GO:0004704

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Name NF-kappaB-inducing kinase activity
Categary Function
Go Slim No
Go Link GO:0004704
Unique Molecular Interactions 16
Total Molecular Interactions 17
Total Single Events 93
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for NF-kappaB-inducing kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for NF-kappaB-inducing kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
2 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
3 INT129293 OPRM1 Positive_regulation of Phosphorylation of IKBKE 1 0.05 0.28 0.35
4 INT109901 RPE Positive_regulation of Positive_regulation of MAP3K14 1 0.54 0.15 0.33
5 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
6 INT87092 Binding of PPP4C and MBD2 1 0.05 0 0.16
7 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
8 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
9 INT335771 MIR155 Regulation of IRAK1 1 0.04 0.29 0.09
10 INT92390 ALK Positive_regulation of Gene_expression of Tnfrsf8 1 0.45 1.14 0.09
11 INT346456 TLR3 Positive_regulation of IKBKE 1 0.02 0.45 0.06
12 INT346454 TICAM1 Positive_regulation of IKBKE 1 0.01 0.45 0.06
13 INT276387 ALK Positive_regulation of Gene_expression of Il22ra1 1 0.00 1.55 0
14 INT249825 Gopc Positive_regulation of Ppp4c 1 0.12 0.06 0
15 INT249824 Ppp4c Positive_regulation of Foxm1 1 0.24 0 0
16 INT87093 CYP3A Positive_regulation of Protein_catabolism of PPP4C 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for NF-kappaB-inducing kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in NF-kappaB-inducing kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26
2 INT65886 Binding of PPP4C 3 0.40 0.08 0.83
3 INT53287 Gene_expression of PPP4C 5 0.63 0 0.76
4 INT129296 Phosphorylation of IKBKE 1 0.35 0.54 0.63
5 INT323751 Gene_expression of IRAK1 3 0.44 1.33 0.6
6 INT136102 Positive_regulation of Gene_expression of ALK 3 0.70 3.21 0.59
7 INT107118 Positive_regulation of ALK 4 0.49 3.64 0.52
8 INT135612 Regulation of IKBKE 1 0.21 1.24 0.48
9 INT135614 Positive_regulation of IKBKE 1 0.23 1.26 0.47
10 INT214458 Binding of ALK 1 0.17 1.84 0.46
11 INT323739 Regulation of IRAK1 3 0.23 1.73 0.43
12 INT270000 Localization of IRAK1 3 0.73 0.82 0.43
13 INT343891 Positive_regulation of Gene_expression of IRAK1 1 0.23 0.3 0.42
14 INT109913 Positive_regulation of MAP3K14 2 0.67 0.51 0.37
15 INT165512 Negative_regulation of ALK 2 0.38 1.78 0.29
16 INT109647 Negative_regulation of Gene_expression of ALK 1 0.41 1.13 0.21
17 INT65887 Negative_regulation of Binding of PPP4C 1 0.20 0 0.18
18 INT65888 Negative_regulation of PPP4C 1 0.20 0 0.18
19 INT323746 Phosphorylation of IRAK1 1 0.46 0.81 0.12
20 INT323732 Regulation of Gene_expression of IRAK1 1 0.26 0.82 0.12
21 INT335789 Negative_regulation of Transcription of IRAK1 1 0.22 0.45 0.11
22 INT335817 Transcription of IRAK1 1 0.35 0.45 0.11
23 INT188326 Regulation of ALK 1 0.01 1.03 0.11
24 INT87096 Negative_regulation of Protein_catabolism of PPP4C 1 0.22 0 0.11
25 INT87097 Protein_catabolism of PPP4C 1 0.58 0 0.11
26 INT335806 Negative_regulation of IRAK1 1 0.30 0.36 0.1
27 INT249796 Positive_regulation of Ppp4c 1 0.25 1.04 0.04
28 INT249782 Gene_expression of Ppp4c 1 0.30 0.38 0.03
29 INT249777 Localization of Ppp4c 1 0.33 0.22 0
30 INT53289 Regulation of Gene_expression of PPP4C 1 0.04 0 0
31 INT249789 Negative_regulation of Localization of Ppp4c 1 0.19 0.22 0
32 INT249784 Positive_regulation of Gene_expression of Ppp4c 1 0.22 0.07 0
33 INT249771 Negative_regulation of Ppp4c 1 0.19 0.31 0
34 INT249781 Binding of Ppp4c 1 0.19 0.05 0
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