GO:0004629

From wiki-pain
Jump to: navigation, search
Name phospholipase C activity
Categary Function
Go Slim No
Go Link GO:0004629
Unique Molecular Interactions 56
Total Molecular Interactions 71
Total Single Events 460
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phospholipase C activity. They are ordered first by their pain relevance and then by number of times they were reported for phospholipase C activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
2 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
3 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
4 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
5 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
6 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
7 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
8 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
9 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
10 INT96260 Pik3cd Regulation of Plcg2 1 0.02 0 0.92
11 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
12 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
13 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
14 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
15 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
16 INT8980 Gal Regulation of PLCB1 1 0.18 0.13 0.68
17 INT75764 Positive_regulation of DYT10 Positive_regulation of Phosphorylation of Plcb3 1 0.04 0.11 0.65
18 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
19 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
20 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
21 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
22 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
23 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
24 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
25 INT118852 Positive_regulation of GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
26 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
27 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
28 INT118846 GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
29 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
30 INT118856 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.01 0.14 0.26
31 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
32 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
33 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
34 INT157957 Ppyr1 Negative_regulation of Phosphorylation of PLCB1 1 0.00 0.24 0.24
35 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
36 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
37 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
38 INT225501 Plcl1 Regulation of Gene_expression of Casr 1 0.04 0.67 0.16
39 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
40 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
41 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
42 INT59807 ADRA1D Positive_regulation of PLCB1 1 0.33 0 0.13
43 INT244032 Binding of Ppp1ca and Plcl1 1 0.00 0.16 0.12
44 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
45 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
46 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
47 INT115934 U Regulation of PLCB4 1 0.00 0.3 0.08
48 INT115935 U Regulation of PLCB3 1 0.00 0.3 0.08
49 INT115933 U Regulation of PLCB1 1 0.00 0.3 0.08
50 INT336993 Binding of PDIA3 and CALCRL 1 0.00 0 0.06
51 INT145056 Binding of Nr1i3 and Plcl1 1 0.21 0.26 0.05
52 INT145057 Binding of Ppara and Plcl1 1 0.36 0.26 0.05
53 INT333926 Binding of PDIA3 and ERLEC1 1 0.02 0.18 0
54 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0
55 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0
56 INT333931 Binding of CALR and PDIA3 1 0.18 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phospholipase C activity. They are ordered first by their pain relevance and then by number of times they were reported in phospholipase C activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
2 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
3 INT96259 Positive_regulation of Plcg1 11 0.49 3.01 11.15
4 INT19155 Binding of Adora1 25 0.47 6.41 10.72
5 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
6 INT110004 Gene_expression of Plcg1 7 0.41 2.61 7.87
7 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
8 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
9 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
10 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
11 INT9167 Binding of Adora1 6 0.40 0.53 6.9
12 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
13 INT75761 Positive_regulation of Phosphorylation of Plcb3 1 0.05 0.22 4.58
14 INT75759 Phosphorylation of Plcb3 1 0.06 0.22 4.42
15 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
16 INT215604 Localization of Adora1 10 0.78 1.47 3.49
17 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
18 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
19 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
20 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
21 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
22 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
23 INT59818 Negative_regulation of PLCB1 7 0.57 2.24 2.28
24 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
25 INT110003 Phosphorylation of Plcg1 2 0.37 0.91 1.96
26 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
27 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
28 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
29 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
30 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
31 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
32 INT59815 Positive_regulation of PLCB1 9 0.67 1.12 1.22
33 INT110001 Binding of Plcg1 2 0.36 0.44 1.21
34 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
35 INT110000 Positive_regulation of Phosphorylation of Plcg1 1 0.23 0.49 1.02
36 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
37 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
38 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
39 INT59817 Gene_expression of PLCB1 4 0.75 0.73 0.65
40 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
41 INT75758 Binding of Plcb3 1 0.03 0 0.63
42 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
43 INT75760 Positive_regulation of Plcb3 1 0.03 0 0.6
44 INT110002 Regulation of Positive_regulation of Plcg1 1 0.11 0.4 0.59
45 INT78238 Binding of PDIA3 2 0.36 0.87 0.54
46 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
47 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
48 INT145053 Negative_regulation of Plcl1 4 0.52 1.65 0.5
49 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
50 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
51 INT79311 Positive_regulation of Positive_regulation of PDIA3 1 0.49 0.34 0.47
52 INT157955 Phosphorylation of PLCB1 1 0.01 0.46 0.46
53 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
54 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
55 INT145049 Gene_expression of Plcl1 2 0.59 1.29 0.35
56 INT74604 Negative_regulation of Gene_expression of PLCB1 1 0.41 0.25 0.35
57 INT278102 Binding of GNA15 1 0.01 0.16 0.32
58 INT59816 Positive_regulation of Gene_expression of PLCB1 2 0.49 0.22 0.31
59 INT92881 Transcription of ADORA1 1 0.69 0 0.31
60 INT224100 Regulation of Negative_regulation of ADORA1 1 0.01 0.05 0.3
61 INT235857 Binding of PLCB1 1 0.36 0.35 0.29
62 INT118873 Binding of GNA14 1 0.01 0.13 0.27
63 INT118875 Gene_expression of GNA14 1 0.02 0.09 0.26
64 INT124366 Gene_expression of GNA15 1 0.11 0 0.25
65 INT243971 Phosphorylation of Plcl1 1 0.11 0.31 0.24
66 INT79313 Positive_regulation of PDIA3 2 0.49 0.27 0.23
67 INT118869 Phosphorylation of GNA14 1 0.02 0.15 0.23
68 INT186700 Localization of Adora1 1 0.23 0 0.23
69 INT157956 Regulation of Phosphorylation of PLCB1 1 0.00 0.22 0.22
70 INT74602 Negative_regulation of Positive_regulation of PLCB1 1 0.41 0.25 0.19
71 INT131584 Gene_expression of PDIA3 2 0.33 0.7 0.15
72 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
73 INT127623 Protein_catabolism of ADORA1 1 0.49 0.19 0.14
74 INT118872 Positive_regulation of GNA14 1 0.02 0.1 0.14
75 INT145044 Regulation of Plcl1 2 0.35 0.97 0.13
76 INT225448 Binding of Plcl1 3 0.13 0.28 0.12
77 INT243983 Localization of Plcl1 1 0.11 0.15 0.11
78 INT111805 Gene_expression of PLCB3 1 0.09 0.08 0.09
79 INT111804 Positive_regulation of Gene_expression of PLCB3 1 0.06 0.08 0.09
80 INT59820 Regulation of Gene_expression of PLCB1 1 0.44 0 0.09
81 INT115930 Regulation of PLCB1 1 0.02 0.29 0.08
82 INT115931 Regulation of PLCB4 1 0.03 0.3 0.08
83 INT115932 Regulation of PLCB3 1 0.03 0.3 0.08
84 INT74606 Regulation of Negative_regulation of PLCB1 1 0.44 0.19 0.07
85 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
86 INT59814 Positive_regulation of Negative_regulation of PLCB1 1 0.45 0 0.04
87 INT225323 Transcription of Plcl1 1 0.16 0.09 0
88 INT225362 Positive_regulation of Gene_expression of Plcl1 1 0.13 0 0
89 INT337006 Positive_regulation of Binding of PDIA3 1 0.21 0 0
90 INT225456 Positive_regulation of Plcl1 1 0.13 0.25 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox