GO:0004351

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Name glutamate decarboxylase activity
Categary Function
Go Slim No
Go Link GO:0004351
Unique Molecular Interactions 90
Total Molecular Interactions 110
Total Single Events 2244
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for glutamate decarboxylase activity. They are ordered first by their pain relevance and then by number of times they were reported for glutamate decarboxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
2 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
3 INT283050 Binding of Gad2 and Trpm8 1 0.23 2.02 1.93
4 INT145940 Binding of Gad1 and Abat 2 0.14 1.44 1.78
5 INT1619 Binding of Gad1 and Oprl1 1 0.14 0 1.13
6 INT1620 Negative_regulation of Binding of Gad1 and Oprl1 1 0.16 0 1.13
7 INT270053 HOXD12 Positive_regulation of Gene_expression of GAD1 1 0.03 0.68 1.12
8 INT270052 GAD1 Positive_regulation of Gene_expression of SFTPA1 1 0.03 0.68 1.11
9 INT12137 Ngf Regulation of Gad1 1 0.27 0.67 0.83
10 INT317705 Gad2 Regulation of Gene_expression of Gabrg1 1 0.28 0.53 0.8
11 INT49585 Binding of Glul and Selenbp2 1 0.20 0.19 0.76
12 INT50634 Ddc Regulation of Gene_expression of Glul 1 0.02 0 0.65
13 INT9163 Tnf Regulation of Gene_expression of Glul 1 0.12 1.99 0.62
14 INT98386 GAD1 Positive_regulation of Gene_expression of Abat 1 0.30 1.67 0.62
15 INT56733 Ddc Positive_regulation of Localization of GLUL 1 0.00 0 0.54
16 INT103535 Obfc1 Negative_regulation of Positive_regulation of Gad1 1 0.03 0.07 0.49
17 INT338447 GAD1 Negative_regulation of Slc32a1 1 0.04 0.59 0.47
18 INT117890 Positive_regulation of Gfap Regulation of Glul 1 0.51 0.36 0.46
19 INT117887 Glul Regulation of Arc 1 0.02 0.37 0.46
20 INT117889 Gfap Regulation of Glul 1 0.30 0.36 0.46
21 INT12139 Ins1 Regulation of Gad1 1 0.15 0.33 0.42
22 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
23 INT148514 Binding of Gad2 and Penk 1 0.25 0 0.4
24 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
25 INT79504 Binding of Gad1 and Chat 1 0.35 0 0.38
26 INT344748 NFKB2 Regulation of Gene_expression of GAD1 1 0.07 0.87 0.33
27 INT55087 Binding of Gad1 and Penk 1 0.08 0 0.32
28 INT42253 Bbx Regulation of Gad1 1 0.15 0 0.3
29 INT98385 Abat Negative_regulation of GAD1 1 0.24 1.28 0.3
30 INT177491 Binding of Gad2 and Slc32a1 1 0.06 0.06 0.25
31 INT272618 Positive_regulation of Binding of GAD1 and CEBPZ 1 0.14 0.91 0.25
32 INT177502 Binding of Gabrg1 and Gad2 1 0.14 0.07 0.25
33 INT272619 Binding of GAD1 and CEBPZ 1 0.10 0.91 0.25
34 INT333927 GLUL Positive_regulation of HSPA5 1 0.17 0.78 0.24
35 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23
36 INT344746 GAD1 Regulation of Gene_expression of ABAT 1 0.19 0.75 0.23
37 INT180247 Binding of Gad1 and Tbca 1 0.02 0.22 0.22
38 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21
39 INT25089 Glul Positive_regulation of Npr1 1 0.00 0 0.2
40 INT6697 Binding of GLUL and Positive_regulation of Positive_regulation of ADRA1D 1 0.23 0.16 0.19
41 INT338443 Binding of Gad1 and Slc32a1 1 0.31 0.64 0.18
42 INT261521 Binding of ADCY1 and GLUL 1 0.01 0.09 0.15
43 INT333930 GLUL Positive_regulation of HRASLS 1 0.01 0.43 0.14
44 INT96955 Glul Positive_regulation of Positive_regulation of Ugcg 1 0.07 0.14 0.14
45 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14
46 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 0.03 0.75 0.14
47 INT271553 Binding of Gad2 and Gfap 1 0.24 0 0.13
48 INT177490 Binding of Gad1 and Gad2 1 0.10 0.19 0.11
49 INT25090 Negative_regulation of Glul Positive_regulation of Npr1 1 0.00 0 0.1
50 INT114367 Binding of GAD2 and SEPHS1 1 0.11 0.55 0.1
51 INT322969 Binding of Gad1 and Fos 1 0.23 0.23 0.08
52 INT227593 Gnaq Negative_regulation of GLUL 1 0.01 0 0.06
53 INT227562 GNAI1 Negative_regulation of GLUL 1 0.01 0 0.06
54 INT79985 Gdnf Negative_regulation of Negative_regulation of GAD1 1 0.04 0.46 0.04
55 INT79986 Gdnf Negative_regulation of Gene_expression of GAD1 1 0.03 0.46 0.04
56 INT227567 FOXI2 Positive_regulation of GLUL 1 0.00 0 0.03
57 INT227563 BRI3 Positive_regulation of GLUL 1 0.04 0 0.03
58 INT233323 GAD1 Regulation of HMGCR 1 0.09 0.2 0
59 INT164736 MIR29A Regulation of Glul 1 0.59 0.06 0
60 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for glutamate decarboxylase activity. They are ordered first by their pain relevance and then by number of times they were reported in glutamate decarboxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11
2 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71
3 INT10453 Positive_regulation of Gad1 65 0.70 10.75 31.9
4 INT1616 Regulation of Gad1 46 0.61 10.2 28.64
5 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95
6 INT82461 Gene_expression of Gad2 40 0.78 19.12 22.79
7 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07
8 INT16326 Transcription of Gad1 58 0.71 15.78 20.45
9 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4
10 INT24798 Negative_regulation of Glul 52 0.55 27.25 15.17
11 INT130280 Positive_regulation of Gene_expression of Gad2 7 0.69 8.13 9.55
12 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53
13 INT336 Negative_regulation of Gad1 19 0.58 7.71 9.51
14 INT26789 Positive_regulation of Gene_expression of Gad1 22 0.70 7.39 9.02
15 INT63739 Regulation of Gad2 15 0.58 3.44 8.86
16 INT46112 Regulation of GAD1 15 0.52 11.09 8.37
17 INT24799 Regulation of Glul 22 0.45 8.3 8
18 INT50633 Regulation of Gene_expression of Glul 12 0.60 1.64 6.59
19 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54
20 INT49011 Regulation of Gene_expression of Gad1 10 0.62 0.55 6.07
21 INT157121 Gene_expression of GAD2 15 0.67 7.21 5.91
22 INT75978 Transcription of Gad2 11 0.69 2.28 5.68
23 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59
24 INT74394 Negative_regulation of Gad2 6 0.42 1.96 5.26
25 INT66388 Positive_regulation of Transcription of Gad1 14 0.67 2.45 4.67
26 INT106971 Positive_regulation of Gene_expression of GAD1 19 0.58 10.89 4.59
27 INT25146 Negative_regulation of Positive_regulation of Glul 5 0.43 0.91 4.53
28 INT50631 Positive_regulation of Gene_expression of Glul 9 0.43 3 4.37
29 INT119785 Localization of GAD1 7 0.63 5.99 4.34
30 INT63740 Positive_regulation of Gad2 11 0.66 0.78 4.32
31 INT50646 Transcription of Glul 12 0.38 3.59 4.07
32 INT141125 Regulation of Gene_expression of GAD1 5 0.52 8.81 3.63
33 INT50648 Negative_regulation of Gene_expression of Glul 9 0.58 2.7 3.53
34 INT42251 Regulation of Gad1 10 0.44 5.25 3.45
35 INT66570 Localization of Glul 4 0.78 0.37 3.45
36 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23
37 INT82462 Positive_regulation of Transcription of Gad2 5 0.49 1.03 3.01
38 INT67952 Regulation of Transcription of Gad1 6 0.51 1.23 2.98
39 INT54170 Positive_regulation of Positive_regulation of Gad1 5 0.69 0 2.89
40 INT173336 Gene_expression of GLUL 16 0.27 6.74 2.78
41 INT165514 Regulation of Gad2 7 0.45 3.15 2.76
42 INT143663 Negative_regulation of Gene_expression of Gad2 2 0.43 2.32 2.75
43 INT54331 Positive_regulation of Glul 8 0.67 3.55 2.74
44 INT42255 Negative_regulation of Gad1 7 0.56 4.83 2.54
45 INT90566 Positive_regulation of Gene_expression of Gad1 5 0.48 1.46 2.42
46 INT67951 Negative_regulation of Gene_expression of Gad1 4 0.43 1.08 2.13
47 INT49723 Localization of GLUL 5 0.27 0.67 2.1
48 INT42256 Positive_regulation of Gad1 4 0.66 1.1 2.09
49 INT49210 Transcription of GAD1 8 0.60 3.48 2.06
50 INT207830 Localization of GAD2 10 0.65 0.49 1.97
51 INT44109 Localization of Gad1 7 0.74 1.06 1.97
52 INT79983 Negative_regulation of Gene_expression of GAD1 7 0.41 4.02 1.9
53 INT49584 Negative_regulation of Glul 3 0.52 1.16 1.88
54 INT55587 Negative_regulation of Positive_regulation of Gad1 6 0.49 1.1 1.82
55 INT259220 Binding of Glul 3 0.36 0.61 1.78
56 INT56201 Negative_regulation of Negative_regulation of Glul 2 0.31 0.97 1.69
57 INT50645 Positive_regulation of Positive_regulation of Glul 2 0.21 0.42 1.66
58 INT96642 Transcription of Gad2 4 0.59 0.88 1.59
59 INT161371 Gene_expression of Glul 7 0.61 2.44 1.58
60 INT87316 Negative_regulation of Gad2 6 0.58 1.61 1.56
61 INT36148 Binding of GAD1 10 0.41 7.91 1.47
62 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46
63 INT103531 Regulation of Positive_regulation of Gad1 3 0.61 0.31 1.43
64 INT259222 Positive_regulation of Binding of Glul 1 0.05 0 1.39
65 INT90567 Negative_regulation of Gene_expression of Gad1 4 0.41 2.88 1.36
66 INT96641 Transcription of Gad1 3 0.60 0.84 1.36
67 INT53548 Negative_regulation of Transcription of Gad1 3 0.43 0.46 1.32
68 INT83833 Localization of Gad2 2 0.72 0.57 1.31
69 INT1618 Binding of Gad1 6 0.37 2.01 1.3
70 INT50649 Positive_regulation of Transcription of Glul 1 0.19 1.28 1.26
71 INT227150 Localization of Gad1 4 0.49 0.15 1.22
72 INT96643 Positive_regulation of Gene_expression of Gad2 3 0.49 0.15 1.18
73 INT51591 Regulation of GLUL 3 0.11 2.62 1.15
74 INT165513 Negative_regulation of Regulation of Gad1 1 0.41 1.59 1.11
75 INT161968 Positive_regulation of Gene_expression of GAD2 2 0.40 0.91 1.04
76 INT148863 Positive_regulation of Localization of GAD1 1 0.38 1.41 1
77 INT90568 Regulation of Gene_expression of Gad1 3 0.27 0.46 0.89
78 INT110298 Regulation of Positive_regulation of GAD1 2 0.38 0.99 0.89
79 INT180240 Binding of Gad1 7 0.47 2.99 0.86
80 INT78003 Regulation of Transcription of Gad2 2 0.26 0.62 0.81
81 INT78001 Negative_regulation of Regulation of Gad2 1 0.29 0.15 0.81
82 INT78000 Negative_regulation of Transcription of Gad2 1 0.29 0.15 0.81
83 INT78002 Regulation of Negative_regulation of Gad2 1 0.18 0.15 0.81
84 INT82465 Regulation of Gene_expression of Gad2 3 0.58 0.47 0.76
85 INT95699 Binding of Gad2 5 0.40 1.14 0.73
86 INT270701 Localization of Gad2 2 0.74 0.12 0.73
87 INT333952 Negative_regulation of Gene_expression of GLUL 1 0.15 1 0.71
88 INT344771 Transcription of GAD2 1 0.27 0.09 0.7
89 INT49211 Positive_regulation of Positive_regulation of GAD1 2 0.50 1.79 0.68
90 INT96639 Positive_regulation of Transcription of Gad2 1 0.45 0.09 0.66
91 INT96638 Regulation of Transcription of Gad2 1 0.26 0.09 0.66
92 INT271481 Regulation of Regulation of Gad2 1 0.21 0.59 0.65
93 INT207835 Positive_regulation of Localization of GAD2 1 0.01 0.1 0.65
94 INT161252 Positive_regulation of GAD2 2 0.49 0.08 0.63
95 INT150209 Regulation of Transcription of GAD1 1 0.04 0.42 0.62
96 INT180244 Positive_regulation of Gad2 4 0.49 1.07 0.61
97 INT177500 Binding of Gad2 3 0.36 0.61 0.55
98 INT180239 Negative_regulation of Gene_expression of Gad2 2 0.42 1.59 0.55
99 INT123645 Negative_regulation of Transcription of Gad1 2 0.42 0.76 0.52
100 INT73540 Regulation of Positive_regulation of Glul 1 0.30 0.71 0.48
101 INT50647 Negative_regulation of Transcription of Glul 1 0.18 0.48 0.47
102 INT207836 Negative_regulation of GAD2 2 0.37 0.19 0.45
103 INT270700 Negative_regulation of Negative_regulation of Gad2 1 0.50 0 0.41
104 INT67950 Regulation of Transcription of Glul 1 0.23 0 0.38
105 INT82464 Negative_regulation of Positive_regulation of Gad2 1 0.55 0 0.37
106 INT292607 Negative_regulation of Transcription of GAD1 1 0.02 0.72 0.36
107 INT82463 Positive_regulation of Positive_regulation of Gad2 1 0.47 0 0.36
108 INT110737 Positive_regulation of Regulation of Gad2 1 0.45 0.45 0.34
109 INT6705 Negative_regulation of Phosphorylation of GLUL 1 0.19 0.18 0.31
110 INT271543 Negative_regulation of Localization of Gad2 1 0.49 0.06 0.31
111 INT6707 Phosphorylation of GLUL 1 0.36 0.18 0.31
112 INT46111 Regulation of Regulation of GAD1 1 0.12 0.18 0.31
113 INT318274 Regulation of Gene_expression of GAD2 1 0.39 0 0.3
114 INT314001 Regulation of Regulation of Glul 1 0.22 0.54 0.3
115 INT98316 Regulation of Gene_expression of Gad2 1 0.26 0.1 0.3
116 INT6702 Binding of GLUL 3 0.21 2.04 0.28
117 INT54169 Regulation of Negative_regulation of Glul 1 0.09 0 0.27
118 INT257802 Positive_regulation of Transcription of Gad1 1 0.44 0 0.23
119 INT185337 Regulation of Gene_expression of GLUL 2 0.22 0.39 0.19
120 INT114368 Binding of GAD2 1 0.30 1.13 0.19
121 INT195077 Negative_regulation of Positive_regulation of Glul 1 0.19 1.06 0.18
122 INT180242 Positive_regulation of Binding of Gad1 1 0.49 0.86 0.17
123 INT104557 Positive_regulation of Binding of Gad1 1 0.50 0.76 0.15
124 INT101575 Negative_regulation of Negative_regulation of Gad1 1 0.07 0.24 0.13
125 INT333946 Transcription of GLUL 1 0.19 0.43 0.13
126 INT328416 Protein_catabolism of Glul 1 0.76 0.11 0.12
127 INT177493 Phosphorylation of Gad1 1 0.45 0.19 0.11
128 INT177501 Phosphorylation of Gad2 1 0.34 0.19 0.11
129 INT318275 Negative_regulation of Gene_expression of GAD2 1 0.37 0.5 0.1
130 INT271549 Negative_regulation of Binding of Gad2 1 0.36 0 0.09
131 INT173323 Positive_regulation of Gene_expression of GLUL 2 0.12 0.23 0.08
132 INT207837 Negative_regulation of Localization of GAD2 1 0.01 0 0.08
133 INT180243 Phosphorylation of Gad2 1 0.52 0.48 0.06
134 INT304627 Regulation of Negative_regulation of GAD1 1 0.39 0.9 0.06
135 INT177498 Positive_regulation of Localization of Gad1 2 0.40 0.48 0.05
136 INT344772 Negative_regulation of Positive_regulation of GAD1 1 0.31 0.17 0.04
137 INT227587 Regulation of Positive_regulation of GLUL 1 0.06 0.07 0.04
138 INT79984 Positive_regulation of Negative_regulation of GAD1 1 0.04 0.42 0.04
139 INT79982 Positive_regulation of Negative_regulation of Gad1 1 0.05 0.41 0.04
140 INT227579 Positive_regulation of Regulation of GLUL 1 0.11 0.07 0.04
141 INT180241 Positive_regulation of Binding of Gad2 1 0.39 0.29 0.03
142 INT142214 Positive_regulation of Negative_regulation of Glul 1 0.48 0 0
143 INT180232 Protein_catabolism of Gad1 1 0.87 0.52 0
144 INT333951 Regulation of Binding of GLUL 1 0.16 0.31 0
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