GO:0004459

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Name L-lactate dehydrogenase activity
Categary Function
Go Slim No
Go Link GO:0004459
Unique Molecular Interactions 70
Total Molecular Interactions 77
Total Single Events 2603
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for L-lactate dehydrogenase activity. They are ordered first by their pain relevance and then by number of times they were reported for L-lactate dehydrogenase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140314 PCSK7 Positive_regulation of LDHA 1 0.07 1.6 1.4
2 INT168019 Ldha Regulation of Gpt 1 0.01 0.15 0.88
3 INT168018 Positive_regulation of Ldha Regulation of Gpt 1 0.01 0.15 0.88
4 INT34823 Regulation of Binding of Ldha and Akr7a3 1 0.43 0.28 0.72
5 INT34824 Binding of Ldha and Akr7a3 1 0.36 0.28 0.71
6 INT134029 Olr696 Regulation of Ldha 1 0.00 0.15 0.68
7 INT125574 CS Regulation of Ldha 1 0.02 0.23 0.42
8 INT347399 RYBP Positive_regulation of Ldha 1 0.01 0 0.33
9 INT355153 Gpt Positive_regulation of Positive_regulation of Ldha 1 0.02 1.33 0.3
10 INT355152 Gpt Positive_regulation of Gene_expression of Ldha 1 0.02 1.26 0.29
11 INT308815 Got1 Positive_regulation of Ldha 1 0.09 0.71 0.24
12 INT308817 Ldha Positive_regulation of Tnf 1 0.06 0.71 0.24
13 INT261459 Sftpd Negative_regulation of Ldha 1 0.08 0.63 0.18
14 INT47426 Chrna7 Positive_regulation of Localization of Ldha 1 0.05 0 0.18
15 INT47427 Chrna7 Positive_regulation of Ldha 1 0.05 0 0.18
16 INT3752 Binding of GOT1 and LDHA 1 0.11 0.68 0.12
17 INT189957 Binding of LDHA and Pttg1 1 0.05 0.35 0.08
18 INT179926 Litaf Positive_regulation of Ldha 1 0.01 0.4 0.04
19 INT188903 MUC5AC Positive_regulation of LDHA 1 0.00 1.2 0.04
20 INT237683 Positive_regulation of LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03
21 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
22 INT237682 LDHA Positive_regulation of MAPK14 1 0.02 0.16 0.03
23 INT237680 LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03
24 INT315499 Ctnnbl1 Positive_regulation of Ldha 1 0.29 0.26 0
25 INT120880 Mb Positive_regulation of Ldha 1 0.07 0.55 0
26 INT181697 Positive_regulation of Ldha Negative_regulation of Cat 1 0.29 0.6 0
27 INT197900 Des Positive_regulation of Gene_expression of Ldha 1 0.02 0.31 0
28 INT348759 Plat Regulation of LDHA 1 0.04 0.23 0
29 INT347353 Binding of Ldha and Sds 1 0.12 0.07 0
30 INT197899 Dlst Positive_regulation of Ldha 1 0.04 0.34 0
31 INT181696 Ldha Negative_regulation of Cat 1 0.27 1.16 0
32 INT318102 Binding of RPL5 and Ldha 1 0.08 0.66 0
33 INT204730 PKD1P2 Negative_regulation of Ldha 1 0.05 0.37 0
34 INT186906 EIF1 Positive_regulation of Localization of LDHA 1 0.03 0 0
35 INT244709 Binding of Ldha and Gpt 1 0.01 1.32 0
36 INT347352 Negative_regulation of Binding of Ldha and Sds 1 0.14 0.07 0
37 INT348758 Plat Positive_regulation of LDHA 1 0.04 0.42 0
38 INT318099 Binding of Ldha and Ppia 1 0.36 0.66 0
39 INT197906 Dlst Positive_regulation of Gene_expression of Ldha 1 0.03 0.31 0
40 INT285232 Binding of CHKB and LDHA 1 0.06 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for L-lactate dehydrogenase activity. They are ordered first by their pain relevance and then by number of times they were reported in L-lactate dehydrogenase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3920 Localization of Ldha 241 0.81 83.08 58.72
2 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43
3 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45
4 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36
5 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11
6 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3
7 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66
8 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35
9 INT373 Regulation of Ldha 37 0.61 17.86 11.41
10 INT9385 Localization of LDHA 74 0.81 31.67 10.5
11 INT45234 Binding of Ldha 20 0.37 9.8 8.18
12 INT11177 Localization of Ldha 17 0.81 5.74 6.13
13 INT39900 Positive_regulation of Gene_expression of Ldha 36 0.50 20.35 5.22
14 INT34822 Regulation of Localization of Ldha 12 0.57 4.03 3.65
15 INT28923 Negative_regulation of Ldha 8 0.58 4.94 3.11
16 INT45565 Positive_regulation of Positive_regulation of Ldha 7 0.39 1.54 2.77
17 INT21516 Negative_regulation of Positive_regulation of Ldha 13 0.43 4.73 2.53
18 INT17963 Gene_expression of Ldha 11 0.75 6.53 2.48
19 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2
20 INT14 Regulation of LDHA 22 0.57 15.26 2.14
21 INT151018 Negative_regulation of Gene_expression of Ldha 8 0.32 5.48 2.05
22 INT54625 Protein_catabolism of Ldha 4 0.78 0.6 1.91
23 INT54626 Positive_regulation of Protein_catabolism of Ldha 2 0.44 0.55 1.73
24 INT63671 Negative_regulation of Protein_catabolism of Ldha 1 0.38 0.31 1.68
25 INT9380 Positive_regulation of Localization of LDHA 14 0.70 4.1 1.66
26 INT20633 Positive_regulation of Gene_expression of LDHA 15 0.49 15.94 1.42
27 INT58861 Positive_regulation of Localization of Ldha 2 0.25 0.1 1.26
28 INT15594 Positive_regulation of Ldha 3 0.26 0.96 1.14
29 INT88466 Regulation of Gene_expression of Ldha 5 0.33 4.07 0.97
30 INT20627 Regulation of Gene_expression of LDHA 5 0.42 4.07 0.92
31 INT63673 Positive_regulation of Binding of Ldha 2 0.44 1.91 0.9
32 INT24815 Binding of LDHA 9 0.36 6.73 0.89
33 INT39901 Negative_regulation of Negative_regulation of Ldha 2 0.53 0 0.76
34 INT165333 Regulation of Ldha 1 0.17 0.62 0.64
35 INT9384 Positive_regulation of Positive_regulation of LDHA 3 0.50 5.5 0.52
36 INT125791 Regulation of Localization of Ldha 1 0.22 0.09 0.52
37 INT39902 Positive_regulation of Negative_regulation of Ldha 3 0.46 0.54 0.46
38 INT20629 Negative_regulation of Gene_expression of LDHA 4 0.41 1.78 0.34
39 INT99126 Negative_regulation of Positive_regulation of LDHA 4 0.43 4.37 0.32
40 INT75119 Negative_regulation of Localization of LDHA 1 0.32 0.48 0.21
41 INT129927 Transcription of Ldha 3 0.42 1.41 0.18
42 INT282122 Positive_regulation of Gene_expression of Ldha 3 0.11 1.58 0.1
43 INT129929 Transcription of LDHA 4 0.17 4.48 0.08
44 INT9379 Regulation of Localization of LDHA 4 0.27 0.96 0.06
45 INT131335 Negative_regulation of Regulation of Ldha 1 0.25 0.56 0.06
46 INT256622 Regulation of Positive_regulation of Ldha 1 0.08 0.9 0.06
47 INT342587 Regulation of Binding of LDHA 1 0.44 1.12 0.04
48 INT179919 Phosphorylation of Ldha 1 0.15 0.4 0.04
49 INT347347 Negative_regulation of Binding of Ldha 1 0.27 0.07 0
50 INT315498 Positive_regulation of Transcription of Ldha 1 0.37 0.27 0
51 INT116899 Negative_regulation of Localization of Ldha 1 0.59 0 0
52 INT282121 Negative_regulation of Gene_expression of Ldha 1 0.09 0.52 0
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