GO:0004465

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Name lipoprotein lipase activity
Categary Function
Go Slim No
Go Link GO:0004465
Unique Molecular Interactions 127
Total Molecular Interactions 179
Total Single Events 1298
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lipoprotein lipase activity. They are ordered first by their pain relevance and then by number of times they were reported for lipoprotein lipase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
2 INT147913 Phosphorylation of Camk2a Positive_regulation of Binding of Lpl 1 0.10 0 0.77
3 INT335054 LPL Positive_regulation of Localization of VLDLR 1 0.04 1.48 0.67
4 INT223934 HSPG2 Negative_regulation of Gene_expression of Cux1 1 0.03 0 0.53
5 INT206960 Lipg Regulation of Tnf 1 0.02 0.85 0.51
6 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
7 INT206961 Lipg Regulation of Ptger2 1 0.01 0.85 0.51
8 INT206958 Lipg Regulation of Gene_expression of Ptger2 1 0.01 0.85 0.51
9 INT88889 Binding of HSPG2 and CALCRL 1 0.00 0 0.48
10 INT137416 Binding of SDC1 and Tnf 1 0.00 1.19 0.47
11 INT223936 HSPG2 Positive_regulation of Gene_expression of Cux1 1 0.03 0 0.46
12 INT223935 HSPG2 Positive_regulation of Cux1 1 0.03 0 0.45
13 INT248242 Binding of COL7A1 and SDC1 1 0.00 0.76 0.41
14 INT248236 Binding of FN1 and SDC1 1 0.00 0.76 0.41
15 INT274531 Il6 Regulation of Localization of Lpl 1 0.04 1.49 0.33
16 INT350214 Binding of GPER and HSPG2 1 0.00 0.12 0.32
17 INT274530 Il6 Regulation of Lpl 1 0.07 1.48 0.32
18 INT253576 Binding of Lpl and Sp3 1 0.22 0.85 0.32
19 INT344714 Nr1h4 Negative_regulation of Gene_expression of Lipg 1 0.02 0.77 0.23
20 INT308084 Binding of HSPG2 and OXT 1 0.04 0.25 0.23
21 INT62090 CXCR1 Positive_regulation of HSPG2 1 0.54 0.18 0.23
22 INT253568 Negative_regulation of Binding of Lpl and Sp3 1 0.19 0.37 0.22
23 INT249759 Positive_regulation of Cnr1 Positive_regulation of Lpl 1 0.29 0.74 0.21
24 INT277072 Binding of PLA2G7 and Lipg 1 0.00 1.32 0.21
25 INT335053 PPARA Positive_regulation of Gene_expression of LPL 1 0.21 0.34 0.19
26 INT236833 Binding of CD19 and SDC1 1 0.26 0.54 0.15
27 INT253564 Binding of Lpl and Sp1 1 0.13 0.9 0.14
28 INT155388 Binding of LPA and Lipg 1 0.00 1.22 0.12
29 INT248259 Binding of HSPG2 and Gtf3a 1 0.00 0.33 0.12
30 INT298828 Binding of PPARA and Lpl 1 0.05 0.77 0.11
31 INT303990 Binding of Lep and Positive_regulation of Gene_expression of LPL 1 0.03 0.35 0.1
32 INT165619 Binding of LPL and TGS1 1 0.04 0.61 0.09
33 INT313846 Olr407 Negative_regulation of Lipg 1 0.00 0.55 0.09
34 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 0.05 0.09 0.09
35 INT253571 Positive_regulation of Binding of Lpl and Sp1 1 0.17 0.42 0.09
36 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 0.05 0.09 0.09
37 INT253579 Negative_regulation of Binding of Lpl and Sp1 1 0.15 0.42 0.09
38 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09
39 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 0.04 0.09 0.08
40 INT315969 Binding of Lipg and Msc 1 0.01 0.14 0.06
41 INT86448 Binding of Cnr1 and Lipg 1 0.28 0.64 0.06
42 INT220537 HSPG2 Positive_regulation of NOSTRIN 1 0.04 0 0.05
43 INT253586 IFN1@ Negative_regulation of Transcription of Lpl 1 0.28 0 0.05
44 INT183302 Tchol1 Negative_regulation of Lipg 1 0.00 0.52 0.05
45 INT337386 Lipg Regulation of GK2 1 0.00 0.15 0.05
46 INT239438 Binding of OPA1 and LIPG 1 0.03 1.21 0.04
47 INT275125 Binding of HLA-DOA and HSPG2 1 0.01 1.42 0.04
48 INT325026 Apoc3 Negative_regulation of Lpl 1 0.03 1.01 0.04
49 INT275124 Binding of HSPG2 and LTA 1 0.12 1.45 0.04
50 INT230423 INS Negative_regulation of Lipg 1 0.03 0.74 0.03
51 INT253574 Sp3 Positive_regulation of Lpl 1 0.22 0 0.03
52 INT253566 Sp1 Positive_regulation of Lpl 1 0.18 0 0.03
53 INT249159 HSPG2 Positive_regulation of Gene_expression of ITPR3 2 0.01 0.06 0
54 INT171598 Binding of APOB and Lipg 1 0.01 0.63 0
55 INT295980 Dap Positive_regulation of Lipg 1 0.17 0.48 0
56 INT332905 Binding of LPL and SNRNP70 1 0.01 1.34 0
57 INT214472 Binding of LPL and GPIHBP1 1 0.29 1.17 0
58 INT171600 INCENP Negative_regulation of Lipg 1 0.00 0.38 0
59 INT323571 Lipg Positive_regulation of Positive_regulation of Mag 1 0.00 0.15 0
60 INT165506 HSPG2 Negative_regulation of Gene_expression of CYBB 1 0.03 0.06 0
61 INT170236 Lpl Regulation of HSD11B1 1 0.04 0.98 0
62 INT206959 Lipg Regulation of Cat 1 0.02 0.5 0
63 INT258725 Binding of GPD1 and Lipg 1 0.12 0.13 0
64 INT211576 Vldlr Positive_regulation of Lpl 1 0.38 0.24 0
65 INT165511 Binding of HSPG2 and NOSTRIN 1 0.02 0.07 0
66 INT171601 INCENP Negative_regulation of Lpl 1 0.01 0.38 0
67 INT302584 Binding of Lpl and Apoa5 1 0.20 0.63 0
68 INT97091 HSPG2 Regulation of PRKCA 1 0.04 0 0
69 INT165510 HSPG2 Negative_regulation of Gene_expression of NFKB1 1 0.01 0.06 0
70 INT309889 Positive_regulation of CNR1 Positive_regulation of LPL 1 0.05 1.25 0
71 INT354789 Tnc Regulation of HSPG2 1 0.02 1.38 0
72 INT165863 Binding of HSPG2 and PTGS2 1 0.01 0.19 0
73 INT258712 Binding of Gpd1 and Lipg 1 0.11 0.14 0
74 INT180470 Cdh23 Positive_regulation of Lpl 1 0.06 1.23 0
75 INT171602 APOC3 Negative_regulation of Lipg 1 0.04 0.38 0
76 INT180469 Apo Positive_regulation of Lpl 1 0.04 1.23 0
77 INT253086 INS Negative_regulation of LPL 1 0.08 0.56 0
78 INT356349 Ins1 Positive_regulation of Lpl 1 0.10 0.45 0
79 INT170211 Binding of HSD11B1 and LPL 1 0.02 1.47 0
80 INT165508 Binding of HSPG2 and VEGFA 1 0.01 0.07 0
81 INT206963 Lipg Regulation of Gpx1 1 0.00 0.5 0
82 INT171603 APOC3 Negative_regulation of Lpl 1 0.48 0.38 0
83 INT170237 Lpl Regulation of CETP 1 0.02 0.99 0
84 INT332907 Binding of LPL and SUGT1 1 0.00 1.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lipoprotein lipase activity. They are ordered first by their pain relevance and then by number of times they were reported in lipoprotein lipase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65
2 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06
3 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24
4 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03
5 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81
6 INT17312 Binding of HSPG2 30 0.41 33.01 4.88
7 INT107771 Localization of HSPG2 10 0.78 8.47 4.3
8 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26
9 INT156416 Gene_expression of Lipg 38 0.67 18.35 4.07
10 INT18515 Gene_expression of Lipg 18 0.66 9.3 3.72
11 INT47678 Positive_regulation of Positive_regulation of HSPG2 7 0.49 3.94 3.56
12 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17
13 INT147907 Positive_regulation of Lpl 12 0.29 6.48 3.13
14 INT12237 Positive_regulation of Lipg 19 0.60 11.09 2.92
15 INT147900 Phosphorylation of Lpl 1 0.16 0 2.73
16 INT1928 Negative_regulation of Lpl 18 0.51 11.22 2.49
17 INT22843 Localization of Lipg 5 0.33 1.95 2.12
18 INT45176 Negative_regulation of LPL 34 0.59 22.22 2.01
19 INT45838 Positive_regulation of LPL 15 0.69 11.33 2
20 INT4691 Regulation of Lipg 10 0.61 4.7 1.99
21 INT120407 Positive_regulation of Localization of HSPG2 2 0.49 2.11 1.92
22 INT147899 Binding of Lpl 6 0.30 2.07 1.82
23 INT7459 Positive_regulation of Lpl 15 0.70 6.96 1.81
24 INT248253 Positive_regulation of Gene_expression of HSPG2 3 0.44 4.61 1.65
25 INT147906 Positive_regulation of Phosphorylation of Lpl 1 0.13 0 1.5
26 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28
27 INT86446 Protein_catabolism of Lipg 9 0.50 3.52 1.25
28 INT147909 Gene_expression of Lpl 21 0.58 9.35 1.14
29 INT38265 Gene_expression of LPL 22 0.78 10.59 1.09
30 INT142914 Negative_regulation of Localization of Lipg 1 0.14 0.49 1.04
31 INT120395 Regulation of HSPG2 4 0.26 5.96 1.03
32 INT90363 Regulation of SDC1 3 0.45 3.68 0.83
33 INT90364 Positive_regulation of Gene_expression of SDC1 3 0.70 2.59 0.83
34 INT168089 Regulation of Localization of HSPG2 2 0.20 0.86 0.81
35 INT147904 Negative_regulation of Binding of Lpl 1 0.08 0 0.78
36 INT207565 Negative_regulation of LIPG 8 0.10 7.83 0.76
37 INT147905 Negative_regulation of Phosphorylation of Lpl 1 0.11 0 0.74
38 INT169652 Positive_regulation of Protein_catabolism of Lipg 1 0.28 0.07 0.72
39 INT335102 Positive_regulation of Positive_regulation of LPL 1 0.14 1.48 0.66
40 INT90362 Negative_regulation of Gene_expression of SDC1 3 0.59 2.88 0.59
41 INT45839 Regulation of LPL 10 0.55 7.64 0.55
42 INT174813 Localization of LIPG 3 0.05 1.18 0.55
43 INT125583 Regulation of Positive_regulation of HSPG2 2 0.44 0.1 0.54
44 INT21871 Binding of Lipg 4 0.14 0.78 0.53
45 INT354787 Regulation of Binding of HSPG2 1 0.23 1.63 0.53
46 INT48694 Regulation of Gene_expression of Lipg 2 0.21 1.5 0.51
47 INT21339 Phosphorylation of Lipg 1 0.19 0.66 0.51
48 INT235512 Transcription of Lpl 10 0.42 2.76 0.49
49 INT126683 Localization of Lipg 7 0.70 3.87 0.46
50 INT75381 Positive_regulation of Negative_regulation of HSPG2 2 0.49 0.09 0.46
51 INT170208 Negative_regulation of Lpl 15 0.49 6.07 0.45
52 INT18514 Positive_regulation of Positive_regulation of Lipg 1 0.13 0.15 0.43
53 INT300893 Protein_catabolism of HSPG2 1 0.27 1.1 0.41
54 INT137415 Regulation of Gene_expression of SDC1 2 0.02 2.53 0.4
55 INT223932 Regulation of Negative_regulation of HSPG2 1 0.03 0.06 0.38
56 INT98870 Negative_regulation of Positive_regulation of HSPG2 2 0.41 0 0.37
57 INT199121 Positive_regulation of Gene_expression of Lipg 4 0.13 2.44 0.32
58 INT274529 Localization of Lpl 2 0.46 2.31 0.32
59 INT253540 Positive_regulation of Transcription of Lpl 3 0.29 1.43 0.3
60 INT88899 Positive_regulation of Binding of HSPG2 1 0.01 0 0.3
61 INT3959 Regulation of Lipg 6 0.27 2.48 0.29
62 INT269370 Negative_regulation of Gene_expression of HSPG2 2 0.07 0.93 0.29
63 INT213281 Localization of LPL 3 0.21 3.48 0.28
64 INT113456 Binding of Lpl 2 0.36 0.81 0.28
65 INT238864 Positive_regulation of Gene_expression of LPL 5 0.24 2.39 0.26
66 INT77031 Gene_expression of LIPG 4 0.51 4.32 0.26
67 INT86447 Binding of Lipg 3 0.18 1.51 0.25
68 INT90361 Localization of SDC1 2 0.62 0.86 0.24
69 INT21340 Regulation of Phosphorylation of Lipg 1 0.14 0.35 0.24
70 INT76857 Transcription of HSPG2 6 0.60 5.07 0.23
71 INT47256 Transcription of Lpl 2 0.69 0.26 0.21
72 INT47258 Regulation of Lpl 1 0.27 0.26 0.21
73 INT47257 Regulation of Transcription of Lpl 1 0.45 0.26 0.21
74 INT42014 Regulation of Localization of Lipg 1 0.16 0.19 0.19
75 INT100573 Gene_expression of Lpl 13 0.53 2.09 0.16
76 INT211546 Regulation of Lpl 6 0.26 1.71 0.16
77 INT235518 Negative_regulation of Transcription of Lpl 2 0.34 1.35 0.15
78 INT111337 Protein_catabolism of Lipg 2 0.66 0.43 0.13
79 INT236578 Negative_regulation of Gene_expression of Lpl 4 0.25 2.25 0.12
80 INT217684 Positive_regulation of LIPG 3 0.04 1.9 0.12
81 INT294603 Positive_regulation of Positive_regulation of Lpl 1 0.12 0.71 0.12
82 INT235505 Protein_catabolism of Lpl 2 0.76 1.4 0.1
83 INT117686 Regulation of LIPG 2 0.04 0.49 0.1
84 INT212876 Negative_regulation of Gene_expression of Lipg 1 0.06 0.37 0.1
85 INT173340 Phosphorylation of HSPG2 2 0.08 0 0.09
86 INT298777 Positive_regulation of Binding of Lpl 1 0.07 0.38 0.09
87 INT213274 Negative_regulation of Localization of LPL 1 0.15 1.89 0.09
88 INT63322 Protein_catabolism of LPL 2 0.57 0.33 0.08
89 INT41694 Transcription of Lipg 1 0.53 0.85 0.08
90 INT342842 Negative_regulation of Protein_catabolism of Lpl 1 0.37 0.73 0.07
91 INT253548 Negative_regulation of Negative_regulation of Lpl 1 0.34 0 0.05
92 INT211529 Localization of Lpl 1 0.63 0.15 0.05
93 INT292414 Regulation of Negative_regulation of Lipg 2 0.09 0.7 0.04
94 INT239290 Regulation of Positive_regulation of Lpl 1 0.10 1.02 0.04
95 INT248258 Regulation of Gene_expression of HSPG2 1 0.13 0.19 0.04
96 INT206957 Negative_regulation of Gene_expression of Lipg 3 0.08 1.01 0.03
97 INT173168 Regulation of Gene_expression of LPL 2 0.14 0.29 0.03
98 INT258794 Positive_regulation of Positive_regulation of LIPG 1 0.03 0.57 0.03
99 INT297359 Phosphorylation of LPL 1 0.19 0.62 0.03
100 INT237344 Negative_regulation of Phosphorylation of Lipg 3 0.14 0.49 0
101 INT237349 Phosphorylation of Lipg 2 0.26 0.82 0
102 INT102264 Positive_regulation of Gene_expression of Lipg 2 0.35 0.3 0
103 INT170209 Positive_regulation of Gene_expression of Lpl 2 0.29 1.59 0
104 INT214478 Binding of LPL 2 0.25 1.91 0
105 INT317659 Protein_catabolism of Lpl 1 0.65 0.72 0
106 INT251000 Transcription of LPL 1 0.39 0.05 0
107 INT281264 Positive_regulation of Negative_regulation of Lipg 1 0.07 0.5 0
108 INT317660 Positive_regulation of Localization of Lpl 1 0.40 0.49 0
109 INT356397 Negative_regulation of SDC1 1 0.01 2.75 0
110 INT238868 Negative_regulation of Gene_expression of LPL 1 0.15 0.73 0
111 INT214927 Binding of SDC1 1 0.11 0 0
112 INT249232 Regulation of Phosphorylation of HSPG2 1 0.03 0 0
113 INT253539 Regulation of Transcription of Lpl 1 0.26 0 0
114 INT334777 Positive_regulation of Negative_regulation of Lpl 1 0.15 0.39 0
115 INT292412 Negative_regulation of Positive_regulation of Lipg 1 0.05 0.07 0
116 INT63323 Regulation of Protein_catabolism of LPL 1 0.24 0 0
117 INT63321 Positive_regulation of Binding of Lipg 1 0.02 0 0
118 INT179190 Negative_regulation of Positive_regulation of Lipg 1 0.51 0.62 0
119 INT297438 Positive_regulation of Gene_expression of Lpl 1 0.47 0 0
120 INT298780 Regulation of Gene_expression of Lpl 1 0.06 0.45 0
121 INT212381 Negative_regulation of Positive_regulation of LPL 1 0.13 1.31 0
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