GO:0004497

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Name monooxygenase activity
Categary Function
Go Slim No
Go Link GO:0004497
Unique Molecular Interactions 725
Total Molecular Interactions 928
Total Single Events 10725
Pain Genes Associated 68

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for monooxygenase activity. They are ordered first by their pain relevance and then by number of times they were reported for monooxygenase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
2 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
3 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
4 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
5 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
6 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
7 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
8 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
9 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
10 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
11 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
12 INT40887 Penk Regulation of Th 1 0.04 0 1.53
13 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
14 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45
15 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
16 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
17 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
18 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
19 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
20 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
21 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
22 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
23 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
24 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
25 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
26 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
27 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
28 INT75806 Cyp2a5 Negative_regulation of Cyp2g1 1 0.48 0.08 1.09
29 INT31547 Binding of Th and Vip 1 0.31 0 1.08
30 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
31 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
32 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
33 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
34 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
35 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
36 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
37 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
38 INT349592 GTF2H5 Negative_regulation of Cyp2c22 1 0.00 0.64 0.98
39 INT155985 Nfkb1 Negative_regulation of Gene_expression of Cyp11a1 1 0.10 0.53 0.95
40 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
41 INT68799 Cyp3a62 Negative_regulation of Cyp2d1 1 0.35 0 0.91
42 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
43 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
44 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
45 INT184916 Binding of da and Th 1 0.09 1.22 0.87
46 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
47 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
48 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
49 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
50 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
51 INT28185 CYP2B6 Positive_regulation of Positive_regulation of RYBP 1 0.29 0 0.82
52 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
53 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
54 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
55 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81
56 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
57 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
58 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
59 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76
60 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
61 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
62 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
63 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
64 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
65 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
66 INT38512 Binding of Cyp2c22 and Atp6v1c2 1 0.00 0.17 0.73
67 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
68 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
69 INT99172 Pomc Positive_regulation of Tyr 1 0.35 0.17 0.69
70 INT102762 Binding of POMC and TYR 1 0.12 0.35 0.69
71 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 1 0.01 1.05 0.66
72 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
73 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
74 INT99170 Binding of Mc1r and Tyr 1 0.11 0.2 0.64
75 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
76 INT135471 Binding of CYP2B6 and UGT2B7 1 0.49 0 0.63
77 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
78 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
79 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
80 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
81 INT102670 Cyp2e1 Regulation of RYBP 1 0.01 0 0.58
82 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
83 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
84 INT160156 Tph2 Regulation of Htr1a 1 0.30 0.75 0.56
85 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56
86 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
87 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
88 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
89 INT123896 CYP2B6 Regulation of UGT2B7 1 0.42 0 0.53
90 INT160829 Tyr Regulation of RYBP 1 0.04 0.75 0.53
91 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
92 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
93 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
94 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49
95 INT31531 Mif-ps1 Regulation of TYR 1 0.11 0 0.49
96 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
97 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
98 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
99 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
100 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
101 INT149690 M1 Negative_regulation of CYP2C8 1 0.19 0.05 0.46
102 INT103026 Ptgis Positive_regulation of Ptgs1 1 0.02 0.42 0.46
103 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
104 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
105 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
106 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
107 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
108 INT103028 Calca Positive_regulation of Gene_expression of Ptgis 1 0.17 0.58 0.44
109 INT151637 Binding of Cyp21a1 and Ear11 1 0.01 0 0.44
110 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
111 INT43587 Binding of OPRD1 and Pah 1 0.00 0.08 0.43
112 INT115915 AHR Regulation of Gene_expression of CYP2B6 1 0.06 0.36 0.43
113 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
114 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
115 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
116 INT61660 Binding of CHAT and CYP21A2 1 0.00 0 0.4
117 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
118 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
119 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
120 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
121 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38
122 INT35685 TYR Regulation of Oxt 1 0.14 0.32 0.36
123 INT352821 Tph2 Regulation of Tst 1 0.31 0.46 0.36
124 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
125 INT69468 CYP2B6 Positive_regulation of Localization of CYP3A 1 0.25 0 0.36
126 INT69467 CYP2E1 Positive_regulation of Localization of CYP3A 1 0.30 0 0.36
127 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
128 INT99171 Negative_regulation of Pomc Positive_regulation of Tyr 1 0.22 0.08 0.35
129 INT159903 Binding of CYP2C8 and CYP2C9 1 0.42 0.22 0.35
130 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
131 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
132 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
133 INT301665 CYP2C9 Regulation of Binding of Ppara 1 0.26 1.79 0.34
134 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
135 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
136 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
137 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
138 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31
139 INT187603 Binding of Ptgis and Ppara 1 0.00 0.26 0.31
140 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
141 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
142 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
143 INT55404 Binding of ENG and Th 1 0.02 0 0.3
144 INT66243 KNG1 Positive_regulation of Ptgis 1 0.01 0 0.3
145 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
146 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29
147 INT59684 Binding of Gmfb and Cyp2c6 1 0.00 0 0.29
148 INT137683 Positive_regulation of Binding of Cyp27b1 and Prkca 1 0.03 0 0.29
149 INT137684 Binding of Cyp27b1 and Prkca 1 0.02 0 0.29
150 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
151 INT301666 Binding of CYP4F2 and Ltb4r1 1 0.02 0.57 0.28
152 INT142450 B4GALNT1 Regulation of Gene_expression of PTGIS 1 0.02 0.24 0.27
153 INT301670 Binding of CYP4F2 and Cyp4f18 1 0.02 1.04 0.27
154 INT71640 Binding of HLA-A and TYR 1 0.16 0.36 0.27
155 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
156 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
157 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27
158 INT310771 Pam Positive_regulation of TNF 1 0.02 0.29 0.27
159 INT114230 NR1I2 Positive_regulation of Positive_regulation of CYP2C9 1 0.13 0.61 0.27
160 INT335130 PPARA Positive_regulation of Cyp8b1 1 0.37 0 0.27
161 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
162 INT310768 Pam Positive_regulation of Cxcl2 1 0.01 0.29 0.26
163 INT179566 Binding of C1qa and Ywhaq 1 0.00 0.56 0.26
164 INT19839 Positive_regulation of Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.26
165 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26
166 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
167 INT335049 PPARA Negative_regulation of Gene_expression of CYP7B1 1 0.27 0 0.26
168 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
169 INT130677 CYP2C9 Regulation of Binding of Ugt2b7 1 0.18 0 0.26
170 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
171 INT110373 CYP4A11 Positive_regulation of PPARG 1 0.00 0.94 0.26
172 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
173 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
174 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
175 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
176 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
177 INT19840 Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.25
178 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
179 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
180 INT86634 POMC Positive_regulation of TYR 2 0.42 0 0.24
181 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
182 INT335015 Fgf15 Negative_regulation of Gene_expression of Cyp7a1 1 0.57 0.2 0.24
183 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
184 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
185 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
186 INT53544 Binding of CYP2B6 and HRH1 1 0.28 0 0.23
187 INT339570 Gene_expression of Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.5 0.23
188 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23
189 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
190 INT339535 FGF2 Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.55 0.22
191 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
192 INT100823 Cyp2e1 Positive_regulation of Ros1 1 0.35 1.22 0.22
193 INT142446 Regulation of CPOX Regulation of Gene_expression of PTGIS 1 0.10 0.26 0.22
194 INT335021 Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.53 1.49 0.21
195 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
196 INT142448 TNF Positive_regulation of Localization of PTGIS 1 0.35 0.28 0.21
197 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
198 INT323346 Positive_regulation of Tyrp1 Positive_regulation of Positive_regulation of Gpr35 1 0.11 0.76 0.21
199 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
200 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2

Single Events

The table below shows the top 100 pain related interactions that have been reported for monooxygenase activity. They are ordered first by their pain relevance and then by number of times they were reported in monooxygenase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
2 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
3 INT7327 Regulation of Th 164 0.62 29.67 110.14
4 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
5 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
6 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
7 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
8 INT350 Localization of Th 79 0.80 10.26 41.17
9 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
10 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
11 INT7326 Transcription of Th 83 0.72 13.5 35.33
12 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
13 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
14 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
15 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
16 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
17 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
18 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
19 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
20 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
21 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
22 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
23 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
24 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
25 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
26 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
27 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
28 INT14111 Positive_regulation of Cyp2c22 41 0.67 7.24 17.88
29 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
30 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
31 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
32 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
33 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59
34 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
35 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
36 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
37 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
38 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
39 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22
40 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
41 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
42 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
43 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
44 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
45 INT141 Binding of Th 21 0.48 3.53 11.04
46 INT85631 Positive_regulation of Tyrp1 40 0.64 18.73 10.84
47 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
48 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
49 INT149015 Gene_expression of Tph2 20 0.78 9.45 10.4
50 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
51 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
52 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
53 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
54 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
55 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
56 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
57 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84
58 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
59 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33
60 INT109265 Transcription of Th 18 0.68 4.5 8.21
61 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17
62 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1
63 INT5481 Binding of TYR 26 0.47 1.3 7.95
64 INT96724 Gene_expression of Cyp3a11 10 0.77 4.82 7.76
65 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
66 INT13675 Gene_expression of Cyp2c22 23 0.39 4.52 7.71
67 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
68 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53
69 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13
70 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
71 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
72 INT76025 Positive_regulation of Cyp3a11 20 0.69 5.88 6.91
73 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
74 INT18759 Positive_regulation of Gene_expression of CYP2E1 22 0.70 5.02 6.84
75 INT66987 Regulation of Th 23 0.61 7.86 6.8
76 INT17145 Binding of Cyp2c22 19 0.42 1.39 6.8
77 INT17143 Regulation of Cyp2c22 18 0.60 3.02 6.7
78 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43
79 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
80 INT103918 Phosphorylation of Tyr 12 0.47 10.12 5.96
81 INT43415 Gene_expression of CYP4A11 11 0.56 7.65 5.94
82 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
83 INT167457 Negative_regulation of Gene_expression of Tph2 5 0.57 2.27 5.9
84 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84
85 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
86 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
87 INT12183 Negative_regulation of Cyp2d1 11 0.58 3.11 5.49
88 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48
89 INT18772 Positive_regulation of Gene_expression of CYP2B6 14 0.49 2.93 5.4
90 INT75800 Gene_expression of Cyp2a5 12 0.77 5.15 5.37
91 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
92 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2
93 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
94 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
95 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
96 INT19934 Negative_regulation of Ptgis 18 0.32 6.18 5.03
97 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
98 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
99 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
100 INT37151 Localization of Th 13 0.57 3.11 4.82
101 INT110549 Negative_regulation of CYP2C8 15 0.59 0.54 4.78
102 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
103 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
104 INT61245 Positive_regulation of Cyp2b2 9 0.64 0.41 4.7
105 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
106 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
107 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
108 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57
109 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51
110 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43
111 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
112 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31
113 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
114 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
115 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04
116 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
117 INT66242 Gene_expression of Ptgis 15 0.64 6.73 3.84
118 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84
119 INT6956 Gene_expression of PTGIS 29 0.76 12.1 3.8
120 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8
121 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
122 INT53395 Positive_regulation of Cyp2c6 6 0.70 0.07 3.73
123 INT142501 Transcription of Tyrp1 4 0.18 2.09 3.71
124 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7
125 INT31528 Regulation of TYR 6 0.44 0.83 3.63
126 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61
127 INT55516 Gene_expression of Cyp2d1 5 0.60 0.83 3.58
128 INT14110 Positive_regulation of Positive_regulation of Cyp2c22 6 0.67 1.45 3.45
129 INT155983 Gene_expression of Cyp11a1 7 0.58 2.6 3.38
130 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
131 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
132 INT59447 Negative_regulation of Tyr 12 0.56 4.57 3.32
133 INT75804 Gene_expression of Cyp2g1 4 0.78 1.43 3.31
134 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
135 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
136 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16
137 INT42485 Binding of Pah 9 0.35 3.42 3.03
138 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01
139 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
140 INT145710 Localization of CYP2C9 9 0.75 1.66 2.89
141 INT28934 Negative_regulation of Gene_expression of Cyp2c22 9 0.12 2.15 2.86
142 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83
143 INT52084 Localization of Cyp2e1 6 0.71 1.99 2.79
144 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77
145 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
146 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
147 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
148 INT49020 Negative_regulation of TYR 11 0.58 1.97 2.68
149 INT83073 Negative_regulation of Tyrp1 10 0.23 4.4 2.65
150 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
151 INT248419 Negative_regulation of Tph2 11 0.59 6.32 2.59
152 INT20304 Transcription of Cyp2e1 11 0.70 2.5 2.57
153 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
154 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
155 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
156 INT81195 Binding of Bcmo1 17 0.33 1.28 2.45
157 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45
158 INT37341 Regulation of Tyrp1 4 0.29 4.53 2.42
159 INT53448 Positive_regulation of Negative_regulation of Cyp2c22 3 0.58 0.71 2.42
160 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41
161 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
162 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
163 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
164 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
165 INT80391 Negative_regulation of Cyp2b2 4 0.54 0.12 2.36
166 INT75801 Negative_regulation of Cyp2g1 3 0.58 0.63 2.36
167 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
168 INT85630 Positive_regulation of Tyr 11 0.56 3.07 2.31
169 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25
170 INT61225 Positive_regulation of Cyp27b1 8 0.31 2.32 2.24
171 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23
172 INT14081 Regulation of Cyp2a5 11 0.50 7.91 2.18
173 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
174 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
175 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
176 INT120234 Positive_regulation of Gene_expression of Cyp3a11 4 0.46 2.21 2.13
177 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08
178 INT43416 Negative_regulation of Gene_expression of CYP4A11 2 0.02 0.55 2.08
179 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
180 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03
181 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
182 INT107091 Regulation of Gene_expression of Cyp2e1 4 0.62 2.17 2.03
183 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
184 INT82722 Negative_regulation of Positive_regulation of Cyp2e1 6 0.59 3.74 2.02
185 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
186 INT82441 Binding of Cyp4f18 4 0.23 1.07 1.99
187 INT179101 Gene_expression of CYP4F3 14 0.65 6.89 1.98
188 INT53387 Negative_regulation of Positive_regulation of Cyp2e1 3 0.42 1.28 1.98
189 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
190 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97
191 INT66237 Positive_regulation of Ptgis 5 0.33 1.49 1.96
192 INT101410 Negative_regulation of Positive_regulation of CYP2C9 5 0.42 0.23 1.96
193 INT66240 Localization of Ptgis 9 0.58 1.36 1.95
194 INT95797 Positive_regulation of CYP2C8 8 0.50 0.55 1.94
195 INT82649 Negative_regulation of Gene_expression of Cyp2e1 3 0.58 2.51 1.93
196 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92
197 INT77072 Positive_regulation of Cyp2a5 18 0.56 15.47 1.92
198 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
199 INT29577 Negative_regulation of Cyp27b1 5 0.37 2.41 1.88
200 INT96723 Regulation of Cyp3a11 5 0.44 2 1.83
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