GO:0004672

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Name protein kinase activity
Categary Function
Go Slim No
Go Link GO:0004672
Unique Molecular Interactions 5033
Total Molecular Interactions 6683
Total Single Events 49719
Pain Genes Associated 309

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
2 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
3 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
4 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
5 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
6 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
7 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
8 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
9 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
10 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
11 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
12 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
13 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
14 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
15 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
16 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
17 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
18 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64
19 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
20 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
21 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
22 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
23 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
24 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
25 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
26 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
27 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
28 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
29 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
30 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
31 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
32 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
33 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
34 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
35 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
36 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
37 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
38 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
39 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
40 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
41 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
42 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
43 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
44 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
45 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
46 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
47 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
48 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
49 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
50 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
51 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
52 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
53 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
54 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
55 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
56 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
57 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
58 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
59 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
60 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
61 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
62 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
63 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
64 INT66803 Oxt Regulation of Avp 7 0.16 0.19 2.15
65 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
66 INT140019 Avp Positive_regulation of Localization of Kitl 1 0.00 1 2.13
67 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
68 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
69 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
70 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
71 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
72 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
73 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
74 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
75 INT138960 Dbi Positive_regulation of Avp 1 0.02 1.53 2
76 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
77 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 0.02 1.53 2
78 INT45423 Avp Positive_regulation of Localization of Prl 4 0.67 1.37 1.98
79 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
80 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
81 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
82 INT149470 Oxt Regulation of Gene_expression of Avp 1 0.46 1.2 1.92
83 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
84 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
85 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
86 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
87 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
88 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
89 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
90 INT40239 Penk Regulation of Avp 1 0.07 0 1.84
91 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
92 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
93 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
94 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
95 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
96 INT117269 Binding of Avp and Prl 1 0.25 0.47 1.8
97 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
98 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
99 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
100 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
101 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
102 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
103 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
104 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71
105 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
106 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
107 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
108 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
109 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
110 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
111 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
112 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
113 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
114 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
115 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
116 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
117 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
118 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
119 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
120 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 0.40 0.77 1.64
121 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
122 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
123 INT140023 Avp Positive_regulation of Gene_expression of Kitl 1 0.00 0.76 1.62
124 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
125 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
126 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
127 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
128 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
129 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
130 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
131 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
132 INT276671 Prkcg Positive_regulation of Nav1 1 0.23 0.21 1.55
133 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
134 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
135 INT140013 Avp Positive_regulation of Gene_expression of Dbi 1 0.07 0.85 1.52
136 INT140016 Avp Positive_regulation of Gene_expression of Pdyn 1 0.21 0.85 1.52
137 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
138 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
139 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
140 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
141 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
142 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
143 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
144 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
145 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
146 INT161865 Mors1 Positive_regulation of Prkcg 1 0.00 0.12 1.47
147 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47
148 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
149 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
150 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
151 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
152 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
153 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
154 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
155 INT140012 Avp Negative_regulation of Dbi 1 0.06 0.8 1.44
156 INT5534 Binding of Oxt and Avp 7 0.04 0.6 1.43
157 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
158 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
159 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
160 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
161 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
162 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
163 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
164 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
165 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
166 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
167 INT142490 Avp Regulation of Oxt 1 0.09 0.74 1.4
168 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
169 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
170 INT140021 Avp Positive_regulation of Pag1 1 0.03 0.85 1.38
171 INT140018 Avp Positive_regulation of Gene_expression of Pag1 1 0.04 0.85 1.38
172 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
173 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
174 INT140020 Avp Positive_regulation of Localization of Pag1 1 0.03 0.85 1.38
175 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
176 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
177 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
178 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
179 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
180 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
181 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
182 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
183 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
184 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
185 INT145473 Mastl Positive_regulation of Dnahc8 1 0.07 0.06 1.33
186 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
187 INT131888 gr Positive_regulation of Gene_expression of Prkcg 1 0.00 0 1.32
188 INT120929 Prkcg Regulation of Gene_expression of Fos 2 0.50 0.34 1.31
189 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
190 INT198957 Binding of Cnr1 and Mastl 1 0.00 0 1.31
191 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
192 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3
193 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
194 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29
195 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
196 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28
197 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
198 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
199 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
200 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
2 INT477 Localization of Avp 813 0.81 131.58 300.4
3 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
4 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
5 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
6 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
7 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
8 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69
9 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7
10 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
11 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
12 INT4207 Regulation of Avp 267 0.62 63.72 115.33
13 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
14 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
15 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
16 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
17 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
18 INT214 Localization of AVP 370 0.81 208.51 91.09
19 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
20 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
21 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
22 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
23 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
24 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
25 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
26 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
27 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
28 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
29 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
30 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58
31 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
32 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
33 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99
34 INT4153 Binding of Insrr 109 0.40 17.99 72.15
35 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
36 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
37 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
38 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
39 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
40 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
41 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
42 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
43 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
44 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
45 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
46 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7
47 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
48 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
49 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
50 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
51 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
52 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
53 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
54 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
55 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
56 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
57 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
58 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
59 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
60 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
61 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
62 INT685 Regulation of AVP 124 0.62 34.9 39.91
63 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
64 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
65 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38
66 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
67 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
68 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
69 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
70 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
71 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
72 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
73 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
74 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19
75 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
76 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
77 INT65698 Localization of CCL2 118 0.81 77.54 32.69
78 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
79 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
80 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
81 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
82 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
83 INT8691 Localization of Insr 85 0.80 9.27 30.32
84 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
85 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
86 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
87 INT894 Binding of Avp 84 0.48 29.16 29.63
88 INT5300 Regulation of Insr 54 0.60 11.33 29.26
89 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
90 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
91 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
92 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45
93 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
94 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21
95 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
96 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
97 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
98 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
99 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
100 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
101 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
102 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
103 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
104 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91
105 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88
106 INT123386 Negative_regulation of Camk2a 48 0.58 12.57 23.78
107 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
108 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
109 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
110 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
111 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
112 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
113 INT121872 Gene_expression of Camk4 156 0.78 70.47 21.39
114 INT117527 Binding of Prkca 25 0.48 6.43 21.05
115 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84
116 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
117 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
118 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
119 INT54708 Gene_expression of Adrbk1 22 0.75 1.06 20.62
120 INT78901 Localization of CCL5 67 0.78 40.79 20.59
121 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
122 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
123 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
124 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
125 INT7470 Positive_regulation of Gene_expression of Avp 37 0.70 19.55 19.96
126 INT5499 Transcription of Avp 52 0.72 7.98 19.87
127 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
128 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
129 INT292049 Gene_expression of Csnk1a1 1 0.59 28.22 19.53
130 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
131 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
132 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
133 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
134 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
135 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
136 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
137 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
138 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
139 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
140 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
141 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
142 INT65211 Binding of Prkcg 38 0.48 14.75 16.92
143 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79
144 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
145 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64
146 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
147 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26
148 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18
149 INT79458 Localization of Prkca 30 0.81 11.13 15.78
150 INT115650 Positive_regulation of Gene_expression of Camk2a 37 0.70 17.68 15.73
151 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
152 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
153 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
154 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
155 INT38253 Localization of Trib3 35 0.63 10.28 15.42
156 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
157 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
158 INT79887 Gene_expression of Prkcc 20 0.78 12.59 14.73
159 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
160 INT8989 Binding of Npr1 25 0.36 5.52 14.58
161 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
162 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
163 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15
164 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
165 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
166 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
167 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
168 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
169 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
170 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
171 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
172 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
173 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
174 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
175 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
176 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
177 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
178 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
179 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36
180 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
181 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19
182 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
183 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
184 INT100821 Localization of Ros1 59 0.60 45.26 11.92
185 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
186 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
187 INT13743 Regulation of Gene_expression of Avp 30 0.62 6.9 11.66
188 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
189 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
190 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
191 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
192 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
193 INT143098 Negative_regulation of Gene_expression of Adrbk1 9 0.58 8.51 11.37
194 INT118676 Positive_regulation of Camk4 34 0.70 16.67 10.9
195 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
196 INT15262 Negative_regulation of Positive_regulation of Avp 22 0.58 3.28 10.81
197 INT118678 Phosphorylation of Camk4 22 0.82 9.4 10.7
198 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69
199 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
200 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
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