GO:0004674

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Name protein serine/threonine kinase activity
Categary Function
Go Slim No
Go Link GO:0004674
Unique Molecular Interactions 4302
Total Molecular Interactions 5364
Total Single Events 40402
Pain Genes Associated 287

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
2 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
3 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
4 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
5 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
6 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
7 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
8 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
9 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
10 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
11 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
12 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
13 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
14 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
15 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
16 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
17 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
18 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
19 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
20 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
21 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
22 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
23 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
24 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
25 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
26 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
27 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
28 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
29 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
30 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
31 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
32 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
33 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
34 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
35 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
36 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
37 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
38 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
39 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
40 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
41 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
42 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
43 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
44 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
45 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
46 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
47 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
48 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
49 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
50 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
51 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
52 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
53 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
54 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
55 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
56 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
57 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
58 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47
59 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
60 INT144454 Binding of DMPK and GPM6A 1 0.00 0 1.45
61 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
62 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
63 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
64 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
65 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
66 INT139768 Binding of TRPV1 and ICK 1 0.41 1.59 1.42
67 INT139767 ICK Regulation of TRPV1 1 0.30 1.59 1.42
68 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
69 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
70 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
71 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
72 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
73 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
74 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
75 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
76 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
77 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
78 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
79 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
80 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
81 INT145473 Mastl Positive_regulation of Dnahc8 1 0.07 0.06 1.33
82 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
83 INT198957 Binding of Cnr1 and Mastl 1 0.00 0 1.31
84 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3
85 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
86 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
87 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
88 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
89 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
90 INT73710 Mastl Positive_regulation of Localization of Oprl1 1 0.02 0 1.26
91 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
92 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
93 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
94 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
95 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
96 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
97 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
98 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
99 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
100 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
101 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
102 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
103 INT166301 Adrbk1 Positive_regulation of Localization of Trpv1 1 0.45 1.17 1.2
104 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
105 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
106 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
107 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
108 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18
109 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
110 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
111 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
112 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
113 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
114 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
115 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
116 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
117 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
118 INT76378 Binding of Cit and Flvcr2 1 0.09 0.17 1.15
119 INT123387 Binding of Camk2a and Gria2 1 0.13 0.32 1.14
120 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
121 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
122 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
123 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
124 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
125 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
126 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
127 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
128 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
129 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
130 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
131 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
132 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
133 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
134 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
135 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
136 INT108546 BCL2L10 Regulation of MAPKAPK5 1 0.03 1.22 1.1
137 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
138 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
139 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
140 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
141 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
142 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
143 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
144 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
145 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
146 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
147 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
148 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
149 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
150 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
151 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
152 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
153 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
154 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
155 INT146496 Snta1 Positive_regulation of Gene_expression of Adrbk1 1 0.13 0.73 1.05
156 INT317534 Regulation of Binding of Camk2a and Grin1 1 0.20 0.06 1.05
157 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
158 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
159 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
160 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
161 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
162 INT101066 MAP3K15 Positive_regulation of CDCP1 1 0.03 0.46 1.03
163 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
164 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
165 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
166 INT122429 Prkci Regulation of Gene_expression of Ighm 1 0.00 0 1.02
167 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 0.00 0 1.02
168 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
169 INT157142 OPA1 Positive_regulation of Gene_expression of Camk2a 1 0.02 0.3 1.02
170 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
171 INT122433 Prkci Negative_regulation of Ighm 1 0.00 0 1.02
172 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
173 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
174 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
175 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
176 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
177 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
178 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
179 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
180 INT69307 Prkcq Negative_regulation of TH1L 1 0.00 0.98 0.98
181 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
182 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
183 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
184 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
185 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97
186 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
187 INT122144 Binding of Trpv1 and Prkd1 1 0.02 0.39 0.96
188 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
189 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
190 INT123052 Gpbar1 Regulation of Phosphorylation of Grk4 1 0.37 0 0.94
191 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
192 INT123049 Grk4 Regulation of Phosphorylation of Gpbar1 1 0.37 0 0.94
193 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
194 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
195 INT252877 Prkaca Positive_regulation of Regulation of Grip2 1 0.01 0.22 0.94
196 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
197 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
198 INT252878 Prkaca Regulation of Regulation of Grip2 1 0.01 0.22 0.94
199 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
200 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
3 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
4 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
5 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
6 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
7 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
8 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
9 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
10 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
11 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
12 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
13 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
14 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
15 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
16 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
17 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7
18 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
19 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
20 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
21 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
22 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
23 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
24 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
25 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
26 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
27 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
28 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
29 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
30 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
31 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38
32 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
33 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
34 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
35 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
36 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
37 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
38 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
39 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19
40 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
41 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
42 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
43 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
44 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
45 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
46 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
47 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
48 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
49 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
50 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
51 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
52 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
53 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
54 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
55 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
56 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
57 INT123386 Negative_regulation of Camk2a 48 0.58 12.57 23.78
58 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
59 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
60 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
61 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
62 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
63 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
64 INT121872 Gene_expression of Camk4 156 0.78 70.47 21.39
65 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
66 INT117527 Binding of Prkca 25 0.48 6.43 21.05
67 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
68 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
69 INT54708 Gene_expression of Adrbk1 22 0.75 1.06 20.62
70 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
71 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
72 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
73 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
74 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89
75 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
76 INT292049 Gene_expression of Csnk1a1 1 0.59 28.22 19.53
77 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
78 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
79 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
80 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
81 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
82 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
83 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
84 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
85 INT79458 Localization of Prkca 30 0.81 11.13 15.78
86 INT115650 Positive_regulation of Gene_expression of Camk2a 37 0.70 17.68 15.73
87 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
88 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
89 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
90 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
91 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
92 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
93 INT79887 Gene_expression of Prkcc 20 0.78 12.59 14.73
94 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
95 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
96 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
97 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
98 INT194421 Gene_expression of DCLK3 27 0.40 1.26 13.94
99 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
100 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
101 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
102 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
103 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
104 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
105 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
106 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
107 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
108 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
109 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
110 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
111 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
112 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
113 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
114 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
115 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
116 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
117 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
118 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
119 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
120 INT86544 Positive_regulation of Camk2a 20 0.47 4.59 11.37
121 INT143098 Negative_regulation of Gene_expression of Adrbk1 9 0.58 8.51 11.37
122 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
123 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
124 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11
125 INT118676 Positive_regulation of Camk4 34 0.70 16.67 10.9
126 INT76434 Negative_regulation of PRKG1 25 0.58 10.36 10.81
127 INT118678 Phosphorylation of Camk4 22 0.82 9.4 10.7
128 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69
129 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
130 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
131 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
132 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
133 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
134 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25
135 INT790 Gene_expression of Mastl 22 0.68 4.56 10.23
136 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
137 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
138 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
139 INT113667 Positive_regulation of Mapk7 15 0.70 12.24 9.72
140 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
141 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69
142 INT54707 Positive_regulation of Adrbk1 14 0.67 0.51 9.51
143 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
144 INT15307 Regulation of Mtor 27 0.48 4.7 9.34
145 INT71565 Negative_regulation of Prkcc 11 0.54 4.16 9.31
146 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
147 INT105839 Positive_regulation of Grk5 5 0.70 0.35 9.2
148 INT40609 Binding of Prkaca 23 0.36 3.42 9.19
149 INT123040 Phosphorylation of Grk4 12 0.60 0.31 9.14
150 INT119527 Regulation of Camk2a 26 0.60 5.55 9.01
151 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
152 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
153 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
154 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
155 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
156 INT119529 Positive_regulation of Phosphorylation of Camk2a 16 0.60 1.49 8.94
157 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
158 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85
159 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
160 INT71590 Gene_expression of Camk2a 17 0.78 2.3 8.63
161 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56
162 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
163 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45
164 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
165 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
166 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
167 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
168 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
169 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
170 INT142526 Positive_regulation of Gene_expression of Prkaca 12 0.46 2.48 8.05
171 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
172 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
173 INT116707 Positive_regulation of Mapk4 8 0.21 9.83 7.96
174 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
175 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
176 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
177 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
178 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
179 INT116706 Phosphorylation of Mapk4 9 0.25 8.5 7.79
180 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
181 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
182 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
183 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
184 INT166596 Binding of DCLK3 2 0.22 0.13 7.5
185 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
186 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
187 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
188 INT98856 Negative_regulation of Gene_expression of Adrbk1 5 0.56 0.43 7.29
189 INT13348 Negative_regulation of Mastl 11 0.36 3.33 7.28
190 INT50779 Positive_regulation of Gene_expression of Adrbk1 9 0.56 2.79 7.23
191 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
192 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
193 INT89052 Positive_regulation of Phosphorylation of Prkaca 13 0.37 2.92 7.05
194 INT110104 Localization of Prkce 17 0.79 3.75 6.92
195 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
196 INT68466 Negative_regulation of Positive_regulation of Prkaca 6 0.57 2.29 6.83
197 INT73709 Binding of Mastl 11 0.40 3.39 6.76
198 INT132468 Positive_regulation of Positive_regulation of Camk2a 20 0.70 2.76 6.7
199 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
200 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
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