GO:0004362

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Name glutathione-disulfide reductase activity
Categary Function
Go Slim No
Go Link GO:0004362
Unique Molecular Interactions 73
Total Molecular Interactions 82
Total Single Events 806
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for glutathione-disulfide reductase activity. They are ordered first by their pain relevance and then by number of times they were reported for glutathione-disulfide reductase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
2 INT243678 Binding of GSR and Ugcg 2 0.03 2.84 0.83
3 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
4 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
5 INT34825 Aap Negative_regulation of Gsr 1 0.01 0.3 0.75
6 INT26230 Binding of GSR and HTR1D 1 0.12 0.15 0.69
7 INT26231 Binding of GSR and HTR1B 1 0.12 0.15 0.66
8 INT38131 Pag1 Negative_regulation of Gsr 1 0.01 0.72 0.58
9 INT347362 RYBP Regulation of Gene_expression of GSR 1 0.01 0 0.57
10 INT347369 RYBP Positive_regulation of GSR 1 0.01 0.43 0.51
11 INT347395 RYBP Positive_regulation of Gsr 1 0.01 0.43 0.5
12 INT347367 RYBP Negative_regulation of GSR 1 0.01 0.09 0.48
13 INT347364 RYBP Regulation of GSR 1 0.01 0.06 0.48
14 INT161662 Gsr Regulation of Gene_expression of TNF 1 0.01 0.93 0.46
15 INT161653 Gsr Regulation of Gene_expression of Ifih1 1 0.04 1.05 0.46
16 INT161652 Gsr Regulation of Gene_expression of Tnf 1 0.17 0.98 0.46
17 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
18 INT161074 Ccbl1 Negative_regulation of Gsr 1 0.00 0 0.41
19 INT83348 GSR Negative_regulation of JUND 1 0.20 0.72 0.33
20 INT83347 GSR Negative_regulation of NFKB1 1 0.25 0.72 0.33
21 INT336936 Binding of GSR and Nr3c2 1 0.06 2.29 0.31
22 INT26235 Binding of GSR and Htr1a 1 0.12 0.09 0.31
23 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27
24 INT179233 IRF6 Negative_regulation of Binding of GSR 1 0.03 0.83 0.25
25 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
26 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
27 INT150514 Decr1 Positive_regulation of Gsr 1 0.13 0.24 0.24
28 INT179230 Binding of MAPK14 and GSR 1 0.03 0.5 0.23
29 INT179229 Binding of GSR and NR3C2 1 0.03 0.37 0.23
30 INT146743 Positive_regulation of Binding of GSR and PLA2G4A 1 0.40 0.14 0.11
31 INT146742 Binding of GSR and PLA2G4A 1 0.28 0.14 0.11
32 INT278604 GSR Regulation of Gene_expression of SULT2A1 1 0.02 0.05 0.07
33 INT179232 Binding of CREM and GSR 1 0.00 0 0.06
34 INT307704 Binding of Gsr and Rb(8.17)6Sic 1 0.01 1.49 0.03
35 INT286268 Binding of GSR and Gpx1 2 0.02 0 0
36 INT79644 CTNNBL1 Positive_regulation of Binding of GSR 1 0.08 0 0
37 INT274215 Mc3r Positive_regulation of Gene_expression of Gsr 1 0.14 0.27 0
38 INT79652 RIMS3 Regulation of GSR 1 0.03 0 0
39 INT177298 Binding of GSR and GMEB1 1 0.01 0 0
40 INT265023 Gsr Negative_regulation of Binding of GSR 1 0.04 0.13 0
41 INT79645 RIMS3 Positive_regulation of Phosphorylation of GSR 1 0.04 0 0
42 INT351596 Regulation of Binding of GSR and Gpx1 1 0.02 0 0
43 INT310320 GSR Negative_regulation of COQ10A 1 0.01 0.06 0
44 INT330060 GSR Positive_regulation of Gene_expression of Ros1 1 0.00 0.61 0
45 INT274216 Mc3r Regulation of Gene_expression of Gsr 1 0.08 0.27 0
46 INT79650 CTNNBL1 Regulation of GSR 1 0.07 0 0
47 INT177266 GSR Positive_regulation of Gene_expression of CXADR 1 0.13 0 0
48 INT79647 RIMS3 Positive_regulation of Binding of GSR 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for glutathione-disulfide reductase activity. They are ordered first by their pain relevance and then by number of times they were reported in glutathione-disulfide reductase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16870 Negative_regulation of Gsr 27 0.59 10.28 11.81
2 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19
3 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37
4 INT52924 Negative_regulation of GSR 49 0.58 28.08 9.28
5 INT26233 Binding of GSR 45 0.46 18.22 3.74
6 INT35683 Gene_expression of Gsr 24 0.46 16.94 3.6
7 INT3842 Positive_regulation of Gsr 14 0.69 3.48 3.55
8 INT91070 Regulation of GSR 27 0.59 16.64 3.42
9 INT60610 Negative_regulation of Gsr 7 0.26 6.88 3.32
10 INT41312 Gene_expression of Gsr 13 0.44 4.62 3.18
11 INT83351 Positive_regulation of Gene_expression of GSR 15 0.64 12.03 2.97
12 INT79658 Transcription of GSR 8 0.68 3.59 2.19
13 INT209439 Localization of Gsr 8 0.26 3.25 2
14 INT58432 Positive_regulation of Gsr 12 0.70 9.4 1.94
15 INT110580 Regulation of Transcription of GSR 2 0.27 0.98 1.94
16 INT110582 Localization of GSR 10 0.79 4.03 1.19
17 INT132617 Regulation of Gsr 3 0.42 1.55 0.96
18 INT170772 Negative_regulation of Gene_expression of GSR 8 0.41 3.05 0.7
19 INT110581 Positive_regulation of Localization of GSR 1 0.68 0.33 0.7
20 INT179248 Positive_regulation of Positive_regulation of GSR 3 0.40 4.65 0.56
21 INT37770 Positive_regulation of Negative_regulation of Gsr 1 0.50 0.52 0.51
22 INT83349 Negative_regulation of Binding of GSR 3 0.39 1.48 0.49
23 INT113891 Binding of Gsr 5 0.21 4.86 0.42
24 INT274209 Phosphorylation of Gsr 2 0.24 2.25 0.36
25 INT355269 Positive_regulation of Phosphorylation of Gsr 1 0.13 2 0.36
26 INT88121 Regulation of Gsr 3 0.22 0.92 0.34
27 INT355257 Positive_regulation of Binding of Gsr 1 0.11 2.44 0.34
28 INT258059 Negative_regulation of Positive_regulation of GSR 3 0.41 1.79 0.33
29 INT286267 Positive_regulation of Negative_regulation of GSR 1 0.12 0.9 0.33
30 INT83354 Positive_regulation of Binding of GSR 2 0.43 0.69 0.31
31 INT87409 Localization of Gsr 3 0.49 1.57 0.3
32 INT140425 Positive_regulation of Positive_regulation of Gsr 1 0.14 0.07 0.28
33 INT16871 Negative_regulation of Positive_regulation of Gsr 1 0.58 0 0.23
34 INT179250 Negative_regulation of Transcription of GSR 2 0.56 1.7 0.18
35 INT355268 Positive_regulation of Localization of Gsr 1 0.11 1.05 0.18
36 INT179247 Negative_regulation of Localization of GSR 1 0.24 0.65 0.18
37 INT274208 Positive_regulation of Gene_expression of Gsr 3 0.14 2.15 0.13
38 INT264609 Regulation of Gene_expression of GSR 3 0.43 2.44 0.07
39 INT242044 Protein_catabolism of GSR 3 0.88 0.05 0.06
40 INT170769 Negative_regulation of Negative_regulation of GSR 2 0.41 0.95 0.06
41 INT336934 Regulation of Regulation of GSR 1 0.07 0.87 0.05
42 INT102642 Positive_regulation of Gene_expression of Gsr 2 0.25 1.07 0.03
43 INT209430 Negative_regulation of Localization of Gsr 1 0.15 0.14 0.03
44 INT156819 Negative_regulation of Gene_expression of Gsr 3 0.28 0 0
45 INT336935 Positive_regulation of Protein_catabolism of GSR 1 0.13 0 0
46 INT274210 Regulation of Gene_expression of Gsr 1 0.08 0.27 0
47 INT276808 Positive_regulation of Transcription of GSR 1 0.19 0 0
48 INT274212 Regulation of Phosphorylation of Gsr 1 0.13 0.27 0
49 INT355273 Negative_regulation of Gene_expression of Gsr 1 0.10 0.55 0
50 INT79653 Phosphorylation of GSR 1 0.59 0 0
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