GO:0004679

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Name AMP-activated protein kinase activity
Categary Function
Go Slim No
Go Link GO:0004679
Unique Molecular Interactions 238
Total Molecular Interactions 320
Total Single Events 1436
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for AMP-activated protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for AMP-activated protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
2 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97
3 INT226126 Negative_regulation of Ghrl Regulation of Prkag1 1 0.06 0.17 0.45
4 INT253145 Il6 Positive_regulation of Prkag1 1 0.11 0.73 0.44
5 INT226127 Regulation of Ghrl Regulation of Prkag1 1 0.05 0.07 0.42
6 INT226129 Ghrl Regulation of Localization of Prkag1 1 0.05 0.07 0.4
7 INT187521 ATIC Positive_regulation of Prkag1 1 0.01 1.07 0.37
8 INT226120 Cnr1 Positive_regulation of Prkag1 1 0.09 0 0.35
9 INT226124 Ghrl Positive_regulation of Prkag1 1 0.06 0.24 0.33
10 INT187518 Positive_regulation of ATIC Positive_regulation of Prkag1 1 0.01 0.99 0.25
11 INT187485 Trib3 Positive_regulation of Prkag1 1 0.00 0.97 0.22
12 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22
13 INT226123 Cnr1 Regulation of Prkag1 1 0.05 0.09 0.18
14 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
15 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
16 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
17 INT226130 Binding of Cnr1 and Prkag1 1 0.06 0 0.13
18 INT226132 Ghrl Positive_regulation of Gene_expression of Prkag1 1 0.06 0 0.12
19 INT226131 Mastl Positive_regulation of Gene_expression of Prkag1 1 0.01 0 0.12
20 INT352501 PRKAB1 Positive_regulation of INS 1 0.04 1.36 0.12
21 INT253124 Ins1 Negative_regulation of Positive_regulation of Prkag1 1 0.02 0.12 0.1
22 INT317403 Negative_regulation of Binding of Prkag1 and Amp1 1 0.03 0.35 0.1
23 INT317401 Binding of Prkag1 and Amp1 1 0.03 0.35 0.1
24 INT317402 Positive_regulation of Amp1 Positive_regulation of Prkag1 1 0.03 0.27 0.09
25 INT305274 Obsty1 Regulation of Gene_expression of Prkag1 1 0.01 0.94 0.08
26 INT157264 PPARA Positive_regulation of PRKAA1 1 0.03 0.92 0.08
27 INT157271 Adipor1 Positive_regulation of PRKAA1 1 0.01 0.89 0.08
28 INT253150 Il6 Positive_regulation of Phosphorylation of Prkag1 1 0.08 0.34 0.07
29 INT317390 Amp1 Positive_regulation of Phosphorylation of Prkag1 1 0.03 0.22 0.07
30 INT329225 Prkag1 Positive_regulation of Akt1 1 0.09 1.27 0.07
31 INT317387 Amp1 Positive_regulation of Prkag1 1 0.04 0.34 0.07
32 INT353489 Negative_regulation of Aldh2 Negative_regulation of Prkag1 1 0.00 0.84 0.07
33 INT317389 Binding of Prkag1 and Stk11 1 0.16 0.2 0.06
34 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
35 INT317397 Negative_regulation of Binding of Prkag1 and Stk11 1 0.19 0.2 0.06
36 INT329218 Phosphorylation of Ppara Positive_regulation of Prkag1 1 0.34 0.2 0.05
37 INT253143 Regulation of Il6 Positive_regulation of Prkag1 1 0.07 0.08 0.05
38 INT253149 Regulation of Ins1 Positive_regulation of Prkag1 1 0.03 0.08 0.05
39 INT329216 Prkag1 Regulation of Mtor 1 0.01 0.35 0.04
40 INT253133 Ins1 Positive_regulation of Prkag1 1 0.04 0.08 0.04
41 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04
42 INT329223 Prkag1 Regulation of Rps6kb1 1 0.14 0.35 0.04
43 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04
44 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
45 INT253365 Il6 Negative_regulation of Prkaa2 1 0.23 0 0.04
46 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
47 INT187520 ATIC Positive_regulation of Phosphorylation of Prkag1 1 0.01 0 0.03
48 INT253415 ATIC Regulation of Phosphorylation of Prkaa2 1 0.03 0 0.03
49 INT253418 ATIC Regulation of Prkaa2 1 0.02 0 0.03
50 INT317388 Stk11 Regulation of Positive_regulation of Prkag1 1 0.23 0.11 0.03
51 INT317400 Acc Positive_regulation of Prkag1 1 0.29 0.06 0.03
52 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
53 INT336107 Negative_regulation of Prkag1 Negative_regulation of Phosphorylation of Mapk14 1 0.02 0.27 0
54 INT308747 Binding of Cftr and Prkag1 1 0.02 0 0
55 INT253359 Positive_regulation of Prkaa2 Negative_regulation of Mtor 1 0.26 0.27 0
56 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
57 INT351980 Agt Positive_regulation of Phosphorylation of Prkag1 1 0.03 0.74 0
58 INT329215 Prkag1 Negative_regulation of Acaca 1 0.08 0.26 0
59 INT253382 Il6 Positive_regulation of Prkaa2 1 0.42 0.19 0
60 INT253361 Il6 Negative_regulation of Phosphorylation of Prkaa2 1 0.26 0.16 0
61 INT330226 Positive_regulation of Prkaa2 Positive_regulation of Trib3 1 0.00 0.07 0
62 INT212413 SLC12A1 Regulation of PRKAB1 1 0.00 0 0
63 INT253369 Prkaa2 Negative_regulation of Mtor 1 0.24 0.27 0
64 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
65 INT330225 Binding of Tmprss5 and Positive_regulation of Positive_regulation of Prkaa2 1 0.01 0.18 0
66 INT317396 Binding of Car2 and Prkag1 1 0.07 0.31 0
67 INT330224 Tmprss5 Positive_regulation of Prkaa2 1 0.01 0 0
68 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
69 INT305263 Obsty1 Regulation of Phosphorylation of Prkag1 1 0.01 0.78 0
70 INT329224 Prkag1 Positive_regulation of Localization of Ins1 1 0.03 1.14 0
71 INT253373 Binding of Mtor and Prkaa2 1 0.20 0.26 0
72 INT289520 Lep Regulation of Prkag1 1 0.00 0.08 0
73 INT253372 Prkaa2 Regulation of Mtor 1 0.13 0.09 0
74 INT253381 Il6 Regulation of Prkaa2 1 0.16 0 0
75 INT151589 Stk11 Positive_regulation of Prkag1 1 0.41 0.17 0
76 INT336108 Mapk14 Positive_regulation of Gene_expression of Prkag1 1 0.03 0.26 0
77 INT305260 Obsty1 Regulation of Prkag1 1 0.01 0.78 0
78 INT329221 Prkag1 Negative_regulation of Hmgcr 1 0.06 0.48 0
79 INT330223 Binding of Tmprss5 and Positive_regulation of Prkaa2 1 0.01 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for AMP-activated protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in AMP-activated protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121608 Positive_regulation of Prkag1 23 0.15 9.35 4.64
2 INT105974 Positive_regulation of PRKAB1 43 0.67 23.47 4.16
3 INT151586 Positive_regulation of Prkag1 51 0.54 18.7 3.34
4 INT162669 Regulation of Prkag1 4 0.09 3.77 2.1
5 INT162670 Gene_expression of Prkag1 5 0.22 4.45 1.73
6 INT151588 Phosphorylation of Prkag1 48 0.73 15.62 1.38
7 INT130998 Regulation of PRKAB1 11 0.45 5.7 1.33
8 INT226111 Gene_expression of Prkag1 24 0.45 9.76 1.05
9 INT71747 Positive_regulation of Prkaa2 19 0.46 8.76 0.98
10 INT151583 Regulation of Prkag1 11 0.21 3.68 0.85
11 INT121603 Positive_regulation of Positive_regulation of Prkag1 3 0.08 0.22 0.78
12 INT151584 Negative_regulation of Prkag1 10 0.38 1.72 0.67
13 INT121607 Transcription of Prkag1 1 0.04 0.08 0.64
14 INT228570 Phosphorylation of Prkaa2 24 0.61 7.9 0.5
15 INT226109 Localization of Prkag1 3 0.43 1.89 0.44
16 INT212415 Positive_regulation of Positive_regulation of PRKAB1 4 0.36 2.63 0.37
17 INT130999 Localization of PRKAB1 5 0.57 4.1 0.35
18 INT71752 Negative_regulation of Prkaa2 17 0.39 2.81 0.3
19 INT317357 Binding of Prkag1 2 0.25 3.23 0.3
20 INT71750 Regulation of Prkaa2 12 0.41 2.98 0.29
21 INT226115 Positive_regulation of PRKAA1 2 0.15 0.45 0.29
22 INT168047 Phosphorylation of PRKAB1 6 0.66 2.16 0.27
23 INT187496 Binding of Prkag1 1 0.04 0.93 0.27
24 INT187507 Phosphorylation of Prkag1 8 0.11 1.92 0.26
25 INT187501 Positive_regulation of Phosphorylation of Prkag1 1 0.06 0.59 0.26
26 INT168043 Gene_expression of PRKAB1 14 0.62 7.01 0.23
27 INT187504 Gene_expression of Prkaa2 5 0.65 1.3 0.22
28 INT253395 Negative_regulation of Phosphorylation of Prkaa2 9 0.39 1.35 0.2
29 INT151580 Negative_regulation of Phosphorylation of Prkag1 7 0.33 3.45 0.18
30 INT253401 Positive_regulation of Positive_regulation of Prkaa2 2 0.33 1.39 0.15
31 INT253110 Positive_regulation of Positive_regulation of Prkag1 5 0.28 0.78 0.14
32 INT151581 Positive_regulation of Phosphorylation of Prkag1 6 0.61 1.97 0.11
33 INT168044 Positive_regulation of Phosphorylation of PRKAB1 2 0.38 0.47 0.11
34 INT187500 Positive_regulation of Gene_expression of Prkag1 1 0.06 0.09 0.11
35 INT187495 Positive_regulation of Gene_expression of Prkaa2 1 0.49 0.09 0.11
36 INT353488 Negative_regulation of Prkag1 1 0.01 0.92 0.1
37 INT253404 Positive_regulation of Phosphorylation of Prkaa2 3 0.29 1.23 0.09
38 INT258050 Regulation of Positive_regulation of PRKAB1 1 0.08 1.05 0.09
39 INT168046 Positive_regulation of Gene_expression of PRKAB1 5 0.38 4.31 0.08
40 INT253390 Negative_regulation of Positive_regulation of Prkaa2 4 0.28 0.76 0.08
41 INT200996 Negative_regulation of PRKAB1 1 0.20 0.18 0.08
42 INT253387 Negative_regulation of Regulation of Prkaa2 1 0.28 0.08 0.05
43 INT305234 Regulation of Phosphorylation of Prkag1 2 0.30 1.07 0.04
44 INT201018 Transcription of PRKAB1 2 0.16 0.16 0.03
45 INT200952 Regulation of Gene_expression of PRKAB1 1 0.15 0.15 0.03
46 INT201015 Positive_regulation of Regulation of PRKAB1 1 0.25 0.16 0.03
47 INT253402 Binding of Prkaa2 2 0.24 0.43 0
48 INT204344 Binding of PRKAB1 2 0.24 0.67 0
49 INT305245 Negative_regulation of Gene_expression of Prkag1 2 0.21 0.95 0
50 INT212417 Positive_regulation of Localization of PRKAB1 1 0.32 0.58 0
51 INT253408 Positive_regulation of Negative_regulation of Prkaa2 1 0.33 0.44 0
52 INT305225 Positive_regulation of Gene_expression of Prkag1 1 0.05 0.8 0
53 INT330234 Localization of Prkaa2 1 0.21 0 0
54 INT345456 Positive_regulation of Transcription of PRKAB1 1 0.08 0 0
55 INT212418 Negative_regulation of Localization of PRKAB1 1 0.27 0.58 0
56 INT253394 Negative_regulation of Negative_regulation of Prkaa2 1 0.28 0.33 0
57 INT345454 Negative_regulation of Transcription of PRKAB1 1 0.06 0 0
58 INT305243 Regulation of Gene_expression of Prkag1 1 0.03 0.91 0
59 INT212416 Positive_regulation of Binding of PRKAB1 1 0.32 0.39 0
60 INT238857 Phosphorylation of PRKAA1 1 0.01 1.73 0
61 INT329205 Negative_regulation of Positive_regulation of Prkag1 1 0.25 1.17 0
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