GO:0004714

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Name transmembrane receptor protein tyrosine kinase activity
Categary Function
Go Slim No
Go Link GO:0004714
Unique Molecular Interactions 1803
Total Molecular Interactions 2829
Total Single Events 22302
Pain Genes Associated 66

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane receptor protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
3 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
4 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
5 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 0.76 8.19 6.66
6 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
7 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
8 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
9 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
10 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
11 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
12 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
13 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 0.55 2.97 4.23
14 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
15 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
16 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
17 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
18 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
19 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
20 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65
21 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
22 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
23 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
24 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
25 INT152699 Bdnf Positive_regulation of Ltp 5 0.05 1.22 2.95
26 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
27 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
28 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
29 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
30 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
31 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
32 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
33 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
34 INT170037 Ngf Regulation of Gene_expression of DRGX 1 0.01 1.37 2.46
35 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
36 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
37 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
38 INT108987 Ngf Regulation of Gene_expression of Sit1 1 0.00 1.46 2.32
39 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
40 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
41 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 0.07 1.35 2.18
42 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
43 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
44 INT113452 Ngf Positive_regulation of Gene_expression of ASIC3 1 0.19 1.34 2.08
45 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
46 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
47 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
48 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
49 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
50 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
51 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
52 INT276668 Ngf Regulation of Nav1 1 0.09 0.98 1.85
53 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 0.06 0.73 1.85
54 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
55 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
56 INT122964 FSCN1 Positive_regulation of Bdnf 1 0.01 1.14 1.79
57 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
58 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71
59 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
60 INT80199 Ngf Regulation of Transcription of Rab38 1 0.01 1.48 1.68
61 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
62 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
63 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
64 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
65 INT170654 Binding of Ntf3 and Ngf 1 0.38 1.66 1.54
66 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
67 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
68 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
69 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
70 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
71 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
72 INT180789 Ngf Regulation of Localization of Trpv1 1 0.28 1.22 1.44
73 INT180804 Bdnf Positive_regulation of Gene_expression of Sorbs1 1 0.01 0 1.44
74 INT180768 Bdnf Regulation of Localization of Trpv1 1 0.13 1.21 1.43
75 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
76 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
77 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
78 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
79 INT180809 Ngf Positive_regulation of Positive_regulation of Sorbs1 1 0.03 0.84 1.4
80 INT180808 Ngf Positive_regulation of Gene_expression of Sorbs1 1 0.03 0.84 1.4
81 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
82 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
83 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
84 INT60993 Ntf4 Negative_regulation of Positive_regulation of CRTAC1 1 0.00 0 1.37
85 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
86 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
87 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
88 INT60992 Ngf Regulation of CRTAC1 1 0.00 0 1.35
89 INT151770 Binding of P2RX3 and Ngf 1 0.18 0.9 1.35
90 INT140531 Ngf Positive_regulation of DYT10 1 0.72 1.83 1.34
91 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
92 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
93 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
94 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
95 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
96 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
97 INT96707 Ntf3 Positive_regulation of Localization of SST 1 0.01 0 1.3
98 INT96708 Bdnf Positive_regulation of Localization of SST 1 0.01 0 1.3
99 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
100 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29
101 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
102 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
103 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
104 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
105 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
106 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
107 INT159655 Binding of BDNF and INSRR 2 0.00 1.25 1.26
108 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
109 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
110 INT50386 Bdnf Regulation of Npy 1 0.21 0.47 1.24
111 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
112 INT50385 Bdnf Positive_regulation of Pomc 1 0.22 0.47 1.23
113 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
114 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 0.24 0.69 1.22
115 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
116 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
117 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
118 INT121724 Ngf Positive_regulation of Ephb1 1 0.40 0.68 1.21
119 INT108065 Negative_regulation of Binding of Ngf and IgG-2a 1 0.01 2.38 1.2
120 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
121 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
122 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2
123 INT108064 Binding of Ngf and IgG-2a 1 0.01 2.36 1.19
124 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
125 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
126 INT122370 Positive_regulation of Tacr1 Positive_regulation of Ngf 1 0.30 0.17 1.18
127 INT170655 Binding of Csf2 and Ngf 1 0.36 1.25 1.18
128 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
129 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18
130 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
131 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
132 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
133 INT148437 Binding of Bdnf and Ngf 2 0.32 1.9 1.17
134 INT148435 Binding of Bdnf and Gdnf 2 0.35 1.9 1.17
135 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
136 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
137 INT349586 Aap Regulation of Gene_expression of Ros1 1 0.03 0.56 1.17
138 INT93290 Ngf Regulation of Transcription of Trpv1 1 0.02 0.34 1.16
139 INT335435 Ngf Positive_regulation of Ltb4r 1 0.52 1.06 1.16
140 INT93289 Ngf Regulation of Trpv1 1 0.05 0.34 1.16
141 INT122369 Tacr1 Positive_regulation of Ngf 1 0.30 0.16 1.14
142 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
143 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
144 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
145 INT121728 Ngf Positive_regulation of Phosphorylation of Pik3cb 1 0.45 0.69 1.11
146 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
147 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
148 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
149 INT298292 Runx3 Positive_regulation of Gene_expression of Ntrk3 1 0.35 1.36 1.09
150 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
151 INT105690 Ngf Positive_regulation of TRPV1 1 0.05 1.43 1.08
152 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
153 INT120315 Gnrhr Negative_regulation of Positive_regulation of Ngf 1 0.11 0.85 1.07
154 INT120318 Gnrhr Negative_regulation of Ngf 1 0.11 0.85 1.07
155 INT69340 Binding of Igh-6 and Ngf 2 0.06 1.04 1.06
156 INT87320 Ngf Regulation of Gene_expression of Bdnf 2 0.38 0.97 1.06
157 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 0.25 0.95 1.06
158 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 0.25 0.95 1.06
159 INT93614 Ngf Positive_regulation of Ntrk1 2 0.52 0.85 1.05
160 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
161 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
162 INT170653 Ngf Regulation of Csf2 1 0.34 1.11 1.05
163 INT134534 Binding of Bdnf and Psds1 1 0.01 0 1.05
164 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
165 INT180806 Ngf Positive_regulation of Regulation of Sorbs1 1 0.03 0.28 1.04
166 INT335401 Hgf Positive_regulation of Ngf 1 0.30 1.13 1.04
167 INT224856 Binding of Bdnf and Eef2 1 0.14 0 1.02
168 INT151768 Ngf Positive_regulation of P2rx6 1 0.00 0.81 1.01
169 INT137441 Ngf Negative_regulation of Sema3a 1 0.46 2.07 1.01
170 INT151765 Ngf Positive_regulation of Positive_regulation of P2rx6 1 0.00 0.81 1.01
171 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
172 INT83987 Ngf Regulation of Atf2 1 0.52 0.49 1
173 INT86662 Ngf Regulation of SCN10A 1 0.27 1.24 0.99
174 INT267886 Arl10 Positive_regulation of Insrr 1 0.00 0.07 0.98
175 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
176 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
177 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
178 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96
179 INT180780 Ngf Regulation of Gdnf 1 0.22 0.28 0.96
180 INT83415 Binding of Oprm1 and Ntrk1 1 0.01 0 0.96
181 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
182 INT70803 Ngf Regulation of Tac4 1 0.06 0.39 0.93
183 INT70802 Ngf Regulation of Ppt1 1 0.21 0.39 0.93
184 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92
185 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
186 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
187 INT13282 Fgf2 Regulation of Ngf 1 0.66 0.21 0.91
188 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
189 INT219037 Creb1 Positive_regulation of Transcription of Bdnf 2 0.43 1.07 0.9
190 INT137092 Ntf3 Negative_regulation of Gene_expression of Gal 1 0.47 1.01 0.9
191 INT13280 Ngf Regulation of Fgf2 1 0.48 0.2 0.9
192 INT180772 Bdnf Regulation of Trpv1 1 0.11 0.29 0.9
193 INT180777 Bdnf Regulation of Gene_expression of Trpv1 1 0.18 0.29 0.9
194 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
195 INT164677 Ngf Positive_regulation of Gene_expression of Fos 1 0.52 0.08 0.89
196 INT152700 Negative_regulation of Nfkb1 Negative_regulation of Bdnf 1 0.04 0.15 0.89
197 INT151961 Rbm39 Positive_regulation of Insrr 1 0.17 0.26 0.89
198 INT84369 Ngf Positive_regulation of KNG1 1 0.04 0.29 0.89
199 INT152701 Nfkb1 Negative_regulation of Bdnf 1 0.04 0.15 0.89
200 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane receptor protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1
2 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56
3 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238
4 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82
5 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01
6 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
7 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
8 INT67682 Localization of Bdnf 204 0.81 72.36 88.92
9 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08
10 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
11 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19
12 INT12001 Regulation of Ngf 97 0.62 54.64 76.25
13 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
14 INT3034 Localization of Ngf 126 0.81 50.81 72.84
15 INT4153 Binding of Insrr 109 0.40 17.99 72.15
16 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5
17 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
18 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98
19 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03
20 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
21 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24
22 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
23 INT19078 Binding of Ngf 78 0.48 31.03 44.33
24 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55
25 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
26 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64
27 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
28 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
29 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
30 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16
31 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5
32 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45
33 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
34 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21
35 INT47685 Positive_regulation of Positive_regulation of Bdnf 32 0.70 20.05 27.03
36 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
37 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
38 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27
39 INT9781 Binding of INSRR 64 0.31 19.1 25.2
40 INT96557 Binding of Bdnf 46 0.47 21.74 24.26
41 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
42 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
43 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
44 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91
45 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
46 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75
47 INT65907 Negative_regulation of Gene_expression of Ngf 36 0.59 19.5 20.03
48 INT64261 Negative_regulation of Positive_regulation of Ngf 21 0.59 16.28 19.78
49 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59
50 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
51 INT49922 Positive_regulation of Positive_regulation of Ngf 21 0.67 14.46 17.68
52 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
53 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
54 INT15358 Transcription of Ngf 29 0.72 10.43 16.94
55 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
56 INT69203 Positive_regulation of Ntf3 43 0.66 19.16 16.49
57 INT96299 Positive_regulation of Localization of Bdnf 35 0.70 15.67 16.09
58 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52
59 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38
60 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71
61 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
62 INT47692 Negative_regulation of Positive_regulation of Bdnf 18 0.59 9.64 13.14
63 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08
64 INT75224 Positive_regulation of Gene_expression of Ntf3 23 0.69 11.79 13.08
65 INT16256 Regulation of Ntf3 15 0.49 9.75 13.07
66 INT55343 Localization of Ros1 39 0.60 34.51 12.5
67 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22
68 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
69 INT112003 Localization of ROS1 94 0.73 66.32 12.16
70 INT16255 Negative_regulation of Ntf3 21 0.51 12.92 11.93
71 INT100821 Localization of Ros1 59 0.60 45.26 11.92
72 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83
73 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
74 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
75 INT94784 Binding of ROS1 113 0.40 71.57 10.26
76 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14
77 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05
78 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85
79 INT75997 Positive_regulation of Localization of Ngf 14 0.69 7.78 9.41
80 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17
81 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09
82 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
83 INT67116 Gene_expression of Ntrk3 20 0.59 7.64 8.94
84 INT55342 Negative_regulation of Gene_expression of Ros1 49 0.37 31.62 8.93
85 INT20999 Negative_regulation of Binding of Insrr 17 0.47 3.53 8.93
86 INT141185 Regulation of Ros1 30 0.24 20.73 8.88
87 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88
88 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75
89 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
90 INT47682 Transcription of Ntrk2 19 0.69 6.32 8.6
91 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
92 INT12859 Localization of Insrr 16 0.32 2.68 8.07
93 INT71689 Localization of Ntf3 23 0.73 11.1 7.91
94 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
95 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
96 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41
97 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38
98 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
99 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
100 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
101 INT49761 Regulation of Positive_regulation of Ngf 6 0.62 3.83 7.1
102 INT92734 Binding of Ephb1 5 0.37 3.86 7.02
103 INT47691 Positive_regulation of Gene_expression of Ntrk2 17 0.62 13.64 6.96
104 INT69439 Regulation of ROS1 46 0.45 31.22 6.94
105 INT62260 Negative_regulation of Gene_expression of Insrr 10 0.06 1.36 6.92
106 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78
107 INT12632 Negative_regulation of Binding of INSRR 13 0.38 6.54 6.39
108 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37
109 INT47681 Regulation of Ntrk2 17 0.62 3.61 6.31
110 INT11154 Binding of EGFR 149 0.48 96.23 6.29
111 INT79737 Positive_regulation of Ntrk1 12 0.49 3.98 6.24
112 INT92662 Negative_regulation of Gene_expression of Ntf3 9 0.57 7.44 6.22
113 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
114 INT91065 Regulation of Transcription of Bdnf 13 0.62 12.48 6.13
115 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
116 INT12631 Positive_regulation of Binding of INSRR 11 0.45 6.13 6.04
117 INT143357 Binding of Ros1 48 0.36 27.76 6
118 INT91159 Negative_regulation of Ros1 35 0.44 26.12 5.97
119 INT62611 Phosphorylation of Ngf 13 0.82 1.12 5.8
120 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77
121 INT49701 Negative_regulation of Localization of Ngf 9 0.58 3.01 5.75
122 INT56047 Negative_regulation of Transcription of Bdnf 16 0.59 8.02 5.67
123 INT16257 Regulation of Gene_expression of Ntf3 8 0.43 4 5.63
124 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
125 INT106552 Positive_regulation of Gene_expression of Ntrk2 19 0.68 9.72 5.51
126 INT115528 Binding of Ros1 37 0.41 22.96 5.5
127 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
128 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
129 INT16262 Positive_regulation of Transcription of Ngf 8 0.50 4.02 5.48
130 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28
131 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
132 INT110666 Phosphorylation of Bdnf 12 0.69 5.67 5.21
133 INT83056 Transcription of Insrr 11 0.11 2.43 5.11
134 INT67681 Negative_regulation of Localization of Bdnf 12 0.50 4.37 5.07
135 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05
136 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
137 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
138 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
139 INT12474 Regulation of INSRR 18 0.29 6.29 4.81
140 INT78981 Regulation of Ntrk1 6 0.44 3.89 4.52
141 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42
142 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
143 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37
144 INT155689 Phosphorylation of Ros1 6 0.32 5.1 4.36
145 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
146 INT122882 Regulation of Ntrk2 13 0.62 9.7 4.3
147 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24
148 INT91158 Regulation of Ros1 26 0.25 17 4.23
149 INT79736 Negative_regulation of Ntrk1 11 0.57 2.31 4.14
150 INT47686 Regulation of Gene_expression of Ntrk2 5 0.44 5.24 4.14
151 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
152 INT88278 Binding of Kit 33 0.37 24.45 4.13
153 INT100372 Gene_expression of Flt1 47 0.71 24.33 4.09
154 INT25841 Regulation of Binding of Insrr 6 0.50 0.4 4.03
155 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95
156 INT49700 Regulation of Localization of Ngf 6 0.59 1.18 3.95
157 INT33332 Positive_regulation of Binding of Insrr 6 0.38 0.77 3.94
158 INT137268 Regulation of Binding of Ngf 5 0.61 1.63 3.91
159 INT75996 Transcription of Ntf3 13 0.67 4.03 3.88
160 INT56768 Positive_regulation of Gene_expression of Ntrk1 5 0.67 3.91 3.83
161 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75
162 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74
163 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74
164 INT134527 Phosphorylation of Ntrk2 7 0.69 3.72 3.65
165 INT82305 Regulation of Localization of Bdnf 10 0.40 3 3.62
166 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61
167 INT242569 Positive_regulation of Ret 17 0.55 3.61 3.54
168 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
169 INT65102 Regulation of Ntf4 3 0.43 0.05 3.42
170 INT69438 Negative_regulation of Positive_regulation of ROS1 20 0.48 10.6 3.33
171 INT48462 Positive_regulation of Negative_regulation of Bdnf 8 0.70 1 3.2
172 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14
173 INT183212 Positive_regulation of Regulation of Bdnf 4 0.45 1.57 3.14
174 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
175 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
176 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
177 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
178 INT51178 Transcription of INSRR 9 0.17 2.09 3.09
179 INT33241 Localization of INSRR 10 0.10 1.24 3.08
180 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06
181 INT298246 Positive_regulation of Ntrk3 7 0.48 3.81 3.01
182 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
183 INT156189 Positive_regulation of Gene_expression of Ntrk1 11 0.49 2.81 2.89
184 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
185 INT142237 Phosphorylation of Ntrk2 8 0.82 2.24 2.82
186 INT256286 Negative_regulation of Gene_expression of Ephb1 1 0.43 3.36 2.78
187 INT95037 Negative_regulation of Regulation of Insrr 1 0.02 0 2.77
188 INT280459 Regulation of Gene_expression of Ntrk2 13 0.62 8.48 2.71
189 INT62610 Phosphorylation of Ntrk1 5 0.56 1.64 2.68
190 INT119516 Positive_regulation of Phosphorylation of Bdnf 3 0.21 2.81 2.68
191 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
192 INT163405 Positive_regulation of Binding of ROS1 15 0.27 9.39 2.58
193 INT67621 Negative_regulation of Gene_expression of Ntrk2 7 0.41 2.71 2.52
194 INT82072 Positive_regulation of Ntf4 5 0.41 1.05 2.49
195 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
196 INT63333 Gene_expression of RET 24 0.76 30.09 2.41
197 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38
198 INT87319 Regulation of Negative_regulation of Ngf 3 0.61 2.4 2.38
199 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37
200 INT242548 Regulation of Gene_expression of Ret 7 0.49 1.2 2.33
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