GO:0004693

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Name cyclin-dependent protein kinase activity
Categary Function
Go Slim No
Go Link GO:0004693
Unique Molecular Interactions 382
Total Molecular Interactions 548
Total Single Events 3033
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for cyclin-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
2 INT139768 Binding of TRPV1 and ICK 1 0.41 1.59 1.42
3 INT139767 ICK Regulation of TRPV1 1 0.30 1.59 1.42
4 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
5 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
6 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
7 INT116107 CDK4 Positive_regulation of Phosphorylation of EID1 1 0.01 0.32 0.86
8 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
9 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
10 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
11 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
12 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
13 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
14 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
15 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
16 INT164262 TGM7 Negative_regulation of E2F1 1 0.16 1.08 0.53
17 INT306828 Binding of E2F2 and E2F3 1 0.20 0.15 0.46
18 INT306824 Binding of E2F1 and E2F2 1 0.15 0.15 0.46
19 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
20 INT193034 PRKCA Regulation of Positive_regulation of CDK20 1 0.05 0.15 0.37
21 INT173356 Gnaq Positive_regulation of CDK20 1 0.06 0 0.37
22 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
23 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
24 INT103385 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of CDK20 1 0.02 0.88 0.32
25 INT100019 TNF Positive_regulation of CDK20 1 0.24 0.79 0.32
26 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
27 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
28 INT339645 Binding of Cdk5r1 and Ebi3 1 0.01 0.78 0.31
29 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
30 INT298996 Il18 Positive_regulation of Gene_expression of Cdk5r1 1 0.03 1.65 0.29
31 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
32 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
33 INT299011 Il18 Positive_regulation of Transcription of Cdk5r1 1 0.03 1.65 0.29
34 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
35 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
36 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
37 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
38 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
39 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
40 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
41 INT326831 Cdk5r2 Positive_regulation of Binding of Cdk5r1 1 0.01 0.95 0.21
42 INT326834 Cdk5r2 Positive_regulation of Cdk5 1 0.02 0.96 0.21
43 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
44 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
45 INT58559 Binding of Pomc and Cdk10 1 0.02 0 0.19
46 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17
47 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
48 INT164790 Cdk5r1 Positive_regulation of Trib3 1 0.02 0.25 0.17
49 INT299001 Il18 Positive_regulation of Cdk5r1 1 0.03 0.36 0.17
50 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
51 INT201619 Binding of Cdk11b and Mc1r 1 0.28 0.74 0.15
52 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
53 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
54 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
55 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
56 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
57 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13
58 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
59 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13
60 INT273239 Cdk5 Positive_regulation of Positive_regulation of GRIN1 1 0.51 0.37 0.12
61 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
62 INT273236 Cdk5 Positive_regulation of Car2 1 0.13 0.45 0.1
63 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
64 INT201748 Car2 Positive_regulation of Cdk5r1 1 0.00 0.67 0.09
65 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
66 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
67 INT201751 Car2 Positive_regulation of Cdk5 1 0.00 0.67 0.09
68 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09
69 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08
70 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
71 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
72 INT201621 Binding of Cdk11b and Uvbi1 1 0.02 0.36 0.08
73 INT201613 Uvbi1 Positive_regulation of Cdk11b 1 0.03 0.36 0.08
74 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
75 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
76 INT297964 Binding of CDK8 and MAP3K11 1 0.26 0.29 0.07
77 INT297969 Positive_regulation of Binding of CDK8 and MAP3K11 1 0.35 0.29 0.07
78 INT297971 Positive_regulation of Binding of CDK8 and MAPK1 1 0.22 0.3 0.07
79 INT182897 Mak Positive_regulation of Gene_expression of Il2 1 0.38 0.09 0.07
80 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
81 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
82 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07
83 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
84 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
85 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
86 INT297963 Binding of CDK8 and MAPK1 1 0.16 0.29 0.07
87 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
88 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
89 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
90 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
91 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
92 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
93 INT257879 Negative_regulation of Eif4e Positive_regulation of Cdkn1b 1 0.28 0.54 0.06
94 INT204079 HP Positive_regulation of Gene_expression of Cdkn1b 1 0.00 0.6 0.05
95 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
96 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
97 INT332329 Binding of Cdk5 and P2rx3 1 0.22 0.05 0.05
98 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
99 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
100 INT332331 Binding of Cdk5 and Rbm39 1 0.00 0.05 0.05
101 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
102 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
103 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
104 INT333852 Binding of Ccna1 and Cdk2 1 0.20 0.48 0.04
105 INT326830 Cdk5r1 Positive_regulation of Positive_regulation of Cdk5 1 0.09 0.16 0.04
106 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
107 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
108 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
109 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
110 INT221661 Sema3a Positive_regulation of Phosphorylation of Cdk5 1 0.19 0.28 0.03
111 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
112 INT332330 Cdk5 Negative_regulation of Pirt 1 0.00 0 0.03
113 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
114 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
115 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
116 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
117 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
118 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
119 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
120 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
121 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
122 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
123 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
124 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0
125 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
126 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
127 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
128 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
129 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
130 INT272514 Cdk4 Positive_regulation of Phosphorylation of Ccnd3 1 0.01 0 0
131 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
132 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
133 INT268316 Cdk1 Positive_regulation of Mcm3 1 0.28 0.25 0
134 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
135 INT246217 Cdkn1b Positive_regulation of VEGFA 1 0.03 1.13 0
136 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
137 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
138 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
139 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
140 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
141 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
142 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
143 INT215706 Binding of Cdk6 and Lamtor1 1 0.04 0 0
144 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
145 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
146 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0
147 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0
148 INT201734 Binding of Akt1 and Cdk5 1 0.01 0.31 0
149 INT201738 Positive_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
150 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
151 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
152 INT215768 Dio1 Regulation of Cdk4 1 0.01 0.05 0
153 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0
154 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
155 INT215697 Lamtor1 Negative_regulation of Cdkn1b 1 0.02 0 0
156 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0
157 INT182912 Binding of CDKN1A and FRA8E 1 0.02 0.37 0
158 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
159 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
160 INT325152 CDKN1A Negative_regulation of CCNE2 1 0.07 0.1 0
161 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
162 INT217149 MIR20A Regulation of Gene_expression of E2F1 1 0.19 0.86 0
163 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
164 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0
165 INT214891 HGF Positive_regulation of CDKN1A 1 0.25 1.15 0
166 INT182935 KCNIP3 Regulation of CDKN1A 1 0.45 0.96 0
167 INT230712 Binding of Mnat1 and Ccnh 1 0.34 0.09 0
168 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
169 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
170 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0
171 INT337491 Binding of E2F1 and Tcf7 1 0.19 0 0
172 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0
173 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
174 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0
175 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
176 INT337261 Binding of E2F1 and PRB1 1 0.17 1.19 0
177 INT214919 Pkd1 Positive_regulation of CDKN1A 1 0.51 2.6 0
178 INT215701 Slc3a1 Regulation of Cdk6 1 0.01 0.05 0
179 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0
180 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
181 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
182 INT295043 Akt1 Positive_regulation of Cdk2 1 0.10 0.93 0
183 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0
184 INT354115 MIR222 Regulation of Gene_expression of CDKN1B 1 0.07 0.98 0
185 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
186 INT285878 Negative_regulation of Binding of CCND1 and CDK4 1 0.00 0.44 0
187 INT182957 CDKN1A Negative_regulation of HNF4A 1 0.02 0.11 0
188 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
189 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
190 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
191 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 0.37 1.46 0
192 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
193 INT238401 PPARA Positive_regulation of Gene_expression of CDKN1A 1 0.11 0.48 0
194 INT164130 TNFSF10 Positive_regulation of CDK20 1 0.50 1.06 0
195 INT215709 Slc3a1 Regulation of Cdk4 1 0.01 0.05 0
196 INT182917 Binding of VDR and Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.31 0
197 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
198 INT217147 MIR17 Regulation of Gene_expression of E2F1 1 0.20 0.85 0
199 INT338972 Binding of CDKN1A and TP53 1 0.10 0.98 0
200 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in cyclin-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
2 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
3 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
4 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
5 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
6 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
7 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
8 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
9 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
10 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
11 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2
12 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
13 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
14 INT109219 Negative_regulation of Cdk5r1 5 0.43 1.22 4.25
15 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
16 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
17 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
18 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
19 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
20 INT201632 Positive_regulation of Cdk5r1 20 0.40 21.6 2.75
21 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
22 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
23 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
24 INT101603 Positive_regulation of Cdk5r1 4 0.56 1.12 2.35
25 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
26 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
27 INT163283 Gene_expression of E2F1 21 0.71 3.77 2.26
28 INT12112 Regulation of ICK 5 0.14 0.76 2.26
29 INT111038 Gene_expression of Cdkn1b 23 0.75 25.35 2.22
30 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
31 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
32 INT103387 Positive_regulation of CDK20 6 0.67 2.8 1.88
33 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
34 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
35 INT101599 Gene_expression of Cdk5r1 5 0.63 1.27 1.68
36 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
37 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
38 INT116116 Phosphorylation of CDK4 3 0.56 2.18 1.56
39 INT101601 Regulation of Cdk5r1 3 0.50 1.2 1.46
40 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39
41 INT158709 Negative_regulation of Phosphorylation of Cdk5 1 0.40 0 1.39
42 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
43 INT306868 Positive_regulation of Gene_expression of E2F1 6 0.46 1.01 1.28
44 INT306857 Binding of E2F3 1 0.21 1.22 1.24
45 INT114220 Negative_regulation of Gene_expression of Cdkn1b 4 0.33 4.11 1.23
46 INT138783 Positive_regulation of Gene_expression of Cdk5r1 2 0.38 0.68 1.15
47 INT118368 Positive_regulation of E2F1 10 0.69 0.8 1.13
48 INT260285 Gene_expression of E2F3 6 0.54 2.51 1.13
49 INT126993 Binding of E2F1 5 0.44 1.39 1.12
50 INT203890 Positive_regulation of Gene_expression of Cdk5r1 9 0.40 9.13 1.11
51 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
52 INT111036 Positive_regulation of Cdkn1b 16 0.45 9 1.06
53 INT111037 Positive_regulation of Gene_expression of Cdkn1b 5 0.39 11.17 1.06
54 INT147602 Negative_regulation of CDK4 8 0.35 4.6 1.04
55 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
56 INT273221 Positive_regulation of Negative_regulation of Cdk5 8 0.49 9.89 1.03
57 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
58 INT250699 Binding of CDK6 3 0.33 2.54 0.97
59 INT109221 Positive_regulation of Negative_regulation of Cdk5r1 1 0.37 0.15 0.95
60 INT306846 Negative_regulation of Binding of E2F3 1 0.24 0.65 0.94
61 INT306891 Negative_regulation of E2F3 1 0.25 0.65 0.94
62 INT203893 Positive_regulation of Gene_expression of Cdk5 2 0.49 7.12 0.92
63 INT138788 Positive_regulation of Gene_expression of Cdk5 1 0.49 0.44 0.91
64 INT127452 Positive_regulation of CDK5 5 0.32 1.88 0.87
65 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86
66 INT203892 Positive_regulation of Positive_regulation of Cdk5 4 0.49 4.02 0.85
67 INT306834 Positive_regulation of Gene_expression of E2F3 2 0.29 1 0.82
68 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81
69 INT138787 Positive_regulation of Positive_regulation of Cdk5 1 0.49 0.38 0.81
70 INT114877 Gene_expression of Cdk4 12 0.69 5.98 0.79
71 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
72 INT126990 Positive_regulation of Binding of E2F1 4 0.58 0 0.79
73 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77
74 INT273220 Positive_regulation of Positive_regulation of Cdk5r1 4 0.40 5.3 0.75
75 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
76 INT306883 Negative_regulation of Phosphorylation of CDK4 1 0.17 1.06 0.71
77 INT114876 Negative_regulation of Gene_expression of Cdk4 3 0.38 2.3 0.7
78 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
79 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
80 INT196790 Localization of Cdk5 6 0.74 2.6 0.67
81 INT134472 Binding of Cdk5r1 4 0.26 4.25 0.65
82 INT241621 Regulation of Cdkn1b 2 0.06 0.36 0.62
83 INT306839 Negative_regulation of Gene_expression of E2F1 2 0.39 0.24 0.61
84 INT114879 Gene_expression of Cdk2 5 0.55 2.33 0.6
85 INT113850 Negative_regulation of Cdkn1b 4 0.42 3.45 0.6
86 INT114872 Negative_regulation of Gene_expression of Cdk2 2 0.35 1.21 0.6
87 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
88 INT127557 Positive_regulation of Phosphorylation of Cdk5 2 0.50 0.43 0.56
89 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
90 INT273230 Negative_regulation of Cdk5r1 1 0.25 4.48 0.53
91 INT118369 Regulation of E2F1 5 0.56 3.51 0.52
92 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
93 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
94 INT201636 Protein_catabolism of Cdk5r1 3 0.18 2.79 0.44
95 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
96 INT326821 Positive_regulation of Protein_catabolism of Cdk5r1 1 0.13 1.9 0.41
97 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
98 INT172626 Localization of E2F1 3 0.78 1.97 0.4
99 INT127451 Positive_regulation of Cdk1 1 0.20 0.27 0.4
100 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39
101 INT147152 Negative_regulation of E2F1 6 0.56 0.89 0.38
102 INT273218 Negative_regulation of Negative_regulation of Cdk5 1 0.42 3.06 0.37
103 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36
104 INT204065 Regulation of Gene_expression of Cdkn1b 1 0.06 3.49 0.34
105 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
106 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
107 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
108 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3
109 INT247937 Localization of Cdk5r1 3 0.41 1.21 0.3
110 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
111 INT126991 Regulation of Binding of E2F1 1 0.23 0 0.28
112 INT298974 Transcription of Cdk5r1 1 0.04 1.64 0.28
113 INT326820 Negative_regulation of Positive_regulation of Cdk5 1 0.36 1.27 0.28
114 INT298972 Transcription of Cdk5 1 0.15 1.63 0.28
115 INT126992 Positive_regulation of Regulation of E2F1 1 0.58 0 0.28
116 INT297997 Negative_regulation of CDK8 1 0.49 1.79 0.28
117 INT173346 Positive_regulation of Positive_regulation of CDK20 1 0.45 0.08 0.25
118 INT273216 Negative_regulation of Gene_expression of Cdk5r1 1 0.25 1.73 0.25
119 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
120 INT201638 Positive_regulation of Cdk4 5 0.58 3.38 0.24
121 INT164788 Regulation of Gene_expression of Cdk5 1 0.27 0.31 0.24
122 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
123 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
124 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
125 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
126 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
127 INT326823 Positive_regulation of Localization of Cdk5r1 1 0.09 0.9 0.2
128 INT132105 Positive_regulation of Gene_expression of CDK20 1 0.25 0.16 0.2
129 INT132102 Gene_expression of CDK20 1 0.34 0.16 0.2
130 INT219375 Localization of CDK5 4 0.52 2.8 0.19
131 INT226422 Negative_regulation of Cdk6 3 0.12 1.83 0.19
132 INT221974 Phosphorylation of CDK5 1 0.56 0.99 0.19
133 INT58557 Binding of Cdk10 1 0.02 0 0.18
134 INT134469 Positive_regulation of Binding of Cdk5r1 1 0.35 0.4 0.18
135 INT273226 Negative_regulation of Gene_expression of Cdk5 2 0.42 0.79 0.17
136 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
137 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
138 INT38649 Positive_regulation of ICK 2 0.21 0.43 0.16
139 INT157582 Regulation of Phosphorylation of Cdk5 1 0.26 0.25 0.16
140 INT221972 Regulation of CDK5 1 0.42 1.87 0.16
141 INT176246 Regulation of Cdk2 6 0.30 3.31 0.15
142 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
143 INT201656 Positive_regulation of Positive_regulation of Cdk4 2 0.06 2.34 0.15
144 INT196421 Negative_regulation of Cdk1 2 0.24 1.17 0.15
145 INT196422 Negative_regulation of Cdk7 1 0.27 1.12 0.15
146 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
147 INT257863 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.45 0.43 0.14
148 INT257865 Negative_regulation of Protein_catabolism of Cdkn1b 1 0.42 0.43 0.14
149 INT257858 Protein_catabolism of Cdkn1b 1 0.64 0.43 0.14
150 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
151 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
152 INT297976 Positive_regulation of CDK8 1 0.42 1.79 0.13
153 INT201462 Binding of CDK2 12 0.39 5.2 0.12
154 INT204063 Gene_expression of Cdk4 3 0.21 0.9 0.12
155 INT326822 Negative_regulation of Phosphorylation of Cdk5 1 0.36 0.43 0.12
156 INT341559 Positive_regulation of Gene_expression of CDK5 1 0.23 0.25 0.11
157 INT148991 Gene_expression of Cdkn1a 1 0.44 0.46 0.11
158 INT170849 Binding of Cdk4 3 0.16 2.44 0.1
159 INT167436 Localization of CDK1 2 0.14 0.41 0.1
160 INT101600 Regulation of Gene_expression of Cdk5r1 1 0.50 0.16 0.1
161 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
162 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
163 INT186055 Binding of CDK1 3 0.35 1.43 0.09
164 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09
165 INT233868 Localization of CDKN1B 2 0.73 0.37 0.09
166 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
167 INT302272 Localization of CDK2 2 0.30 1.09 0.09
168 INT346497 Negative_regulation of Phosphorylation of Cdkn1a 1 0.41 0.83 0.09
169 INT201655 Negative_regulation of Binding of Cdk5 1 0.06 0.9 0.09
170 INT157669 Regulation of CDK20 2 0.19 2.05 0.08
171 INT326819 Negative_regulation of Cdk1 1 0.16 0.39 0.08
172 INT57343 Negative_regulation of ICK 1 0.15 0.16 0.08
173 INT233871 Negative_regulation of Protein_catabolism of CDKN1B 1 0.57 0.27 0.08
174 INT185284 Binding of CDK4 7 0.25 4.79 0.07
175 INT163282 Negative_regulation of Phosphorylation of E2F1 1 0.35 0.33 0.07
176 INT163288 Phosphorylation of E2F1 1 0.66 0.33 0.07
177 INT341567 Negative_regulation of Gene_expression of CDK5 1 0.27 0.24 0.07
178 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
179 INT219355 Binding of CDK5 3 0.35 2.02 0.06
180 INT173191 Regulation of CDK4 1 0.26 0.39 0.06
181 INT271084 Negative_regulation of Gene_expression of Cdk6 1 0.11 1.1 0.06
182 INT271086 Gene_expression of Cdk6 1 0.14 1.09 0.06
183 INT177944 Phosphorylation of CDK20 3 0.61 1.45 0.05
184 INT176238 Gene_expression of Cdk1 5 0.46 0.94 0.04
185 INT282568 Positive_regulation of Cdk2 6 0.34 2.95 0.03
186 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
187 INT309477 Positive_regulation of Cdk1 2 0.35 0.21 0.03
188 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
189 INT224295 Protein_catabolism of CDKN1A 1 0.12 0.55 0.03
190 INT243081 Positive_regulation of Gene_expression of Mak 1 0.33 0.14 0.03
191 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
192 INT243083 Regulation of Mak 1 0.30 0.41 0.03
193 INT243092 Gene_expression of Mak 1 0.51 0.64 0.03
194 INT230665 Gene_expression of Ccnh 8 0.76 2.77 0
195 INT196430 Gene_expression of Ccnd3 5 0.14 1.92 0
196 INT190468 Gene_expression of CDK8 5 0.65 4.74 0
197 INT260292 Positive_regulation of E2F3 3 0.55 1.33 0
198 INT204060 Gene_expression of Cdk6 3 0.26 0.83 0
199 INT236713 Regulation of Cdk4 3 0.22 1.35 0
200 INT236692 Phosphorylation of Cdk4 2 0.35 0.82 0
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