GO:0004675

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Name transmembrane receptor protein serine/threonine kinase activity
Categary Function
Go Slim No
Go Link GO:0004675
Unique Molecular Interactions 78
Total Molecular Interactions 101
Total Single Events 563
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane receptor protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
2 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
3 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
4 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
5 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
6 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
7 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
8 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
9 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
10 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
11 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
12 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41
13 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
14 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
15 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34
16 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
17 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
18 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
19 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
20 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
21 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
22 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16
23 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
24 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
25 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
26 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
27 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
28 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
29 INT189550 Binding of BMPR2 and PAH 1 0.06 2.68 0.08
30 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
31 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
32 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
33 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
34 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
35 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
36 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
37 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
38 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03
39 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
40 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03
41 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
42 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
43 INT205409 Binding of BMP6 and BMPR2 1 0.07 0.05 0
44 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
45 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
46 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
47 INT310186 Binding of Gdf2 and Bmpr2 1 0.02 0 0
48 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
49 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
50 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
51 INT265344 sb Negative_regulation of Tgfbr1 1 0.00 0.06 0
52 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
53 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
54 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
55 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
56 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
57 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
58 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
59 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
60 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
61 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0
62 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0
63 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
64 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane receptor protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
2 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
3 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
4 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
5 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
6 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
7 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55
8 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
9 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
10 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
11 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
12 INT114664 Binding of BMP2 12 0.37 6.54 0.91
13 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
14 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
15 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
16 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
17 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
18 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
19 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
20 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
21 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
22 INT3831 Negative_regulation of TGFBR2 4 0.28 4.99 0.55
23 INT110924 Regulation of BMPR2 3 0.17 1.75 0.54
24 INT85808 Localization of BMP2 7 0.77 1.94 0.51
25 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
26 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
27 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
28 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
29 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
30 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
31 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34
32 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34
33 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34
34 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
35 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
36 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
37 INT251327 Regulation of Binding of Bmpr2 1 0.20 2.27 0.27
38 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
39 INT81981 Negative_regulation of Bmpr2 4 0.27 2.88 0.21
40 INT150332 Negative_regulation of Gene_expression of BMPR2 1 0.01 0 0.2
41 INT150331 Positive_regulation of Gene_expression of BMPR2 2 0.02 0.59 0.19
42 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19
43 INT123935 Positive_regulation of BMPR2 3 0.26 1.65 0.18
44 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
45 INT189604 Negative_regulation of BMPR2 2 0.26 0.95 0.15
46 INT192082 Localization of BMPR2 1 0.32 0.55 0.15
47 INT302662 Negative_regulation of Negative_regulation of TGFBR1 1 0.14 0 0.13
48 INT166623 Binding of BMPR2 1 0.29 0.35 0.13
49 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
50 INT210224 Localization of Acvrl1 1 0.03 0.33 0.12
51 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
52 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
53 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1
54 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
55 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09
56 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
57 INT254819 Regulation of Negative_regulation of Tgfbr1 1 0.15 1.2 0.09
58 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
59 INT128091 Binding of TGFBR2 1 0.02 0.08 0.08
60 INT254332 Negative_regulation of Gene_expression of Bmpr2 3 0.22 2.41 0.07
61 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06
62 INT268389 Positive_regulation of TGFBR2 1 0.39 0.62 0.05
63 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
64 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
65 INT278039 Phosphorylation of BMPR2 1 0.08 0.26 0.03
66 INT278022 Phosphorylation of Bmpr2 1 0.21 0.27 0.03
67 INT302312 Localization of Bmpr2 4 0.46 0.47 0
68 INT219929 Positive_regulation of Gene_expression of Bmpr2 3 0.15 0.9 0
69 INT265340 Binding of Acvrl1 3 0.30 0.46 0
70 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
71 INT265316 Binding of Tgfbr1 2 0.35 0.59 0
72 INT265326 Regulation of Tgfbr1 2 0.43 0.17 0
73 INT222633 Negative_regulation of Acvr2a 1 0.10 0 0
74 INT310166 Regulation of Acvrl1 1 0.07 0 0
75 INT286084 Regulation of Acvr2a 1 0.02 0.32 0
76 INT315214 Negative_regulation of Regulation of Tgfbr1 1 0.41 0 0
77 INT268388 Positive_regulation of Positive_regulation of TGFBR1 1 0.35 0.61 0
78 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0
79 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
80 INT286081 Regulation of Gene_expression of Acvr2a 1 0.05 0.32 0
81 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
82 INT319209 Regulation of Positive_regulation of Bmpr2 1 0.28 0.08 0
83 INT189623 Transcription of BMPR2 1 0.32 0.71 0
84 INT355333 Regulation of Transcription of Bmpr2 1 0.03 0.15 0
85 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
86 INT272228 Localization of TGFBR1 1 0.34 0.74 0
87 INT310177 Binding of Tgfbr2 1 0.24 0 0
88 INT265319 Positive_regulation of Negative_regulation of Tgfbr1 1 0.47 0.53 0
89 INT218282 Regulation of Acvr2a 1 0.23 0.33 0
90 INT144920 Positive_regulation of Gene_expression of TGFBR1 1 0.65 0 0
91 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
92 INT310165 Negative_regulation of Transcription of Bmpr2 1 0.22 2.1 0
93 INT83122 Transcription of TGFBR2 1 0.09 0 0
94 INT310168 Phosphorylation of Tgfbr2 1 0.41 1.5 0
95 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
96 INT218289 Gene_expression of Acvr2a 1 0.65 1.44 0
97 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0
98 INT310176 Localization of Tgfbr1 1 0.11 0.83 0
99 INT239992 Negative_regulation of Tgfbr2 1 0.06 0 0
100 INT260145 Positive_regulation of Gene_expression of TGFBR2 1 0.45 1.04 0
101 INT222620 Binding of Acvr2a 1 0.08 0 0
102 INT286082 Positive_regulation of Gene_expression of Acvr2a 1 0.06 1.25 0
103 INT218281 Binding of Acvr2b 1 0.36 0.07 0
104 INT319208 Regulation of Bmpr2 1 0.28 0.08 0
105 INT310179 Positive_regulation of Positive_regulation of Tgfbr1 1 0.08 0 0
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