GO:0004712

From wiki-pain
Jump to: navigation, search
Name protein serine/threonine/tyrosine kinase activity
Categary Function
Go Slim No
Go Link GO:0004712
Unique Molecular Interactions 30
Total Molecular Interactions 34
Total Single Events 307
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein serine/threonine/tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for protein serine/threonine/tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
2 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
3 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
4 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
5 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
6 INT278077 Binding of BPHL and AURKC 1 0.16 4.29 0.69
7 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
8 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
9 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
10 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
11 INT179424 Map2k2 Regulation of Mapk3 1 0.00 0.17 0.12
12 INT304499 Map2k1 Positive_regulation of Mapk1 1 0.12 0.8 0.1
13 INT224531 Positive_regulation of Map2k1 Positive_regulation of Positive_regulation of Ankh 1 0.07 0.54 0.09
14 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
15 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
16 INT194677 Binding of GADD45A and MAP2K1 1 0.27 0 0.04
17 INT194719 MAP2K1 Positive_regulation of MAPK1 1 0.27 0 0.04
18 INT194701 MAP2K1 Positive_regulation of MAP2K4 1 0.21 0 0.04
19 INT194732 MAP2K1 Positive_regulation of Gene_expression of MAPK1 1 0.27 0 0.04
20 INT194691 MAP2K1 Positive_regulation of MAP2K3 1 0.23 0 0.04
21 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
22 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03
23 INT239185 Binding of Clk1 and Shc1 1 0.04 2.42 0
24 INT217877 Binding of CLK1 and BCC1 1 0.00 0 0
25 INT297856 Pdk4 Positive_regulation of Positive_regulation of Gopc 1 0.07 0.1 0
26 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
27 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
28 INT297849 Pdk4 Positive_regulation of Positive_regulation of Snord116 1 0.50 0.1 0
29 INT336606 Binding of Mapk8 and Map2k1 1 0.09 0.72 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein serine/threonine/tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in protein serine/threonine/tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
2 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
3 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
4 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
5 INT28734 Gene_expression of Reln 7 0.74 5.76 4.33
6 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
7 INT179391 Phosphorylation of Map2k2 1 0.02 7.01 3.89
8 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
9 INT179396 Positive_regulation of Map2k2 7 0.30 2.84 2.56
10 INT236867 Gene_expression of AURKC 6 0.55 31.96 1.86
11 INT265064 Binding of Reln 1 0.02 2.7 1.83
12 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
13 INT265066 Positive_regulation of Reln 1 0.02 1.59 1.72
14 INT28735 Localization of Reln 2 0.12 1.49 1.7
15 INT179420 Positive_regulation of Phosphorylation of Map2k2 1 0.01 2.17 1.58
16 INT236868 Negative_regulation of AURKC 3 0.48 12.2 1.46
17 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
18 INT159312 Regulation of Reln 4 0.43 1.79 1.4
19 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
20 INT236871 Binding of AURKC 2 0.39 8.53 0.83
21 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
22 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
23 INT211908 Regulation of Positive_regulation of Map2k2 1 0.27 0.48 0.76
24 INT211910 Negative_regulation of Map2k2 2 0.26 0.59 0.63
25 INT179409 Regulation of Phosphorylation of Map2k2 1 0.01 0.74 0.56
26 INT236865 Positive_regulation of AURKC 3 0.57 18.45 0.54
27 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
28 INT130270 Gene_expression of Map2k2 2 0.24 0.25 0.45
29 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
30 INT235841 Negative_regulation of Gene_expression of Clk1 1 0.11 0.62 0.4
31 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37
32 INT235850 Gene_expression of Clk1 1 0.15 0.56 0.37
33 INT236870 Positive_regulation of Gene_expression of AURKC 3 0.41 10.18 0.35
34 INT304526 Binding of Map2k1 1 0.11 0.6 0.32
35 INT240205 Regulation of MAP2K1 3 0.26 0.44 0.28
36 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22
37 INT159314 Positive_regulation of Gene_expression of Reln 1 0.44 0.47 0.2
38 INT265533 Negative_regulation of Phosphorylation of Map2k1 1 0.41 0 0.14
39 INT150109 Gene_expression of Pdk4 2 0.53 3.79 0.12
40 INT150105 Positive_regulation of Gene_expression of Pdk4 2 0.41 2.96 0.12
41 INT179397 Positive_regulation of Positive_regulation of Map2k2 1 0.01 0.17 0.11
42 INT236878 Regulation of Gene_expression of AURKC 3 0.15 2.33 0.09
43 INT236874 Regulation of AURKC 3 0.37 2.83 0.09
44 INT265068 Transcription of Reln 1 0.03 0.07 0.09
45 INT215418 Positive_regulation of Phosphorylation of MAP2K1 1 0.03 0.51 0.08
46 INT215420 Phosphorylation of MAP2K1 1 0.05 0.51 0.08
47 INT239166 Negative_regulation of Clk1 1 0.06 0.74 0.06
48 INT217902 Regulation of CLK1 1 0.12 0 0.04
49 INT217903 Gene_expression of CLK1 1 0.16 0 0.04
50 INT335078 Phosphorylation of Pdk4 1 0.27 0.22 0.03
51 INT297780 Positive_regulation of Pdk4 5 0.61 2.39 0
52 INT236866 Localization of AURKC 2 0.61 2.22 0
53 INT329571 Binding of MAP2K1 2 0.11 0.4 0
54 INT236873 Positive_regulation of Localization of AURKC 1 0.17 1.43 0
55 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
56 INT297817 Negative_regulation of Pdk4 1 0.38 0.99 0
57 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
58 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
59 INT297835 Regulation of Pdk4 1 0.40 0.57 0
60 INT218281 Binding of Acvr2b 1 0.36 0.07 0
61 INT278078 Regulation of Positive_regulation of AURKC 1 0.37 2.03 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox