GO:0004667

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Name prostaglandin-D synthase activity
Categary Function
Go Slim No
Go Link GO:0004667
Unique Molecular Interactions 92
Total Molecular Interactions 108
Total Single Events 1138
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-D synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for prostaglandin-D synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT25111 Binding of PTGDS and PLEKHM1 1 0.01 0 0.97
2 INT126766 Binding of PTGDS and PTGDR2 4 0.40 1.62 0.93
3 INT38905 Ptgfr Regulation of Ptgds 1 0.20 0 0.63
4 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
5 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
6 INT264522 Binding of GPER and PTGDS 1 0.03 1.22 0.4
7 INT264525 Binding of PTGDS and PTGFR 1 0.02 1.22 0.39
8 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
9 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38
10 INT255555 Binding of Ptgds and Tfdp1 1 0.14 1.14 0.36
11 INT126767 Positive_regulation of Binding of PTGDS and PTGDR2 1 0.54 0.3 0.35
12 INT264521 PTGDS Negative_regulation of Positive_regulation of MMP1 1 0.06 1.42 0.34
13 INT147984 Ptgds Positive_regulation of Cpox 1 0.17 0.29 0.32
14 INT147982 Cpox Positive_regulation of Gene_expression of Ptgds 1 0.17 0.3 0.32
15 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
16 INT46339 Ptgds Regulation of Localization of Lh 1 0.25 0 0.29
17 INT67529 PTGDS Positive_regulation of Positive_regulation of IL6 1 0.30 0.69 0.29
18 INT102923 Ptgds Regulation of Avp 1 0.02 0 0.27
19 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
20 INT139357 Nr1h2 Regulation of Gene_expression of Ptges 1 0.07 0.5 0.25
21 INT352890 Binding of PTGDS and ROS1 1 0.13 0.67 0.25
22 INT264524 PTGDS Negative_regulation of Gene_expression of MMP1 1 0.09 0.5 0.22
23 INT69869 Binding of Ptgdr and Ptgds 1 0.06 0 0.22
24 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22
25 INT149882 Binding of Ptgs1 and Ptges 1 0.01 0.15 0.22
26 INT264517 PTGDS Positive_regulation of TFDP1 1 0.17 0.5 0.22
27 INT264519 PTGDS Negative_regulation of Positive_regulation of TFDP1 1 0.15 0.5 0.22
28 INT69868 Binding of Ptgds and Ptger1 1 0.01 0 0.18
29 INT352896 PTGDS Positive_regulation of Gene_expression of ROS1 1 0.12 0.91 0.18
30 INT207345 PTGDS Negative_regulation of Gene_expression of ABCA1 1 0.21 0 0.17
31 INT207342 PTGDS Negative_regulation of Gene_expression of CYP27A1 1 0.02 0 0.17
32 INT49058 Binding of IGHE and Positive_regulation of Localization of PTGDS 1 0.29 0.35 0.17
33 INT168807 Binding of Nfkb1 and Ptges 1 0.04 0.35 0.16
34 INT352067 Binding of B4GALNT1 and HPGDS 1 0.01 0.12 0.16
35 INT242318 Ptgds Positive_regulation of Trpa1 1 0.29 0.06 0.16
36 INT106506 Binding of Pparg and Ptgds 1 0.42 0.31 0.14
37 INT207360 PTGDS Negative_regulation of Negative_regulation of ABCA1 1 0.25 0 0.14
38 INT207335 PTGDS Negative_regulation of Negative_regulation of CYP27A1 1 0.02 0 0.14
39 INT234604 Tlr4 Positive_regulation of Ptges 1 0.04 0 0.14
40 INT134405 Binding of PTGS1 and HPGDS 1 0.01 0.33 0.14
41 INT207358 PTGDS Negative_regulation of CPOX 1 0.05 0 0.14
42 INT227556 Ptgds Positive_regulation of Ppara 1 0.18 0.62 0.13
43 INT116788 Bsg Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.09
44 INT168808 Tlr4 Positive_regulation of Gene_expression of Ptges 1 0.02 0.13 0.08
45 INT106515 Binding of Ptges and Cpox 1 0.00 0.17 0.04
46 INT269545 PTGDS Regulation of PTGIR 1 0.01 0 0.04
47 INT207361 PTGDS Regulation of Gene_expression of CYP27A1 1 0.01 0.05 0.03
48 INT269567 TMPO Positive_regulation of PTGDS 1 0.07 0 0
49 INT352064 Binding of PTGS2 and HPGDS 1 0.20 0 0
50 INT352065 Binding of PTGDS and PTGS2 1 0.28 0 0
51 INT269582 Negative_regulation of TMPO Positive_regulation of PTGDS 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-D synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in prostaglandin-D synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01
2 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67
3 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14
4 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75
5 INT69866 Positive_regulation of Ptgds 26 0.70 16.25 8.33
6 INT4810 Localization of PTGDS 20 0.81 4.19 6.97
7 INT7996 Gene_expression of Ptgds 18 0.64 6.47 5.51
8 INT143925 Negative_regulation of Ptges 18 0.42 10.5 5.18
9 INT27758 Positive_regulation of PTGDS 20 0.67 10.74 4.22
10 INT6994 Binding of Ptgds 15 0.36 7.06 3.54
11 INT50143 Negative_regulation of Gene_expression of Ptgds 10 0.48 5.82 3.54
12 INT134413 Gene_expression of HPGDS 20 0.77 8.93 3.28
13 INT50149 Positive_regulation of Gene_expression of Ptgds 12 0.61 4.88 2.73
14 INT25119 Binding of PTGDS 9 0.35 3.86 2.54
15 INT50139 Regulation of Gene_expression of Ptgds 6 0.50 3.5 2.39
16 INT14596 Localization of Ptgds 11 0.73 4.41 2.12
17 INT108982 Regulation of Gene_expression of Ptgds 6 0.51 1.64 2.07
18 INT106508 Positive_regulation of Gene_expression of Ptges 12 0.20 5.37 2.06
19 INT118700 Positive_regulation of Ptges 12 0.49 5.04 1.68
20 INT27438 Negative_regulation of Ptgds 3 0.51 0.24 1.61
21 INT28425 Regulation of Ptgds 4 0.28 2.07 1.53
22 INT118699 Binding of Ptges 4 0.33 1.15 1.5
23 INT6991 Negative_regulation of Ptgds 5 0.55 3.83 1.32
24 INT44917 Negative_regulation of Gene_expression of PTGDS 6 0.50 2.98 1.27
25 INT146381 Localization of Ptges 3 0.10 5.55 1.26
26 INT106509 Negative_regulation of Gene_expression of Ptges 6 0.17 1.95 1.25
27 INT68359 Positive_regulation of HPGDS 9 0.32 4.63 1.18
28 INT33803 Positive_regulation of Ptgds 4 0.50 1.09 1.1
29 INT89524 Transcription of Ptgds 3 0.46 1.34 1.09
30 INT111613 Regulation of PTGDS 6 0.52 3.29 0.93
31 INT220275 Protein_catabolism of Ptgds 1 0.81 2.18 0.74
32 INT89525 Positive_regulation of Transcription of Ptgds 1 0.41 0.32 0.73
33 INT139353 Regulation of Gene_expression of Ptges 3 0.18 2.05 0.71
34 INT264537 Transcription of HPGDS 1 0.33 1.33 0.69
35 INT115952 Negative_regulation of Positive_regulation of Ptgds 1 0.02 0.43 0.65
36 INT51284 Negative_regulation of Localization of PTGDS 1 0.51 0 0.6
37 INT46338 Negative_regulation of Regulation of Ptgds 1 0.37 0 0.58
38 INT68360 Regulation of HPGDS 3 0.23 0.72 0.56
39 INT28421 Negative_regulation of Regulation of Ptgds 1 0.26 0 0.56
40 INT177864 Negative_regulation of HPGDS 6 0.49 1.92 0.54
41 INT151360 Positive_regulation of Binding of Ptgds 1 0.39 1.3 0.54
42 INT234588 Transcription of Ptges 1 0.06 0.9 0.51
43 INT104675 Positive_regulation of Gene_expression of Ptgds 1 0.13 0.34 0.48
44 INT206864 Transcription of PTGDS 3 0.45 1.04 0.45
45 INT147980 Regulation of Localization of Ptgds 1 0.26 0.34 0.45
46 INT146382 Positive_regulation of Localization of Ptges 1 0.00 0.36 0.45
47 INT58360 Negative_regulation of Positive_regulation of Ptgds 1 0.15 0.8 0.45
48 INT6992 Negative_regulation of Binding of Ptgds 2 0.39 0.93 0.44
49 INT134412 Binding of HPGDS 9 0.42 1.7 0.43
50 INT234585 Negative_regulation of Positive_regulation of Ptges 1 0.04 0.91 0.37
51 INT270028 Positive_regulation of Localization of Ptgds 2 0.45 0.61 0.36
52 INT234594 Positive_regulation of Transcription of Ptges 1 0.04 0.9 0.36
53 INT44916 Negative_regulation of PTGDS 3 0.43 1.6 0.33
54 INT220269 Positive_regulation of Phosphorylation of Ptgds 1 0.41 1.12 0.32
55 INT220278 Phosphorylation of Ptgds 1 0.66 1.06 0.32
56 INT151718 Regulation of Ptges 3 0.27 1.63 0.31
57 INT46337 Regulation of Ptgds 1 0.39 0 0.29
58 INT264539 Localization of HPGDS 1 0.46 0.48 0.24
59 INT140796 Localization of Ptgds 1 0.69 0.56 0.24
60 INT159475 Positive_regulation of Binding of PTGDS 1 0.04 0.1 0.23
61 INT161817 Regulation of Localization of PTGDS 1 0.10 0.39 0.22
62 INT350864 Negative_regulation of Gene_expression of HPGDS 1 0.36 0.52 0.2
63 INT350865 Negative_regulation of Binding of HPGDS 1 0.36 0.51 0.19
64 INT100734 Binding of Ptgds 1 0.31 0.19 0.19
65 INT264543 Positive_regulation of Positive_regulation of PTGDS 1 0.42 0.35 0.14
66 INT264533 Regulation of Regulation of PTGDS 1 0.38 0.23 0.12
67 INT264540 Regulation of Gene_expression of PTGDS 1 0.52 0.23 0.06
68 INT206878 Negative_regulation of Transcription of PTGDS 1 0.25 0.07 0
69 INT245086 Positive_regulation of Negative_regulation of PTGDS 1 0.26 0.75 0
70 INT200111 Phosphorylation of PTGDS 1 0.10 0.41 0
71 INT264547 Regulation of Positive_regulation of PTGDS 1 0.38 0 0
72 INT206867 Positive_regulation of Transcription of PTGDS 1 0.29 0.14 0
73 INT81680 Regulation of Binding of Ptgds 1 0.09 0 0
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