GO:0004438

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Name phosphatidylinositol-3-phosphatase activity
Categary Function
Go Slim No
Go Link GO:0004438
Unique Molecular Interactions 162
Total Molecular Interactions 196
Total Single Events 2271
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-3-phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol-3-phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
2 INT281383 FSCN1 Positive_regulation of Fig4 1 0.02 0.44 1.19
3 INT255335 Fig4 Regulation of Phosphorylation of Nav1 1 0.01 0 1.03
4 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83
5 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
6 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
7 INT239638 Sst Regulation of Fig4 1 0.12 0.39 0.78
8 INT215630 Fig4 Regulation of Npy 1 0.01 0.26 0.76
9 INT202909 Binding of Tacr1 and Fig4 1 0.03 0.33 0.74
10 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
11 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
12 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
13 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
14 INT246336 Fig4 Regulation of Localization of Nts 1 0.18 0 0.66
15 INT222253 Binding of Cxcl10 and Fig4 1 0.09 0.66 0.65
16 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
17 INT313703 Binding of Calca and Fig4 1 0.11 0 0.65
18 INT281378 FSCN1 Positive_regulation of Gene_expression of Fig4 1 0.02 0.22 0.56
19 INT281648 Negative_regulation of Binding of Trpv1 and Fig4 1 0.14 0.69 0.55
20 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
21 INT281647 Binding of Trpv1 and Fig4 1 0.12 0.68 0.55
22 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
23 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54
24 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
25 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
26 INT232293 Abat Regulation of Binding of Fig4 1 0.11 0 0.43
27 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
28 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
29 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
30 INT330598 Binding of Il6 and Fig4 1 0.11 1.78 0.4
31 INT232292 Abat Positive_regulation of Fig4 1 0.12 0 0.4
32 INT215629 Binding of Kcnj5 and Fig4 1 0.00 0.37 0.39
33 INT303444 Timp1 Regulation of Fig4 1 0.15 0.43 0.39
34 INT321292 Fig4 Negative_regulation of Pck1 1 0.10 0.33 0.39
35 INT321301 Fig4 Negative_regulation of G6pc 1 0.07 0.33 0.39
36 INT266553 Ppp2r1a Positive_regulation of Fig4 1 0.00 0 0.38
37 INT266530 Ppyr1 Positive_regulation of Fig4 1 0.01 0 0.38
38 INT215655 Fig4 Regulation of REG1A 1 0.00 0.13 0.38
39 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
40 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
41 INT177426 Izumo1 Positive_regulation of Positive_regulation of Fig4 1 0.16 0.59 0.34
42 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
43 INT244422 Binding of DST and Fig4 1 0.01 0.42 0.29
44 INT291383 Fig4 Regulation of Gene_expression of Cntf 1 0.10 0 0.28
45 INT179425 Fig4 Regulation of Creb1 1 0.02 0.32 0.28
46 INT179423 Fig4 Regulation of Mapk3 1 0.02 0.32 0.28
47 INT321288 Fig4 Positive_regulation of Nr0b2 1 0.15 0.47 0.27
48 INT231037 Fig4 Regulation of Gene_expression of Fos 1 0.03 0.31 0.27
49 INT290847 Regulation of Binding of Stx1a and Fig4 1 0.05 0.26 0.24
50 INT178720 NOVA2 Regulation of Fig4 1 0.01 0 0.23
51 INT177425 Binding of Fig4 and Izumo1 1 0.12 0.59 0.23
52 INT290846 Binding of Stx1a and Fig4 1 0.07 0.26 0.22
53 INT296172 Fig4 Positive_regulation of Gene_expression of NOVA2 1 0.04 0 0.22
54 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
55 INT290857 PPR Regulation of Fig4 1 0.02 0.45 0.21
56 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
57 INT261787 Positive_regulation of Bdnf Positive_regulation of Fig4 1 0.02 0.77 0.2
58 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
59 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
60 INT352945 Fig4 Regulation of Negative_regulation of Pik3cb 1 0.03 0.38 0.19
61 INT175073 Fig4 Regulation of Psmc1 1 0.05 0.07 0.18
62 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
63 INT268947 Fig4 Positive_regulation of Ros1 1 0.01 0.06 0.18
64 INT175078 Fig4 Regulation of Klk1c9 1 0.02 0.07 0.18
65 INT330798 Fig4 Negative_regulation of Gene_expression of Accn2 1 0.03 0 0.16
66 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
67 INT219913 Fig4 Positive_regulation of Trpv1 1 0.03 0 0.13
68 INT280618 Fig4 Regulation of Ucp3 1 0.09 0 0.13
69 INT280617 Fig4 Regulation of Pdk4 1 0.09 0 0.13
70 INT298548 Itgam Regulation of Fig4 1 0.08 0.05 0.12
71 INT303877 Binding of Nav1 and Fig4 1 0.09 0.07 0.12
72 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
73 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
74 INT229424 Atp6v0a2 Regulation of Fig4 1 0.00 1.14 0.1
75 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
76 INT251623 Car2 Regulation of Gene_expression of Fig4 1 0.02 0.31 0.08
77 INT251712 Fig4 Regulation of Ache 1 0.02 0.23 0.08
78 INT251710 Fig4 Regulation of Chat 1 0.03 0.23 0.08
79 INT293471 Binding of Map2 and Fig4 1 0.03 0 0.08
80 INT251705 Fig4 Regulation of Localization of Chat 1 0.05 0.23 0.08
81 INT251703 Fig4 Regulation of Localization of Ache 1 0.07 0.23 0.08
82 INT208989 Binding of CALM1 and Fig4 1 0.01 0 0.07
83 INT297230 Binding of Abcc8 and Fig4 1 0.10 0 0.07
84 INT281879 Cat Negative_regulation of Fig4 1 0.01 0.96 0.06
85 INT321295 Negative_regulation of Fig4 Positive_regulation of Nr0b2 1 0.09 0.13 0.06
86 INT321284 Regulation of Fig4 Positive_regulation of Nr0b2 1 0.06 0.13 0.06
87 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
88 INT237351 Binding of Mtm1 and Gopc 1 0.19 0.17 0.05
89 INT292334 Binding of Sds and Fig4 1 0.02 0.07 0.05
90 INT303878 Fig4 Negative_regulation of Nav1 1 0.11 0.4 0.05
91 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
92 INT340271 Fig4 Positive_regulation of Localization of RELA 1 0.01 0.68 0.04
93 INT228679 Binding of Rps6kb1 and Fig4 1 0.08 0.08 0.04
94 INT296113 Fig4 Negative_regulation of Gene_expression of Csf2 1 0.01 0.91 0.04
95 INT249991 Agt Regulation of Fig4 1 0.12 0.57 0.04
96 INT216086 Binding of Nrtn and Fig4 1 0.03 0.23 0.04
97 INT340273 Fig4 Regulation of BGLAP 1 0.00 0.55 0.04
98 INT296115 Fig4 Negative_regulation of Csf2 1 0.01 0.91 0.04
99 INT182699 Binding of VEGFA and Fig4 2 0.04 0 0.03
100 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
101 INT295351 Egf Positive_regulation of Fig4 1 0.12 0.06 0.03
102 INT321287 Positive_regulation of Fig4 Positive_regulation of Nr0b2 1 0.10 0.07 0.03
103 INT217274 Avp Negative_regulation of Gene_expression of Fig4 1 0.02 0.06 0.03
104 INT351973 Agt Positive_regulation of Gene_expression of Fig4 1 0.07 1.33 0.03
105 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
106 INT268942 Binding of Crmp1 and Fig4 1 0.01 0.28 0.03
107 INT217270 Cpox Negative_regulation of Gene_expression of Fig4 1 0.01 0.06 0.03
108 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
109 INT283341 Binding of Ctbp1 and Fig4 1 0.06 0 0
110 INT242657 Fig4 Regulation of Ptger2 1 0.01 0.98 0
111 INT322126 Binding of Trpv4 and Fig4 1 0.02 0 0
112 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
113 INT182688 Binding of Vim and Fig4 1 0.08 0.07 0
114 INT349033 Binding of Cnp and Fig4 1 0.04 0.56 0
115 INT182686 Binding of Son and Fig4 1 0.12 0.07 0
116 INT256079 Serpina3k Negative_regulation of Fig4 1 0.07 0.16 0
117 INT256082 Serpina3k Negative_regulation of Positive_regulation of Fig4 1 0.07 0.16 0
118 INT280960 Binding of Cav3 and Fig4 1 0.08 0 0
119 INT280615 Fig4 Regulation of Gene_expression of Irs1 1 0.05 0 0
120 INT234145 Fig4 Negative_regulation of Gene_expression of Trib3 1 0.01 0.31 0
121 INT295340 Binding of Ptpn11 and Fig4 1 0.04 0 0
122 INT292330 Binding of Mb and Fig4 1 0.06 0 0
123 INT197910 Des Positive_regulation of Fig4 1 0.02 0 0
124 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
125 INT292326 Binding of Fig4 and LOC360919 1 0.00 0.08 0
126 INT184824 ALPP Regulation of Fig4 1 0.04 0 0
127 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0
128 INT254747 Positive_regulation of Binding of Skil and Fig4 1 0.03 0.14 0
129 INT280613 Fig4 Regulation of Gene_expression of Mpl 1 0.03 0 0
130 INT280620 Fig4 Regulation of Gene_expression of Edn1 1 0.03 0 0
131 INT234141 Fig4 Negative_regulation of Trib3 1 0.01 0.13 0
132 INT283354 Binding of Ctbp2 and Fig4 1 0.04 0 0
133 INT227213 Binding of Fig4 and SCO 1 0.00 0 0
134 INT319042 Negative_regulation of Binding of Fgf7 and Fig4 1 0.07 0.2 0
135 INT209570 Fig4 Positive_regulation of Gene_expression of Gfap 1 0.40 0.17 0
136 INT348723 ED Positive_regulation of PTEN 1 0.04 1.3 0
137 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0
138 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
139 INT351682 Fut1 Positive_regulation of PTEN 1 0.01 1.81 0
140 INT283351 Binding of Srr and Fig4 1 0.04 0 0
141 INT295347 Egf Regulation of Fig4 1 0.11 0 0
142 INT223574 PTEN Negative_regulation of AKT1 1 0.06 0.56 0
143 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
144 INT293114 Fig4 Regulation of Gene_expression of Aqp2 1 0.08 1.53 0
145 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
146 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0
147 INT254746 Binding of Skil and Fig4 1 0.02 0.14 0
148 INT307451 Fig4 Regulation of Phosphorylation of Gsk3a 1 0.01 0.06 0
149 INT254748 Binding of Fig4 and Regulation of Skil 1 0.02 0.53 0
150 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0
151 INT319043 Binding of Fgf7 and Fig4 1 0.06 0.26 0
152 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0
153 INT241964 Acpt Negative_regulation of Gene_expression of Fig4 1 0.10 0 0
154 INT340238 Tnfsf11 Positive_regulation of Gene_expression of Fig4 1 0.02 0.4 0
155 INT251702 Fig4 Regulation of Positive_regulation of Ache 1 0.07 0.42 0
156 INT295355 Binding of Fig4 and She 1 0.01 0 0
157 INT286186 Binding of Blm and Fig4 1 0.09 0.34 0
158 INT293804 PTEN Regulation of AKT1 1 0.04 0.07 0
159 INT349032 Negative_regulation of Binding of Cnp and Fig4 1 0.05 0.56 0
160 INT234144 Fig4 Negative_regulation of Transcription of Tyms 1 0.05 0.18 0
161 INT228588 Ppara Regulation of Gene_expression of Fig4 1 0.05 0 0
162 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-3-phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol-3-phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32
2 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81
3 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92
4 INT177581 Regulation of Fig4 113 0.41 39.26 27.75
5 INT171820 Localization of Fig4 144 0.65 27.38 20.88
6 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69
7 INT174844 Binding of Fig4 81 0.41 18.03 12.87
8 INT173272 Phosphorylation of Fig4 45 0.48 13.85 11.42
9 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
10 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
11 INT171146 Negative_regulation of Gene_expression of Fig4 38 0.37 11.41 7.42
12 INT218698 Negative_regulation of Positive_regulation of Fig4 11 0.20 6.01 6.32
13 INT173273 Positive_regulation of Phosphorylation of Fig4 16 0.30 7.3 4.62
14 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
15 INT173751 Transcription of Fig4 31 0.46 8.28 3.7
16 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
17 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
18 INT187505 Positive_regulation of Localization of Fig4 16 0.24 1.21 3.17
19 INT192676 Binding of PTEN 14 0.46 10.58 3.06
20 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
21 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
22 INT187499 Positive_regulation of Positive_regulation of Fig4 9 0.21 3.28 2.69
23 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
24 INT174876 Regulation of Gene_expression of Fig4 18 0.39 7.83 2.44
25 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
26 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
27 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
28 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
29 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
30 INT186022 Negative_regulation of Transcription of Fig4 6 0.28 2.09 1.5
31 INT228249 Binding of Pten 7 0.48 3.26 1.45
32 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
33 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
34 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
35 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
36 INT190014 Regulation of Pten 8 0.62 6.03 1.2
37 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
38 INT223133 Regulation of Localization of Fig4 5 0.39 0.5 0.88
39 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
40 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
41 INT176460 Protein_catabolism of Fig4 6 0.71 3.23 0.69
42 INT276199 Binding of Pten 2 0.30 0.4 0.67
43 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
44 INT276179 Regulation of Pten 1 0.46 0.81 0.63
45 INT171717 Regulation of Positive_regulation of Fig4 2 0.36 0.66 0.6
46 INT161322 Localization of PTEN 9 0.73 5.65 0.57
47 INT240718 Negative_regulation of Negative_regulation of Fig4 5 0.18 1.57 0.56
48 INT216271 Positive_regulation of Protein_catabolism of Fig4 2 0.13 1.21 0.54
49 INT249520 Negative_regulation of Phosphorylation of Fig4 3 0.15 0.52 0.52
50 INT251694 Regulation of Regulation of Fig4 3 0.06 0.05 0.52
51 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
52 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
53 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
54 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
55 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
56 INT203816 Localization of Pten 4 0.75 1.37 0.4
57 INT197774 Positive_regulation of Binding of Fig4 3 0.08 1.46 0.4
58 INT215889 Positive_regulation of Transcription of Fig4 3 0.29 0.15 0.39
59 INT336923 Localization of Fig4 1 0.20 0.69 0.38
60 INT331921 Positive_regulation of Fig4 1 0.27 1.43 0.38
61 INT200757 Gene_expression of Fig4 2 0.20 1.27 0.37
62 INT182690 Negative_regulation of Regulation of Fig4 1 0.15 0 0.36
63 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
64 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
65 INT281469 Transcription of Pten 2 0.72 1.12 0.32
66 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
67 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
68 INT200760 Positive_regulation of Gene_expression of Fig4 1 0.16 0.96 0.29
69 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
70 INT227102 Gene_expression of Mtm1 2 0.77 9.58 0.26
71 INT266566 Regulation of Transcription of Fig4 2 0.11 0.56 0.23
72 INT321354 Positive_regulation of Regulation of Fig4 1 0.16 0.23 0.21
73 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
74 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
75 INT237340 Positive_regulation of Mtm1 1 0.60 1.52 0.14
76 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
77 INT181573 Regulation of Phosphorylation of Fig4 1 0.02 1.26 0.12
78 INT179115 Negative_regulation of Localization of Fig4 5 0.33 1.94 0.11
79 INT225131 Negative_regulation of Binding of Fig4 5 0.19 1.43 0.08
80 INT237346 Localization of Mtm1 1 0.80 0.71 0.08
81 INT237345 Positive_regulation of Gene_expression of Mtm1 1 0.69 3.03 0.08
82 INT237341 Binding of Mtm1 1 0.48 1.16 0.07
83 INT237348 Negative_regulation of Gene_expression of Mtm1 1 0.42 0.23 0.05
84 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04
85 INT176144 Positive_regulation of Phosphorylation of PTEN 1 0.36 0.29 0.04
86 INT233844 Negative_regulation of Positive_regulation of Pten 1 0.17 0.73 0.04
87 INT185512 Positive_regulation of Negative_regulation of Fig4 2 0.20 0 0
88 INT315882 Regulation of Negative_regulation of PTEN 2 0.44 1.39 0
89 INT305346 Positive_regulation of Negative_regulation of Pten 2 0.41 0.91 0
90 INT321706 Negative_regulation of Phosphorylation of Pten 1 0.38 0.16 0
91 INT254733 Regulation of Binding of Fig4 1 0.06 0.15 0
92 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0
93 INT351091 Negative_regulation of Binding of PTEN 1 0.09 0.23 0
94 INT237339 Positive_regulation of Binding of Mtm1 1 0.50 0.26 0
95 INT334324 Positive_regulation of Negative_regulation of PTEN 1 0.41 0.81 0
96 INT176158 Regulation of Positive_regulation of PTEN 1 0.32 0.23 0
97 INT227111 Transcription of Mtm1 1 0.63 0 0
98 INT237343 Regulation of Mtm1 1 0.27 0.37 0
99 INT228244 Negative_regulation of Binding of Pten 1 0.16 0.72 0
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