GO:0004518

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Name nuclease activity
Categary Function
Go Slim Yes
Go Link GO:0004518
Unique Molecular Interactions 62
Total Molecular Interactions 74
Total Single Events 310
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nuclease activity. They are ordered first by their pain relevance and then by number of times they were reported for nuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 0.06 0.29 0.71
2 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 0.06 0.29 0.7
3 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
4 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
5 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
6 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 0.01 0.52 0.57
7 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
8 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
9 INT326473 Positive_regulation of PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.41
10 INT326470 PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.4
11 INT326472 AGXT Negative_regulation of PGAP1 1 0.00 0.05 0.39
12 INT203151 Binding of Rnase1 and Trav6-3 1 0.03 1.51 0.36
13 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
14 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
15 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
16 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
17 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
18 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
19 INT316375 Ang Positive_regulation of Nfkb1 1 0.08 0.73 0.23
20 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2
21 INT218937 Akt1 Positive_regulation of Parn 1 0.01 0.65 0.16
22 INT316376 Binding of Ang and Atp6ap2 1 0.06 0.87 0.16
23 INT304187 Ang Negative_regulation of Gene_expression of VEGFA 1 0.05 0.16 0.13
24 INT306921 Ang Positive_regulation of Gene_expression of Ephx2 1 0.15 0.79 0.12
25 INT161174 Binding of Ang and Trpc6 1 0.29 0.74 0.11
26 INT204993 Eri1 Positive_regulation of Gene_expression of Pink1 1 0.22 0.61 0.08
27 INT320881 Ang Positive_regulation of Agtrap 1 0.12 1.35 0.08
28 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08
29 INT307805 Ace Positive_regulation of Ang 1 0.32 1.52 0.07
30 INT304186 Ang Positive_regulation of Gene_expression of VEGFA 2 0.05 2.5 0.06
31 INT204998 Hmmr Positive_regulation of Eri1 1 0.00 0.58 0.06
32 INT172349 Eri1 Regulation of Gene_expression of Agrp 1 0.03 0.28 0.05
33 INT316371 Ang Negative_regulation of Ren1 1 0.16 0.64 0.05
34 INT172348 Eri1 Negative_regulation of Gene_expression of Agrp 1 0.07 0.28 0.05
35 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 0.03 0.15 0.03
36 INT315263 Eri1 Regulation of Rela 1 0.00 0.49 0
37 INT161177 Ang Positive_regulation of Trpc6 1 0.31 0.5 0
38 INT315271 Eri1 Regulation of Nfe2l2 1 0.00 0.48 0
39 INT172347 Eri1 Negative_regulation of Hras1 1 0.00 0.76 0
40 INT325607 Positive_regulation of Gopc Regulation of Ang 1 0.15 0.26 0
41 INT315265 Eri1 Negative_regulation of Keap1 1 0.01 0.26 0
42 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
43 INT161176 Ang Positive_regulation of Positive_regulation of Trpc6 1 0.31 0.5 0
44 INT325590 Gopc Regulation of Ang 1 0.13 0.25 0
45 INT325595 Nppa Negative_regulation of Ang 1 0.25 0.46 0
46 INT315260 Eri1 Regulation of Keap1 1 0.00 0.48 0
47 INT218973 Gen1 Regulation of Gene_expression of Pgr 1 0.06 0.09 0
48 INT325587 Binding of Ang and Nppa 1 0.21 0.24 0
49 INT185353 Eri1 Negative_regulation of Transcription of Egfr 1 0.01 0.5 0
50 INT325594 Binding of Ang and Olfml3 1 0.01 0.1 0
51 INT328422 Protein_catabolism of Neu1 Positive_regulation of Dnase2b 1 0.01 0.67 0
52 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 0.25 0.46 0
53 INT172345 Eri1 Negative_regulation of Gene_expression of Hras1 1 0.00 0.76 0
54 INT325598 Ang Positive_regulation of Camk2a 1 0.21 0.29 0
55 INT161179 Positive_regulation of Ang Positive_regulation of Trpc6 1 0.31 0.5 0
56 INT172344 Eri1 Negative_regulation of Positive_regulation of Hras1 1 0.00 0.76 0
57 INT109815 Ace2 Positive_regulation of Ang 1 0.06 0.3 0
58 INT245039 Binding of Xrcc1 and Tdp1 1 0.39 0.77 0
59 INT244063 Binding of Gabarap and Eri3 1 0.00 0 0
60 INT218974 Gen1 Negative_regulation of Gnrh1 1 0.13 0.16 0
61 INT325601 Ang Positive_regulation of Phosphorylation of Camk2a 1 0.21 0.29 0
62 INT185357 Eri1 Negative_regulation of Gene_expression of Egfr 1 0.01 0.57 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nuclease activity. They are ordered first by their pain relevance and then by number of times they were reported in nuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
2 INT142694 Positive_regulation of PGAP1 3 0.08 2.78 8.68
3 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
4 INT322474 Regulation of PGAP1 1 0.38 4.82 5.06
5 INT322475 Negative_regulation of PGAP1 9 0.36 4.78 4.69
6 INT131808 Localization of Apex1 2 0.16 13.46 4.61
7 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
8 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
9 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84
10 INT96861 Binding of Ang 11 0.32 4.46 1.1
11 INT87637 Localization of Ang 11 0.63 4.42 1.03
12 INT38172 Regulation of Ang 8 0.31 4.13 0.9
13 INT326487 Positive_regulation of Positive_regulation of PGAP1 1 0.01 0.07 0.8
14 INT117427 Gene_expression of Parn 1 0.44 1.18 0.79
15 INT81325 Transcription of Ang 2 0.52 1.43 0.76
16 INT81327 Positive_regulation of Transcription of Ang 1 0.45 1.32 0.76
17 INT117547 Gene_expression of SND1 2 0.57 1.27 0.71
18 INT117542 Positive_regulation of SND1 2 0.34 2.19 0.69
19 INT253750 Positive_regulation of Gene_expression of Apex1 1 0.10 1.43 0.64
20 INT326485 Negative_regulation of Positive_regulation of PGAP1 1 0.01 0.08 0.49
21 INT62300 Regulation of SND1 1 0.47 1.07 0.48
22 INT169943 Gene_expression of Eri1 22 0.35 10.45 0.41
23 INT92197 Gene_expression of PGAP1 1 0.00 0.3 0.4
24 INT200 Positive_regulation of Rnase1 6 0.44 0.19 0.28
25 INT322476 Positive_regulation of Negative_regulation of PGAP1 1 0.29 0.46 0.28
26 INT227426 Positive_regulation of Apex1 2 0.08 1.98 0.23
27 INT199 Negative_regulation of Rnase1 5 0.59 0.58 0.22
28 INT96860 Positive_regulation of Binding of Ang 3 0.33 1.4 0.21
29 INT253752 Negative_regulation of Localization of Apex1 1 0.08 1.26 0.2
30 INT181059 Gene_expression of Rnase1 5 0.25 0.98 0.19
31 INT161173 Negative_regulation of Localization of Ang 3 0.39 2.19 0.18
32 INT218968 Positive_regulation of Gen1 1 0.26 1.15 0.18
33 INT218902 Phosphorylation of Parn 1 0.03 0.64 0.16
34 INT324893 Positive_regulation of Localization of Ang 1 0.10 0.59 0.16
35 INT190110 Positive_regulation of Eri1 2 0.27 3.47 0.15
36 INT197894 Binding of Gen1 2 0.20 0.09 0.14
37 INT204967 Negative_regulation of Eri1 2 0.17 1.41 0.12
38 INT307797 Negative_regulation of Gene_expression of Ang 2 0.39 1.3 0.11
39 INT190501 Regulation of Apex1 1 0.12 0.32 0.1
40 INT273338 Protein_catabolism of Apex1 4 0.05 0.57 0.09
41 INT169935 Positive_regulation of Gene_expression of Eri1 3 0.19 2.46 0.09
42 INT172342 Regulation of Eri1 2 0.03 0.3 0.08
43 INT320864 Negative_regulation of Positive_regulation of Ang 1 0.19 1.37 0.08
44 INT190102 Protein_catabolism of Eri1 3 0.25 1.69 0.04
45 INT204991 Positive_regulation of Positive_regulation of Eri1 1 0.19 0.96 0
46 INT218967 Gene_expression of Gen1 1 0.25 0.45 0
47 INT35638 Localization of PGAP1 1 0.01 0.69 0
48 INT279861 Positive_regulation of Gene_expression of Rnase1 1 0.15 0 0
49 INT309506 Positive_regulation of Tdp1 1 0.23 1.19 0
50 INT328418 Protein_catabolism of Dnase2b 1 0.42 0.72 0
51 INT283730 Binding of Eri1 1 0.01 0.26 0
52 INT316365 Positive_regulation of Negative_regulation of Ang 1 0.33 0.76 0
53 INT219055 Regulation of Gene_expression of Eri1 1 0.00 0.1 0
54 INT218966 Regulation of Gen1 1 0.17 0.15 0
55 INT303276 Regulation of Gene_expression of Ang 1 0.24 0.89 0
56 INT325550 Positive_regulation of Regulation of Ang 1 0.33 0.27 0
57 INT198 Regulation of Rnase1 1 0.39 0 0
58 INT337668 Positive_regulation of Gene_expression of SND1 1 0.51 0.99 0
59 INT218969 Negative_regulation of Gen1 1 0.16 0.18 0
60 INT204984 Transcription of Eri1 1 0.21 0.78 0
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