
168 INT11488 Negative_regulation of KLK1 15 0.57 9.92 3.06
169 INT211192 Localization of ACR 8 0.73 3.04 3.03
170 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02
171 INT14485 Positive_regulation of Cela1 15 0.44 10.55 3.01
172 INT28731 Negative_regulation of Elane 14 0.14 8.97 3.01
173 INT21299 Negative_regulation of Hp 14 0.44 10.97 2.97
174 INT115857 Gene_expression of PRSS3 10 0.72 4.13 2.96
175 INT71117 Positive_regulation of Gene_expression of Plau 9 0.69 0.22 2.92
176 INT201952 Binding of DPP4 11 0.37 8.81 2.91
177 INT58527 Gene_expression of Prtn3 20 0.71 15.99 2.9
178 INT15288 Regulation of Hp 11 0.60 3.68 2.89
179 INT146029 Positive_regulation of Positive_regulation of Tmprss11d 2 0.67 2.12 2.88
180 INT46201 Gene_expression of KLKB1 21 0.53 3.01 2.87
181 INT266745 Regulation of Gene_expression of ACR 6 0.10 1.53 2.87
182 INT124489 Regulation of Gene_expression of Plat 5 0.45 0.48 2.87
183 INT38204 Gene_expression of Acr 4 0.66 4.23 2.85
184 INT16949 Negative_regulation of CLPP 8 0.49 2.47 2.83
185 INT115464 Gene_expression of Plau 41 0.72 30.21 2.79
186 INT10101 Binding of PLAT 24 0.36 12.62 2.78
187 INT104474 Gene_expression of Mmp8 15 0.71 3.1 2.76
188 INT38967 Positive_regulation of Ctrc 12 0.40 2.55 2.75
189 INT192964 Positive_regulation of Hp 7 0.28 2 2.75
190 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74
191 INT157048 Regulation of Localization of Mcpt1 3 0.18 0.31 2.73
192 INT113149 Gene_expression of Tmprss11d 15 0.75 8.51 2.72
193 INT73029 Negative_regulation of Klkb1 7 0.35 0 2.72
194 INT10512 Positive_regulation of Gene_expression of Plat 8 0.46 1.4 2.69
195 INT14447 Localization of F2 20 0.79 12.77 2.67
196 INT67884 Positive_regulation of PLAU 15 0.68 11.21 2.61
197 INT67318 Positive_regulation of Hgf 13 0.69 5.47 2.6
198 INT35407 Positive_regulation of C2 25 0.69 7.74 2.59
199 INT101998 Gene_expression of Klk1c9 12 0.13 0.62 2.59
200 INT102000 Negative_regulation of Klk1c9 1 0.09 0 2.59
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