GO:0004528

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Name phosphodiesterase I activity
Categary Function
Go Slim No
Go Link GO:0004528
Unique Molecular Interactions 42
Total Molecular Interactions 52
Total Single Events 384
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphodiesterase I activity. They are ordered first by their pain relevance and then by number of times they were reported for phosphodiesterase I activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93
2 INT107602 Binding of OPLL and Enpp1 1 0.15 1.12 0.76
3 INT167583 ENPP2 Positive_regulation of Gene_expression of LPA 1 0.08 0.93 0.51
4 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44
5 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28
6 INT225784 Il1 Negative_regulation of Gene_expression of Enpp1 1 0.08 0.99 0.28
7 INT167582 ENPP2 Regulation of Gene_expression of LPA 1 0.05 0.61 0.26
8 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
9 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
10 INT118257 Binding of ENPP1 and SUGT1 1 0.00 0.87 0.16
11 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
12 INT174892 Binding of ADRB3 and ENPP3 1 0.04 0.4 0.14
13 INT89763 Positive_regulation of APEX1 Positive_regulation of Positive_regulation of NR4A1 1 0.10 0.87 0.14
14 INT225783 Enpp1 Regulation of Ppi-rs 1 0.07 0.68 0.13
15 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
16 INT167757 Binding of Enpp2 and Dmbx1 1 0.22 0.33 0.13
17 INT238036 Binding of ENPP1 and OPLL 1 0.27 0.66 0.12
18 INT225785 Enpp3 Regulation of Ppi-rs 1 0.00 0.69 0.11
19 INT225805 Binding of SNRNP70 and Enpp1 1 0.42 1.43 0.09
20 INT301402 Enpp2 Positive_regulation of Lpar1 2 0.33 0.55 0.07
21 INT301411 Enpp2 Positive_regulation of Csf2 1 0.04 0.59 0.07
22 INT301403 Enpp2 Positive_regulation of Tnfrsf11a 1 0.05 0.59 0.07
23 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05
24 INT225786 Enpp3 Positive_regulation of Ppi-rs 1 0.00 0.32 0.05
25 INT225808 SNRNP70 Regulation of Enpp1 1 0.30 0.71 0.04
26 INT247768 Fcer2a Positive_regulation of Enpp1 1 0.00 0.29 0.04
27 INT225801 Binding of Enpp1 and Npp 1 0.17 0.46 0.04
28 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
29 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
30 INT225802 Binding of Enpp1 and Ppi-rs 1 0.04 1 0.03
31 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
32 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
33 INT345149 Enpp2 Regulation of Gene_expression of Lpar1 1 0.01 0.41 0
34 INT262915 ENPP2 Regulation of SMG1 1 0.22 0.07 0
35 INT262913 ENPP2 Regulation of PCSK7 1 0.02 0.07 0
36 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0
37 INT225807 Enpp2 Positive_regulation of ALPI 1 0.00 0.23 0
38 INT345153 Dmbx1 Regulation of Enpp2 1 0.00 0.41 0
39 INT301401 Binding of Enpp1 and Enpp2 1 0.23 0.54 0
40 INT225782 Tnfrsf11b Regulation of Enpp1 1 0.12 0.74 0
41 INT225792 Gene_expression of Enpp2 Positive_regulation of Ppi-rs 1 0.01 0.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphodiesterase I activity. They are ordered first by their pain relevance and then by number of times they were reported in phosphodiesterase I activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8
2 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82
3 INT167755 Gene_expression of Enpp2 12 0.77 57.31 5.3
4 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3
5 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96
6 INT167585 Negative_regulation of ENPP2 7 0.36 5.19 2.74
7 INT107597 Binding of Enpp1 5 0.37 3.35 2.23
8 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97
9 INT10976 Negative_regulation of ENPP3 13 0.42 5.11 1.92
10 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81
11 INT105325 Gene_expression of ENPP2 5 0.75 1.32 1.72
12 INT332460 Regulation of Binding of Enpp1 1 0.05 0.78 1.5
13 INT10975 Gene_expression of ENPP3 16 0.76 3.28 1.36
14 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24
15 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16
16 INT216372 Localization of ENPP3 1 0.13 2.97 0.99
17 INT99477 Negative_regulation of Enpp3 3 0.30 2.45 0.88
18 INT225769 Positive_regulation of Gene_expression of Enpp2 3 0.69 16.67 0.74
19 INT216384 Positive_regulation of ENPP3 3 0.54 0.84 0.69
20 INT35098 Localization of Enpp1 4 0.75 0.81 0.67
21 INT160705 Positive_regulation of Enpp3 2 0.20 1.26 0.56
22 INT225772 Regulation of Gene_expression of Enpp1 1 0.62 1.6 0.4
23 INT160707 Regulation of Positive_regulation of Enpp3 1 0.13 0.19 0.38
24 INT225768 Positive_regulation of Enpp2 7 0.69 8.11 0.37
25 INT174895 Binding of ENPP3 2 0.06 0.74 0.37
26 INT182073 Binding of APEX1 4 0.12 1.72 0.32
27 INT216382 Transcription of ENPP3 1 0.11 0.43 0.3
28 INT109156 Negative_regulation of ENPP1 2 0.34 1.34 0.29
29 INT167586 Regulation of ENPP2 2 0.20 0.59 0.25
30 INT262928 Localization of ENPP2 1 0.58 1.11 0.24
31 INT335482 Regulation of Gene_expression of ENPP3 1 0.48 0 0.23
32 INT89772 Positive_regulation of APEX1 4 0.21 2.29 0.19
33 INT216375 Negative_regulation of Localization of ENPP3 1 0.07 0.55 0.18
34 INT335483 Regulation of ENPP3 1 0.35 0 0.17
35 INT153911 Localization of Enpp2 4 0.75 2.6 0.16
36 INT175900 Regulation of ENPP1 1 0.00 1.96 0.16
37 INT252419 Phosphorylation of Enpp1 1 0.08 0.21 0.16
38 INT225771 Negative_regulation of Gene_expression of Enpp1 4 0.43 3.68 0.13
39 INT174896 Protein_catabolism of ENPP3 1 0.07 0.39 0.13
40 INT182078 Gene_expression of APEX1 3 0.59 4.77 0.12
41 INT153908 Negative_regulation of Enpp2 2 0.42 1.4 0.07
42 INT301393 Positive_regulation of Positive_regulation of Enpp2 1 0.50 0.49 0.07
43 INT301398 Positive_regulation of Binding of Enpp2 1 0.50 0.49 0.07
44 INT301392 Negative_regulation of Gene_expression of Enpp2 1 0.58 3.16 0.07
45 INT301396 Binding of Enpp2 1 0.37 0.49 0.07
46 INT189231 Binding of ENPP1 1 0.07 0.56 0.06
47 INT182080 Localization of APEX1 2 0.57 2.3 0.05
48 INT214043 Positive_regulation of Localization of APEX1 1 0.38 0.64 0.05
49 INT301400 Negative_regulation of Negative_regulation of Enpp2 1 0.42 0.9 0.04
50 INT301387 Regulation of Gene_expression of Enpp2 1 0.61 9.41 0.04
51 INT153910 Regulation of Enpp2 2 0.45 2.1 0.03
52 INT10977 Negative_regulation of Gene_expression of ENPP3 2 0.34 0.13 0.03
53 INT301386 Positive_regulation of Localization of Enpp2 1 0.44 0.77 0.03
54 INT319969 Positive_regulation of Negative_regulation of Enpp1 1 0.06 0.77 0.03
55 INT182079 Negative_regulation of APEX1 5 0.18 1.75 0
56 INT125075 Gene_expression of Enpp3 2 0.19 0.35 0
57 INT160706 Positive_regulation of Gene_expression of Enpp3 1 0.14 0 0
58 INT301390 Transcription of Enpp2 1 0.69 0 0
59 INT262932 Positive_regulation of ENPP2 1 0.34 0.07 0
60 INT125073 Regulation of Enpp3 1 0.06 0.33 0
61 INT182075 Negative_regulation of Positive_regulation of APEX1 1 0.13 0.63 0
62 INT125074 Localization of Enpp3 1 0.15 0.67 0
63 INT182072 Regulation of APEX1 1 0.08 0.76 0
64 INT214034 Positive_regulation of Gene_expression of APEX1 1 0.53 0.85 0
65 INT310100 Transcription of APEX1 1 0.09 0 0
66 INT262930 Negative_regulation of Gene_expression of ENPP2 1 0.35 0 0
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