GO:0004383

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Name guanylate cyclase activity
Categary Function
Go Slim No
Go Link GO:0004383
Unique Molecular Interactions 160
Total Molecular Interactions 225
Total Single Events 2006
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for guanylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported for guanylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
2 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
3 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
4 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
5 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
6 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
7 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
8 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
9 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
10 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
11 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
12 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
13 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
14 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
15 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
16 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
17 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
18 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
19 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
20 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
21 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
22 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
23 INT111790 Penk Regulation of Gene_expression of Npr1 1 0.22 0.56 0.86
24 INT41156 Sst Negative_regulation of Npr1 1 0.05 0 0.84
25 INT29781 PDYN Negative_regulation of Npr1 1 0.00 0.22 0.84
26 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
27 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
28 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
29 INT57658 ASNA1 Positive_regulation of Npr1 1 0.00 0.15 0.74
30 INT169603 Nppb Regulation of Npr1 1 0.26 0.95 0.69
31 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
32 INT111555 Negative_regulation of Npr1 Negative_regulation of Positive_regulation of Creb1 1 0.02 0.58 0.66
33 INT6464 Sst Regulation of Negative_regulation of Npr1 1 0.01 0 0.64
34 INT6463 Oprd1 Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
35 INT6465 Trh Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
36 INT43075 Slc6a14 Regulation of Positive_regulation of Npr1 1 0.01 0 0.51
37 INT43076 Slc6a14 Regulation of Npr1 1 0.01 0 0.51
38 INT55265 Ptgdr Negative_regulation of Npr1 1 0.01 0 0.46
39 INT52679 Positive_regulation of Npr1 Positive_regulation of Positive_regulation of VSX1 1 0.00 0 0.45
40 INT251430 Gnat3 Positive_regulation of Gucy1b2 1 0.04 0.48 0.42
41 INT131353 Binding of Npr1 and Nppb 1 0.27 1.73 0.4
42 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4
43 INT57649 Oprd1 Positive_regulation of Npr1 1 0.01 0.1 0.39
44 INT95999 Binding of Npr1 and Cnr1 1 0.05 0 0.39
45 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37
46 INT84085 Binding of Gucy1a2 and Nisch 1 0.00 0.22 0.35
47 INT46663 Guca2a Positive_regulation of Gucy2f 1 0.02 0 0.32
48 INT46664 GYPA Positive_regulation of Gucy2f 1 0.00 0 0.32
49 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
50 INT96436 Binding of Npr1 and Oprl1 1 0.05 0 0.29
51 INT136245 Gucy1a2 Positive_regulation of Nppa 1 0.06 0.22 0.27
52 INT208499 Positive_regulation of Nkx1-1 Positive_regulation of Npr1 1 0.00 0 0.27
53 INT149358 Binding of Oprm1 and Positive_regulation of Positive_regulation of Npr1 1 0.00 0.09 0.26
54 INT83220 Gucy1a2 Positive_regulation of Positive_regulation of Glp1r 1 0.02 0 0.26
55 INT136246 Gucy1a2 Negative_regulation of Nppa 1 0.05 0.22 0.26
56 INT47012 Regulation of Pck1 Positive_regulation of Npr1 1 0.01 0 0.26
57 INT131355 Npr1 Regulation of Nppb 1 0.39 0.88 0.22
58 INT131354 Npr1 Regulation of Nppa 1 0.40 0.88 0.22
59 INT25089 Glul Positive_regulation of Npr1 1 0.00 0 0.2
60 INT154355 Binding of Nppc and Npr1 1 0.19 0.43 0.18
61 INT29959 Ahsp Positive_regulation of Npr1 1 0.00 0.18 0.17
62 INT33141 Pck1 Regulation of Npr1 1 0.00 0.17 0.16
63 INT310595 Ros1 Positive_regulation of Npr1 1 0.03 0.84 0.16
64 INT251435 Gnat3 Positive_regulation of NPR1 1 0.22 0.2 0.15
65 INT251424 Positive_regulation of Gnat3 Positive_regulation of Gucy1b2 1 0.02 0.2 0.15
66 INT251431 Negative_regulation of Gnat3 Positive_regulation of Gucy1b2 1 0.02 0.1 0.14
67 INT173725 Binding of Gucy2c and Ccl4 1 0.08 0.53 0.12
68 INT25090 Negative_regulation of Glul Positive_regulation of Npr1 1 0.00 0 0.1
69 INT43284 Binding of Npr1 and Gcg 1 0.05 0 0.1
70 INT164428 Gsta3 Positive_regulation of Npr1 1 0.00 0 0.1
71 INT46240 Npr1 Positive_regulation of Localization of Avp 1 0.05 0 0.09
72 INT25269 Hmmr Negative_regulation of Npr1 1 0.01 0.63 0.08
73 INT91097 Ptprg Positive_regulation of Npr1 1 0.00 0.62 0.08
74 INT257226 Phosphorylation of Prkacb Positive_regulation of Npr1 1 0.00 0 0.08
75 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
76 INT91098 Gcgr Positive_regulation of Npr1 1 0.01 0.38 0.06
77 INT43283 Gcg Positive_regulation of Npr1 1 0.07 0 0.05
78 INT171399 Binding of Npr1 and Prkcg 1 0.00 0.23 0.04
79 INT171401 Binding of Adcyap1 and Npr1 1 0.02 0.23 0.04
80 INT44815 Sct Positive_regulation of Npr1 1 0.06 0 0.03
81 INT91095 Naf1 Positive_regulation of Npr1 1 0.01 0.18 0
82 INT247031 Npr1 Positive_regulation of Prkaca 1 0.00 0 0
83 INT91096 Naf1 Positive_regulation of Binding of Npr1 1 0.02 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for guanylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported in guanylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
2 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
3 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
4 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
5 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
6 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
7 INT8989 Binding of Npr1 25 0.36 5.52 14.58
8 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
9 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
10 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79
11 INT6459 Regulation of Negative_regulation of Npr1 10 0.53 0.16 6.44
12 INT7021 Positive_regulation of Negative_regulation of Npr1 8 0.22 1.02 6.36
13 INT6195 Transcription of Npr1 9 0.69 3 5.94
14 INT7018 Positive_regulation of Gene_expression of Npr1 10 0.59 5.09 5.66
15 INT13706 Localization of Npr1 10 0.59 0.83 5.42
16 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78
17 INT83407 Negative_regulation of Gucy1b2 11 0.58 0.9 4.2
18 INT157056 Gene_expression of Gucy1a2 4 0.09 0.71 3.67
19 INT54449 Positive_regulation of Transcription of Npr1 3 0.45 1.73 2.81
20 INT99104 Gene_expression of Npr1 5 0.78 3.31 2.8
21 INT83404 Positive_regulation of Gucy1b2 9 0.68 5.18 2.74
22 INT26205 Positive_regulation of Positive_regulation of NPR1 3 0.24 1.57 2.52
23 INT80463 Localization of Gucy1a2 4 0.07 0.49 2.5
24 INT11065 Gene_expression of NPR1 6 0.55 3.41 2.32
25 INT6460 Regulation of Gene_expression of Npr1 4 0.52 2.19 2.13
26 INT83218 Negative_regulation of Gucy1a2 6 0.24 0.82 1.9
27 INT183450 Positive_regulation of GUCY2C 6 0.04 4.45 1.88
28 INT14413 Regulation of Positive_regulation of Npr1 7 0.62 0.71 1.78
29 INT11098 Regulation of NPR1 5 0.37 1.39 1.74
30 INT99834 Gene_expression of Gucy1b2 5 0.73 1.02 1.74
31 INT55704 Positive_regulation of Gucy1a2 6 0.50 1.24 1.7
32 INT43045 Negative_regulation of Regulation of Npr1 3 0.12 0.17 1.65
33 INT26488 Regulation of Npr1 4 0.39 0.88 1.56
34 INT31921 Negative_regulation of Localization of Npr1 2 0.17 0 1.51
35 INT6194 Regulation of Transcription of Npr1 2 0.05 0.08 1.46
36 INT67465 Positive_regulation of Regulation of Npr1 1 0.05 0.14 1.4
37 INT99835 Positive_regulation of Gene_expression of Gucy1b2 2 0.66 0.47 1.26
38 INT78355 Negative_regulation of Gene_expression of Npr1 2 0.06 0.15 1.22
39 INT11099 Localization of NPR1 5 0.67 1.49 1.21
40 INT89756 Positive_regulation of Positive_regulation of Npr1 2 0.47 0.9 1.19
41 INT40170 Regulation of Localization of Npr1 2 0.05 0.12 1.16
42 INT81136 Binding of Npr1 6 0.48 1.45 1.15
43 INT91427 Gene_expression of Gucy2c 2 0.37 0.18 1
44 INT11100 Positive_regulation of Gene_expression of NPR1 2 0.37 1.49 0.98
45 INT11066 Negative_regulation of NPR1 5 0.27 0.89 0.88
46 INT42356 Negative_regulation of Binding of Npr1 1 0.32 0.37 0.82
47 INT32513 Regulation of Localization of NPR1 3 0.36 0.84 0.81
48 INT54452 Regulation of Regulation of Npr1 1 0.03 0 0.72
49 INT5569 Phosphorylation of Npr1 3 0.18 0.61 0.7
50 INT70520 Regulation of Gucy1b2 3 0.27 0 0.67
51 INT70530 Binding of NPR1 3 0.17 0.71 0.65
52 INT89855 Localization of Npr1 1 0.20 0.32 0.57
53 INT84084 Binding of Gucy1a2 2 0.08 0.38 0.56
54 INT91426 Positive_regulation of Gucy2c 1 0.37 0.06 0.54
55 INT70532 Regulation of Regulation of NPR1 1 0.12 0.31 0.49
56 INT83406 Negative_regulation of Positive_regulation of Gucy1b2 1 0.42 0.07 0.39
57 INT70531 Negative_regulation of Negative_regulation of NPR1 1 0.19 0.24 0.37
58 INT42659 Positive_regulation of Localization of Npr1 1 0.10 0.36 0.34
59 INT83405 Regulation of Positive_regulation of Gucy1b2 1 0.27 0 0.34
60 INT32566 Positive_regulation of Localization of NPR1 1 0.58 0.17 0.33
61 INT252267 Positive_regulation of Positive_regulation of GUCY2C 1 0.03 0.59 0.3
62 INT72112 Positive_regulation of Positive_regulation of Gucy1a2 1 0.07 0 0.3
63 INT242985 Regulation of Gene_expression of Npr1 1 0.03 0.85 0.29
64 INT149920 Regulation of Gucy1a2 1 0.11 0.35 0.28
65 INT55703 Negative_regulation of Positive_regulation of Gucy1a2 1 0.31 0.28 0.27
66 INT80465 Regulation of Localization of Gucy1a2 1 0.03 0.49 0.23
67 INT252264 Binding of GUCY2C 1 0.01 0.34 0.22
68 INT95576 Gene_expression of GUCY2C 4 0.42 1.78 0.21
69 INT116053 Binding of Gucy1b2 2 0.20 1.04 0.19
70 INT41153 Regulation of Binding of Npr1 1 0.01 0 0.19
71 INT95575 Localization of GUCY2C 1 0.43 0 0.19
72 INT89848 Positive_regulation of Localization of Npr1 1 0.13 0.15 0.18
73 INT158445 Gene_expression of Npr2 3 0.36 1.19 0.15
74 INT260458 Localization of Gucy2f 1 0.24 0.17 0.13
75 INT61064 Regulation of Npr2 1 0.23 0 0.1
76 INT54547 Positive_regulation of Phosphorylation of Npr1 1 0.05 0 0.1
77 INT257197 Phosphorylation of Npr1 1 0.03 0 0.08
78 INT125747 Positive_regulation of Gene_expression of Npr1 1 0.70 0.62 0.07
79 INT31800 Positive_regulation of Binding of Npr1 1 0.08 0.06 0.06
80 INT273620 Positive_regulation of Gene_expression of GUCY2C 1 0.01 1.48 0
81 INT273619 Negative_regulation of Gene_expression of GUCY2C 1 0.01 0.79 0
82 INT274107 Negative_regulation of Phosphorylation of Npr1 1 0.08 0.32 0
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