GO:0004677

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Name DNA-dependent protein kinase activity
Categary Function
Go Slim No
Go Link GO:0004677
Unique Molecular Interactions 52
Total Molecular Interactions 79
Total Single Events 328
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for DNA-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
2 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
3 INT322048 Prkdc Negative_regulation of Col7a1 1 0.00 0.45 0.5
4 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 0.07 0.44 0.26
5 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
6 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
7 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
8 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
9 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
10 INT350736 PRKDC Negative_regulation of CA2 1 0.02 0.16 0.11
11 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11
12 INT249201 PRKDC Regulation of Regulation of CYBB 1 0.01 0.09 0.05
13 INT352669 PRKDC Positive_regulation of Memor1 1 0.00 1.02 0.04
14 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
15 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
16 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
17 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
18 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
19 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
20 INT249169 PMAIP1 Positive_regulation of PRKDC 1 0.00 0 0
21 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
22 INT225593 Ncoa6 Positive_regulation of Prkdc 1 0.02 0 0
23 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
24 INT225480 Binding of Prkdc and Acsl1 1 0.00 0 0
25 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
26 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
27 INT276904 Regulation of Binding of Egfr and Prkdc 1 0.03 0.42 0
28 INT225613 TARBP2 Positive_regulation of Prkdc 1 0.00 0 0
29 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0
30 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
31 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
32 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
33 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
34 INT276905 Binding of Egfr and Prkdc 1 0.04 0.41 0
35 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
36 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
37 INT252904 Binding of PRKDC and XRCC5 1 0.00 0.14 0
38 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
39 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
40 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
41 INT253013 Binding of PRKDC and Zic2 1 0.00 0.14 0
42 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
43 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
44 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
45 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
46 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
47 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
48 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
49 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
50 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
51 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
52 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in DNA-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
2 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
3 INT108148 Positive_regulation of Prkdc 2 0.16 0.49 2.31
4 INT118155 Regulation of Positive_regulation of Prkdc 1 0.10 0.49 1.42
5 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
6 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21
7 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
8 INT166935 Gene_expression of Prkdc 10 0.65 3.14 0.9
9 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74
10 INT28118 Binding of Atm 13 0.38 12.24 0.68
11 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
12 INT48212 Binding of ATM 5 0.47 3.89 0.57
13 INT160778 Transcription of ATM 1 0.40 1.03 0.57
14 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
15 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
16 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
17 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
18 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
19 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
20 INT125524 Positive_regulation of Gene_expression of PRKDC 2 0.09 1 0.29
21 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
22 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
23 INT167438 Localization of ATM 3 0.55 1.61 0.27
24 INT180393 Positive_regulation of Gene_expression of Prkdc 3 0.49 1.17 0.26
25 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
26 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
27 INT327888 Localization of Prkdc 1 0.14 1.11 0.23
28 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
29 INT290726 Binding of Prkdc 1 0.03 1.05 0.13
30 INT167440 Regulation of ATM 2 0.20 0.68 0.12
31 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
32 INT352666 Regulation of PRKDC 1 0.01 0.36 0.09
33 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
34 INT249260 Positive_regulation of Phosphorylation of PRKDC 1 0.03 0.06 0.08
35 INT249280 Phosphorylation of PRKDC 2 0.13 0.3 0.07
36 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
37 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
38 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
39 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
40 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
41 INT207803 Regulation of Atm 3 0.41 1.15 0.03
42 INT352653 Positive_regulation of Positive_regulation of PRKDC 1 0.01 0.56 0.03
43 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
44 INT207807 Localization of Atm 4 0.74 0.21 0
45 INT180394 Phosphorylation of Prkdc 2 0.07 0.6 0
46 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
47 INT252642 Transcription of Atm 1 0.53 0.18 0
48 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
49 INT352658 Negative_regulation of PRKDC 1 0.01 0.33 0
50 INT196923 Binding of Hmga2 1 0.47 2.5 0
51 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
52 INT300344 Localization of HMGA2 1 0.42 1.75 0
53 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
54 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
55 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
56 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
57 INT268581 Regulation of HMGA2 1 0.18 0.72 0
58 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
59 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
60 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
61 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
62 INT196921 Localization of Hmga2 1 0.74 0.44 0
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