GO:0004710

From wiki-pain
Jump to: navigation, search
Name MAPK/ERK kinase kinase activity
Categary Function
Go Slim No
Go Link GO:0004710
Unique Molecular Interactions 124
Total Molecular Interactions 198
Total Single Events 2049
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MAPK/ERK kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for MAPK/ERK kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
3 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
4 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
5 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
6 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
7 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
8 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
9 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
10 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
11 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
12 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
13 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
14 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
15 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
16 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
17 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
18 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
19 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
20 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
21 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
22 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
23 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
24 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
25 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
26 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
27 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
28 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
29 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
30 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
31 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
32 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13
33 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
34 INT341828 Binding of BTC and EGFR 1 0.22 0.95 0.12
35 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12
36 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
37 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
38 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
39 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
40 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
41 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
42 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
43 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
44 INT145153 JUN Positive_regulation of EGFR 1 0.24 0.94 0.09
45 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
46 INT145154 Positive_regulation of JUN Positive_regulation of EGFR 1 0.24 0.95 0.09
47 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
48 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09
49 INT249332 GPNMB Positive_regulation of EGFR 1 0.17 2.63 0.08
50 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
51 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06
52 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
53 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06
54 INT279290 EGFR Regulation of CDCP1 1 0.01 0.98 0.05
55 INT302165 PTGER2 Positive_regulation of Localization of EGFR 1 0.06 1.73 0.05
56 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
57 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
58 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
59 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04
60 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
61 INT302166 Positive_regulation of PTGER2 Positive_regulation of EGFR 1 0.07 1.49 0.04
62 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
63 INT352356 Gene_expression of CNR1 Positive_regulation of Gene_expression of EGFR 1 0.24 0.95 0.04
64 INT302291 Positive_regulation of EGFR Positive_regulation of Myc 1 0.18 1.3 0.04
65 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04
66 INT188732 EGFR Positive_regulation of Gene_expression of Egfr 1 0.21 0.6 0.04
67 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
68 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
69 INT188731 Egfr Regulation of EGFR 1 0.46 0.59 0.03
70 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
71 INT187640 Binding of EGFR and KLF1 3 0.01 2.54 0
72 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 0.04 0.33 0
73 INT250665 EGFR Positive_regulation of PIK3CB 1 0.21 1.39 0
74 INT145150 Positive_regulation of Binding of EGFR and JUN 1 0.24 0.11 0
75 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0
76 INT223577 TXK Negative_regulation of EGFR 1 0.08 0.18 0
77 INT206058 EGFR Negative_regulation of Gene_expression of IL6 1 0.07 0.62 0
78 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
79 INT341631 EGFR Positive_regulation of TXK 1 0.05 0.42 0
80 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
81 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0
82 INT213583 Binding of EGFR and NRG2 1 0.16 0.13 0
83 INT145148 Positive_regulation of Binding of EGFR and FOS 1 0.50 0.05 0
84 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
85 INT351604 TXK Positive_regulation of EGFR 1 0.02 1.78 0
86 INT339117 Binding of EGFR and GRB7 1 0.28 1.18 0
87 INT277664 Negative_regulation of Binding of EGF and EGFR 1 0.18 0.5 0
88 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
89 INT298191 EGFR Regulation of IFI27 1 0.05 1.14 0
90 INT334321 EGFR Positive_regulation of MAPK1 1 0.25 0.76 0
91 INT345506 Binding of EGFR and FNDC3A 1 0.00 0.08 0
92 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
93 INT298195 Negative_regulation of EGFR Regulation of IFI27 1 0.08 0.58 0
94 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0
95 INT334323 IL8 Positive_regulation of EGFR 1 0.50 1.29 0
96 INT145149 Binding of EGFR and JUN 1 0.16 0.11 0
97 INT279282 Binding of EGFR and ESR2 1 0.45 1.39 0
98 INT341856 Binding of EGFR and IgG1 1 0.27 1.12 0
99 INT278446 Binding of EGFR and EMR1 1 0.00 0.75 0
100 INT323506 ROS1 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.69 0
101 INT277663 Binding of EGFR and TTPA 1 0.05 0.41 0
102 INT344405 Binding of EGFR and Spp1 1 0.09 1.34 0
103 INT319319 Binding of EGFR and KRAS 1 0.22 0.27 0
104 INT191181 Binding of EGFR and H3F3B 1 0.32 0.17 0
105 INT307586 Binding of EGFR and CDCP1 1 0.01 0.51 0
106 INT191186 Binding of EGFR and RECQL5 1 0.35 0.34 0
107 INT194362 PDGFA Regulation of EGFR 1 0.23 1.56 0
108 INT188734 Egfr Positive_regulation of Gene_expression of EGFR 1 0.52 0.61 0
109 INT215416 MAP3K1 Regulation of MAPK9 1 0.14 0.64 0
110 INT277836 EGFR Positive_regulation of VEGFA 1 0.24 0.47 0
111 INT215412 Binding of MAP3K1 and ITC1 1 0.03 0 0
112 INT307585 Binding of EGFR and MET 1 0.11 0.52 0
113 INT220461 Binding of VCAN and EGFR 1 0.00 0.86 0
114 INT277766 EGFR Regulation of Gene_expression of VEGFA 1 0.54 0.14 0
115 INT242301 Binding of EGFR and ACCS 1 0.11 1.31 0
116 INT236615 Binding of RERE and EGFR 1 0.04 0.35 0
117 INT307584 Binding of EGFR and IGF1R 1 0.03 0.52 0
118 INT339100 Binding of ASIP and EGFR 1 0.00 0.58 0
119 INT194361 VEGFA Regulation of EGFR 1 0.22 1.58 0
120 INT145151 Binding of EGFR and FOS 1 0.48 0.05 0
121 INT351085 Binding of EGFR and Positive_regulation of Phosphorylation of TXK 1 0.04 0.35 0
122 INT277772 Binding of EGFR and fc 1 0.01 0.57 0
123 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0
124 INT341632 Binding of EGFR and FOXM1 1 0.02 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MAPK/ERK kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in MAPK/ERK kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
2 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
3 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
4 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
5 INT11154 Binding of EGFR 149 0.48 96.23 6.29
6 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
7 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
8 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
9 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
10 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
11 INT65545 Localization of EGFR 35 0.79 20.8 1.88
12 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
13 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
14 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
15 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
16 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
17 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
18 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
19 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
20 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
21 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
22 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
23 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
24 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
25 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
26 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
27 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
28 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
29 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
30 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
31 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
32 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
33 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
34 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
35 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
36 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
37 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
38 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
39 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
40 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
41 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
42 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
43 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
44 INT183275 Positive_regulation of Regulation of EGFR 1 0.36 0.21 0.05
45 INT250022 Regulation of Map3k1 2 0.18 1.02 0.04
46 INT145156 Regulation of Regulation of EGFR 1 0.24 1.31 0.03
47 INT266931 Positive_regulation of Binding of EGFR 6 0.50 5.44 0
48 INT315831 Positive_regulation of Localization of EGFR 2 0.49 0.6 0
49 INT319331 Regulation of Localization of EGFR 2 0.32 1.85 0
50 INT202475 Positive_regulation of Positive_regulation of Map3k1 2 0.33 1.54 0
51 INT215426 Negative_regulation of Negative_regulation of MAP3K1 1 0.39 0.32 0
52 INT189990 Negative_regulation of Map3k1 1 0.01 1.48 0
53 INT333617 Transcription of MAP3K1 1 0.23 0.09 0
54 INT215425 Positive_regulation of Negative_regulation of MAP3K1 1 0.45 0.78 0
55 INT215419 Regulation of Localization of MAP3K1 1 0.41 0.22 0
56 INT215423 Localization of MAP3K1 1 0.68 0.22 0
57 INT333621 Positive_regulation of Transcription of MAP3K1 1 0.16 0.09 0
58 INT215428 Binding of MAP3K1 1 0.44 0.05 0
59 INT202470 Negative_regulation of Positive_regulation of Map3k1 1 0.38 0.62 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox