GO:0004301

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Name epoxide hydrolase activity
Categary Function
Go Slim No
Go Link GO:0004301
Unique Molecular Interactions 23
Total Molecular Interactions 28
Total Single Events 283
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for epoxide hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported for epoxide hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61130 LTA4H Positive_regulation of CPQ 1 0.28 0 0.83
2 INT14062 Binding of POMC and RNPEP 1 0.01 0 0.33
3 INT223424 Binding of Rnpep and Lta4h 1 0.02 0.37 0.19
4 INT75030 Slc6a14 Positive_regulation of Gene_expression of Ephx1 1 0.01 0.17 0.17
5 INT306921 Ang Positive_regulation of Gene_expression of Ephx2 1 0.15 0.79 0.12
6 INT279435 Positive_regulation of Binding of LTA4H and Lts1 1 0.00 0.16 0.08
7 INT325489 Agtr2 Positive_regulation of Ephx2 1 0.04 0.51 0.08
8 INT325488 Negative_regulation of Ephx2 Positive_regulation of Alox5 1 0.13 0.24 0.08
9 INT279436 Binding of LTA4H and Lts1 1 0.00 0.16 0.08
10 INT75031 Slc6a14 Positive_regulation of Ephx1 1 0.01 0.07 0.07
11 INT75038 Ass1 Positive_regulation of Transcription of Ephx1 1 0.00 0.08 0.07
12 INT75037 Ass1 Positive_regulation of Ephx1 1 0.00 0.08 0.07
13 INT306922 Negative_regulation of Ephx2 Positive_regulation of Hdl1 1 0.05 1.06 0
14 INT172893 Binding of Lta4h and Ltc4s 1 0.00 0.24 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for epoxide hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported in epoxide hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169697 Negative_regulation of Ephx2 35 0.59 38.21 5.92
2 INT187 Positive_regulation of Ephx1 17 0.69 0.51 3.69
3 INT161105 Gene_expression of Ephx2 20 0.78 17.84 3.58
4 INT184 Regulation of Ephx1 10 0.60 0.54 3.27
5 INT164270 Gene_expression of Lta4h 4 0.59 3.13 1.84
6 INT164274 Transcription of Lta4h 1 0.47 2.09 1.33
7 INT33664 Negative_regulation of LTA4H 4 0.59 2.34 0.95
8 INT31607 Gene_expression of Ephx1 3 0.35 0.35 0.74
9 INT61133 Positive_regulation of LTA4H 1 0.49 0 0.74
10 INT306912 Protein_catabolism of Ephx2 1 1.00 1.95 0.68
11 INT306910 Negative_regulation of Gene_expression of Ephx2 4 0.55 3.8 0.67
12 INT14063 Gene_expression of RNPEP 1 0.04 0 0.66
13 INT306911 Positive_regulation of Ephx2 4 0.69 5.39 0.63
14 INT158678 Positive_regulation of Lta4h 2 0.33 0.55 0.55
15 INT2437 Regulation of Positive_regulation of Ephx1 1 0.21 0 0.53
16 INT2436 Regulation of Regulation of Ephx1 1 0.47 0 0.51
17 INT46155 Binding of Ephx1 2 0.28 0.16 0.43
18 INT46156 Regulation of Binding of Ephx1 1 0.34 0.09 0.43
19 INT36120 Positive_regulation of RNPEP 1 0.25 0 0.33
20 INT31610 Regulation of Gene_expression of Ephx1 2 0.20 0.1 0.31
21 INT306913 Regulation of Ephx2 2 0.45 2.36 0.31
22 INT306916 Binding of Ephx2 7 0.37 5.88 0.29
23 INT17441 Gene_expression of LTA4H 3 0.78 0.6 0.26
24 INT325486 Negative_regulation of Binding of Ephx2 1 0.40 0.92 0.23
25 INT322285 Transcription of LTA4H 1 0.05 0.89 0.23
26 INT322287 Positive_regulation of Transcription of LTA4H 1 0.04 0.89 0.23
27 INT261081 Localization of LTA4H 2 0.15 0.41 0.2
28 INT325487 Localization of Ephx2 1 0.71 0.65 0.2
29 INT306915 Positive_regulation of Gene_expression of Ephx2 1 0.69 1.94 0.19
30 INT325484 Regulation of Negative_regulation of Ephx2 1 0.43 0.99 0.14
31 INT42630 Negative_regulation of Ephx1 1 0.01 0 0.09
32 INT325481 Positive_regulation of Regulation of Ephx2 1 0.47 0.58 0.08
33 INT306917 Negative_regulation of Negative_regulation of Ephx2 1 0.43 1.11 0.07
34 INT75007 Transcription of Ephx1 1 0.12 0.08 0.07
35 INT306919 Positive_regulation of Negative_regulation of Ephx2 1 0.50 2.12 0
36 INT223422 Localization of Lta4h 1 0.50 0 0
37 INT172856 Gene_expression of Lta4h 1 0.08 0.16 0
38 INT223418 Negative_regulation of Lta4h 1 0.28 0 0
39 INT172867 Binding of Lta4h 1 0.04 0.23 0
40 INT306909 Transcription of Ephx2 1 0.53 2.04 0
41 INT223415 Negative_regulation of Negative_regulation of Lta4h 1 0.28 0 0
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