GO:0004694

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Name eukaryotic translation initiation factor 2alpha kinase activity
Categary Function
Go Slim No
Go Link GO:0004694
Unique Molecular Interactions 45
Total Molecular Interactions 46
Total Single Events 352
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for eukaryotic translation initiation factor 2alpha kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for eukaryotic translation initiation factor 2alpha kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
2 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
3 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
4 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
5 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
6 INT349647 Eif2ak1 Positive_regulation of Positive_regulation of Hmox1 1 0.00 1.07 0.2
7 INT349646 Eif2ak1 Regulation of Gene_expression of Hmox1 1 0.00 0.78 0.2
8 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09
9 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
10 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06
11 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06
12 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06
13 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
14 INT349645 Eif2ak1 Positive_regulation of Hmox1 1 0.00 0.18 0.05
15 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05
16 INT5608 Gnl3 Regulation of Eif2ak3 1 0.05 0 0.04
17 INT244464 EIF2AK3 Positive_regulation of Positive_regulation of EIF2S2 1 0.17 0.37 0.04
18 INT244463 EIF2AK3 Regulation of Phosphorylation of EIF2S2 1 0.09 0.37 0.04
19 INT349648 Eif2ak1 Positive_regulation of Gene_expression of Hmox1 1 0.00 0.17 0.04
20 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
21 INT244454 Binding of EIF2AK3 and SIL1 1 0.05 0.41 0
22 INT203853 Eif2ak3 Positive_regulation of Eif2ak1 1 0.05 0.63 0
23 INT244466 EIF2AK3 Positive_regulation of Localization of SIL1 1 0.06 0.47 0
24 INT292504 Mlph Regulation of EIF2AK3 1 0.00 0.21 0
25 INT244465 Binding of EIF2AK3 and ATF6 1 0.14 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for eukaryotic translation initiation factor 2alpha kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in eukaryotic translation initiation factor 2alpha kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
2 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
3 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
4 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
5 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
6 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
7 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
8 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
9 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
10 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
11 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
12 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
13 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
14 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
15 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
16 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
17 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
18 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
19 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
20 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
21 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
22 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8
23 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
24 INT127901 Positive_regulation of Gene_expression of EIF2AK3 3 0.49 1.8 0.77
25 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67
26 INT5601 Regulation of Eif2ak3 1 0.43 0 0.53
27 INT18336 Positive_regulation of Positive_regulation of Eif2ak3 1 0.33 0 0.49
28 INT15696 Regulation of EIF2AK3 2 0.26 1.1 0.39
29 INT15697 Negative_regulation of EIF2AK3 1 0.41 0 0.33
30 INT15698 Transcription of EIF2AK3 1 0.52 0 0.32
31 INT127902 Negative_regulation of Gene_expression of EIF2AK3 1 0.42 0.47 0.3
32 INT215861 Positive_regulation of Negative_regulation of Eif2ak3 1 0.50 1.04 0.13
33 INT44884 Phosphorylation of Eif2ak1 1 0.06 0.17 0.08
34 INT349650 Negative_regulation of Eif2ak1 1 0.00 0.59 0.03
35 INT203821 Positive_regulation of Eif2ak1 1 0.22 1.33 0
36 INT244533 Negative_regulation of Phosphorylation of EIF2AK3 1 0.20 0.39 0
37 INT203832 Positive_regulation of Positive_regulation of Eif2ak1 1 0.16 0.7 0
38 INT271085 Positive_regulation of Regulation of Eif2ak3 1 0.03 0.66 0
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