GO:0004435

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Name phosphatidylinositol phospholipase C activity
Categary Function
Go Slim No
Go Link GO:0004435
Unique Molecular Interactions 251
Total Molecular Interactions 368
Total Single Events 2979
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol phospholipase C activity. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol phospholipase C activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
3 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
4 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
5 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
6 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
7 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
8 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
9 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
10 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
11 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
12 INT266811 Binding of HRH1 and HTR2C 1 0.23 2.06 1.4
13 INT222213 TFAM Positive_regulation of Gene_expression of Ccr1 1 0.02 3.96 1.4
14 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
15 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
16 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
17 INT175553 Binding of CASR and CP 1 0.11 1.65 1.03
18 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02
19 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
20 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
21 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
22 INT66712 Binding of BDKRB2 and KNG1 1 0.06 0.22 0.97
23 INT66711 Negative_regulation of Binding of BDKRB2 and KNG1 1 0.07 0.22 0.97
24 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
25 INT96260 Pik3cd Regulation of Plcg2 1 0.02 0 0.92
26 INT301079 Binding of GNAT1 and INPP5E 1 0.00 0.59 0.89
27 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
28 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84
29 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
30 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
31 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77
32 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
33 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
34 INT209035 Il2 Positive_regulation of Ccr1 1 0.00 0.38 0.73
35 INT209038 Il4 Positive_regulation of Ccr1 1 0.01 0.38 0.73
36 INT209065 Il3 Positive_regulation of Ccr1 1 0.00 0.38 0.73
37 INT209031 Il12b Positive_regulation of Ccr1 1 0.02 0.37 0.72
38 INT209041 Il10 Positive_regulation of Ccr1 1 0.01 0.37 0.72
39 INT209060 Il6 Positive_regulation of Ccr1 1 0.01 0.38 0.72
40 INT222211 TFAM Positive_regulation of Ccr1 1 0.02 1.89 0.68
41 INT8980 Gal Regulation of PLCB1 1 0.18 0.13 0.68
42 INT297307 Negative_regulation of Binding of Ccr1 and Ccl3 1 0.27 0.73 0.67
43 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
44 INT129313 HTR2A Positive_regulation of Oxt 1 0.41 0.22 0.67
45 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67
46 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66
47 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
48 INT75764 Positive_regulation of DYT10 Positive_regulation of Phosphorylation of Plcb3 1 0.04 0.11 0.65
49 INT106247 Binding of CCR5 and CCL4 1 0.54 0.06 0.64
50 INT334594 Binding of GNAI1 and MRGPRD 1 0.01 0.19 0.63
51 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
52 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
53 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
54 INT36511 Binding of Htr2a and Eef1a1 1 0.22 0 0.62
55 INT36512 Binding of Htr2a and Man2a2 1 0.19 0 0.62
56 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
57 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
58 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
59 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
60 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
61 INT254637 Bdkrb2 Regulation of Gene_expression of Ccl5 1 0.17 1.22 0.56
62 INT97635 ABCF1 Positive_regulation of Localization of CCR1 1 0.05 0.51 0.55
63 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
64 INT47745 Binding of Slc6a4 and Htr2a 1 0.33 0.09 0.52
65 INT171278 TNFSF12 Positive_regulation of CCL5 1 0.02 0.93 0.48
66 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45
67 INT74085 Binding of Htr1d and Htr2a 1 0.40 0.65 0.45
68 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
69 INT118136 Binding of HTR1A and HTR2A 1 0.36 0.77 0.45
70 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
71 INT178664 Binding of CCR5 and TH1L 1 0.04 1.04 0.44
72 INT80233 Positive_regulation of OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
73 INT80232 OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
74 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
75 INT186758 Il13 Regulation of Ccl5 2 0.17 0.17 0.39
76 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39
77 INT181081 Binding of Ccr1 and Darc 1 0.01 1.08 0.39
78 INT332701 Binding of BDKRB1 and BDKRB2 1 0.01 0.5 0.39
79 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
80 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
81 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36
82 INT136008 Binding of BDKRB2 and INSRR 1 0.01 0.17 0.34
83 INT80205 HTR1B Positive_regulation of Positive_regulation of HTR2A 1 0.54 0 0.33
84 INT175552 Binding of CASR and UPF1 1 0.01 0.89 0.33
85 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
86 INT337327 KNG1 Positive_regulation of BDKRB2 1 0.21 0.4 0.32
87 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
88 INT244233 Ccr1 Positive_regulation of Cxcr1 1 0.16 0.08 0.32
89 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
90 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
91 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
92 INT181432 Csf2 Positive_regulation of Ccl5 1 0.03 0.81 0.29
93 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
94 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
95 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27
96 INT237088 Binding of Cxcl9 and Ccl5 1 0.29 1.51 0.26
97 INT268766 Tlr4 Positive_regulation of Gene_expression of Ccr1 1 0.04 0.4 0.26
98 INT246438 Ccl5 Positive_regulation of Gene_expression of Cd79a 1 0.13 0.83 0.26
99 INT219918 Positive_regulation of EDNRA Positive_regulation of Trpv1 1 0.13 0 0.26
100 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
101 INT252815 Binding of CCL5 and TNF 1 0.02 0.75 0.25
102 INT157957 Ppyr1 Negative_regulation of Phosphorylation of PLCB1 1 0.00 0.24 0.24
103 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
104 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
105 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
106 INT66681 Positive_regulation of HTR2A Positive_regulation of Localization of SFTPA1 1 0.22 0.07 0.24
107 INT268768 Mip Regulation of Positive_regulation of Ccr1 1 0.44 0.83 0.23
108 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
109 INT80287 IL4 Positive_regulation of Gene_expression of CCL5 1 0.21 0.37 0.23
110 INT170993 IL10 Positive_regulation of Gene_expression of CCR1 1 0.12 0.34 0.22
111 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
112 INT193033 Binding of CHRM1 and EGF 1 0.01 1.96 0.22
113 INT36876 EDNRA Regulation of Negative_regulation of PRB1 1 0.00 0 0.21
114 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
115 INT295713 PTGER2 Positive_regulation of Regulation of CCL5 1 0.01 0.82 0.21
116 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2
117 INT158209 Binding of CCR1 and AHSA1 1 0.17 0.3 0.2
118 INT158225 Binding of CCR1 and MAPK1 1 0.18 0.3 0.2
119 INT158231 TNFSF14 Positive_regulation of CCR1 1 0.07 0.3 0.2
120 INT158210 Binding of CCR1 and TNFSF14 1 0.05 0.3 0.2
121 INT158212 Negative_regulation of Binding of CCR1 and AHSA1 1 0.20 0.3 0.2
122 INT158200 Positive_regulation of Binding of CCR1 and AHSA1 1 0.23 0.3 0.2
123 INT158201 Positive_regulation of Binding of CCR1 and TNFSF14 1 0.07 0.3 0.2
124 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
125 INT158221 Positive_regulation of Binding of CCR1 and MAPK1 1 0.25 0.3 0.2
126 INT158230 Negative_regulation of Binding of CCR1 and TNFSF14 1 0.06 0.3 0.2
127 INT158219 Negative_regulation of Binding of CCR1 and MAPK1 1 0.21 0.3 0.2
128 INT50886 HTR2A Positive_regulation of HTR1D 1 0.54 0.07 0.2
129 INT23585 Binding of KRIT1 and CCR1 1 0.40 0.97 0.19
130 INT170995 Binding of IFNA1 and Positive_regulation of Localization of CCL5 1 0.03 0.34 0.19
131 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
132 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
133 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
134 INT226344 Gene_expression of IL9 Positive_regulation of CCL5 1 0.07 1.03 0.18
135 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
136 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17
137 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
138 INT172250 Binding of APLNR and CCR1 1 0.12 0 0.17
139 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17
140 INT225501 Plcl1 Regulation of Gene_expression of Casr 1 0.04 0.67 0.16
141 INT88311 ITIH4 Positive_regulation of CCR5 1 0.49 1.57 0.16
142 INT246440 Ccl5 Positive_regulation of Positive_regulation of Xcl1 1 0.27 1.28 0.16
143 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
144 INT261520 Binding of DLG4 and HTR2A 1 0.06 0 0.14
145 INT268765 Tlr4 Positive_regulation of Positive_regulation of Ccr1 1 0.04 0.27 0.13
146 INT219920 EDNRA Positive_regulation of Trpv1 1 0.14 0 0.13
147 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
148 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
149 INT59807 ADRA1D Positive_regulation of PLCB1 1 0.33 0 0.13
150 INT244032 Binding of Ppp1ca and Plcl1 1 0.00 0.16 0.12
151 INT171295 CXCL10 Positive_regulation of CCL5 1 0.04 0.06 0.12
152 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11
153 INT189301 Atp6v1e1 Positive_regulation of Positive_regulation of Htr2a 1 0.01 1.13 0.11
154 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1
155 INT336990 Binding of AGTR1 and BDKRB2 1 0.03 0 0.1
156 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
157 INT174093 Htr2c Regulation of Gene_expression of Csf2 1 0.00 0 0.09
158 INT284141 Binding of EDNRA and PAH 1 0.05 0.1 0.09
159 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
160 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
161 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
162 INT115934 U Regulation of PLCB4 1 0.00 0.3 0.08
163 INT115935 U Regulation of PLCB3 1 0.00 0.3 0.08
164 INT115933 U Regulation of PLCB1 1 0.00 0.3 0.08
165 INT278611 Binding of CASR and SULT2A1 1 0.03 0 0.07
166 INT186767 Ccl11 Regulation of Ccl5 1 0.01 0 0.07
167 INT171297 TNF Positive_regulation of Localization of CCL5 1 0.17 0.66 0.07
168 INT186766 Il5 Regulation of Ccl5 1 0.01 0 0.07
169 INT278685 Binding of CASR and Rxra 1 0.00 0 0.07
170 INT246441 Ccl5 Positive_regulation of Gene_expression of Aif1 1 0.03 0.71 0.06
171 INT246436 Ccl5 Regulation of Aif1 1 0.01 0.67 0.06
172 INT337297 PTAFR Positive_regulation of EDNRA 1 0.04 1.2 0.06
173 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 0.10 0.88 0.06
174 INT227562 GNAI1 Negative_regulation of GLUL 1 0.01 0 0.06
175 INT337303 Positive_regulation of PTAFR Positive_regulation of EDNRA 1 0.04 1.21 0.06
176 INT278606 CASR Regulation of SULT2A1 1 0.04 0 0.05
177 INT145056 Binding of Nr1i3 and Plcl1 1 0.21 0.26 0.05
178 INT281906 BDKRB2 Positive_regulation of ANG 1 0.11 0.51 0.05
179 INT339778 Binding of EDNRA and PTH 1 0.12 0.35 0.05
180 INT73194 GRB2 Positive_regulation of Positive_regulation of PLCG2 1 0.19 0.81 0.05
181 INT145057 Binding of Ppara and Plcl1 1 0.36 0.26 0.05
182 INT122216 IL1B Positive_regulation of CCL5 3 0.67 0.53 0.04
183 INT247774 Binding of Ccl5 and Ccrl2 1 0.14 0.29 0.04
184 INT245219 Binding of C3AR1 and C5AR1 1 0.34 1.21 0.04
185 INT274095 Binding of EDNRA and OPA1 1 0.12 0.65 0.04
186 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04
187 INT171279 IL6 Positive_regulation of CCL5 1 0.04 0.38 0.04
188 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 0.16 0.71 0.04
189 INT245216 Binding of C3 and C3AR1 1 0.19 1.21 0.04
190 INT107859 PRSS1 Positive_regulation of EDNRA 1 0.03 0.69 0.04
191 INT171301 TNF Positive_regulation of CCL5 1 0.16 0.38 0.04
192 INT247766 Binding of Ccl2 and Ccl5 1 0.14 0.28 0.04
193 INT183767 Csf2 Negative_regulation of Transcription of CCR5 1 0.17 0.92 0.03
194 INT316217 BDKRB1 Positive_regulation of BDKRB2 1 0.09 0.71 0.03
195 INT316218 GOPC Positive_regulation of BDKRB2 1 0.08 0.71 0.03
196 INT183758 INCENP Negative_regulation of Transcription of CCR5 1 0.00 0.93 0.03
197 INT122217 IL1B Positive_regulation of Gene_expression of CCL5 2 0.52 0.08 0
198 INT115611 Binding of EDNRA and ERBB2 1 0.08 0.78 0
199 INT121652 Binding of CCR5 and CXCL12 1 0.33 0.2 0
200 INT233506 Tlr4 Positive_regulation of Htr2b 1 0.06 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol phospholipase C activity. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol phospholipase C activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
2 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
3 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
4 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
5 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14
6 INT78901 Localization of CCL5 67 0.78 40.79 20.59
7 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04
8 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
9 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
10 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
11 INT5324 Binding of Htr2a 23 0.47 7.14 14.66
12 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14
13 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87
14 INT30961 Binding of HTR2A 33 0.47 11.44 12.86
15 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
16 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6
17 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
18 INT96259 Positive_regulation of Plcg1 11 0.49 3.01 11.15
19 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06
20 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
21 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75
22 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
23 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
24 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81
25 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63
26 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
27 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07
28 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
29 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
30 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25
31 INT27785 Regulation of HTR2A 11 0.44 8 8.18
32 INT166881 Positive_regulation of Ccr1 31 0.69 18.14 7.9
33 INT110004 Gene_expression of Plcg1 7 0.41 2.61 7.87
34 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
35 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
36 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
37 INT91758 Binding of CCR5 28 0.45 20.16 7.07
38 INT93144 Gene_expression of CCR1 18 0.75 14.69 6.84
39 INT181348 Localization of Ccl5 24 0.65 19.55 6.8
40 INT141611 Positive_regulation of Gene_expression of Ccr1 25 0.69 20.32 6.42
41 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11
42 INT35452 Gene_expression of Htr2a 11 0.65 5.11 6.1
43 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07
44 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86
45 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
46 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
47 INT83095 Regulation of Gene_expression of BDKRB2 2 0.59 4.06 5.39
48 INT181022 Binding of Ccr1 15 0.37 10.69 5.37
49 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
50 INT181363 Regulation of Ccl5 16 0.46 13.65 5.09
51 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05
52 INT181362 Negative_regulation of Ccl5 21 0.40 15.63 4.96
53 INT82887 Positive_regulation of Ccl5 10 0.40 3.4 4.91
54 INT176614 Positive_regulation of Gene_expression of Ccl5 20 0.59 16.2 4.81
55 INT49748 Binding of HTR2C 10 0.47 3.03 4.76
56 INT150237 Localization of Ccr1 10 0.75 9.25 4.72
57 INT17391 Gene_expression of GNAI1 11 0.75 5.26 4.7
58 INT89590 Negative_regulation of Gene_expression of Ccl5 8 0.36 3.97 4.67
59 INT17393 Positive_regulation of GNAI1 17 0.49 2.42 4.66
60 INT75761 Positive_regulation of Phosphorylation of Plcb3 1 0.05 0.22 4.58
61 INT181042 Binding of Ccl5 18 0.41 9.34 4.51
62 INT75759 Phosphorylation of Plcb3 1 0.06 0.22 4.42
63 INT98057 Regulation of Htr2a 9 0.44 5.06 4.28
64 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26
65 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
66 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
67 INT65700 Localization of CCR1 7 0.51 4 3.91
68 INT175555 Gene_expression of CASR 17 0.78 14.83 3.73
69 INT60667 Transcription of HTR2A 5 0.67 0.44 3.71
70 INT103281 Transcription of CCL5 10 0.67 5.95 3.7
71 INT89592 Localization of Ccl5 10 0.61 7.65 3.62
72 INT181378 Negative_regulation of Gene_expression of Ccl5 12 0.46 9.64 3.59
73 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
74 INT53347 Localization of BDKRB2 5 0.75 4.96 3.39
75 INT124123 Positive_regulation of Localization of CCL5 12 0.67 7 3.37
76 INT181418 Regulation of Gene_expression of Ccl5 11 0.52 9.86 3.37
77 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
78 INT59275 Positive_regulation of Transcription of Htr2a 6 0.49 4.65 3.34
79 INT35450 Negative_regulation of Htr2a 7 0.47 3.46 3.33
80 INT66617 Localization of HTR2A 6 0.80 1.35 3.32
81 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17
82 INT78898 Regulation of Gene_expression of CCL5 9 0.42 5.7 3.11
83 INT115617 Binding of Ccl5 5 0.33 0.58 3.11
84 INT66720 Negative_regulation of BDKRB2 5 0.57 1.92 3.11
85 INT53348 Binding of BDKRB2 7 0.37 2.85 3
86 INT301081 Positive_regulation of GNAT1 1 0.12 4.16 3
87 INT54754 Localization of Htr2a 6 0.73 0.73 2.85
88 INT49843 Positive_regulation of Gene_expression of Htr2a 3 0.49 1.53 2.84
89 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
90 INT110233 Regulation of Gene_expression of CCR5 6 0.34 7.14 2.76
91 INT106433 Regulation of CCR5 11 0.59 6.93 2.75
92 INT194661 Binding of CCL5 9 0.46 6.07 2.73
93 INT20593 Positive_regulation of Positive_regulation of Htr2a 6 0.49 1.29 2.55
94 INT62141 Positive_regulation of Gene_expression of HTR2A 8 0.67 2.47 2.42
95 INT15201 Positive_regulation of CHRM1 8 0.54 2.14 2.35
96 INT20072 Positive_regulation of Positive_regulation of HTR2A 5 0.67 2.96 2.33
97 INT59818 Negative_regulation of PLCB1 7 0.57 2.24 2.28
98 INT113775 Negative_regulation of Gene_expression of CCR5 6 0.43 3.97 2.28
99 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25
100 INT45392 Regulation of CHRM1 3 0.26 0.52 2.25
101 INT23588 Positive_regulation of CCR1 6 0.67 4.44 2.24
102 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
103 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22
104 INT181402 Negative_regulation of Ccr1 8 0.42 7 2.2
105 INT115616 Positive_regulation of Binding of Ccl5 3 0.25 0.59 2.04
106 INT17390 Regulation of GNAI1 5 0.04 3.58 2.03
107 INT110003 Phosphorylation of Plcg1 2 0.37 0.91 1.96
108 INT112970 Regulation of Ccr1 8 0.29 7.77 1.93
109 INT50658 Positive_regulation of HTR2C 5 0.67 2.3 1.9
110 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9
111 INT55640 Gene_expression of CHRM1 7 0.44 2.24 1.89
112 INT301080 Binding of GNAT1 1 0.10 2.04 1.85
113 INT74088 Negative_regulation of Positive_regulation of Htr2c 1 0.41 0 1.75
114 INT194660 Positive_regulation of Binding of CCL5 1 0.42 2.74 1.72
115 INT25192 Positive_regulation of Gene_expression of GNAI1 5 0.49 1.08 1.7
116 INT78896 Negative_regulation of Localization of CCL5 8 0.57 2.43 1.59
117 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
118 INT171015 Positive_regulation of Positive_regulation of CCL5 3 0.42 3.63 1.51
119 INT189286 Regulation of Gene_expression of Htr2a 1 0.01 1.12 1.49
120 INT106831 Negative_regulation of Regulation of CHRM1 1 0.15 0.16 1.49
121 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
122 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
123 INT13730 Negative_regulation of CHRM1 5 0.35 1.78 1.41
124 INT189290 Positive_regulation of Positive_regulation of Htr2a 1 0.02 2.51 1.41
125 INT286696 Binding of Htr2a 2 0.35 0.71 1.4
126 INT216512 Gene_expression of C3AR1 13 0.70 8.44 1.31
127 INT115895 Phosphorylation of Ccl5 1 0.55 0 1.31
128 INT53160 Gene_expression of HTR2C 3 0.75 0.62 1.3
129 INT120406 Positive_regulation of Positive_regulation of BDKRB2 2 0.27 1.48 1.28
130 INT272340 Transcription of Htr2c 1 0.52 2.77 1.28
131 INT25806 Binding of GNAI1 5 0.47 0.15 1.24
132 INT59815 Positive_regulation of PLCB1 9 0.67 1.12 1.22
133 INT110001 Binding of Plcg1 2 0.36 0.44 1.21
134 INT125338 Regulation of HTR2C 2 0.26 1.32 1.18
135 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
136 INT241757 Localization of CCR5 6 0.71 5.7 1.14
137 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
138 INT149554 Transcription of Ccl5 2 0.59 0.55 1.14
139 INT115893 Negative_regulation of Binding of Ccl5 1 0.37 0 1.14
140 INT268754 Negative_regulation of Gene_expression of Ccr1 5 0.43 2.76 1.13
141 INT59274 Positive_regulation of Binding of Htr2a 2 0.67 0.93 1.12
142 INT35451 Negative_regulation of Gene_expression of Htr2a 2 0.35 0.34 1.04
143 INT110000 Positive_regulation of Phosphorylation of Plcg1 1 0.23 0.49 1.02
144 INT208244 Regulation of Gene_expression of Ccl5 1 0.26 1.92 1.01
145 INT77639 Phosphorylation of Plcg1 5 0.68 0.47 0.97
146 INT83857 Negative_regulation of Binding of HTR2A 1 0.42 0.52 0.97
147 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
148 INT268753 Negative_regulation of Positive_regulation of Ccr1 1 0.42 2.59 0.96
149 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
150 INT6708 Phosphorylation of GNAI1 2 0.25 0.36 0.93
151 INT181351 Transcription of Ccl5 5 0.64 2.19 0.9
152 INT103285 Regulation of Localization of CCL5 3 0.44 1.11 0.89
153 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
154 INT49842 Regulation of Gene_expression of Htr2a 2 0.44 0.18 0.88
155 INT149555 Negative_regulation of Positive_regulation of Ccl5 1 0.15 0 0.88
156 INT96967 Positive_regulation of Positive_regulation of GNAI1 2 0.49 0.16 0.87
157 INT40639 Binding of CHRM1 2 0.26 0.43 0.87
158 INT7001 Negative_regulation of Positive_regulation of Htr2a 2 0.41 0.44 0.86
159 INT98869 Gene_expression of GNAT1 1 0.13 0.13 0.81
160 INT181359 Transcription of Ccr1 4 0.53 1.66 0.8
161 INT268746 Positive_regulation of Binding of Ccr1 1 0.50 1.81 0.79
162 INT181390 Negative_regulation of Positive_regulation of Ccl5 2 0.31 2.31 0.77
163 INT290271 Negative_regulation of Binding of BDKRB2 1 0.37 0.99 0.76
164 INT62702 Negative_regulation of HTR2C 2 0.42 1.14 0.75
165 INT125261 Positive_regulation of Gene_expression of Htr2c 2 0.67 2.22 0.7
166 INT106127 Negative_regulation of CASR 7 0.43 7.12 0.67
167 INT216510 Binding of C3AR1 2 0.06 1.59 0.67
168 INT96968 Regulation of Positive_regulation of GNAI1 1 0.07 0.17 0.66
169 INT115897 Positive_regulation of Phosphorylation of Ccl5 1 0.41 0 0.66
170 INT171946 Positive_regulation of Binding of CCR5 1 0.47 3.86 0.66
171 INT59817 Gene_expression of PLCB1 4 0.75 0.73 0.65
172 INT67093 Binding of CASR 3 0.41 3.32 0.64
173 INT57127 Binding of Htr2b 2 0.36 0.05 0.63
174 INT75758 Binding of Plcb3 1 0.03 0 0.63
175 INT272356 Positive_regulation of Transcription of Htr2c 1 0.45 1.66 0.63
176 INT181349 Positive_regulation of Localization of Ccl5 2 0.37 0.89 0.62
177 INT38720 Protein_catabolism of C3AR1 2 0.17 0.18 0.62
178 INT175558 Positive_regulation of CASR 5 0.47 3.55 0.6
179 INT75760 Positive_regulation of Plcb3 1 0.03 0 0.6
180 INT110002 Regulation of Positive_regulation of Plcg1 1 0.11 0.4 0.59
181 INT189481 Regulation of Gene_expression of Ccr1 3 0.45 1.97 0.58
182 INT100754 Negative_regulation of Binding of Htr2c 1 0.41 0.49 0.57
183 INT286691 Transcription of Htr2a 1 0.08 0 0.57
184 INT172297 Binding of CCR1 1 0.36 0.08 0.56
185 INT194225 Positive_regulation of Positive_regulation of Ccl5 1 0.07 1.13 0.55
186 INT97637 Positive_regulation of Localization of CCR1 1 0.08 0.51 0.55
187 INT186686 Regulation of Positive_regulation of EDNRA 5 0.22 2.35 0.51
188 INT260124 Positive_regulation of Positive_regulation of CCR5 1 0.14 0.84 0.51
189 INT145053 Negative_regulation of Plcl1 4 0.52 1.65 0.5
190 INT230986 Positive_regulation of Transcription of Htr2c 1 0.45 0.25 0.49
191 INT73215 Negative_regulation of Gene_expression of HTR2A 1 0.41 0.45 0.49
192 INT120405 Phosphorylation of EDNRA 1 0.61 0.38 0.48
193 INT182225 Transcription of CCR1 1 0.57 0.45 0.47
194 INT157955 Phosphorylation of PLCB1 1 0.01 0.46 0.46
195 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45
196 INT148156 Positive_regulation of Gene_expression of HTR2C 1 0.67 0.26 0.45
197 INT146313 Negative_regulation of Localization of HTR2C 1 0.42 0 0.45
198 INT146315 Positive_regulation of Localization of HTR2C 1 0.45 0 0.44
199 INT194658 Positive_regulation of Transcription of CCL5 1 0.45 0.68 0.44
200 INT146314 Localization of HTR2C 1 0.68 0 0.44
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