GO:0004622

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Name lysophospholipase activity
Categary Function
Go Slim No
Go Link GO:0004622
Unique Molecular Interactions 62
Total Molecular Interactions 75
Total Single Events 761
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lysophospholipase activity. They are ordered first by their pain relevance and then by number of times they were reported for lysophospholipase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
2 INT317559 Binding of Hint1 and Pla2g4a 1 0.01 0.06 0.94
3 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93
4 INT270218 P2rx3 Positive_regulation of Pla2g4a 1 0.34 0.63 0.85
5 INT231390 Pla2g4a Regulation of Pla2g2a 1 0.08 0.92 0.77
6 INT231388 Pla2g4a Regulation of Pla2g6 1 0.08 0.92 0.77
7 INT308484 Car2 Positive_regulation of Pla2g4a 1 0.03 1.23 0.65
8 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58
9 INT222183 Binding of HDLBP and PLA2G15 1 0.01 0.7 0.57
10 INT167583 ENPP2 Positive_regulation of Gene_expression of LPA 1 0.08 0.93 0.51
11 INT248146 PLA2G6 Negative_regulation of Phosphorylation of PLA2G4A 1 0.07 0.72 0.4
12 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
13 INT167582 ENPP2 Regulation of Gene_expression of LPA 1 0.05 0.61 0.26
14 INT146744 Binding of NR3C1 and PLA2G4A 1 0.26 0.25 0.15
15 INT231838 Pcdh8 Regulation of Cel 1 0.00 0.39 0.15
16 INT231846 Pcdh8 Negative_regulation of Positive_regulation of Cel 1 0.00 0.91 0.14
17 INT344710 Lipc Positive_regulation of Positive_regulation of Hdl1 1 0.04 0.87 0.14
18 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
19 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
20 INT167757 Binding of Enpp2 and Dmbx1 1 0.22 0.33 0.13
21 INT146743 Positive_regulation of Binding of GSR and PLA2G4A 1 0.40 0.14 0.11
22 INT146742 Binding of GSR and PLA2G4A 1 0.28 0.14 0.11
23 INT246535 Binding of Cel and Mag 1 0.01 7.26 0.1
24 INT327557 Pla2g4a Positive_regulation of Phosphorylation of Ptgs2 1 0.14 1.03 0.1
25 INT327559 Pla2g4a Positive_regulation of Gene_expression of Ptgs2 1 0.14 1 0.09
26 INT197776 Pla2g10 Regulation of Pla2g4a 1 0.18 0.61 0.08
27 INT301402 Enpp2 Positive_regulation of Lpar1 2 0.33 0.55 0.07
28 INT301411 Enpp2 Positive_regulation of Csf2 1 0.04 0.59 0.07
29 INT301403 Enpp2 Positive_regulation of Tnfrsf11a 1 0.05 0.59 0.07
30 INT234606 Tlr4 Positive_regulation of Transcription of PLA2G4A 1 0.57 0 0.06
31 INT231834 Trip12 Positive_regulation of Positive_regulation of Cel 1 0.00 0.75 0.05
32 INT249199 CA2 Positive_regulation of PLA2G4A 1 0.15 0 0.04
33 INT195837 Tlr4 Positive_regulation of Pla2g4a 1 0.01 0.44 0.03
34 INT328362 LYPLA1 Regulation of Ghrl 1 0.04 0.07 0.03
35 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
36 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03
37 INT104540 FOXG1 Regulation of Lipc 1 0.02 0 0
38 INT239325 Eef1a2 Negative_regulation of Lipc 1 0.11 0.84 0
39 INT345149 Enpp2 Regulation of Gene_expression of Lpar1 1 0.01 0.41 0
40 INT262915 ENPP2 Regulation of SMG1 1 0.22 0.07 0
41 INT262913 ENPP2 Regulation of PCSK7 1 0.02 0.07 0
42 INT249179 PLA2G4A Regulation of CYBB 1 0.18 0 0
43 INT225807 Enpp2 Positive_regulation of ALPI 1 0.00 0.23 0
44 INT345153 Dmbx1 Regulation of Enpp2 1 0.00 0.41 0
45 INT301401 Binding of Enpp1 and Enpp2 1 0.23 0.54 0
46 INT249191 CYBB Positive_regulation of PLA2G4A 1 0.20 0 0
47 INT249187 Binding of CYBB and PLA2G4A 1 0.14 0 0
48 INT246536 Mag Regulation of Gene_expression of Cel 1 0.01 1.28 0
49 INT225792 Gene_expression of Enpp2 Positive_regulation of Ppi-rs 1 0.01 0.21 0
50 INT302586 Binding of Lipc and Apoa5 1 0.26 0.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lysophospholipase activity. They are ordered first by their pain relevance and then by number of times they were reported in lysophospholipase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
2 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
3 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
4 INT270238 Localization of Pla2g4a 1 0.72 17.99 11.35
5 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07
6 INT167755 Gene_expression of Enpp2 12 0.77 57.31 5.3
7 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09
8 INT162125 Gene_expression of Pla2g4a 4 0.54 7.69 3.75
9 INT175442 Gene_expression of Cel 22 0.34 21.36 3.33
10 INT270224 Positive_regulation of Positive_regulation of Pla2g4a 1 0.62 6.63 3.22
11 INT53813 Positive_regulation of Cel 20 0.58 19.39 3.05
12 INT126172 Negative_regulation of Pla2g4a 7 0.39 9.01 2.89
13 INT167585 Negative_regulation of ENPP2 7 0.36 5.19 2.74
14 INT122376 Localization of Pla2g4a 12 0.73 7.18 2.58
15 INT270235 Negative_regulation of Phosphorylation of Pla2g4a 1 0.39 3.4 2.34
16 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3
17 INT152076 Negative_regulation of Pla2g4a 3 0.55 3.22 2.21
18 INT86814 Transcription of Pla2g4a 4 0.49 2.35 2.14
19 INT195828 Positive_regulation of Phosphorylation of Pla2g4a 3 0.45 5.05 2.12
20 INT105325 Gene_expression of ENPP2 5 0.75 1.32 1.72
21 INT91773 Positive_regulation of PLA2G4A 10 0.50 4.4 1.54
22 INT91764 Positive_regulation of Gene_expression of PLA2G4A 8 0.69 5.43 1.52
23 INT270223 Negative_regulation of Localization of Pla2g4a 1 0.39 1.83 1.5
24 INT268619 Phosphorylation of Pla2g4a 5 0.69 2.14 1.36
25 INT11415 Negative_regulation of Cel 5 0.38 5.67 1.29
26 INT86812 Negative_regulation of Transcription of Pla2g4a 1 0.13 0.49 1.18
27 INT64863 Localization of PLA2G4A 9 0.44 3.33 1.07
28 INT195832 Regulation of Phosphorylation of Pla2g4a 3 0.34 2.91 1.02
29 INT162126 Positive_regulation of Gene_expression of Pla2g4a 4 0.42 2.52 1.01
30 INT65166 Negative_regulation of PLA2G4A 7 0.57 1.55 0.96
31 INT86816 Negative_regulation of Gene_expression of Pla2g4a 3 0.50 2.27 0.93
32 INT270236 Regulation of Localization of Pla2g4a 1 0.24 1.68 0.93
33 INT270231 Regulation of Positive_regulation of Pla2g4a 1 0.24 1.92 0.92
34 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9
35 INT168990 Positive_regulation of Positive_regulation of Pla2g4a 2 0.43 2.14 0.86
36 INT77928 Binding of Pla2g4a 3 0.10 2.5 0.84
37 INT270226 Negative_regulation of Positive_regulation of Pla2g4a 1 0.38 2.34 0.84
38 INT166807 Gene_expression of PLA2G15 2 0.65 1.31 0.83
39 INT146746 Transcription of PLA2G4A 3 0.69 1.03 0.8
40 INT322101 Localization of Cel 2 0.29 1.11 0.76
41 INT225769 Positive_regulation of Gene_expression of Enpp2 3 0.69 16.67 0.74
42 INT113400 Positive_regulation of Transcription of Pla2g4a 1 0.08 0.96 0.7
43 INT175450 Positive_regulation of Gene_expression of Cel 4 0.25 2.69 0.68
44 INT308475 Regulation of Positive_regulation of Pla2g4a 1 0.09 1.14 0.67
45 INT116048 Negative_regulation of Positive_regulation of PLA2G15 1 0.41 2.49 0.61
46 INT97321 Positive_regulation of PLA2G15 3 0.49 2.75 0.6
47 INT116049 Positive_regulation of Positive_regulation of PLA2G15 1 0.49 2.47 0.6
48 INT183163 Positive_regulation of Positive_regulation of Cel 9 0.31 11.55 0.58
49 INT45724 Positive_regulation of Lipc 2 0.08 0.84 0.58
50 INT231823 Negative_regulation of Positive_regulation of Cel 2 0.17 2.34 0.56
51 INT222195 Binding of PLA2G15 1 0.11 0.7 0.56
52 INT270227 Positive_regulation of Localization of Pla2g4a 1 0.45 1.31 0.56
53 INT78775 Regulation of PLA2G4A 4 0.25 1.45 0.55
54 INT76858 Binding of PLA2G4A 4 0.30 1.22 0.52
55 INT270229 Binding of Pla2g4a 1 0.29 1.23 0.45
56 INT53811 Regulation of Cel 4 0.23 2.1 0.43
57 INT228731 Negative_regulation of Gene_expression of Cel 2 0.17 1.12 0.41
58 INT248153 Phosphorylation of PLA2G4A 1 0.20 0.65 0.38
59 INT225768 Positive_regulation of Enpp2 7 0.69 8.11 0.37
60 INT126173 Negative_regulation of Regulation of Pla2g4a 1 0.40 1.01 0.37
61 INT126174 Positive_regulation of Regulation of Pla2g4a 1 0.37 1.03 0.34
62 INT205894 Regulation of Gene_expression of Pla2g4a 3 0.52 1.9 0.33
63 INT146747 Negative_regulation of Gene_expression of PLA2G4A 1 0.43 0.66 0.33
64 INT53814 Regulation of Positive_regulation of Cel 2 0.23 0.45 0.29
65 INT126171 Negative_regulation of Positive_regulation of Pla2g4a 1 0.39 0.91 0.27
66 INT167586 Regulation of ENPP2 2 0.20 0.59 0.25
67 INT175459 Binding of Cel 2 0.11 6.62 0.24
68 INT262928 Localization of ENPP2 1 0.58 1.11 0.24
69 INT323315 Gene_expression of LYPLA1 1 0.50 1.23 0.24
70 INT312523 Negative_regulation of Phosphorylation of Pla2g4a 1 0.16 0.68 0.22
71 INT312522 Positive_regulation of Phosphorylation of Pla2g4a 1 0.14 0.68 0.21
72 INT146748 Positive_regulation of Transcription of PLA2G4A 1 0.50 0.22 0.17
73 INT153911 Localization of Enpp2 4 0.75 2.6 0.16
74 INT195826 Negative_regulation of Gene_expression of Pla2g4a 1 0.28 1.38 0.15
75 INT195829 Regulation of Pla2g4a 1 0.20 2.54 0.15
76 INT175454 Positive_regulation of Binding of Cel 1 0.15 0.92 0.14
77 INT83316 Positive_regulation of LYPLA1 3 0.50 0.56 0.13
78 INT84395 Protein_catabolism of Pla2g4a 1 0.02 0.41 0.12
79 INT93878 Positive_regulation of Lipc 4 0.47 3.09 0.11
80 INT159902 Negative_regulation of PLA2G15 1 0.41 0.83 0.09
81 INT153908 Negative_regulation of Enpp2 2 0.42 1.4 0.07
82 INT301393 Positive_regulation of Positive_regulation of Enpp2 1 0.50 0.49 0.07
83 INT301398 Positive_regulation of Binding of Enpp2 1 0.50 0.49 0.07
84 INT301392 Negative_regulation of Gene_expression of Enpp2 1 0.58 3.16 0.07
85 INT301396 Binding of Enpp2 1 0.37 0.49 0.07
86 INT46943 Binding of Lipc 2 0.31 1.92 0.06
87 INT253445 Positive_regulation of Binding of Pla2g4a 1 0.12 0.91 0.06
88 INT189245 Binding of LYPLA1 1 0.02 0.56 0.06
89 INT211537 Localization of Lipc 1 0.61 0.15 0.05
90 INT211555 Gene_expression of Lipc 1 0.52 0.16 0.05
91 INT301400 Negative_regulation of Negative_regulation of Enpp2 1 0.42 0.9 0.04
92 INT301387 Regulation of Gene_expression of Enpp2 1 0.61 9.41 0.04
93 INT249275 Positive_regulation of Localization of PLA2G4A 1 0.25 0 0.04
94 INT153910 Regulation of Enpp2 2 0.45 2.1 0.03
95 INT301386 Positive_regulation of Localization of Enpp2 1 0.44 0.77 0.03
96 INT323317 Regulation of LYPLA1 1 0.34 0.09 0.03
97 INT143410 Regulation of Localization of PLA2G4A 2 0.34 0 0
98 INT195830 Regulation of Regulation of Pla2g4a 1 0.20 0.62 0
99 INT238790 Regulation of Gene_expression of Cel 1 0.07 1.27 0
100 INT301390 Transcription of Enpp2 1 0.69 0 0
101 INT262932 Positive_regulation of ENPP2 1 0.34 0.07 0
102 INT323312 Protein_catabolism of LYPLA1 1 0.49 0.08 0
103 INT174763 Gene_expression of Lipc 1 0.56 0.72 0
104 INT174765 Transcription of Lipc 1 0.57 0.61 0
105 INT337080 Positive_regulation of Localization of Pla2g4a 1 0.18 1 0
106 INT174764 Negative_regulation of Lipc 1 0.35 0.5 0
107 INT211559 Regulation of Lipc 1 0.20 0.22 0
108 INT262930 Negative_regulation of Gene_expression of ENPP2 1 0.35 0 0
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