GO:0004707

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Name MAP kinase activity
Categary Function
Go Slim No
Go Link GO:0004707
Unique Molecular Interactions 1973
Total Molecular Interactions 2315
Total Single Events 23170
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MAP kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for MAP kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
2 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
3 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
4 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
5 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
6 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
7 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
8 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
9 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
10 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
11 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
12 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
13 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
14 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
15 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
16 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
17 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
18 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
19 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
20 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
21 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
22 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
23 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
24 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
25 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
26 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
27 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
28 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
29 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
30 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
31 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
32 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
33 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
34 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
35 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
36 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
37 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
38 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
39 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
40 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
41 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
42 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
43 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
44 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
45 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
46 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
47 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
48 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
49 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
50 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
51 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
52 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
53 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
54 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
55 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
56 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
57 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
58 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
59 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
60 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
61 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
62 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
63 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
64 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
65 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
66 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
67 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
68 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
69 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
70 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
71 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
72 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
73 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
74 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88
75 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
76 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
77 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
78 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
79 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
80 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
81 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
82 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
83 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
84 INT128590 Mapk14 Regulation of Nav1 1 0.21 0.25 0.82
85 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
86 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8
87 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
88 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79
89 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
90 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
91 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
92 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
93 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
94 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
95 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
96 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
97 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
98 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
99 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
100 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
101 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
102 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75
103 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
104 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
105 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
106 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
107 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
108 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
109 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
110 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
111 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
112 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
113 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
114 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
115 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
116 INT164783 Positive_regulation of Mapk14 Regulation of Gene_expression of Cx3cr1 1 0.19 0.81 0.68
117 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
118 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
119 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
120 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
121 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
122 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
123 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
124 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
125 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
126 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
127 INT166299 Binding of Mapk14 and Gpbar1 1 0.13 0.64 0.65
128 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
129 INT166302 Negative_regulation of Binding of Mapk14 and Gpbar1 1 0.12 0.64 0.65
130 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
131 INT288202 Negative_regulation of Cd14 Positive_regulation of Positive_regulation of Mapk14 1 0.09 1.08 0.64
132 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
133 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
134 INT223155 Binding of Mapk14 and Stat4 1 0.36 0.84 0.63
135 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
136 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
137 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
138 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
139 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
140 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
141 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
142 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
143 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61
144 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61
145 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
146 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61
147 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
148 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
149 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
150 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
151 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
152 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
153 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57
154 INT110032 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il12a 1 0.36 0 0.57
155 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
156 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
157 INT196585 Mapk14 Regulation of TNF 1 0.02 0.36 0.55
158 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
159 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
160 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
161 INT328744 TNF Regulation of Positive_regulation of Mapk14 1 0.02 0.81 0.55
162 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
163 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54
164 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
165 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
166 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
167 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
168 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
169 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
170 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
171 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
172 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
173 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
174 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
175 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
176 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
177 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
178 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
179 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
180 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
181 INT313376 Cnr1 Positive_regulation of Phosphorylation of Mapk14 1 0.20 0.38 0.5
182 INT356286 Ngf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
183 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
184 INT313375 Cnr2 Positive_regulation of Phosphorylation of Mapk14 1 0.18 0.39 0.5
185 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
186 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
187 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
188 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
189 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
190 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
191 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
192 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
193 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
194 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
195 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
196 INT131504 Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.14 0.2 0.47
197 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
198 INT131507 Ngf Positive_regulation of Mapk14 1 0.13 0.2 0.47
199 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
200 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47

Single Events

The table below shows the top 100 pain related interactions that have been reported for MAP kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in MAP kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
3 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
4 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
5 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
6 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
7 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
8 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
9 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
10 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
11 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
12 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
13 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
14 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
15 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
16 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
17 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
18 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
19 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
20 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
21 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
22 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
23 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
24 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
25 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
26 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
27 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
28 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
29 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
30 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
31 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
32 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
33 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
34 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
35 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
36 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
37 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
38 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
39 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
40 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
41 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
42 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
43 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
44 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
45 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
46 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
47 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
48 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
49 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
50 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
51 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
52 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
53 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
54 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
55 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
56 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
57 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
58 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
59 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
60 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
61 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
62 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
63 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
64 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
65 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
66 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
67 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
68 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
69 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
70 INT113667 Positive_regulation of Mapk7 15 0.70 12.24 9.72
71 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
72 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
73 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
74 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
75 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
76 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
77 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
78 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
79 INT116707 Positive_regulation of Mapk4 8 0.21 9.83 7.96
80 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
81 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
82 INT116706 Phosphorylation of Mapk4 9 0.25 8.5 7.79
83 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
84 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
85 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
86 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
87 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
88 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
89 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
90 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
91 INT128587 Localization of Mapk14 15 0.81 8.41 6.1
92 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
93 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
94 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
95 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
96 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
97 INT92571 Regulation of Mapk7 8 0.54 4.8 5.25
98 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
99 INT176524 Binding of Mapk14 19 0.43 12.54 5.21
100 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
101 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03
102 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
103 INT116710 Positive_regulation of Phosphorylation of Mapk4 4 0.11 5.45 4.85
104 INT171472 Binding of Mapk14 10 0.36 6.79 4.83
105 INT92572 Gene_expression of Mapk7 17 0.78 3.71 4.76
106 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74
107 INT92570 Negative_regulation of Mapk7 6 0.53 2.53 4.34
108 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
109 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
110 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
111 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21
112 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
113 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
114 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
115 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
116 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
117 INT131782 Regulation of Positive_regulation of Mapk14 7 0.43 2.68 4.02
118 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
119 INT116709 Negative_regulation of Mapk4 5 0.10 4.48 3.97
120 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
121 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86
122 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
123 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
124 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
125 INT104480 Phosphorylation of Mapk9 8 0.80 6.59 3.62
126 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
127 INT162307 Gene_expression of Mapk4 2 0.23 2.89 3.44
128 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
129 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
130 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
131 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
132 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
133 INT152622 Positive_regulation of MAPK4 7 0.14 1.19 3.1
134 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
135 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
136 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
137 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
138 INT155453 Protein_catabolism of Mapk14 6 0.36 4.24 2.85
139 INT144607 Positive_regulation of Gene_expression of Mapk7 8 0.61 2.09 2.82
140 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
141 INT96901 Regulation of Negative_regulation of Mapk14 3 0.45 4.07 2.79
142 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
143 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
144 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
145 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
146 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
147 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
148 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
149 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
150 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
151 INT170482 Regulation of Gene_expression of Mapk1 5 0.43 5.73 2.1
152 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
153 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
154 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
155 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
156 INT162305 Positive_regulation of Gene_expression of Mapk4 1 0.21 1.69 2.01
157 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
158 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99
159 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
160 INT121781 Regulation of Mapk3 5 0.44 1.96 1.98
161 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
162 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
163 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
164 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81
165 INT104478 Positive_regulation of Mapk9 5 0.67 5.56 1.81
166 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
167 INT118907 Negative_regulation of Negative_regulation of Mapk14 2 0.57 2.09 1.77
168 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
169 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74
170 INT104479 Negative_regulation of Mapk9 3 0.37 2.83 1.69
171 INT168686 Transcription of Mapk14 6 0.52 2.96 1.67
172 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
173 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
174 INT149994 Gene_expression of Mapk3 16 0.65 3.45 1.62
175 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
176 INT169461 Regulation of Gene_expression of Mapk1 7 0.44 1.64 1.61
177 INT142678 Positive_regulation of Phosphorylation of Mapk9 4 0.51 2.1 1.6
178 INT103988 Localization of Mapk7 2 0.71 1.07 1.57
179 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
180 INT82761 Regulation of Positive_regulation of Mapk3 3 0.40 1.34 1.52
181 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
182 INT132886 Negative_regulation of Positive_regulation of Mapk3 2 0.30 1.27 1.49
183 INT142676 Phosphorylation of Mapk9 5 0.61 1.48 1.48
184 INT157362 Negative_regulation of MAPK9 7 0.35 4.27 1.44
185 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
186 INT190646 Regulation of Regulation of Mapk1 1 0.30 1.16 1.43
187 INT153627 Binding of Mapk1 5 0.36 2.88 1.4
188 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37
189 INT142679 Negative_regulation of Phosphorylation of Mapk9 1 0.17 0.51 1.37
190 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
191 INT90226 Gene_expression of Mapk9 3 0.65 1.94 1.34
192 INT169656 Positive_regulation of Regulation of Mapk7 1 0.44 0.76 1.27
193 INT202365 Regulation of Gene_expression of Mapk14 6 0.45 4.89 1.26
194 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
195 INT153127 Negative_regulation of Gene_expression of Mapk7 2 0.17 1.02 1.24
196 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
197 INT112823 Negative_regulation of Positive_regulation of MAPK14 5 0.36 1.49 1.22
198 INT157364 Positive_regulation of Phosphorylation of MAPK9 3 0.56 2.33 1.15
199 INT238919 Regulation of Gene_expression of MAPK3 3 0.16 1.6 1.13
200 INT126525 Regulation of Negative_regulation of Mapk14 2 0.41 0.81 1.11
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