GO:0004527

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Name exonuclease activity
Categary Function
Go Slim No
Go Link GO:0004527
Unique Molecular Interactions 55
Total Molecular Interactions 63
Total Single Events 551
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for exonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported for exonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74
2 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
3 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
4 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 0.01 0.52 0.57
5 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
6 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
7 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
8 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
9 INT299787 Binding of IL2 and ISG20 1 0.04 0.82 0.21
10 INT218937 Akt1 Positive_regulation of Parn 1 0.01 0.65 0.16
11 INT104327 Fen1 Negative_regulation of Baat 1 0.31 0.75 0.12
12 INT104325 Regulation of Fen1 Negative_regulation of Baat 1 0.19 0.75 0.12
13 INT303815 Binding of Igfals and Tdp1 1 0.11 1.68 0.1
14 INT292623 ISG20 Positive_regulation of Gene_expression of IL9 1 0.10 0 0.09
15 INT204993 Eri1 Positive_regulation of Gene_expression of Pink1 1 0.22 0.61 0.08
16 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08
17 INT204998 Hmmr Positive_regulation of Eri1 1 0.00 0.58 0.06
18 INT229601 Binding of DIS3 and RLS 1 0.14 2.19 0.06
19 INT172349 Eri1 Regulation of Gene_expression of Agrp 1 0.03 0.28 0.05
20 INT351010 ISG20 Positive_regulation of Transcription of IL2 1 0.31 0.46 0.05
21 INT172348 Eri1 Negative_regulation of Gene_expression of Agrp 1 0.07 0.28 0.05
22 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 0.03 0.15 0.03
23 INT282553 POU5F1 Positive_regulation of REXO1 1 0.21 0.1 0.03
24 INT294829 STAT3 Regulation of Gene_expression of REXO1 1 0.10 0.48 0
25 INT315263 Eri1 Regulation of Rela 1 0.00 0.49 0
26 INT315271 Eri1 Regulation of Nfe2l2 1 0.00 0.48 0
27 INT172347 Eri1 Negative_regulation of Hras1 1 0.00 0.76 0
28 INT315265 Eri1 Negative_regulation of Keap1 1 0.01 0.26 0
29 INT294825 Phosphorylation of GRAP2 Regulation of Gene_expression of REXO1 1 0.03 0.48 0
30 INT282557 NANOG Regulation of REXO1 1 0.07 0.23 0
31 INT315260 Eri1 Regulation of Keap1 1 0.00 0.48 0
32 INT294830 Phosphorylation of STAT3 Regulation of Gene_expression of REXO1 1 0.08 0.48 0
33 INT351013 PROK1 Regulation of ISG20 1 0.01 0.76 0
34 INT303822 Tdp1 Regulation of TREH 1 0.02 0.92 0
35 INT104328 Fen1 Positive_regulation of Baat 1 0.33 0.63 0
36 INT294881 Phosphorylation of Mdk Regulation of Gene_expression of REXO1 1 0.02 0.48 0
37 INT185353 Eri1 Negative_regulation of Transcription of Egfr 1 0.01 0.5 0
38 INT260128 Binding of ISG20 and Trav6-3 1 0.01 0 0
39 INT282547 SOX2 Regulation of REXO1 1 0.12 0.23 0
40 INT172345 Eri1 Negative_regulation of Gene_expression of Hras1 1 0.00 0.76 0
41 INT276665 Binding of Lig3 and Polg 1 0.32 0 0
42 INT104326 Regulation of Fen1 Positive_regulation of Baat 1 0.19 0.63 0
43 INT172344 Eri1 Negative_regulation of Positive_regulation of Hras1 1 0.00 0.76 0
44 INT229602 Binding of ETFA and DIS3 1 0.08 1.12 0
45 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0
46 INT245039 Binding of Xrcc1 and Tdp1 1 0.39 0.77 0
47 INT244063 Binding of Gabarap and Eri3 1 0.00 0 0
48 INT282544 GOPC Regulation of REXO1 1 0.03 0 0
49 INT294827 DPYD Positive_regulation of Gene_expression of REXO1 1 0.01 0.47 0
50 INT185357 Eri1 Negative_regulation of Gene_expression of Egfr 1 0.01 0.57 0
51 INT198006 ERI3 Negative_regulation of MCL1 1 0.01 1.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for exonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported in exonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58
2 INT131808 Localization of Apex1 2 0.16 13.46 4.61
3 INT15802 Positive_regulation of Gene_expression of ISG20 16 0.42 8.16 4.03
4 INT303796 Gene_expression of Tdp1 1 0.77 70.15 2.55
5 INT15799 Positive_regulation of ISG20 18 0.38 9.78 2.01
6 INT49867 Negative_regulation of Polg 7 0.39 4.07 1.86
7 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84
8 INT10669 Localization of Fen1 3 0.57 0.36 1.44
9 INT260114 Regulation of ISG20 5 0.37 4.98 1.27
10 INT260111 Localization of ISG20 6 0.41 3.46 1.25
11 INT82547 Negative_regulation of Gene_expression of ISG20 7 0.29 3.04 1.18
12 INT174516 Regulation of Gene_expression of ISG20 6 0.27 4.2 0.85
13 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79
14 INT117427 Gene_expression of Parn 1 0.44 1.18 0.79
15 INT142157 Positive_regulation of Protein_catabolism of Polg 1 0.04 0.32 0.77
16 INT142156 Protein_catabolism of Polg 1 0.06 0.32 0.75
17 INT251735 Binding of FEN1 1 0.17 1.13 0.74
18 INT44409 Gene_expression of Fen1 3 0.59 0 0.72
19 INT303799 Phosphorylation of Tdp1 1 0.82 22.84 0.71
20 INT253750 Positive_regulation of Gene_expression of Apex1 1 0.10 1.43 0.64
21 INT76623 Negative_regulation of Fen1 1 0.33 0.63 0.62
22 INT44413 Regulation of Fen1 2 0.39 0.44 0.6
23 INT303804 Localization of Tdp1 1 0.80 11.71 0.59
24 INT44410 Binding of Fen1 1 0.42 0.19 0.49
25 INT158837 Binding of POLG 4 0.37 4.69 0.44
26 INT169943 Gene_expression of Eri1 22 0.35 10.45 0.41
27 INT260121 Regulation of Localization of ISG20 1 0.14 0.81 0.41
28 INT44411 Positive_regulation of Fen1 1 0.49 0.76 0.38
29 INT303808 Positive_regulation of Gene_expression of Tdp1 1 0.69 9.07 0.35
30 INT303811 Binding of Tdp1 1 0.37 8.69 0.33
31 INT82541 Negative_regulation of ISG20 2 0.27 0.15 0.27
32 INT234410 Binding of ISG20 4 0.22 1.66 0.26
33 INT44412 Positive_regulation of Binding of Fen1 1 0.44 0.1 0.24
34 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23
35 INT227426 Positive_regulation of Apex1 2 0.08 1.98 0.23
36 INT210199 Negative_regulation of Positive_regulation of ISG20 2 0.15 2.52 0.2
37 INT253752 Negative_regulation of Localization of Apex1 1 0.08 1.26 0.2
38 INT303812 Regulation of Tdp1 1 0.45 3.32 0.19
39 INT169582 Phosphorylation of POLG 2 0.54 1.98 0.18
40 INT218902 Phosphorylation of Parn 1 0.03 0.64 0.16
41 INT190110 Positive_regulation of Eri1 2 0.27 3.47 0.15
42 INT192952 Negative_regulation of DIS3 1 0.21 0.42 0.15
43 INT318836 Binding of ERI3 1 0.11 0.18 0.14
44 INT282602 Gene_expression of REXO1 6 0.35 6.38 0.13
45 INT230640 Negative_regulation of REXO1 3 0.33 1.28 0.12
46 INT204967 Negative_regulation of Eri1 2 0.17 1.41 0.12
47 INT230642 Positive_regulation of Negative_regulation of REXO1 2 0.36 0.49 0.12
48 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11
49 INT190501 Regulation of Apex1 1 0.12 0.32 0.1
50 INT302692 Localization of POLG 1 0.69 0.99 0.1
51 INT273338 Protein_catabolism of Apex1 4 0.05 0.57 0.09
52 INT169935 Positive_regulation of Gene_expression of Eri1 3 0.19 2.46 0.09
53 INT303805 Positive_regulation of Phosphorylation of Tdp1 1 0.50 3.27 0.09
54 INT172342 Regulation of Eri1 2 0.03 0.3 0.08
55 INT303795 Negative_regulation of Tdp1 1 0.43 1.71 0.08
56 INT251829 Positive_regulation of POLG 1 0.53 1.5 0.08
57 INT303806 Negative_regulation of Gene_expression of Tdp1 1 0.58 3.26 0.08
58 INT282574 Positive_regulation of Gene_expression of REXO1 3 0.22 2.71 0.07
59 INT294859 Regulation of Gene_expression of REXO1 1 0.19 0.57 0.07
60 INT349638 Positive_regulation of Transcription of ISG20 1 0.31 0 0.07
61 INT349639 Transcription of ISG20 1 0.43 0 0.07
62 INT303801 Positive_regulation of Tdp1 1 0.60 9.8 0.06
63 INT234416 Positive_regulation of Binding of ISG20 1 0.23 0.38 0.06
64 INT190102 Protein_catabolism of Eri1 3 0.25 1.69 0.04
65 INT282600 Positive_regulation of REXO1 3 0.31 1.44 0.04
66 INT251827 Regulation of POLG 3 0.59 2.94 0.04
67 INT303810 Positive_regulation of Localization of Tdp1 1 0.46 0.67 0.03
68 INT276649 Gene_expression of Polg 6 0.70 1.31 0
69 INT201547 Gene_expression of ERI3 4 0.20 2.19 0
70 INT138714 Positive_regulation of Polg 3 0.18 0.39 0
71 INT282577 Transcription of REXO1 3 0.24 0.51 0
72 INT233709 Positive_regulation of ERI3 2 0.16 0.08 0
73 INT282595 Negative_regulation of Transcription of REXO1 2 0.19 0.37 0
74 INT266162 Transcription of POLG 2 0.68 0.76 0
75 INT204991 Positive_regulation of Positive_regulation of Eri1 1 0.19 0.96 0
76 INT229605 Binding of DIS3 1 0.11 1.88 0
77 INT198044 Protein_catabolism of ERI3 1 0.01 1.17 0
78 INT309506 Positive_regulation of Tdp1 1 0.23 1.19 0
79 INT276663 Negative_regulation of Gene_expression of Polg 1 0.39 0 0
80 INT266161 Regulation of Negative_regulation of POLG 1 0.38 0.56 0
81 INT294848 Negative_regulation of Gene_expression of REXO1 1 0.18 0.91 0
82 INT266164 Negative_regulation of Gene_expression of POLG 1 0.41 1.08 0
83 INT303803 Transcription of Tdp1 1 0.53 0.56 0
84 INT294853 Phosphorylation of REXO1 1 0.27 0.54 0
85 INT283730 Binding of Eri1 1 0.01 0.26 0
86 INT266170 Negative_regulation of Transcription of POLG 1 0.36 1.43 0
87 INT219055 Regulation of Gene_expression of Eri1 1 0.00 0.1 0
88 INT251832 Positive_regulation of Positive_regulation of POLG 1 0.35 0.28 0
89 INT276659 Positive_regulation of Gene_expression of Polg 1 0.45 0 0
90 INT292660 Phosphorylation of ISG20 1 0.26 0 0
91 INT318842 Localization of ERI3 1 0.23 0 0
92 INT219496 Negative_regulation of FEN1 1 0.35 0.36 0
93 INT285950 Positive_regulation of Transcription of REXO1 1 0.06 0.14 0
94 INT282584 Localization of REXO1 1 0.33 0.17 0
95 INT294854 Negative_regulation of Phosphorylation of REXO1 1 0.18 0.54 0
96 INT204984 Transcription of Eri1 1 0.21 0.78 0
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