GO:0004553

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Name hydrolase activity, hydrolyzing O-glycosyl compounds
Categary Function
Go Slim No
Go Link GO:0004553
Unique Molecular Interactions 55
Total Molecular Interactions 69
Total Single Events 624
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity, hydrolyzing O-glycosyl compounds. They are ordered first by their pain relevance and then by number of times they were reported for hydrolase activity, hydrolyzing O-glycosyl compounds. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
2 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
3 INT118634 Chi3l1 Negative_regulation of Positive_regulation of Vegfc 1 0.03 0.24 0.76
4 INT51705 Binding of Penk and Naga 1 0.19 0.08 0.69
5 INT70819 Binding of GBE1 and CTRC 1 0.01 0.63 0.67
6 INT35862 PRSS1 Regulation of Localization of GBE1 1 0.00 0.35 0.59
7 INT37583 Naga Regulation of Odc1 1 0.20 0 0.51
8 INT65909 LAMB1 Positive_regulation of GANAB 1 0.00 0 0.45
9 INT37584 Naga Positive_regulation of Odc1 1 0.51 0 0.4
10 INT128018 Binding of Grm1 and Chi3l4 1 0.01 0.08 0.38
11 INT59189 Negative_regulation of GBE1 Negative_regulation of ALOX5 1 0.00 0.33 0.31
12 INT139778 Binding of AQP1 and GBE1 1 0.00 0.22 0.3
13 INT245920 Binding of GLA and TRPV1 1 0.09 0.36 0.26
14 INT179968 GBE1 Negative_regulation of IK 1 0.00 0.3 0.25
15 INT41787 IFNA2 Negative_regulation of Glb1 1 0.04 0.09 0.23
16 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19
17 INT13020 Binding of SCN4A and GANAB 1 0.15 0.95 0.19
18 INT195424 SNRNP70 Negative_regulation of GBE1 1 0.00 0.22 0.19
19 INT111380 Musk Negative_regulation of Phka2 1 0.03 0.92 0.19
20 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
21 INT12525 Binding of POMC and GANAB 1 0.04 1.9 0.17
22 INT86895 Glp2r Regulation of Gene_expression of Si 1 0.23 0 0.17
23 INT86896 Glp2r Regulation of Si 1 0.23 0 0.16
24 INT347807 GLA Positive_regulation of Positive_regulation of A4GALT 1 0.05 1.57 0.13
25 INT190631 Gusb Positive_regulation of Tlr4 1 0.08 0.44 0.11
26 INT279400 GANAB Regulation of ITGAL 1 0.01 0.75 0.09
27 INT12520 Binding of FSHR and GANAB 1 0.03 0.97 0.09
28 INT204904 Tlr4 Positive_regulation of Hexb 1 0.14 0.09 0.09
29 INT37744 Negative_regulation of CPQ Negative_regulation of GBE1 1 0.02 0 0.09
30 INT204884 Tlr4 Negative_regulation of Negative_regulation of Hexb 1 0.13 0.09 0.09
31 INT354962 Gene_expression of Shank3 Positive_regulation of Gusb 1 0.10 0.45 0.08
32 INT337072 Binding of Fmr1 and Gusb 1 0.19 1.55 0.08
33 INT320880 Chi3l1 Positive_regulation of Agtr2 1 0.01 1.22 0.08
34 INT271493 Ctbs Negative_regulation of Hand1 1 0.04 0.63 0.07
35 INT102886 Binding of GBE1 and CTSA 1 0.00 0 0.07
36 INT256487 Si Regulation of Csi 1 0.00 0.08 0.06
37 INT178968 Slc7a2 Negative_regulation of Glb1 1 0.02 1.77 0.05
38 INT80067 Penk Positive_regulation of Gene_expression of Glb1 1 0.07 0.1 0.05
39 INT14440 Binding of GLB1 and NEU1 1 0.00 0.09 0.05
40 INT204906 Tlr4 Negative_regulation of Hexb 1 0.13 0.09 0.04
41 INT245922 Binding of GLA and FIBP 1 0.00 0 0.03
42 INT245917 Binding of GLA and ABCC1 1 0.05 0 0.03
43 INT314401 Binding of Ctbs and Gpsm2 1 0.10 0 0
44 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0
45 INT279241 Binding of ELF3 and GLA 1 0.20 0.53 0
46 INT265562 Gla Positive_regulation of Gene_expression of Kdr 1 0.05 0.51 0
47 INT245925 GLA Regulation of TRPV1 1 0.07 0 0
48 INT245589 Binding of Glb1 and B3galt6 1 0.01 0.94 0
49 INT279242 Negative_regulation of Binding of GLA and SH3GL3 1 0.08 1.22 0
50 INT109502 GBE1 Negative_regulation of HIVEP1 1 0.00 1.85 0
51 INT265563 Gla Positive_regulation of Transcription of Kdr 1 0.04 0.51 0
52 INT279240 Binding of GLA and SH3GL3 1 0.07 1.21 0
53 INT314398 Ptpn6 Regulation of Gene_expression of Ctbs 1 0.03 0 0
54 INT265546 Gla Regulation of C6 1 0.01 0.98 0
55 INT256486 Si Negative_regulation of Gene_expression of Ces1c 1 0.00 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity, hydrolyzing O-glycosyl compounds. They are ordered first by their pain relevance and then by number of times they were reported in hydrolase activity, hydrolyzing O-glycosyl compounds. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3755 Positive_regulation of GBE1 29 0.40 8.99 8.91
2 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15
3 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14
4 INT9779 Gene_expression of Glb1 23 0.58 8.01 6.04
5 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26
6 INT1755 Gene_expression of GBE1 28 0.26 8.32 5.18
7 INT14442 Localization of GBE1 19 0.31 9.09 5.03
8 INT55044 Positive_regulation of Si 15 0.24 1.73 4.2
9 INT16723 Regulation of GBE1 16 0.11 4.3 3.7
10 INT42523 Binding of GBE1 10 0.16 1.03 3.64
11 INT40844 Localization of Naga 2 0.53 2.88 3.42
12 INT47011 Positive_regulation of Gusb 14 0.44 8.93 2.87
13 INT78568 Negative_regulation of Gene_expression of Glb1 4 0.30 0.78 2.84
14 INT73359 Gene_expression of GLB1 8 0.75 3.18 1.92
15 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79
16 INT151743 Binding of Gusb 11 0.24 8.73 1.63
17 INT99097 Positive_regulation of GLB1 7 0.49 3.45 1.52
18 INT37104 Binding of GANAB 2 0.27 1.76 1.51
19 INT128016 Binding of Chi3l4 1 0.10 0.34 1.44
20 INT67133 Gene_expression of Gusb 14 0.75 18.57 1.37
21 INT66274 Gene_expression of Ctbs 9 0.39 1.16 1.35
22 INT147540 Negative_regulation of Si 5 0.20 3.58 1.32
23 INT96374 Binding of Chi3l1 1 0.00 0 1.29
24 INT47010 Negative_regulation of Gusb 6 0.43 4.16 1.2
25 INT36179 Regulation of GLA 11 0.44 6.56 1.12
26 INT57209 Regulation of Gene_expression of Glb1 3 0.23 0.99 1.09
27 INT132505 Regulation of Si 3 0.06 0.68 1.06
28 INT34490 Negative_regulation of Localization of GBE1 3 0.01 2.08 1.02
29 INT78569 Positive_regulation of Gene_expression of Glb1 2 0.38 0.24 0.99
30 INT45299 Binding of Naga 1 0.30 0 0.95
31 INT57560 Positive_regulation of GLA 14 0.54 5.01 0.83
32 INT37747 Localization of Gusb 4 0.69 1.91 0.82
33 INT84457 Positive_regulation of Localization of Naga 1 0.07 0.98 0.81
34 INT84456 Regulation of Gene_expression of Naga 1 0.06 0.87 0.78
35 INT84455 Gene_expression of Naga 2 0.43 1.11 0.77
36 INT164589 Negative_regulation of Positive_regulation of Glb1 1 0.43 1.16 0.67
37 INT143742 Positive_regulation of Gene_expression of GBE1 2 0.20 0.36 0.66
38 INT217987 Negative_regulation of Chi3l4 1 0.40 1.6 0.66
39 INT164258 Positive_regulation of Gene_expression of GLA 6 0.47 0.55 0.65
40 INT164590 Positive_regulation of Glb1 2 0.69 1.77 0.64
41 INT128015 Gene_expression of Chi3l4 2 0.56 0.47 0.61
42 INT128014 Negative_regulation of Binding of Chi3l4 1 0.12 0.13 0.54
43 INT204863 Gene_expression of Hexb 3 0.44 2.57 0.52
44 INT215854 Positive_regulation of Gene_expression of Hexb 1 0.34 2.42 0.52
45 INT46994 Positive_regulation of Positive_regulation of GBE1 1 0.40 0.41 0.5
46 INT155290 Negative_regulation of Negative_regulation of GBE1 2 0.03 1 0.48
47 INT86890 Gene_expression of Si 6 0.37 0.38 0.47
48 INT72872 Positive_regulation of Regulation of GBE1 2 0.03 0.48 0.47
49 INT142484 Positive_regulation of Gene_expression of GLB1 1 0.49 2.33 0.45
50 INT48326 Negative_regulation of Localization of Gusb 1 0.23 0.65 0.43
51 INT9778 Regulation of Glb1 4 0.19 1.48 0.37
52 INT79189 Transcription of Glb1 1 0.29 0 0.34
53 INT23442 Regulation of Naga 1 0.04 0 0.32
54 INT140424 Binding of Si 1 0.02 0.07 0.28
55 INT140423 Positive_regulation of Binding of Si 1 0.02 0.07 0.28
56 INT12531 Localization of GANAB 3 0.09 2.79 0.26
57 INT78047 Negative_regulation of GLB1 2 0.51 1.3 0.25
58 INT74441 Positive_regulation of Negative_regulation of GLA 1 0.50 1.33 0.25
59 INT161927 Negative_regulation of Gene_expression of Gusb 2 0.57 2.51 0.24
60 INT210070 Localization of GLA 1 0.70 1.96 0.24
61 INT117050 Binding of GLA 8 0.47 2.41 0.22
62 INT47548 Negative_regulation of Glb1 3 0.55 1.59 0.21
63 INT42366 Positive_regulation of Localization of GBE1 1 0.04 0.16 0.2
64 INT111379 Negative_regulation of Phka2 1 0.41 0.92 0.19
65 INT62208 Positive_regulation of Binding of GBE1 1 0.02 0 0.19
66 INT161264 Localization of Hexb 2 0.40 0.94 0.18
67 INT86887 Positive_regulation of Gene_expression of Si 2 0.23 0 0.17
68 INT95663 Binding of Glb1 2 0.05 0.17 0.16
69 INT161265 Negative_regulation of Localization of Hexb 1 0.29 0.88 0.16
70 INT333942 Negative_regulation of GANAB 1 0.39 0.45 0.16
71 INT217992 Regulation of Chi3l4 1 0.19 0.44 0.15
72 INT188608 Negative_regulation of Gene_expression of NAGA 1 0.15 1.02 0.15
73 INT34491 Regulation of Localization of GBE1 1 0.01 0.14 0.15
74 INT13022 Regulation of GANAB 1 0.13 0.85 0.15
75 INT57561 Regulation of Gene_expression of GLA 2 0.60 0.49 0.13
76 INT188614 Gene_expression of NAGA 1 0.23 1 0.13
77 INT352180 Negative_regulation of Gene_expression of GLA 1 0.42 1.06 0.13
78 INT330336 Regulation of Positive_regulation of Gusb 1 0.16 1.05 0.12
79 INT210059 Negative_regulation of Localization of GLA 1 0.40 0.77 0.12
80 INT320865 Positive_regulation of Chi3l1 1 0.02 1.97 0.1
81 INT57210 Positive_regulation of Regulation of GLB1 1 0.05 0.63 0.1
82 INT57211 Regulation of GLB1 1 0.07 0.63 0.1
83 INT245630 Positive_regulation of Transcription of Si 1 0.21 0 0.09
84 INT245627 Transcription of Si 1 0.24 0 0.09
85 INT12526 Positive_regulation of Localization of GANAB 1 0.05 0.88 0.07
86 INT210222 Phosphorylation of Gusb 1 0.12 0.84 0.07
87 INT160942 Negative_regulation of Negative_regulation of GLA 1 0.41 0.39 0.06
88 INT67134 Positive_regulation of Gene_expression of Gusb 3 0.34 1.37 0.05
89 INT14443 Binding of GLB1 2 0.36 0.09 0.05
90 INT320869 Regulation of Chi3l1 1 0.01 1.32 0.05
91 INT204858 Negative_regulation of Hexb 1 0.16 0.09 0.04
92 INT202418 Positive_regulation of Binding of Gusb 1 0.35 0.91 0.04
93 INT210071 Positive_regulation of Transcription of GLA 2 0.54 0.67 0.03
94 INT210062 Transcription of GLA 2 0.56 0.67 0.03
95 INT320863 Localization of Chi3l1 1 0.03 1.11 0.03
96 INT314382 Localization of Ctbs 1 0.26 0 0.03
97 INT245940 Regulation of Positive_regulation of GLA 1 0.11 0.4 0.03
98 INT275790 Positive_regulation of Gene_expression of Ctbs 3 0.15 0.33 0
99 INT307865 Regulation of Gene_expression of Gusb 1 0.08 0.09 0
100 INT314380 Regulation of Ctbs 1 0.13 0 0
101 INT179314 Transcription of GANAB 1 0.04 0 0
102 INT129970 Negative_regulation of Binding of GLA 1 0.41 0.41 0
103 INT314385 Negative_regulation of Gene_expression of Ctbs 1 0.13 0 0
104 INT265552 Gene_expression of Gla 1 0.18 4.54 0
105 INT271491 Binding of Ctbs 1 0.09 0.65 0
106 INT352181 Regulation of NAGA 1 0.11 0.34 0
107 INT204868 Negative_regulation of Gene_expression of Hexb 1 0.18 0.09 0
108 INT314383 Negative_regulation of Positive_regulation of Ctbs 1 0.13 0 0
109 INT265551 Regulation of Gene_expression of Gla 1 0.11 0 0
110 INT314384 Positive_regulation of Ctbs 1 0.21 0 0
111 INT265556 Positive_regulation of Gene_expression of Gla 1 0.13 0.8 0
112 INT258076 Regulation of Gene_expression of GANAB 1 0.00 1.19 0
113 INT245625 Negative_regulation of Transcription of Si 1 0.20 0 0
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