GO:0004709

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Name MAP kinase kinase kinase activity
Categary Function
Go Slim No
Go Link GO:0004709
Unique Molecular Interactions 135
Total Molecular Interactions 154
Total Single Events 724
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MAP kinase kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for MAP kinase kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
2 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
3 INT101066 MAP3K15 Positive_regulation of CDCP1 1 0.03 0.46 1.03
4 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
5 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
6 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
7 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
8 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
9 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
10 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
11 INT166385 Binding of Araf and Gnb2l1 1 0.23 0.24 0.6
12 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
13 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
14 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
15 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
16 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42
17 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
18 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
19 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
20 INT346221 Positive_regulation of Braf Positive_regulation of Positive_regulation of Map2k2 1 0.11 0.67 0.39
21 INT346219 Positive_regulation of Braf Positive_regulation of Map2k2 1 0.11 0.67 0.39
22 INT124798 RAF1 Regulation of PRKCA 1 0.06 0 0.39
23 INT88192 IFNG Regulation of Gene_expression of ZAK 1 0.01 0.75 0.36
24 INT87023 ZAK Positive_regulation of Gene_expression of IL36RN 1 0.03 0.62 0.36
25 INT346226 Binding of TPPP and Braf 1 0.06 0.6 0.33
26 INT109901 RPE Positive_regulation of Positive_regulation of MAP3K14 1 0.54 0.15 0.33
27 INT284689 Binding of Tspo and Map3k12 1 0.00 0.59 0.32
28 INT291240 Map3k8 Positive_regulation of Positive_regulation of Mapk1 1 0.16 0.72 0.32
29 INT291241 Map3k8 Positive_regulation of Gene_expression of Mapk1 1 0.17 0.72 0.32
30 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
31 INT291254 MAP3K3 Regulation of Mapk1 1 0.00 1.25 0.29
32 INT346220 Binding of Kras and Braf 1 0.03 0.58 0.28
33 INT291257 Map3k8 Regulation of Positive_regulation of MAPK1 1 0.09 1 0.28
34 INT302438 Binding of Raf1 and Rtn4r 1 0.04 0.08 0.26
35 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
36 INT149357 Trib3 Negative_regulation of Raf1 1 0.01 0.08 0.25
37 INT149356 Prkaca Negative_regulation of Raf1 1 0.10 0.08 0.25
38 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
39 INT292561 MAP3K5 Positive_regulation of Positive_regulation of RAC1 1 0.03 0 0.23
40 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
41 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
42 INT88191 Binding of NCOR2 and ZAK 1 0.00 0.17 0.21
43 INT291255 MAP3K3 Positive_regulation of Tlr4 1 0.00 0.63 0.21
44 INT291253 MAP3K3 Positive_regulation of Mdk 1 0.00 0.62 0.21
45 INT291259 MAP3K3 Positive_regulation of Mapk1 1 0.00 0.62 0.21
46 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2
47 INT337154 Binding of Iqgap1 and Braf 1 0.13 0.64 0.18
48 INT65744 Map3k7 Negative_regulation of Gene_expression of Il2 1 0.10 0.74 0.18
49 INT181144 Raf1 Positive_regulation of Gene_expression of El4 1 0.06 0.35 0.17
50 INT291252 Gene_expression of Map3k8 Positive_regulation of MAPK1 1 0.09 0.64 0.14
51 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
52 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12
53 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12
54 INT291251 Map3k8 Regulation of Gene_expression of MAPK8 1 0.05 0.52 0.11
55 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11
56 INT291260 Map3k8 Regulation of Gene_expression of MAPK14 1 0.07 0.52 0.11
57 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
58 INT291239 Map3k8 Regulation of Positive_regulation of Mdk 1 0.08 0.53 0.11
59 INT252778 RAF1 Positive_regulation of Positive_regulation of ROS1 1 0.04 2.05 0.11
60 INT332806 Positive_regulation of Ccl20 Regulation of Map3k8 1 0.05 0.05 0.1
61 INT314588 Binding of Ifnar1 and Positive_regulation of Raf1 1 0.13 0 0.1
62 INT202409 Binding of Osm and Map3k3 1 0.20 0.13 0.09
63 INT202401 Binding of Map3k3 and Mapk14 1 0.41 0.13 0.09
64 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
65 INT269334 Regulation of PRKCA Regulation of ZAK 1 0.02 0 0.07
66 INT269328 PRKCA Regulation of ZAK 1 0.02 0 0.07
67 INT269331 PRKG1 Regulation of ZAK 1 0.03 0 0.07
68 INT269329 Regulation of PRKG1 Regulation of ZAK 1 0.03 0 0.07
69 INT194727 MAP3K4 Positive_regulation of MAP2K6 1 0.06 0 0.04
70 INT194673 MAP3K4 Positive_regulation of MAP2K4 1 0.06 0 0.04
71 INT194731 MAP3K4 Positive_regulation of MAPK8 1 0.02 0 0.04
72 INT194726 Binding of GADD45A and MAP3K4 1 0.06 0 0.04
73 INT194681 MAP3K4 Positive_regulation of MAP2K3 1 0.07 0 0.04
74 INT194680 MAP3K4 Positive_regulation of MAPK1 1 0.08 0 0.04
75 INT194729 MAP3K4 Positive_regulation of Gene_expression of MAPK1 1 0.08 0 0.04
76 INT298000 MAP3K4 Positive_regulation of Gene_expression of Gadd45b 1 0.27 0.72 0.03
77 INT223826 GSTM1 Negative_regulation of MAP3K5 1 0.02 0.71 0.03
78 INT223824 Binding of GSTM1 and MAP3K5 1 0.02 0.68 0.03
79 INT298001 Gene_expression of Gadd45b Positive_regulation of MAP3K4 1 0.25 0.72 0.03
80 INT297962 MAP3K4 Positive_regulation of MAPK14 1 0.21 0.66 0.03
81 INT280568 MRAS Positive_regulation of RAF1 1 0.01 0.7 0
82 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
83 INT348018 Map3k7 Positive_regulation of Chuk 1 0.19 0.06 0
84 INT283183 Binding of S100A4 and ZAK 1 0.06 0 0
85 INT199581 Braf Negative_regulation of Phosphorylation of tk 1 0.05 0.6 0
86 INT303332 ras Positive_regulation of Raf1 1 0.02 0.07 0
87 INT226900 Binding of Mdk and Map3k8 1 0.05 0.14 0
88 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
89 INT217785 POLR2B Regulation of Gene_expression of MAP3K3 1 0.06 0.2 0
90 INT339708 MBL2 Regulation of MAP3K2 1 0.00 0.1 0
91 INT350426 Binding of BRAF and KRAS 1 0.05 1.78 0
92 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0
93 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
94 INT104866 ZAK Positive_regulation of NXT1 1 0.07 0 0
95 INT217778 MAP3K3 Regulation of Gene_expression of RASGRP1 1 0.09 0.19 0
96 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0
97 INT339706 LGALS2 Regulation of MAP3K2 1 0.00 0.1 0
98 INT205984 Mapk8 Positive_regulation of Map3k12 1 0.15 0.24 0
99 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 0.11 0.6 0
100 INT225874 Positive_regulation of ras Positive_regulation of RAF1 1 0.00 0 0
101 INT274076 Binding of Map3k5 and Gmcl1 1 0.06 1.23 0
102 INT175400 RASGRP1 Positive_regulation of MAP3K5 1 0.00 1.2 0
103 INT217777 EIF4E Regulation of Gene_expression of MAP3K3 1 0.05 0.19 0
104 INT205987 Ptn Positive_regulation of Map3k12 1 0.03 0.24 0
105 INT199582 Braf Negative_regulation of Akt1 1 0.00 0.79 0
106 INT202394 Ass1 Positive_regulation of Map3k3 1 0.01 0 0
107 INT199579 Tnk1 Negative_regulation of Raf1 1 0.01 0.78 0
108 INT225871 RAF1 Positive_regulation of Mdk 1 0.00 0 0
109 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0
110 INT215416 MAP3K1 Regulation of MAPK9 1 0.14 0.64 0
111 INT348035 Map3k7 Positive_regulation of Binding of Chuk 1 0.20 0.06 0
112 INT215412 Binding of MAP3K1 and ITC1 1 0.03 0 0
113 INT225875 ras Positive_regulation of RAF1 1 0.00 0 0
114 INT104863 IL2 Positive_regulation of ZAK 1 0.19 0 0
115 INT199578 Tnk1 Negative_regulation of Braf 1 0.01 0.78 0
116 INT217783 MIR208A Regulation of Gene_expression of MAP3K3 1 0.26 0.2 0
117 INT226908 Binding of Nfkb1 and Map3k8 1 0.14 0.14 0
118 INT350433 KRAS Regulation of Gene_expression of BRAF 1 0.08 1.77 0
119 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
120 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0
121 INT104867 ZAK Positive_regulation of TH1L 1 0.33 0 0
122 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0
123 INT217789 CCNL1 Regulation of Gene_expression of MAP3K3 1 0.19 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MAP kinase kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in MAP kinase kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT161352 Gene_expression of Map3k12 3 0.24 0.59 6.16
2 INT162365 Gene_expression of Map3k8 33 0.58 22.75 4.95
3 INT199560 Binding of Braf 4 0.30 8.83 4.8
4 INT155512 Positive_regulation of Braf 2 0.49 7.88 4.2
5 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
6 INT162366 Positive_regulation of Map3k8 24 0.50 15.69 3.71
7 INT88197 Binding of ZAK 9 0.46 6.23 3.54
8 INT162368 Negative_regulation of Map3k8 17 0.42 7.96 3.34
9 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34
10 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
11 INT346210 Phosphorylation of Braf 1 0.44 5.3 2.77
12 INT148846 Positive_regulation of MAP3K3 3 0.26 1.67 2.59
13 INT196919 Regulation of Braf 3 0.32 6.14 2.55
14 INT24129 Positive_regulation of ZAK 13 0.70 2.29 2.39
15 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
16 INT135523 Gene_expression of MAP3K2 2 0.53 1.22 2.03
17 INT85359 Negative_regulation of Map3k12 6 0.51 0.07 1.89
18 INT226868 Transcription of Map3k8 2 0.52 17.13 1.73
19 INT281639 Binding of Map3k12 2 0.02 3.05 1.68
20 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
21 INT82143 Gene_expression of Raf1 2 0.18 0.33 1.59
22 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55
23 INT291207 Positive_regulation of Transcription of Map3k8 1 0.50 11.36 1.53
24 INT109507 Regulation of Map3k12 2 0.54 0 1.43
25 INT82140 Negative_regulation of Raf1 3 0.14 1.7 1.38
26 INT82141 Positive_regulation of Raf1 2 0.12 0.81 1.38
27 INT82139 Positive_regulation of Gene_expression of Raf1 2 0.12 0.28 1.29
28 INT354377 Negative_regulation of Negative_regulation of Map3k12 1 0.10 0 1.27
29 INT85672 Phosphorylation of MAP3K2 2 0.18 0.62 1.26
30 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
31 INT354379 Negative_regulation of Gene_expression of Map3k12 1 0.12 0 1.24
32 INT354378 Regulation of Gene_expression of Map3k12 1 0.12 0 1.23
33 INT148845 Positive_regulation of Positive_regulation of MAP3K3 1 0.19 0.49 1.2
34 INT148491 Negative_regulation of Map3k3 3 0.02 1.71 1.18
35 INT127805 Positive_regulation of Phosphorylation of RAF1 3 0.45 1.21 1.17
36 INT151243 Regulation of Positive_regulation of MAP3K3 1 0.02 0.33 1.16
37 INT108740 Localization of Map3k12 2 0.68 0.09 1.15
38 INT268662 Regulation of Araf 4 0.17 2.5 1.13
39 INT82138 Negative_regulation of Gene_expression of Raf1 1 0.01 0.28 1.04
40 INT101069 Negative_regulation of MAP3K15 1 0.33 0.47 1.04
41 INT82142 Negative_regulation of Positive_regulation of Raf1 1 0.01 0.28 1.04
42 INT291221 Regulation of Gene_expression of Map3k8 1 0.44 5.59 1
43 INT101075 Positive_regulation of MAP3K15 1 0.38 0.39 0.95
44 INT166379 Gene_expression of Araf 11 0.49 5.2 0.9
45 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
46 INT162367 Regulation of Map3k8 4 0.33 2.09 0.81
47 INT181129 Positive_regulation of Araf 8 0.21 4.3 0.79
48 INT26289 Positive_regulation of Map3k12 2 0.11 0 0.79
49 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
50 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73
51 INT24128 Negative_regulation of ZAK 3 0.39 0 0.7
52 INT202344 Positive_regulation of Map3k3 7 0.49 2.08 0.67
53 INT291214 Positive_regulation of Gene_expression of Map3k8 1 0.50 4.2 0.63
54 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
55 INT291223 Protein_catabolism of Map3k8 1 0.72 3.22 0.58
56 INT53195 Localization of ZAK 3 0.80 1.85 0.56
57 INT233661 Regulation of Map3k3 1 0.02 0.33 0.55
58 INT274072 Gene_expression of Map3k5 1 0.60 6.69 0.5
59 INT236928 Negative_regulation of Araf 1 0.06 1.49 0.5
60 INT171362 Gene_expression of Raf1 13 0.66 8.36 0.49
61 INT162364 Binding of Map3k8 2 0.35 1.26 0.49
62 INT92328 Gene_expression of Map3k11 1 0.06 0.46 0.49
63 INT274069 Binding of Map3k5 1 0.29 2.68 0.49
64 INT72750 Regulation of Positive_regulation of ZAK 1 0.10 0 0.49
65 INT161378 Binding of BRAF 1 0.08 2.24 0.48
66 INT98946 Negative_regulation of Phosphorylation of MAP3K2 1 0.13 0.62 0.47
67 INT346209 Localization of Braf 1 0.49 0.78 0.44
68 INT291244 Regulation of MAP3K3 1 0.00 1.35 0.44
69 INT323167 Negative_regulation of Phosphorylation of RAF1 1 0.08 0 0.43
70 INT252737 Gene_expression of RAF1 12 0.58 10.97 0.42
71 INT291212 Positive_regulation of Protein_catabolism of Map3k8 1 0.34 2.86 0.42
72 INT109913 Positive_regulation of MAP3K14 2 0.67 0.51 0.37
73 INT346208 Regulation of Positive_regulation of Braf 1 0.19 0.7 0.37
74 INT321424 Positive_regulation of MAP3K5 1 0.18 6.64 0.37
75 INT291213 Negative_regulation of Gene_expression of Map3k8 1 0.31 0.97 0.36
76 INT181130 Positive_regulation of Gene_expression of Raf1 1 0.59 2.29 0.36
77 INT343970 Regulation of ZAK 1 0.07 0.14 0.34
78 INT291224 Negative_regulation of Protein_catabolism of Map3k8 1 0.42 1.07 0.33
79 INT236623 Positive_regulation of BRAF 3 0.45 2.05 0.32
80 INT91692 Positive_regulation of Binding of ZAK 1 0.44 0.76 0.31
81 INT330099 Binding of Map3k11 1 0.24 1.21 0.31
82 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
83 INT202728 Localization of Map3k8 4 0.54 1.19 0.28
84 INT291215 Positive_regulation of Positive_regulation of Map3k8 1 0.36 1.42 0.27
85 INT327250 Regulation of Positive_regulation of Araf 1 0.09 1.09 0.26
86 INT327266 Positive_regulation of Positive_regulation of Araf 1 0.07 1.08 0.26
87 INT321428 Positive_regulation of Positive_regulation of MAP3K5 1 0.13 4.65 0.25
88 INT222841 Phosphorylation of Map3k7 1 0.16 0.55 0.25
89 INT65739 Gene_expression of Map3k7 1 0.54 1.41 0.25
90 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
91 INT199569 Negative_regulation of Braf 4 0.36 3.73 0.23
92 INT274071 Positive_regulation of Map3k5 3 0.38 2.31 0.22
93 INT123129 Negative_regulation of MAP3K3 1 0.03 0.66 0.22
94 INT252745 Positive_regulation of Positive_regulation of RAF1 3 0.20 4.62 0.21
95 INT344913 Regulation of Map3k5 1 0.48 0.61 0.2
96 INT224563 Positive_regulation of Positive_regulation of Raf1 1 0.11 0 0.2
97 INT291228 Positive_regulation of Localization of Map3k8 1 0.36 1.19 0.19
98 INT181125 Transcription of Raf1 2 0.59 1.14 0.18
99 INT291211 Negative_regulation of Transcription of Map3k8 1 0.31 0.87 0.18
100 INT132524 Positive_regulation of Gene_expression of BRAF 1 0.37 0.95 0.18
101 INT291205 Phosphorylation of Map3k8 1 0.59 0.83 0.18
102 INT181127 Phosphorylation of Araf 2 0.37 0.51 0.16
103 INT111538 Phosphorylation of Map3k3 2 0.61 0.85 0.15
104 INT111537 Negative_regulation of Phosphorylation of Map3k3 1 0.00 0.77 0.15
105 INT291206 Negative_regulation of Positive_regulation of Map3k8 1 0.31 0.61 0.15
106 INT330973 Regulation of Phosphorylation of RAF1 1 0.30 1.09 0.14
107 INT263138 Phosphorylation of ZAK 5 0.17 0.13 0.12
108 INT284981 Protein_catabolism of RAF1 2 0.08 1.62 0.12
109 INT315042 Positive_regulation of Gene_expression of RAF1 1 0.05 0.23 0.12
110 INT347994 Positive_regulation of Gene_expression of Map3k7 1 0.26 1.27 0.11
111 INT280585 Negative_regulation of Gene_expression of RAF1 1 0.13 1.88 0.11
112 INT347985 Gene_expression of Map3k7 1 0.35 1.26 0.11
113 INT325046 Negative_regulation of Positive_regulation of Map3k5 1 0.07 0.64 0.11
114 INT171373 Positive_regulation of Raf1 3 0.14 0.67 0.1
115 INT284684 Negative_regulation of Binding of Map3k12 1 0.01 0.36 0.1
116 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
117 INT181126 Negative_regulation of Gene_expression of Araf 1 0.19 0.68 0.08
118 INT252703 Localization of RAF1 2 0.32 1.3 0.07
119 INT193807 Positive_regulation of MAP3K4 2 0.13 1.12 0.07
120 INT190543 Localization of Map3k7 1 0.33 0.74 0.07
121 INT252753 Positive_regulation of Localization of RAF1 1 0.06 1.35 0.07
122 INT224326 Binding of RAF1 3 0.13 3.11 0.05
123 INT194793 Negative_regulation of MAP3K4 1 0.12 0 0.04
124 INT193806 Positive_regulation of Positive_regulation of MAP3K4 1 0.03 1.03 0.04
125 INT269654 Positive_regulation of Phosphorylation of ZAK 1 0.10 0 0.04
126 INT181128 Localization of Raf1 1 0.69 7.07 0.04
127 INT269412 Regulation of Gene_expression of ZAK 1 0.07 0 0.04
128 INT269621 Negative_regulation of Positive_regulation of ZAK 1 0.09 0 0.04
129 INT258556 Negative_regulation of BRAF 4 0.42 2.48 0.03
130 INT320723 Negative_regulation of Gene_expression of BRAF 2 0.38 1 0.03
131 INT274068 Positive_regulation of Gene_expression of Map3k5 1 0.53 2.85 0.03
132 INT215417 Gene_expression of MAP3K5 4 0.23 0.59 0
133 INT213908 Negative_regulation of MAP3K5 2 0.41 0.87 0
134 INT236620 Regulation of BRAF 2 0.46 1.96 0
135 INT143795 Phosphorylation of BRAF 1 0.08 0 0
136 INT215426 Negative_regulation of Negative_regulation of MAP3K1 1 0.39 0.32 0
137 INT266482 Phosphorylation of Map3k7 1 0.18 0.26 0
138 INT274073 Negative_regulation of Map3k5 1 0.33 0.28 0
139 INT202339 Transcription of Map3k3 1 0.70 0.29 0
140 INT339759 Positive_regulation of MAP3K2 1 0.01 0.1 0
141 INT202375 Gene_expression of Map3k3 1 0.66 0.32 0
142 INT269643 Negative_regulation of Phosphorylation of ZAK 1 0.09 0 0
143 INT224535 Localization of Raf1 1 0.17 0 0
144 INT332805 Regulation of Regulation of Map3k8 1 0.14 0 0
145 INT333617 Transcription of MAP3K1 1 0.23 0.09 0
146 INT215425 Positive_regulation of Negative_regulation of MAP3K1 1 0.45 0.78 0
147 INT202337 Positive_regulation of Gene_expression of Map3k3 1 0.45 0 0
148 INT108739 Negative_regulation of Localization of Map3k12 1 0.42 0.09 0
149 INT315132 Localization of BRAF 1 0.50 0.26 0
150 INT293481 Negative_regulation of Gene_expression of Raf1 1 0.24 0.38 0
151 INT215419 Regulation of Localization of MAP3K1 1 0.41 0.22 0
152 INT347996 Binding of Map3k7 1 0.19 0.06 0
153 INT280590 Transcription of RAF1 1 0.52 0.75 0
154 INT252739 Localization of MAP3K5 1 0.19 0.74 0
155 INT215423 Localization of MAP3K1 1 0.68 0.22 0
156 INT217836 Gene_expression of MAP3K3 1 0.56 0.19 0
157 INT333621 Positive_regulation of Transcription of MAP3K1 1 0.16 0.09 0
158 INT215428 Binding of MAP3K1 1 0.44 0.05 0
159 INT199562 Positive_regulation of Binding of Braf 1 0.31 0.25 0
160 INT181135 Localization of Araf 1 0.28 0.49 0
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