GO:0004517

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Name nitric-oxide synthase activity
Categary Function
Go Slim No
Go Link GO:0004517
Unique Molecular Interactions 872
Total Molecular Interactions 1130
Total Single Events 19959
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nitric-oxide synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for nitric-oxide synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
2 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
3 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
4 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
5 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
6 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
7 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
8 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
9 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
10 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
11 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
12 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
13 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
14 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
15 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
16 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
17 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
18 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
19 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
20 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
21 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
22 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
23 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
24 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
25 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
26 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
27 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
28 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
29 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
30 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
31 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
32 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
33 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
34 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
35 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
36 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
37 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
38 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
39 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
40 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
41 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
42 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
43 INT235087 NOS1 Positive_regulation of Localization of ABAT 1 0.02 0.61 0.81
44 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
45 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
46 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
47 INT96501 Il11 Regulation of Gene_expression of NOS2 1 0.00 1.04 0.8
48 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
49 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
50 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
51 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
52 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77
53 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
54 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
55 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
56 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
57 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
58 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
59 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
60 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
61 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
62 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
63 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
64 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
65 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
66 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
67 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
68 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
69 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
70 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
71 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
72 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
73 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
74 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
75 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63
76 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
77 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
78 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
79 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
80 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
81 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
82 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
83 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
84 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
85 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
86 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
87 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
88 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
89 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
90 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
91 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
92 INT121081 Negative_regulation of NOS1 Negative_regulation of Slep1 1 0.00 0 0.52
93 INT191947 NFKB2 Positive_regulation of Gene_expression of NOS2 1 0.08 1.51 0.52
94 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
95 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
96 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
97 INT90131 NOS1 Regulation of Fos 1 0.00 0.25 0.49
98 INT235090 Positive_regulation of GRIN1 Positive_regulation of NOS1 1 0.42 0.81 0.49
99 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
100 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
101 INT186713 IK Positive_regulation of Gene_expression of NOS1 1 0.00 0.55 0.49
102 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
103 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
104 INT191950 NFKB2 Regulation of Gene_expression of NOS2 1 0.08 1 0.47
105 INT72928 Magel2 Negative_regulation of Positive_regulation of NOS1 1 0.01 0 0.47
106 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
107 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
108 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
109 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
110 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
111 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
112 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
113 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
114 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
115 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
116 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
117 INT148634 Abat Negative_regulation of Transcription of Nos2 1 0.19 0.52 0.44
118 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
119 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
120 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
121 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
122 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
123 INT135972 Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.41
124 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
125 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
126 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
127 INT97789 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Nos2 1 0.12 0.23 0.4
128 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4
129 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
130 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
131 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
132 INT61954 IFNA1 Positive_regulation of Nos2 1 0.05 0.46 0.38
133 INT109683 NOS1 Positive_regulation of Positive_regulation of ISYNA1 1 0.01 0.11 0.38
134 INT235091 CALM1 Positive_regulation of NOS1 1 0.02 0.63 0.37
135 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
136 INT168426 RYBP Regulation of Nos2 1 0.01 0.4 0.36
137 INT168424 Ptger2 Regulation of Binding of Nos2 1 0.22 0.52 0.36
138 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
139 INT152240 Nfasc Regulation of Gene_expression of Nos2 1 0.06 0.19 0.36
140 INT168423 Ptger2 Regulation of Nos2 1 0.13 0.52 0.36
141 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
142 INT89500 Nos2 Positive_regulation of Il6 1 0.04 1.07 0.35
143 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
144 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35
145 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34
146 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34
147 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
148 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
149 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
150 INT110758 Tnfaip8 Positive_regulation of Positive_regulation of Nos2 1 0.14 0.88 0.34
151 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34
152 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
153 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34
154 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
155 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
156 INT110761 Tnfaip8 Positive_regulation of Nos2 1 0.13 0.88 0.34
157 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33
158 INT333158 asa Positive_regulation of Nos3 1 0.11 0.18 0.32
159 INT333166 Tlx2 Positive_regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
160 INT344036 Binding of NOS1 and SPTB 1 0.01 0.31 0.32
161 INT333155 Tlx2 Regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
162 INT333152 Tlx2 Positive_regulation of Nos3 1 0.08 0.18 0.32
163 INT333169 asa Positive_regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
164 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
165 INT333164 asa Regulation of Nos3 1 0.11 0.18 0.32
166 INT333149 asa Regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
167 INT333167 Tlx2 Regulation of Nos3 1 0.08 0.18 0.32
168 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
169 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
170 INT191949 NFKB2 Positive_regulation of NOS2 1 0.05 1.16 0.31
171 INT313740 Negative_regulation of NOS1 Positive_regulation of Gene_expression of Ccl2 1 0.02 0.38 0.3
172 INT354821 Nos2 Positive_regulation of Eif2ak2 1 0.06 0.64 0.3
173 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3
174 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
175 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
176 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
177 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28
178 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
179 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 0.14 0.52 0.28
180 INT156440 Cpox Positive_regulation of NOS1 1 0.01 0.52 0.28
181 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
182 INT349506 S100a8 Positive_regulation of Gene_expression of Nos2 1 0.02 0.67 0.28
183 INT278971 IL1B Positive_regulation of Gene_expression of NOS2 1 0.14 0.79 0.27
184 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
185 INT314305 Ptger2 Positive_regulation of Nos2 1 0.00 0.07 0.26
186 INT242763 Olr1746 Negative_regulation of Nos1 1 0.02 0.97 0.26
187 INT278954 MST1 Regulation of Gene_expression of NOS2 1 0.01 0.41 0.25
188 INT278945 NOS2 Regulation of Gene_expression of CPOX 1 0.02 0.41 0.25
189 INT278963 IL6 Regulation of Gene_expression of NOS2 1 0.12 0.41 0.25
190 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
191 INT328707 Trat1 Negative_regulation of Nos1 1 0.02 2.32 0.24
192 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
193 INT127101 Memo1 Negative_regulation of Gene_expression of Nos2 1 0.10 0.55 0.24
194 INT327321 Binding of Elavl1 and Nos2 1 0.05 0.6 0.24
195 INT327320 Positive_regulation of Binding of Elavl1 and Nos2 1 0.06 0.6 0.24
196 INT257223 Ltp Positive_regulation of Gene_expression of Nos1 1 0.03 0.07 0.24
197 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
198 INT273055 Plat Positive_regulation of Gene_expression of Nos2 1 0.01 1.34 0.23
199 INT235088 NOS1 Regulation of ISYNA1 1 0.07 0.75 0.23
200 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for nitric-oxide synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in nitric-oxide synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
3 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
4 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85
5 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71
6 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
7 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
8 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
9 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32
10 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
11 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
12 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
13 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
14 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
15 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
16 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
17 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
18 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
19 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
20 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
21 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
22 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84
23 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
24 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72
25 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
26 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
27 INT48766 Regulation of NOS1 73 0.61 37.01 24.59
28 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
29 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
30 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96
31 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
32 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72
33 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
34 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
35 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
36 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
37 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
38 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
39 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
40 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
41 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
42 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
43 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
44 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47
45 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
46 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
47 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37
48 INT80251 Binding of Nos1 21 0.30 8.24 11.31
49 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
50 INT48912 Localization of NOS1 52 0.77 24.14 10.92
51 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
52 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42
53 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
54 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
55 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
56 INT48908 Transcription of NOS1 27 0.55 13.46 8.39
57 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
58 INT116605 Binding of Nos2 28 0.37 16.88 8.18
59 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
60 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
61 INT71381 Localization of Nos1 33 0.79 11.46 8.05
62 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
63 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
64 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
65 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
66 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
67 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
68 INT89131 Negative_regulation of NOS2 20 0.58 9.68 6.56
69 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
70 INT69499 Binding of Nos1 15 0.36 2.56 6.23
71 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
72 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
73 INT48911 Binding of NOS1 24 0.40 11.21 5.89
74 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
75 INT94428 Negative_regulation of Gene_expression of NOS2 20 0.47 11.61 5.62
76 INT84673 Localization of Nos1 19 0.80 5.01 5.62
77 INT86717 Negative_regulation of Positive_regulation of NOS1 18 0.30 8.88 5.2
78 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
79 INT73608 Localization of Nos2 21 0.75 9.58 5.05
80 INT89132 Regulation of NOS2 9 0.61 7.34 4.95
81 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
82 INT76581 Regulation of Negative_regulation of NOS1 14 0.45 7.49 4.4
83 INT94427 Positive_regulation of Positive_regulation of NOS2 14 0.47 11.15 4.3
84 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
85 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
86 INT102515 Binding of Nos3 19 0.45 9.41 4.01
87 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
88 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
89 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
90 INT70958 Binding of NOS3 19 0.37 11.84 3.29
91 INT126223 Binding of Nos2 17 0.37 6 3.22
92 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
93 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
94 INT89133 Transcription of NOS2 13 0.71 6.84 2.93
95 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
96 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
97 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
98 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
99 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
100 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
101 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
102 INT97523 Phosphorylation of NOS1 3 0.46 0.59 2.58
103 INT89852 Localization of Nos2 22 0.78 14.89 2.56
104 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
105 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
106 INT76094 Localization of NOS2 8 0.72 2.76 2.34
107 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
108 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
109 INT132669 Positive_regulation of Transcription of NOS1 7 0.44 4.43 2.19
110 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
111 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
112 INT104263 Regulation of Positive_regulation of NOS1 5 0.28 3.15 2.15
113 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
114 INT89130 Positive_regulation of Transcription of NOS2 7 0.50 3.32 2.14
115 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
116 INT91594 Localization of NOS3 12 0.78 5.39 2.02
117 INT76532 Binding of Nos3 13 0.37 9.32 1.87
118 INT60999 Localization of Nos3 12 0.74 5.28 1.75
119 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
120 INT79063 Regulation of Gene_expression of NOS2 6 0.43 3.68 1.7
121 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
122 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
123 INT181574 Phosphorylation of Nos2 9 0.70 2.92 1.55
124 INT96047 Positive_regulation of Localization of NOS1 6 0.38 4.24 1.47
125 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
126 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39
127 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
128 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
129 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
130 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
131 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
132 INT61395 Negative_regulation of Negative_regulation of NOS1 5 0.30 1.83 1.25
133 INT144392 Negative_regulation of Negative_regulation of Nos2 2 0.42 1.83 1.24
134 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23
135 INT144393 Negative_regulation of Negative_regulation of Nos1 2 0.32 0.96 1.15
136 INT121052 Binding of NOS2 3 0.35 3.12 1.12
137 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
138 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
139 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
140 INT89847 Positive_regulation of Localization of Nos1 10 0.49 2.45 1.01
141 INT89288 Positive_regulation of Negative_regulation of NOS1 5 0.40 4.84 0.96
142 INT132667 Regulation of Transcription of NOS1 1 0.30 2.58 0.95
143 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
144 INT89856 Positive_regulation of Localization of Nos2 6 0.49 1.79 0.9
145 INT132668 Negative_regulation of Transcription of NOS1 3 0.18 1.72 0.87
146 INT92836 Regulation of Transcription of Nos2 3 0.58 1.79 0.85
147 INT147138 Positive_regulation of Phosphorylation of NOS1 1 0.12 0.45 0.8
148 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75
149 INT216258 Positive_regulation of Regulation of Nos1 2 0.40 1.45 0.74
150 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
151 INT92547 Regulation of Localization of Nos1 2 0.43 0.61 0.7
152 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
153 INT97192 Regulation of Transcription of Nos1 1 0.55 1.94 0.68
154 INT85855 Negative_regulation of Binding of NOS1 6 0.37 3.4 0.66
155 INT201270 Regulation of Positive_regulation of Nos1 2 0.38 2.27 0.63
156 INT110019 Negative_regulation of Phosphorylation of NOS1 1 0.08 0 0.62
157 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
158 INT144447 Regulation of Regulation of Nos1 1 0.43 0.1 0.59
159 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
160 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
161 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54
162 INT117882 Regulation of Positive_regulation of NOS2 1 0.45 0.43 0.54
163 INT145099 Regulation of Transcription of Nos1 3 0.44 1.24 0.53
164 INT278983 Regulation of Negative_regulation of NOS2 1 0.17 1.71 0.53
165 INT95368 Negative_regulation of Positive_regulation of NOS2 4 0.37 0.89 0.52
166 INT96037 Positive_regulation of Localization of Nos2 2 0.49 0.78 0.52
167 INT349037 Regulation of Phosphorylation of Nos2 1 0.39 1.02 0.51
168 INT229773 Positive_regulation of Regulation of Nos2 3 0.41 2.97 0.5
169 INT92549 Negative_regulation of Localization of Nos1 1 0.37 0.26 0.5
170 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
171 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46
172 INT108735 Regulation of Localization of Nos2 3 0.42 0.52 0.46
173 INT144095 Localization of Nos3 8 0.57 4.5 0.43
174 INT186288 Negative_regulation of Binding of Nos2 3 0.35 1.08 0.42
175 INT149650 Protein_catabolism of Nos2 3 0.55 0.79 0.42
176 INT208368 Negative_regulation of Regulation of Nos2 1 0.42 0.35 0.42
177 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
178 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
179 INT235457 Negative_regulation of Regulation of Nos2 3 0.42 1.55 0.39
180 INT104414 Negative_regulation of Transcription of Nos1 1 0.42 0.96 0.38
181 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
182 INT106275 Regulation of Localization of Nos2 1 0.25 0.38 0.32
183 INT94432 Negative_regulation of Transcription of NOS2 4 0.39 0.67 0.31
184 INT120320 Positive_regulation of Transcription of Nos1 3 0.46 0.58 0.29
185 INT159474 Positive_regulation of Binding of NOS1 2 0.44 0.63 0.29
186 INT132377 Negative_regulation of Binding of Nos2 5 0.29 0.75 0.28
187 INT107757 Regulation of Negative_regulation of Nos1 2 0.39 0 0.27
188 INT112278 Positive_regulation of Regulation of Nos1 4 0.38 0.99 0.25
189 INT117878 Positive_regulation of Regulation of Nos2 3 0.41 1.35 0.25
190 INT181915 Negative_regulation of Binding of NOS2 1 0.16 0.95 0.25
191 INT124200 Negative_regulation of Localization of Nos2 1 0.22 0.7 0.25
192 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24
193 INT227750 Positive_regulation of Binding of Nos2 1 0.18 0.8 0.23
194 INT172796 Regulation of Negative_regulation of Nos3 1 0.16 1.4 0.23
195 INT105900 Regulation of Binding of Nos1 1 0.35 0.52 0.22
196 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22
197 INT73810 Negative_regulation of Regulation of Nos3 2 0.36 1.01 0.21
198 INT118276 Regulation of Positive_regulation of Nos3 1 0.09 0 0.21
199 INT133634 Positive_regulation of Negative_regulation of Nos1 1 0.47 0.57 0.2
200 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
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