GO:0004702

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Name receptor signaling protein serine/threonine kinase activity
Categary Function
Go Slim No
Go Link GO:0004702
Unique Molecular Interactions 55
Total Molecular Interactions 85
Total Single Events 395
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for receptor signaling protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for receptor signaling protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
2 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
3 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
4 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
5 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
6 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
7 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
8 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
9 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
10 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
11 INT254206 Il10 Negative_regulation of Chuk 1 0.05 0.59 0.29
12 INT254208 Il10 Negative_regulation of Regulation of Chuk 1 0.05 0.59 0.29
13 INT324801 Positive_regulation of Binding of Chuk and Irak1 1 0.03 0.86 0.28
14 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
15 INT324810 Binding of Chuk and Irak1 1 0.02 0.85 0.28
16 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
17 INT143725 Chuk Negative_regulation of Phosphorylation of Nfkb1 1 0.17 0.71 0.26
18 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
19 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
20 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
21 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
22 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
23 INT209851 TGFB2 Negative_regulation of Gene_expression of CD36 1 0.16 0.16 0.21
24 INT222874 NDUFA6 Regulation of Chuk 1 0.01 1.57 0.15
25 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
26 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
27 INT222876 Binding of NDUFA6 and Chuk 1 0.02 2.02 0.13
28 INT222875 Binding of NDUFA6 and Positive_regulation of Chuk 1 0.01 0.74 0.13
29 INT149178 IL4 Negative_regulation of Positive_regulation of TGFB2 1 0.15 0.29 0.1
30 INT222873 NDUFA6 Negative_regulation of Phosphorylation of Chuk 1 0.01 0.24 0.08
31 INT163619 Ikbkb Regulation of Rela 1 0.18 0.23 0.08
32 INT163618 Chuk Regulation of Rela 1 0.16 0.23 0.08
33 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
34 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
35 INT222878 NDUFA6 Negative_regulation of Chuk 1 0.01 2.06 0.05
36 INT348024 Binding of Chuk and Traf3 1 0.13 0.65 0.04
37 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
38 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
39 INT348018 Map3k7 Positive_regulation of Chuk 1 0.19 0.06 0
40 INT222868 Binding of Chuk and Pkn1 1 0.00 0 0
41 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
42 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
43 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
44 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
45 INT314862 Binding of Ltbp3 and Tgfb2 1 0.24 0.52 0
46 INT222871 Binding of Chuk and Ikbkg 1 0.02 0 0
47 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
48 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
49 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
50 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
51 INT348035 Map3k7 Positive_regulation of Binding of Chuk 1 0.20 0.06 0
52 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0
53 INT222870 Traf2 Positive_regulation of Chuk 1 0.03 0.37 0
54 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0
55 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for receptor signaling protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in receptor signaling protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69
2 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
3 INT174958 Negative_regulation of Chuk 21 0.25 8.73 2.96
4 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
5 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
6 INT222845 Gene_expression of Chuk 27 0.52 25.15 2.67
7 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
8 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
9 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35
10 INT217438 Binding of Chuk 24 0.25 7.29 1.29
11 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
12 INT81878 Gene_expression of TGFB2 3 0.42 2.02 0.97
13 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
14 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
15 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
16 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
17 INT93737 Gene_expression of Tgfb2 2 0.03 1.16 0.77
18 INT93736 Positive_regulation of Gene_expression of Tgfb2 2 0.02 1.16 0.77
19 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
20 INT111059 Regulation of Ikbkb 1 0.26 0.56 0.71
21 INT115297 Positive_regulation of TGFB2 4 0.29 1.91 0.65
22 INT115292 Regulation of TGFB2 4 0.17 2.79 0.58
23 INT143713 Positive_regulation of Phosphorylation of Chuk 4 0.25 1.38 0.58
24 INT3831 Negative_regulation of TGFBR2 4 0.28 4.99 0.55
25 INT272887 Negative_regulation of Ikbkb 2 0.29 2.18 0.55
26 INT130047 Localization of TGFB2 3 0.16 3.65 0.53
27 INT202494 Regulation of Chuk 5 0.20 2.17 0.46
28 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
29 INT222850 Positive_regulation of Gene_expression of Chuk 7 0.34 4.91 0.44
30 INT248931 Positive_regulation of Tgfb2 1 0.03 0 0.4
31 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
32 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
33 INT222838 Negative_regulation of Gene_expression of Chuk 5 0.25 3.43 0.31
34 INT316692 Regulation of Localization of TGFB2 1 0.03 1.13 0.3
35 INT140380 Phosphorylation of Ikbkb 2 0.31 1.5 0.29
36 INT140381 Positive_regulation of Phosphorylation of Ikbkb 1 0.12 1.21 0.29
37 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
38 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
39 INT278145 Positive_regulation of Positive_regulation of Chuk 2 0.29 1.45 0.28
40 INT222844 Positive_regulation of Binding of Chuk 1 0.13 0.58 0.26
41 INT308984 Positive_regulation of Negative_regulation of Ikbkb 1 0.35 1.44 0.24
42 INT206047 Negative_regulation of Positive_regulation of Chuk 2 0.11 0.6 0.23
43 INT222836 Negative_regulation of Phosphorylation of Chuk 5 0.16 0.98 0.19
44 INT222837 Regulation of Binding of Chuk 1 0.12 1.18 0.18
45 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
46 INT302181 Positive_regulation of Negative_regulation of Chuk 1 0.04 0.54 0.16
47 INT243679 Protein_catabolism of Chuk 1 0.02 0 0.14
48 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
49 INT210224 Localization of Acvrl1 1 0.03 0.33 0.12
50 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1
51 INT202489 Localization of Chuk 3 0.53 1.63 0.08
52 INT128091 Binding of TGFBR2 1 0.02 0.08 0.08
53 INT343551 Positive_regulation of Localization of TGFB2 1 0.10 1.48 0.08
54 INT251229 Negative_regulation of Tgfb2 1 0.34 0.06 0.07
55 INT268389 Positive_regulation of TGFBR2 1 0.39 0.62 0.05
56 INT258058 Phosphorylation of TGFB2 1 0.08 0.89 0.04
57 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
58 INT298990 Localization of Ikbkb 1 0.05 0.2 0.03
59 INT298981 Positive_regulation of Localization of Ikbkb 1 0.04 0.2 0.03
60 INT265340 Binding of Acvrl1 3 0.30 0.46 0
61 INT222633 Negative_regulation of Acvr2a 1 0.10 0 0
62 INT314821 Binding of Tgfb2 1 0.36 0.51 0
63 INT310166 Regulation of Acvrl1 1 0.07 0 0
64 INT286084 Regulation of Acvr2a 1 0.02 0.32 0
65 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0
66 INT159211 Positive_regulation of Gene_expression of TGFB2 1 0.06 0 0
67 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
68 INT286081 Regulation of Gene_expression of Acvr2a 1 0.05 0.32 0
69 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
70 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
71 INT310177 Binding of Tgfbr2 1 0.24 0 0
72 INT351109 Transcription of TGFB2 1 0.24 0.94 0
73 INT202479 Positive_regulation of Localization of Chuk 1 0.35 0.33 0
74 INT218282 Regulation of Acvr2a 1 0.23 0.33 0
75 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
76 INT83122 Transcription of TGFBR2 1 0.09 0 0
77 INT310168 Phosphorylation of Tgfbr2 1 0.41 1.5 0
78 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
79 INT218289 Gene_expression of Acvr2a 1 0.65 1.44 0
80 INT239992 Negative_regulation of Tgfbr2 1 0.06 0 0
81 INT260145 Positive_regulation of Gene_expression of TGFBR2 1 0.45 1.04 0
82 INT222620 Binding of Acvr2a 1 0.08 0 0
83 INT286082 Positive_regulation of Gene_expression of Acvr2a 1 0.06 1.25 0
84 INT218281 Binding of Acvr2b 1 0.36 0.07 0
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