GO:0004420

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Name hydroxymethylglutaryl-CoA reductase (NADPH) activity
Categary Function
Go Slim No
Go Link GO:0004420
Unique Molecular Interactions 19
Total Molecular Interactions 21
Total Single Events 352
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hydroxymethylglutaryl-CoA reductase (NADPH) activity. They are ordered first by their pain relevance and then by number of times they were reported for hydroxymethylglutaryl-CoA reductase (NADPH) activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
2 INT270723 Negative_regulation of HMGCR Positive_regulation of LDLR 1 0.02 0.52 0.12
3 INT176020 IL8 Negative_regulation of Phosphorylation of HMGCR 1 0.00 0.1 0.11
4 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06
5 INT239320 Eef1a2 Negative_regulation of Hmgcr 1 0.06 0.89 0.04
6 INT217648 Binding of fa and Hmgcr 1 0.00 0.89 0.03
7 INT233323 GAD1 Regulation of HMGCR 1 0.09 0.2 0
8 INT316355 Binding of CR1 and Hmgcr 1 0.01 0.59 0
9 INT282288 Binding of Hmgcr and Nos2 1 0.03 1.99 0
10 INT339693 HMGCR Positive_regulation of SREBF2 1 0.05 0.54 0
11 INT326064 APOA1 Positive_regulation of HMGCR 1 0.16 0.19 0
12 INT339709 HMGCR Positive_regulation of Gene_expression of SREBF2 1 0.05 0.54 0
13 INT236171 Binding of LIF and Hmgcr 1 0.02 0 0
14 INT282287 Binding of Cpox and Hmgcr 1 0.01 0.99 0
15 INT329221 Prkag1 Negative_regulation of Hmgcr 1 0.06 0.48 0
16 INT326066 APOA1 Positive_regulation of Positive_regulation of HMGCR 1 0.17 0.19 0
17 INT295499 Lcat Regulation of Transcription of Hmgcr 1 0.04 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hydroxymethylglutaryl-CoA reductase (NADPH) activity. They are ordered first by their pain relevance and then by number of times they were reported in hydroxymethylglutaryl-CoA reductase (NADPH) activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4
2 INT70801 Gene_expression of Hmgcr 12 0.42 3.08 4.1
3 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54
4 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94
5 INT113777 Binding of Hmgcr 3 0.09 2.29 1.35
6 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3
7 INT236163 Localization of Hmgcr 6 0.64 0.66 1.12
8 INT98975 Positive_regulation of Hmgcr 7 0.16 3.4 1.06
9 INT203688 Positive_regulation of Hmgcr 10 0.17 6.08 0.52
10 INT142695 Gene_expression of HMGCR 17 0.65 3.75 0.32
11 INT232236 Negative_regulation of Gene_expression of Hmgcr 3 0.35 1.36 0.31
12 INT176039 Regulation of HMGCR 6 0.17 2.32 0.29
13 INT322907 Positive_regulation of Gene_expression of Hmgcr 4 0.03 1.45 0.28
14 INT250545 Regulation of Hmgcr 5 0.11 4.94 0.23
15 INT182749 Binding of Hmgcr 3 0.32 0.55 0.22
16 INT176036 Phosphorylation of HMGCR 1 0.05 0.19 0.22
17 INT87196 Regulation of Hmgcr 3 0.45 0.7 0.14
18 INT176038 Binding of HMGCR 1 0.03 0.72 0.14
19 INT142342 Regulation of Negative_regulation of Hmgcr 1 0.20 0.48 0.1
20 INT228554 Negative_regulation of Negative_regulation of Hmgcr 1 0.24 0.44 0.08
21 INT197011 Regulation of Gene_expression of HMGCR 1 0.32 0.09 0.08
22 INT153688 Negative_regulation of Negative_regulation of Hmgcr 1 0.42 1.21 0.06
23 INT153690 Localization of Hmgcr 1 0.74 1.21 0.06
24 INT153689 Negative_regulation of Localization of Hmgcr 1 0.42 1.21 0.06
25 INT176037 Transcription of HMGCR 2 0.37 0.07 0.04
26 INT282271 Positive_regulation of Regulation of Hmgcr 1 0.12 1.44 0.04
27 INT295501 Negative_regulation of Gene_expression of Hmgcr 1 0.26 0.21 0.04
28 INT176040 Negative_regulation of Transcription of HMGCR 1 0.04 0.07 0.04
29 INT311758 Regulation of Gene_expression of Hmgcr 1 0.08 0 0.04
30 INT176033 Positive_regulation of HMGCR 8 0.33 2.56 0.03
31 INT243183 Regulation of Negative_regulation of HMGCR 1 0.15 0.06 0.03
32 INT197015 Positive_regulation of Gene_expression of HMGCR 2 0.29 0.76 0
33 INT176185 Transcription of Hmgcr 2 0.31 0.56 0
34 INT197013 Localization of HMGCR 1 0.36 0 0
35 INT247129 Positive_regulation of Protein_catabolism of Hmgcr 1 0.06 0.38 0
36 INT176209 Negative_regulation of Transcription of Hmgcr 1 0.25 0.3 0
37 INT173493 Regulation of Gene_expression of Hmgcr 1 0.33 0 0
38 INT247134 Protein_catabolism of Hmgcr 1 0.14 0.38 0
39 INT203686 Negative_regulation of Positive_regulation of Hmgcr 1 0.02 0.4 0
40 INT258070 Positive_regulation of Regulation of HMGCR 1 0.10 0.44 0
41 INT295506 Transcription of Hmgcr 1 0.43 0.19 0
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