GO:0004630

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Name phospholipase D activity
Categary Function
Go Slim No
Go Link GO:0004630
Unique Molecular Interactions 116
Total Molecular Interactions 170
Total Single Events 1708
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phospholipase D activity. They are ordered first by their pain relevance and then by number of times they were reported for phospholipase D activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
2 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
3 INT162165 WDTC1 Positive_regulation of PLD2 1 0.50 0 1.25
4 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
5 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
6 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
7 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
8 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
9 INT107739 Prkcg Negative_regulation of Positive_regulation of Pld2 1 0.46 0 0.79
10 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
11 INT162164 ARF6 Regulation of Positive_regulation of PLD2 1 0.60 0 0.74
12 INT107741 Binding of OPRM1 and Pld2 1 0.01 0 0.69
13 INT99743 Olr1742 Regulation of Gene_expression of Hmox1 1 0.00 0 0.68
14 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
15 INT134287 PLD2 Regulation of Regulation of MRGPRX1 1 0.31 0 0.67
16 INT86519 Binding of Hmox1 and Hmox2 1 0.08 0.1 0.66
17 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
18 INT99744 Calca Positive_regulation of Positive_regulation of Hmox1 1 0.48 0 0.64
19 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
20 INT160880 Pld2 Positive_regulation of Oprm1 1 0.07 0.08 0.63
21 INT160882 Pld2 Positive_regulation of Gene_expression of Oprm1 1 0.06 0.08 0.63
22 INT308803 Binding of Pld1 and Pld2 1 0.13 1.11 0.59
23 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
24 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53
25 INT350076 Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 1.29 0.5
26 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
27 INT160881 Positive_regulation of Oprm1 Positive_regulation of Positive_regulation of Pld2 1 0.05 0.08 0.48
28 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
29 INT148466 Ccl4 Positive_regulation of Hmox1 1 0.28 0.06 0.47
30 INT73831 Binding of Mc1r and Pld1 1 0.00 0.16 0.45
31 INT242402 Negative_regulation of Bdkrb1 Positive_regulation of Hmox1 1 0.17 1.44 0.45
32 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
33 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
34 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
35 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
36 INT216881 Binding of Apoc4 and Hmox1 1 0.01 1.78 0.4
37 INT147473 Nfe2l2 Positive_regulation of Gene_expression of Hmox1 1 0.74 0.49 0.39
38 INT147472 co Positive_regulation of Gene_expression of Hmox1 1 0.01 0.57 0.36
39 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
40 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27
41 INT216880 Apoc4 Positive_regulation of Hmox1 1 0.03 1.06 0.25
42 INT349652 Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk 1 0.01 0.85 0.25
43 INT350099 Gene_expression of Hmox1 Positive_regulation of Gene_expression of MRXS5 1 0.01 0.51 0.24
44 INT308805 Positive_regulation of Pld1 Positive_regulation of TNF 1 0.05 0.74 0.24
45 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23
46 INT350065 Gene_expression of Hmox1 Negative_regulation of Gene_expression of Tlr4 1 0.18 0.35 0.22
47 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
48 INT103867 SFTPA1 Positive_regulation of Hmox1 1 0.00 0.35 0.22
49 INT64340 Zc3h15 Negative_regulation of Hmox1 1 0.12 0.47 0.22
50 INT350078 Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 0.35 0.22
51 INT103869 Binding of IRF6 and Positive_regulation of Hmox1 1 0.10 0.27 0.21
52 INT349647 Eif2ak1 Positive_regulation of Positive_regulation of Hmox1 1 0.00 1.07 0.2
53 INT350096 Hmox1 Negative_regulation of Gene_expression of MRXS5 1 0.01 0.32 0.2
54 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2
55 INT349646 Eif2ak1 Regulation of Gene_expression of Hmox1 1 0.00 0.78 0.2
56 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
57 INT199192 Gnat3 Positive_regulation of Hmox1 1 0.27 0.23 0.19
58 INT81296 Positive_regulation of Pparg Regulation of Gene_expression of Hmox1 1 0.25 0.17 0.17
59 INT350072 Ptger2 Positive_regulation of Hmox1 1 0.02 0.2 0.15
60 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15
61 INT216882 Tlr4 Positive_regulation of Hmox1 1 0.17 0.19 0.15
62 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
63 INT350069 Prkaca Positive_regulation of Hmox1 1 0.05 0.2 0.15
64 INT199195 Gnat3 Regulation of Transcription of Hmox1 1 0.24 0.12 0.14
65 INT295267 Binding of Hmox1 and Gtf3a 1 0.01 0.49 0.13
66 INT295261 Binding of Hmox1 and Nfe2l2 1 0.17 0.49 0.13
67 INT295264 Positive_regulation of Binding of Hmox1 and Nfe2l2 1 0.25 0.5 0.13
68 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12
69 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11
70 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11
71 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1
72 INT231773 IRF6 Negative_regulation of Gene_expression of HMOX1 1 0.06 1.27 0.09
73 INT201456 Hmox1 Positive_regulation of Gene_expression of Bcl2 1 0.06 0.74 0.08
74 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
75 INT244290 Il6 Positive_regulation of Hmox1 1 0.38 0.09 0.07
76 INT244291 Nos2 Positive_regulation of Positive_regulation of Hmox1 1 0.34 0.07 0.07
77 INT231760 TNF Positive_regulation of Protein_catabolism of HMOX1 1 0.31 0.41 0.06
78 INT349645 Eif2ak1 Positive_regulation of Hmox1 1 0.00 0.18 0.05
79 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05
80 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05
81 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04
82 INT231759 IL10 Positive_regulation of Gene_expression of HMOX1 1 0.06 0.7 0.04
83 INT349648 Eif2ak1 Positive_regulation of Gene_expression of Hmox1 1 0.00 0.17 0.04
84 INT227333 Il2 Positive_regulation of Hmox1 1 0.05 0.93 0.04
85 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04
86 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
87 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
88 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03
89 INT350071 Hmox1 Regulation of Tlr4 1 0.22 0.33 0.03
90 INT169794 Binding of Pld1 and Aia1 1 0.00 0 0
91 INT229818 Fos Positive_regulation of Hmox1 1 0.43 0.37 0
92 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
93 INT326898 Positive_regulation of Tcf4 Regulation of PLD2 1 0.26 0.33 0
94 INT326899 Tcf4 Positive_regulation of PLD2 1 0.28 0.49 0
95 INT326836 Binding of HNF4A and PLD2 1 0.03 0.35 0
96 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
97 INT326895 Binding of PLD2 and Tcf4 1 0.27 0.39 0
98 INT259670 CSE Positive_regulation of Hmox1 1 0.06 0.97 0
99 INT326900 Tcf4 Regulation of PLD2 1 0.15 0.33 0
100 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
101 INT330735 GSTK1 Regulation of HMOX1 1 0.08 0.25 0
102 INT260398 Dclk2 Regulation of Gene_expression of Hmox1 1 0.01 1.02 0
103 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0
104 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
105 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0
106 INT343082 Binding of Prm3 and Pld4 1 0.05 0 0
107 INT326892 Tcf4 Positive_regulation of Pld1 1 0.28 0.05 0
108 INT326901 Binding of PLD2 and Pld1 1 0.28 0.46 0
109 INT260393 Hmox1 Regulation of Positive_regulation of Bcl2 1 0.22 0.86 0
110 INT301906 Binding of HMOX1 and HSD11B1 1 0.05 2.41 0
111 INT350068 Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptgs2 1 0.03 0.16 0
112 INT343083 Binding of Pld1 and Gopc 1 0.05 0 0
113 INT326897 Tcf4 Positive_regulation of Gene_expression of PLD2 1 0.26 0.41 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phospholipase D activity. They are ordered first by their pain relevance and then by number of times they were reported in phospholipase D activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
2 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
3 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
4 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
5 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
6 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
7 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
8 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
9 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
10 INT107737 Positive_regulation of Pld2 11 0.67 0.33 6.45
11 INT134290 Positive_regulation of PLD2 10 0.68 3.06 6.44
12 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
13 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
14 INT115805 Gene_expression of PLD2 7 0.76 12.49 4.51
15 INT107113 Gene_expression of Pld1 6 0.78 2.71 4.28
16 INT64338 Negative_regulation of Hmox1 16 0.56 12.72 4.2
17 INT97096 Regulation of Hmox1 18 0.61 6.42 3.9
18 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52
19 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32
20 INT102634 Transcription of Hmox1 22 0.62 4.5 3.3
21 INT193827 Gene_expression of Pld1 31 0.72 13.41 3.19
22 INT115806 Positive_regulation of Gene_expression of PLD2 5 0.57 7.12 3.11
23 INT127904 Negative_regulation of Gene_expression of Hmox1 11 0.42 9.54 2.8
24 INT81291 Regulation of Gene_expression of Hmox1 11 0.60 8.78 2.46
25 INT99742 Negative_regulation of Gene_expression of Hmox1 12 0.58 9.94 1.77
26 INT80227 Regulation of Gene_expression of Hmox1 12 0.44 11.04 1.61
27 INT91232 Regulation of Positive_regulation of Hmox1 5 0.45 2.43 1.55
28 INT103305 Positive_regulation of Positive_regulation of Hmox1 8 0.49 4.81 1.49
29 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48
30 INT107735 Positive_regulation of Positive_regulation of Pld2 3 0.48 0 1.47
31 INT115807 Negative_regulation of PLD2 3 0.57 0.69 1.43
32 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41
33 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28
34 INT91320 Localization of Hmox1 8 0.81 4.06 1.28
35 INT107732 Gene_expression of Pld2 1 0.75 0 1.25
36 INT308797 Negative_regulation of Pld1 5 0.54 4.7 1.2
37 INT115831 Transcription of Hmox1 16 0.66 5.31 1.14
38 INT199187 Localization of Hmox1 2 0.78 3.36 1.11
39 INT193851 Positive_regulation of Pld1 16 0.57 6.07 1.04
40 INT116529 Binding of HMOX1 10 0.47 15.38 1.04
41 INT308800 Regulation of Gene_expression of Pld1 2 0.42 4.16 0.99
42 INT105445 Localization of HMOX1 5 0.71 3.11 0.98
43 INT201454 Positive_regulation of Positive_regulation of Hmox1 6 0.35 5.2 0.94
44 INT148461 Positive_regulation of Transcription of Hmox1 6 0.33 1.83 0.93
45 INT162169 Negative_regulation of Positive_regulation of PLD2 1 0.56 0 0.92
46 INT82568 Protein_catabolism of Hmox1 5 0.86 1.03 0.79
47 INT162170 Regulation of Positive_regulation of PLD2 1 0.26 0 0.74
48 INT107736 Positive_regulation of Gene_expression of Pld2 1 0.67 0 0.74
49 INT107114 Positive_regulation of Gene_expression of Pld1 1 0.70 0.45 0.67
50 INT107112 Regulation of Pld1 1 0.27 0.44 0.65
51 INT287003 Negative_regulation of Positive_regulation of Hmox1 2 0.34 3.1 0.63
52 INT134289 Positive_regulation of Positive_regulation of PLD2 2 0.46 0 0.6
53 INT308802 Binding of Pld2 1 0.13 1.11 0.59
54 INT165681 Positive_regulation of Transcription of HMOX1 2 0.69 4.29 0.53
55 INT115803 Regulation of PLD2 1 0.44 0.43 0.53
56 INT270030 Negative_regulation of Positive_regulation of Hmox1 3 0.30 2.49 0.47
57 INT308799 Localization of Pld1 2 0.69 2.51 0.44
58 INT157157 Negative_regulation of Localization of HMOX1 1 0.37 0.74 0.37
59 INT281659 Regulation of Transcription of HMOX1 2 0.27 2.12 0.33
60 INT216879 Binding of Hmox1 4 0.36 2.82 0.31
61 INT135772 Regulation of Positive_regulation of HMOX1 3 0.39 1.52 0.29
62 INT328227 Positive_regulation of Localization of Hmox1 1 0.45 0.67 0.28
63 INT308793 Gene_expression of Pld2 9 0.32 0.51 0.27
64 INT91231 Binding of Hmox1 4 0.36 0.29 0.27
65 INT308795 Negative_regulation of Gene_expression of Pld1 2 0.39 1.86 0.25
66 INT343068 Gene_expression of Pld4 1 0.61 0.27 0.25
67 INT201453 Protein_catabolism of Hmox1 3 0.95 4.25 0.23
68 INT350048 Negative_regulation of Regulation of Hmox1 1 0.30 0.37 0.23
69 INT140390 Binding of Pld1 1 0.00 0.1 0.23
70 INT115829 Regulation of Transcription of Hmox1 1 0.35 1.03 0.17
71 INT343069 Transcription of Pld4 1 0.56 0.23 0.16
72 INT201467 Protein_catabolism of HMOX1 2 0.77 0.83 0.13
73 INT193861 Positive_regulation of Gene_expression of Pld1 9 0.57 3.56 0.06
74 INT115824 Positive_regulation of Transcription of Hmox1 3 0.45 0.43 0.06
75 INT293311 Positive_regulation of Positive_regulation of HMOX1 3 0.69 1.99 0.04
76 INT308794 Positive_regulation of Gene_expression of Pld2 2 0.17 0.07 0.04
77 INT326879 Binding of PLD2 1 0.31 2.21 0.04
78 INT350052 Positive_regulation of Negative_regulation of Hmox1 1 0.35 0.34 0.04
79 INT343064 Localization of Pld4 1 0.59 0 0.03
80 INT326842 Binding of Pld1 4 0.30 0.54 0
81 INT343060 Negative_regulation of Gene_expression of Pld4 1 0.34 0 0
82 INT343071 Negative_regulation of Gene_expression of Pld2 1 0.18 0.1 0
83 INT326849 Regulation of Negative_regulation of Pld1 1 0.37 0.09 0
84 INT343067 Regulation of Pld4 1 0.21 0 0
85 INT326876 Transcription of PLD2 1 0.57 0.27 0
86 INT326873 Regulation of Transcription of PLD2 1 0.37 0.22 0
87 INT343063 Positive_regulation of Gene_expression of Pld4 1 0.39 0 0
88 INT326848 Positive_regulation of Positive_regulation of Pld1 1 0.41 0 0
89 INT337766 Phosphorylation of Hmox1 1 0.79 0.08 0
90 INT343072 Binding of Pld4 1 0.28 0 0
91 INT270641 Regulation of Pld1 1 0.37 0.83 0
92 INT326871 Regulation of Gene_expression of PLD2 1 0.37 1.28 0
93 INT326851 Transcription of Pld1 1 0.56 0.06 0
94 INT326880 Negative_regulation of Gene_expression of PLD2 1 0.35 1.19 0
95 INT343065 Positive_regulation of Transcription of Pld4 1 0.39 0.16 0
96 INT343074 Positive_regulation of Pld2 1 0.17 0 0
97 INT337767 Positive_regulation of Phosphorylation of Hmox1 1 0.49 0.08 0
98 INT343061 Negative_regulation of Transcription of Pld4 1 0.34 0.07 0
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