GO:0004713

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Name protein tyrosine kinase activity
Categary Function
Go Slim No
Go Link GO:0004713
Unique Molecular Interactions 2958
Total Molecular Interactions 4080
Total Single Events 36538
Pain Genes Associated 151

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
2 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
3 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
4 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
5 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
6 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
7 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
8 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
9 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
10 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
11 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
12 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
13 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
14 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
15 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
16 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
17 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
18 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
19 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
20 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
21 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
22 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
23 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
24 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
25 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
26 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
27 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
28 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
29 INT273120 NOVA2 Regulation of Gene_expression of MET 1 0.23 1.17 2.11
30 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
31 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
32 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
33 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
34 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
35 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
36 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
37 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
38 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
39 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 0.06 0.73 1.85
40 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
41 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
42 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
43 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
44 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
45 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71
46 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
47 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
48 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
49 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
50 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
51 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
52 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
53 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
54 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
55 INT158778 Ptges3l1 Regulation of Ephb1 1 0.06 0.09 1.53
56 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
57 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
58 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
59 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
60 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
61 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
62 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
63 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
64 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4
65 INT249494 Binding of Ephb1 and Efnb1 1 0.01 1.34 1.4
66 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
67 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
68 INT261483 Binding of Ephb1 and Trpv1 1 0.39 1.37 1.37
69 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
70 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
71 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
72 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
73 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
74 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
75 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29
76 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
77 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
78 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
79 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
80 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
81 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
82 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
83 INT30128 Binding of MET and Gast 1 0.06 0.18 1.25
84 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
85 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
86 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
87 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
88 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
89 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 0.24 0.69 1.22
90 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
91 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
92 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
93 INT121724 Ngf Positive_regulation of Ephb1 1 0.40 0.68 1.21
94 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
95 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
96 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2
97 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
98 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
99 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18
100 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
101 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
102 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
103 INT349586 Aap Regulation of Gene_expression of Ros1 1 0.03 0.56 1.17
104 INT125284 FSCN1 Positive_regulation of Positive_regulation of EPHB2 1 0.04 0.4 1.14
105 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
106 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12
107 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
108 INT269190 Positive_regulation of Ephb1 Positive_regulation of Ceacam3 1 0.03 0.66 1.12
109 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
110 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
111 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
112 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
113 INT298292 Runx3 Positive_regulation of Gene_expression of Ntrk3 1 0.35 1.36 1.09
114 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
115 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
116 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
117 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
118 INT93614 Ngf Positive_regulation of Ntrk1 2 0.52 0.85 1.05
119 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
120 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
121 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
122 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
123 INT40950 Binding of Penk and Srms 1 0.05 0 1
124 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
125 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
126 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98
127 INT267886 Arl10 Positive_regulation of Insrr 1 0.00 0.07 0.98
128 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
129 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
130 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
131 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
132 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
133 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
134 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96
135 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
136 INT83415 Binding of Oprm1 and Ntrk1 1 0.01 0 0.96
137 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
138 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
139 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
140 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92
141 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
142 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
143 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
144 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
145 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
146 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
147 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
148 INT341371 CRX Positive_regulation of Gene_expression of Ephb1 1 0.02 0.99 0.9
149 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
150 INT151961 Rbm39 Positive_regulation of Insrr 1 0.17 0.26 0.89
151 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
152 INT199189 Binding of Aldh2 and Ros1 1 0.06 0.3 0.88
153 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
154 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
155 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
156 INT297463 Binding of Ntrk1 and Ngf 1 0.10 0.78 0.87
157 INT121745 Tacr1 Negative_regulation of Positive_regulation of Ephb1 1 0.04 0 0.87
158 INT134993 P2rx6 Regulation of Ephb1 1 0.20 1.27 0.87
159 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
160 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
161 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
162 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
163 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
164 INT60719 Insrr Positive_regulation of Fos 1 0.03 1.23 0.84
165 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
166 INT29323 Trmt2a Negative_regulation of Binding of Srms 1 0.00 0 0.84
167 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
168 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84
169 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
170 INT256045 Binding of BDNF and Ntrk1 3 0.34 0.65 0.83
171 INT46085 Binding of MET and Penk 1 0.02 0.06 0.83
172 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
173 INT46076 Binding of MET and SELL 1 0.39 0.06 0.83
174 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83
175 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
176 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
177 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
178 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82
179 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82
180 INT99578 Binding of CEL and Kit 1 0.04 1.07 0.81
181 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
182 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 0.22 0.2 0.8
183 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8
184 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79
185 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
186 INT240456 Ephb1 Regulation of Prkcg 1 0.19 0.51 0.79
187 INT117971 Cd8a Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.98 0.79
188 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
189 INT78714 Ntrk1 Positive_regulation of Ngf 2 0.50 0.63 0.78
190 INT151453 Gtf3a Regulation of Kit 1 0.04 0.25 0.78
191 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
192 INT242626 Binding of Ngf and Ntrk3 3 0.15 0.27 0.77
193 INT70058 Binding of Pnoc and Insrr 1 0.01 0.09 0.77
194 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
195 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
196 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
197 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
198 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
199 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
200 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
2 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
3 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
4 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
5 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
6 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
7 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
8 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
9 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
10 INT4153 Binding of Insrr 109 0.40 17.99 72.15
11 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
12 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98
13 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
14 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
15 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
16 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
17 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
18 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
19 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
20 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
21 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
22 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
23 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
24 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
25 INT14823 Gene_expression of MET 103 0.75 51.92 32.48
26 INT8691 Localization of Insr 85 0.80 9.27 30.32
27 INT6762 Binding of Srms 56 0.31 6.62 30.27
28 INT5300 Regulation of Insr 54 0.60 11.33 29.26
29 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68
30 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45
31 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
32 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21
33 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
34 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
35 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27
36 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
37 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
38 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91
39 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
40 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75
41 INT109379 Regulation of Phosphorylation of Ephb1 22 0.59 12.58 18.84
42 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
43 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
44 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
45 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
46 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
47 INT128921 Negative_regulation of Gene_expression of Ephb1 18 0.49 9.54 14.93
48 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92
49 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71
50 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
51 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
52 INT12464 Binding of MET 38 0.47 10.3 13.15
53 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
54 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64
55 INT55343 Localization of Ros1 39 0.60 34.51 12.5
56 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22
57 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
58 INT112003 Localization of ROS1 94 0.73 66.32 12.16
59 INT100821 Localization of Ros1 59 0.60 45.26 11.92
60 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
61 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
62 INT94784 Binding of ROS1 113 0.40 71.57 10.26
63 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
64 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14
65 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
66 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05
67 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17
68 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09
69 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
70 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
71 INT55342 Negative_regulation of Gene_expression of Ros1 49 0.37 31.62 8.93
72 INT20999 Negative_regulation of Binding of Insrr 17 0.47 3.53 8.93
73 INT141185 Regulation of Ros1 30 0.24 20.73 8.88
74 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88
75 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
76 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39
77 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25
78 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21
79 INT12859 Localization of Insrr 16 0.32 2.68 8.07
80 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
81 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
82 INT127853 Localization of Ephb1 20 0.74 5.47 7.96
83 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
84 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
85 INT9398 Localization of MET 15 0.78 2.34 7.69
86 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
87 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
88 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
89 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
90 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38
91 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35
92 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
93 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
94 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
95 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
96 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
97 INT145299 Negative_regulation of Jak3 25 0.48 17.66 7.13
98 INT9397 Regulation of MET 17 0.60 8.36 7.04
99 INT92734 Binding of Ephb1 5 0.37 3.86 7.02
100 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97
101 INT69439 Regulation of ROS1 46 0.45 31.22 6.94
102 INT62260 Negative_regulation of Gene_expression of Insrr 10 0.06 1.36 6.92
103 INT150287 Positive_regulation of Ephb2 5 0.33 5.54 6.9
104 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
105 INT167049 Binding of Ednra 3 0.07 3.47 6.84
106 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78
107 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
108 INT48922 Regulation of Gene_expression of Ephb1 14 0.50 5.73 6.47
109 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37
110 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
111 INT11154 Binding of EGFR 149 0.48 96.23 6.29
112 INT79737 Positive_regulation of Ntrk1 12 0.49 3.98 6.24
113 INT143357 Binding of Ros1 48 0.36 27.76 6
114 INT91159 Negative_regulation of Ros1 35 0.44 26.12 5.97
115 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
116 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77
117 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
118 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
119 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
120 INT106552 Positive_regulation of Gene_expression of Ntrk2 19 0.68 9.72 5.51
121 INT115528 Binding of Ros1 37 0.41 22.96 5.5
122 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
123 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
124 INT100222 Binding of Src 9 0.26 5.41 5.37
125 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35
126 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28
127 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
128 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
129 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
130 INT126847 Binding of Ephb1 15 0.46 6.47 5.17
131 INT83056 Transcription of Insrr 11 0.11 2.43 5.11
132 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09
133 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05
134 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
135 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
136 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
137 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
138 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
139 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
140 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
141 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
142 INT246315 Localization of Ednra 22 0.15 2.73 4.64
143 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
144 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
145 INT97903 Negative_regulation of FGFR1 16 0.17 5.6 4.57
146 INT78981 Regulation of Ntrk1 6 0.44 3.89 4.52
147 INT108342 Negative_regulation of EPHB2 18 0.57 9.48 4.46
148 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
149 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
150 INT74531 Regulation of PDGFB 14 0.26 7.57 4.38
151 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37
152 INT155689 Phosphorylation of Ros1 6 0.32 5.1 4.36
153 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
154 INT122882 Regulation of Ntrk2 13 0.62 9.7 4.3
155 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
156 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
157 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24
158 INT91158 Regulation of Ros1 26 0.25 17 4.23
159 INT51084 Binding of Insr 13 0.30 4.25 4.23
160 INT79736 Negative_regulation of Ntrk1 11 0.57 2.31 4.14
161 INT114162 Localization of Srms 5 0.60 2.22 4.14
162 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
163 INT88278 Binding of Kit 33 0.37 24.45 4.13
164 INT83035 Binding of INSR 16 0.47 9.29 4.11
165 INT25841 Regulation of Binding of Insrr 6 0.50 0.4 4.03
166 INT158573 Negative_regulation of Jak3 3 0.43 8.2 3.99
167 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
168 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
169 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95
170 INT33332 Positive_regulation of Binding of Insrr 6 0.38 0.77 3.94
171 INT179391 Phosphorylation of Map2k2 1 0.02 7.01 3.89
172 INT56768 Positive_regulation of Gene_expression of Ntrk1 5 0.67 3.91 3.83
173 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
174 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
175 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75
176 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
177 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74
178 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
179 INT4922 Negative_regulation of MET 19 0.57 13.97 3.7
180 INT264972 Positive_regulation of MAP2K3 4 0.65 6.92 3.68
181 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
182 INT109391 Gene_expression of Fgfr1 7 0.56 1.78 3.67
183 INT328808 Negative_regulation of Jak1 1 0.42 7.01 3.64
184 INT137702 Binding of TTN 7 0.35 4.48 3.62
185 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61
186 INT122327 Regulation of Src 6 0.59 0.59 3.6
187 INT242569 Positive_regulation of Ret 17 0.55 3.61 3.54
188 INT70897 Positive_regulation of Gene_expression of PDGFB 15 0.57 13.04 3.52
189 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
190 INT10116 Localization of INSR 11 0.57 5.43 3.48
191 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
192 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
193 INT70895 Localization of PDGFB 20 0.52 8.98 3.4
194 INT29322 Negative_regulation of Srms 5 0.37 0.31 3.37
195 INT69438 Negative_regulation of Positive_regulation of ROS1 20 0.48 10.6 3.33
196 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33
197 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
198 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29
199 INT133086 Positive_regulation of Phosphorylation of Map2k7 1 0.05 4.34 3.27
200 INT29332 Gene_expression of Srms 7 0.06 1.21 3.26
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