GO:0004522

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Name pancreatic ribonuclease activity
Categary Function
Go Slim No
Go Link GO:0004522
Unique Molecular Interactions 64
Total Molecular Interactions 76
Total Single Events 403
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pancreatic ribonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported for pancreatic ribonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
2 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
3 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
4 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
5 INT19297 ANG Positive_regulation of AVP 1 0.28 0 0.46
6 INT151637 Binding of Cyp21a1 and Ear11 1 0.01 0 0.44
7 INT19298 ANG Regulation of OXT 1 0.07 0 0.41
8 INT137732 Binding of Nts and Ang 1 0.30 0 0.33
9 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
10 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
11 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
12 INT242215 Binding of ANG and OLR1 1 0.02 1.63 0.25
13 INT316375 Ang Positive_regulation of Nfkb1 1 0.08 0.73 0.23
14 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2
15 INT346459 Binding of RNASE1 and ROS1 1 0.06 1.42 0.18
16 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
17 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17
18 INT316376 Binding of Ang and Atp6ap2 1 0.06 0.87 0.16
19 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15
20 INT128903 Binding of RNASE2 and Itga7 1 0.00 0.08 0.15
21 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
22 INT281911 Binding of ANG and MAS1 1 0.05 0.39 0.13
23 INT304187 Ang Negative_regulation of Gene_expression of VEGFA 1 0.05 0.16 0.13
24 INT325056 Binding of E2f1 and Ang 1 0.06 1.3 0.12
25 INT306921 Ang Positive_regulation of Gene_expression of Ephx2 1 0.15 0.79 0.12
26 INT325057 Binding of Hand1 and Ang 1 0.01 1.29 0.12
27 INT161174 Binding of Ang and Trpc6 1 0.29 0.74 0.11
28 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
29 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
30 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
31 INT320881 Ang Positive_regulation of Agtrap 1 0.12 1.35 0.08
32 INT206072 ANG Positive_regulation of IL6 1 0.05 0.5 0.08
33 INT201543 Binding of NPC1 and RNASE1 1 0.07 1.33 0.08
34 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
35 INT21649 ANG Regulation of Alb 1 0.04 0.64 0.07
36 INT307805 Ace Positive_regulation of Ang 1 0.32 1.52 0.07
37 INT206080 ANG Regulation of Gene_expression of IL6 1 0.03 0.4 0.07
38 INT206063 ANG Positive_regulation of Gene_expression of KRT20 1 0.00 1.01 0.07
39 INT304186 Ang Positive_regulation of Gene_expression of VEGFA 2 0.05 2.5 0.06
40 INT281906 BDKRB2 Positive_regulation of ANG 1 0.11 0.51 0.05
41 INT316371 Ang Negative_regulation of Ren1 1 0.16 0.64 0.05
42 INT336132 Binding of AGTR1 and ANG 1 0.00 0.38 0.05
43 INT102887 Binding of ANG and SGCG 1 0.37 0 0.03
44 INT329641 Rrm2 Regulation of Ear11 1 0.01 0.49 0
45 INT161177 Ang Positive_regulation of Trpc6 1 0.31 0.5 0
46 INT206079 ANG Regulation of KRT20 1 0.00 0.54 0
47 INT325607 Positive_regulation of Gopc Regulation of Ang 1 0.15 0.26 0
48 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
49 INT161176 Ang Positive_regulation of Positive_regulation of Trpc6 1 0.31 0.5 0
50 INT206069 ANG Positive_regulation of Gene_expression of IL6 1 0.05 0.51 0
51 INT329653 Binding of VEGFA and Ear11 1 0.00 0.63 0
52 INT325590 Gopc Regulation of Ang 1 0.13 0.25 0
53 INT325595 Nppa Negative_regulation of Ang 1 0.25 0.46 0
54 INT336129 Binding of ANG and EXTL3 1 0.01 0.38 0
55 INT325587 Binding of Ang and Nppa 1 0.21 0.24 0
56 INT336131 Binding of ANG and ATP6AP2 1 0.00 0.38 0
57 INT325594 Binding of Ang and Olfml3 1 0.01 0.1 0
58 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 0.25 0.46 0
59 INT281904 ANG Positive_regulation of PTGIS 1 0.04 0 0
60 INT325598 Ang Positive_regulation of Camk2a 1 0.21 0.29 0
61 INT161179 Positive_regulation of Ang Positive_regulation of Trpc6 1 0.31 0.5 0
62 INT336130 Binding of ANG and REN 1 0.06 0.38 0
63 INT109815 Ace2 Positive_regulation of Ang 1 0.06 0.3 0
64 INT325601 Ang Positive_regulation of Phosphorylation of Camk2a 1 0.21 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pancreatic ribonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported in pancreatic ribonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
2 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
3 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
4 INT8270 Positive_regulation of Ear11 8 0.60 1.74 3.42
5 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
6 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
7 INT1554 Positive_regulation of RNASE1 10 0.67 9.44 1.78
8 INT29739 Positive_regulation of ANG 11 0.69 4.37 1.75
9 INT102893 Positive_regulation of Gene_expression of ANG 10 0.69 5.62 1.71
10 INT59903 Positive_regulation of Localization of Ear11 1 0.51 0 1.58
11 INT59901 Localization of Ear11 3 0.59 0.72 1.57
12 INT26606 Gene_expression of RNASE1 19 0.65 7.18 1.46
13 INT251834 Negative_regulation of Gene_expression of ANG 5 0.59 3.95 1.38
14 INT73365 Positive_regulation of Ang 10 0.67 3.8 1.36
15 INT96861 Binding of Ang 11 0.32 4.46 1.1
16 INT19303 Regulation of ANG 3 0.62 1.08 1.09
17 INT90785 Negative_regulation of Ang 3 0.42 8.34 1.06
18 INT87637 Localization of Ang 11 0.63 4.42 1.03
19 INT5679 Negative_regulation of RNASE1 7 0.40 2.39 1
20 INT108477 Gene_expression of Ear11 3 0.44 0.86 0.93
21 INT118538 Binding of ANG 5 0.47 3.02 0.92
22 INT38172 Regulation of Ang 8 0.31 4.13 0.9
23 INT76551 Regulation of Ang 7 0.45 2.6 0.9
24 INT109079 Negative_regulation of ANG 4 0.57 2.2 0.8
25 INT59902 Negative_regulation of Localization of Ear11 1 0.32 0 0.8
26 INT108476 Transcription of Ear11 1 0.30 0 0.77
27 INT81325 Transcription of Ang 2 0.52 1.43 0.76
28 INT108478 Positive_regulation of Gene_expression of Ear11 1 0.39 0 0.76
29 INT81327 Positive_regulation of Transcription of Ang 1 0.45 1.32 0.76
30 INT28869 Regulation of Ear11 3 0.18 1.62 0.75
31 INT28870 Regulation of Positive_regulation of Ear11 1 0.11 0.34 0.6
32 INT143278 Regulation of Gene_expression of ANG 2 0.62 1.13 0.59
33 INT14294 Localization of RNASE1 2 0.36 1.32 0.53
34 INT183472 Localization of RNASE2 2 0.27 1.46 0.46
35 INT12003 Gene_expression of Ang 4 0.64 3.87 0.44
36 INT183465 Positive_regulation of Localization of RNASE2 1 0.18 0.65 0.4
37 INT350672 Protein_catabolism of RNASE1 1 0.07 1.24 0.38
38 INT3527 Regulation of RNASE1 3 0.15 1.22 0.33
39 INT25606 Negative_regulation of Protein_catabolism of Ang 1 0.26 0 0.33
40 INT25605 Protein_catabolism of Ang 1 0.40 0 0.33
41 INT25153 Binding of RNASE1 3 0.36 1.8 0.32
42 INT100494 Negative_regulation of Positive_regulation of RNASE1 1 0.24 1.22 0.32
43 INT12004 Localization of Ang 3 0.39 1.3 0.31
44 INT102890 Localization of ANG 9 0.72 0.41 0.26
45 INT40005 Positive_regulation of Regulation of RNASE1 1 0.25 0.9 0.26
46 INT151636 Binding of Ear11 2 0.19 0.06 0.22
47 INT96860 Positive_regulation of Binding of Ang 3 0.33 1.4 0.21
48 INT161173 Negative_regulation of Localization of Ang 3 0.39 2.19 0.18
49 INT324893 Positive_regulation of Localization of Ang 1 0.10 0.59 0.16
50 INT128902 Binding of RNASE2 1 0.00 0.08 0.15
51 INT57780 Gene_expression of RNASE2 1 0.03 1.49 0.13
52 INT325044 Binding of Ang 1 0.12 0.47 0.12
53 INT307797 Negative_regulation of Gene_expression of Ang 2 0.39 1.3 0.11
54 INT325052 Regulation of Negative_regulation of Ang 1 0.10 1.08 0.11
55 INT44744 Regulation of Positive_regulation of RNASE1 1 0.39 0.44 0.09
56 INT320864 Negative_regulation of Positive_regulation of Ang 1 0.19 1.37 0.08
57 INT242229 Negative_regulation of Positive_regulation of ANG 1 0.08 0.63 0.06
58 INT336137 Negative_regulation of Binding of ANG 1 0.08 0.38 0.05
59 INT323760 Protein_catabolism of ANG 1 0.24 0.44 0
60 INT212037 Transcription of RNASE1 1 0.18 0 0
61 INT329639 Negative_regulation of Ear11 1 0.05 1.4 0
62 INT212032 Negative_regulation of Binding of RNASE1 1 0.11 0 0
63 INT316365 Positive_regulation of Negative_regulation of Ang 1 0.33 0.76 0
64 INT244497 Negative_regulation of Gene_expression of RNASE1 1 0.05 0.7 0
65 INT303276 Regulation of Gene_expression of Ang 1 0.24 0.89 0
66 INT325550 Positive_regulation of Regulation of Ang 1 0.33 0.27 0
67 INT281924 Transcription of ANG 1 0.39 0.1 0
68 INT329640 Positive_regulation of Negative_regulation of Ear11 1 0.04 0.54 0
69 INT281916 Negative_regulation of Transcription of ANG 1 0.23 0.1 0
70 INT212034 Regulation of Transcription of RNASE1 1 0.12 0 0
71 INT212033 Positive_regulation of Gene_expression of RNASE1 1 0.13 0 0
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