GO:0004488

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Name methylenetetrahydrofolate dehydrogenase (NADP+) activity
Categary Function
Go Slim No
Go Link GO:0004488
Unique Molecular Interactions 60
Total Molecular Interactions 68
Total Single Events 467
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for methylenetetrahydrofolate dehydrogenase (NADP+) activity. They are ordered first by their pain relevance and then by number of times they were reported for methylenetetrahydrofolate dehydrogenase (NADP+) activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
2 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
3 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
4 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
5 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
6 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
7 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56
8 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56
9 INT177782 PDCD2 Positive_regulation of MTHFD2 1 0.06 0.76 0.46
10 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
11 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
12 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
13 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33
14 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
15 INT276602 Paf Positive_regulation of Gene_expression of Mthfd1 1 0.13 0.37 0.31
16 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
17 INT252340 Binding of Cd70 and Mthfd1 1 0.03 1.05 0.24
18 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
19 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
20 INT213974 Vip Positive_regulation of Localization of Mthfd1 1 0.08 0.41 0.17
21 INT204790 Binding of Lat2 and Mthfd1 1 0.05 0.85 0.16
22 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
23 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13
24 INT289407 Mthfd1 Negative_regulation of Cd55 1 0.01 0.6 0.12
25 INT188594 Binding of Mthfd1 and Radil 1 0.01 0.25 0.12
26 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
27 INT289405 Mthfd1 Positive_regulation of C3ar1 1 0.00 0.53 0.11
28 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1
29 INT252344 Binding of Cd40 and Mthfd1 2 0.16 0.34 0.08
30 INT297317 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Il18 1 0.07 0.79 0.08
31 INT297309 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Ifng 1 0.07 0.79 0.08
32 INT311988 Il4 Positive_regulation of Mthfd1 1 0.08 0.28 0.08
33 INT311986 Csf2 Positive_regulation of Mthfd1 1 0.03 0.28 0.08
34 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08
35 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07
36 INT284565 Gopc Positive_regulation of Mthfd1 1 0.11 0.22 0.05
37 INT284564 Binding of Itgax and Mthfd1 1 0.08 0.09 0.05
38 INT314967 Binding of Cd4 and Mthfd1 1 0.09 0.11 0.04
39 INT252346 Binding of Apcs and Mthfd1 1 0.02 0.13 0.03
40 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
41 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03
42 INT252339 Binding of Cd40 and Positive_regulation of Mthfd1 1 0.04 0.19 0
43 INT189108 Mthfd1 Positive_regulation of H2 1 0.00 0.17 0
44 INT143067 Mthfd1 Positive_regulation of Serpine1 1 0.00 0 0
45 INT189106 Mthfd1 Positive_regulation of Gene_expression of H2 1 0.00 0.17 0
46 INT252331 Binding of Cd40lg and Mthfd1 1 0.03 0.1 0
47 INT143066 Mthfd1 Regulation of Gene_expression of Plau 1 0.00 0 0
48 INT189112 Tap1 Positive_regulation of Gene_expression of Mthfd1 1 0.07 0.3 0
49 INT315941 Binding of Tlr4 and Mthfd1 1 0.05 0 0
50 INT252337 Mthfd1 Positive_regulation of Gene_expression of Cd80 1 0.04 0.1 0
51 INT284556 Tspan7 Positive_regulation of Mthfd1 1 0.00 1.66 0
52 INT143065 Mthfd1 Positive_regulation of Gene_expression of Serpine1 1 0.00 0 0
53 INT286884 Binding of Gopc and Mthfd1 1 0.02 0 0
54 INT293694 Binding of Ccl21a and Mthfd1 1 0.01 0 0
55 INT314969 Binding of Lbr and Mthfd1 1 0.01 0 0
56 INT252333 Mthfd1 Positive_regulation of Gene_expression of Cd86 1 0.04 0.1 0
57 INT189114 Mtap1a Positive_regulation of Gene_expression of Mthfd1 1 0.01 0.3 0
58 INT284566 Tlr3 Positive_regulation of Mthfd1 1 0.17 2.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for methylenetetrahydrofolate dehydrogenase (NADP+) activity. They are ordered first by their pain relevance and then by number of times they were reported in methylenetetrahydrofolate dehydrogenase (NADP+) activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
2 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
3 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
4 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4
5 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37
6 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84
7 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94
8 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93
9 INT204772 Negative_regulation of Gene_expression of Mthfd1 10 0.15 3.48 1.29
10 INT96480 Negative_regulation of Positive_regulation of Mthfd1 5 0.30 0.99 0.83
11 INT188591 Positive_regulation of Binding of Mthfd1 3 0.26 0.9 0.69
12 INT127776 Regulation of Mthfd1 1 0.20 0.65 0.64
13 INT287810 Regulation of Gene_expression of Mthfd1 4 0.17 2.14 0.58
14 INT213967 Positive_regulation of Localization of Mthfd1 4 0.30 2.52 0.46
15 INT177878 Positive_regulation of Gene_expression of MTHFD2 1 0.26 1.16 0.46
16 INT177882 Gene_expression of MTHFD2 1 0.40 1.16 0.46
17 INT209498 Negative_regulation of Negative_regulation of Mthfd1 1 0.09 0 0.4
18 INT280121 Negative_regulation of Binding of Mthfd1 2 0.41 0.38 0.3
19 INT293693 Phosphorylation of Mthfd1 1 0.34 0.18 0.18
20 INT289385 Negative_regulation of Localization of Mthfd1 1 0.03 0.6 0.12
21 INT96481 Regulation of Positive_regulation of Mthfd1 2 0.02 1.3 0.04
22 INT188589 Transcription of Mthfd1 1 0.35 0.07 0.03
23 INT177852 Negative_regulation of Gene_expression of MTHFD2 1 0.22 0.4 0
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