GO:0004715

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Name non-membrane spanning protein tyrosine kinase activity
Categary Function
Go Slim No
Go Link GO:0004715
Unique Molecular Interactions 623
Total Molecular Interactions 775
Total Single Events 4052
Pain Genes Associated 67

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for non-membrane spanning protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for non-membrane spanning protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
2 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
3 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
4 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
5 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
6 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
7 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
8 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
9 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
10 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
11 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
12 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
13 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
14 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
15 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
16 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
17 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
18 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
19 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
20 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
21 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
22 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
23 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
24 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
25 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
26 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
27 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
28 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
29 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
30 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
31 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
32 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
33 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
34 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
35 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
36 INT231751 Binding of Il2rg and Jak3 1 0.03 1.56 0.67
37 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
38 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
39 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
40 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64
41 INT192332 UBR7 Negative_regulation of TXK 1 0.00 1.38 0.63
42 INT177979 Binding of STAT3 and FOXI2 1 0.00 1.83 0.61
43 INT56700 Penk Regulation of FER 1 0.00 0 0.59
44 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
45 INT169290 CNR1 Positive_regulation of Negative_regulation of TXK 1 0.10 0.18 0.58
46 INT118001 Csk Regulation of Trpv1 1 0.08 0.09 0.58
47 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
48 INT231750 LOC690550 Negative_regulation of Jak3 1 0.02 1.3 0.52
49 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
50 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
51 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
52 INT121822 Binding of STAT3 and Olr1583 1 0.00 0.21 0.51
53 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
54 INT121821 Binding of STAT1 and Olr1583 1 0.00 0.21 0.51
55 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
56 INT221630 Binding of Fes and Plxna1 1 0.01 1.02 0.5
57 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
58 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48
59 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
60 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
61 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
62 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
63 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
64 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
65 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
66 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
67 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
68 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
69 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
70 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
71 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
72 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
73 INT83567 Matk Negative_regulation of Oprl1 1 0.00 0 0.42
74 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
75 INT184092 Il11ra1 Positive_regulation of Jak1 1 0.17 0.3 0.39
76 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39
77 INT237369 SOAT1 Negative_regulation of Phosphorylation of JAK1 1 0.00 0 0.38
78 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
79 INT263433 Abl1 Regulation of Abl1 1 0.04 0.28 0.38
80 INT118002 Binding of Trpv1 and Csk 1 0.06 0.08 0.38
81 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38
82 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
83 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
84 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
85 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
86 INT303982 Il6 Positive_regulation of STAT3 1 0.03 0.41 0.37
87 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37
88 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
89 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
90 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
91 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
92 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
93 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
94 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
95 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
96 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
97 INT263383 Abl1 Regulation of Trib3 1 0.01 0.28 0.35
98 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
99 INT75941 Negative_regulation of Binding of Cpe and Frk 1 0.01 1.28 0.34
100 INT75946 Binding of Cpe and Frk 1 0.01 1.28 0.34
101 INT75942 Positive_regulation of Binding of Cpe and Frk 1 0.02 1.28 0.34
102 INT75943 Binding of Frk and Sst 1 0.08 1.27 0.34
103 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
104 INT75944 Negative_regulation of Binding of Frk and Sst 1 0.09 1.28 0.34
105 INT75947 Positive_regulation of Binding of Frk and Ptafr 1 0.11 1.26 0.34
106 INT181451 Lck Regulation of Mbp 1 0.08 1.43 0.34
107 INT188204 Negative_regulation of IL6 Positive_regulation of STAT3 1 0.28 0.54 0.34
108 INT75950 Positive_regulation of Binding of Frk and Sst 1 0.11 1.27 0.34
109 INT75954 Negative_regulation of Binding of Frk and Ptafr 1 0.09 1.28 0.34
110 INT254213 Binding of Jak1 and Tyk2 1 0.09 0.84 0.33
111 INT75945 Binding of Frk and Ptafr 1 0.08 1.25 0.33
112 INT254217 Tyk2 Positive_regulation of Stat3 1 0.23 0.83 0.33
113 INT254209 Jak1 Positive_regulation of Stat3 1 0.18 0.84 0.33
114 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
115 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
116 INT184110 Jak1 Positive_regulation of Stat1 1 0.32 0.3 0.33
117 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
118 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
119 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
120 INT285077 CCL16 Positive_regulation of ITK 1 0.05 1.95 0.31
121 INT345421 IFNA1 Positive_regulation of Eif2ak2 2 0.03 1.25 0.3
122 INT354821 Nos2 Positive_regulation of Eif2ak2 1 0.06 0.64 0.3
123 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
124 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
125 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
126 INT109098 Binding of ABL2 and PON1 1 0.36 1.32 0.28
127 INT339494 Eif2ak2 Positive_regulation of Tlr4 1 0.13 0.18 0.28
128 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
129 INT118860 MCC Positive_regulation of Phosphorylation of STAT3 1 0.01 0.1 0.27
130 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
131 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
132 INT118856 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.01 0.14 0.26
133 INT300779 STAT3 Positive_regulation of CRP 1 0.41 0.62 0.26
134 INT300778 STAT3 Positive_regulation of Transcription of CRP 1 0.38 0.62 0.26
135 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
136 INT259937 Binding of CSK and PTPN22 1 0.21 1.69 0.25
137 INT349652 Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk 1 0.01 0.85 0.25
138 INT325312 IL20 Positive_regulation of Phosphorylation of STAT3 1 0.13 0.58 0.24
139 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
140 INT325316 IL22 Positive_regulation of Phosphorylation of STAT3 1 0.19 0.58 0.24
141 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
142 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
143 INT325315 Binding of STAT3 and TH1L 1 0.16 0.6 0.23
144 INT339509 Tlr4 Regulation of Eif2ak2 1 0.08 0.16 0.23
145 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
146 INT339516 Binding of Eif2ak2 and TIRAP 1 0.25 0.19 0.23
147 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
148 INT118861 OPRD1 Positive_regulation of STAT3 1 0.07 0.07 0.23
149 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
150 INT339501 Binding of Eif2ak2 and Tlr4 1 0.14 0.19 0.23
151 INT349653 Nfe2l2 Positive_regulation of Itk 1 0.00 0.79 0.22
152 INT337295 PTAFR Positive_regulation of Localization of STAT3 1 0.43 0.85 0.22
153 INT325314 Binding of IL12A and STAT3 1 0.19 0.6 0.22
154 INT237748 Negative_regulation of Jak3 Negative_regulation of Positive_regulation of Stat3 1 0.25 1.01 0.22
155 INT9288 Stk16 Positive_regulation of Prl 1 0.02 0 0.22
156 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
157 INT188201 OSM Positive_regulation of Phosphorylation of STAT3 1 0.40 0.24 0.21
158 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21
159 INT240535 Il12a Positive_regulation of Tyk2 1 0.10 0.75 0.21
160 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
161 INT279964 STAT3 Regulation of Transcription of FGG 1 0.22 1.37 0.2
162 INT221642 Binding of Fes and Fer 1 0.32 0.27 0.2
163 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
164 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
165 INT221641 Binding of Dpysl2 and Fes 1 0.23 0.27 0.2
166 INT319311 Binding of Glud1 and Ptk2b 1 0.36 0 0.19
167 INT339503 Tlr2 Positive_regulation of Eif2ak2 1 0.12 0.09 0.19
168 INT339505 Tlr3 Positive_regulation of Eif2ak2 1 0.14 0.09 0.19
169 INT286965 Binding of STAT3 and FOXP3 1 0.27 1.84 0.19
170 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19
171 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
172 INT226346 Binding of IL21 and Positive_regulation of Positive_regulation of JAK3 1 0.08 0.48 0.18
173 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18
174 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
175 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
176 INT226339 Binding of IK and JAK1 1 0.00 0.46 0.16
177 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16
178 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16
179 INT343848 Positive_regulation of TLR4 Positive_regulation of STAT1 1 0.17 0.16 0.15
180 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
181 INT241177 Abl2 Regulation of Cat 1 0.14 0.3 0.15
182 INT221632 Plxna1 Negative_regulation of Fes 1 0.02 0.58 0.15
183 INT226366 Binding of CISH and JAK1 1 0.00 0.46 0.15
184 INT295273 STAT1 Regulation of Transcription of Hp 1 0.00 0.63 0.15
185 INT339513 Binding of Socs1 and Eif2ak2 1 0.04 0.07 0.15
186 INT343835 TLR4 Positive_regulation of STAT1 1 0.17 0.11 0.15
187 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
188 INT319314 Binding of Ptk2b and Rbm39 1 0.01 0.08 0.14
189 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
190 INT148800 VEGFA Positive_regulation of Positive_regulation of Csk 1 0.06 0 0.14
191 INT285076 CCL16 Positive_regulation of Gene_expression of ITK 1 0.05 1.8 0.14
192 INT295272 STAT1 Regulation of Hp 1 0.00 0.63 0.14
193 INT319316 Binding of GRIN1 and Ptk2b 1 0.52 0.08 0.14
194 INT148802 Negative_regulation of VEGFA Positive_regulation of Csk 1 0.05 0 0.14
195 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
196 INT148801 VEGFA Positive_regulation of Csk 1 0.06 0 0.14
197 INT82802 Binding of ABL2 and POMC 1 0.00 0 0.14
198 INT343861 Binding of IFN1@ and STAT1 1 0.00 0.13 0.14
199 INT221662 Fes Positive_regulation of Phosphorylation of Dpysl2 1 0.24 0.14 0.14
200 INT295271 STAT1 Regulation of Gbp2 1 0.00 0.63 0.14

Single Events

The table below shows the top 100 pain related interactions that have been reported for non-membrane spanning protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in non-membrane spanning protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
2 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
3 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59
4 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
5 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
6 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
7 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35
8 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
9 INT145299 Negative_regulation of Jak3 25 0.48 17.66 7.13
10 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
11 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
12 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
13 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
14 INT100222 Binding of Src 9 0.26 5.41 5.37
15 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09
16 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
17 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
18 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
19 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
20 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
21 INT20459 Regulation of Ripk2 5 0.44 0 4.53
22 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
23 INT114162 Localization of Srms 5 0.60 2.22 4.14
24 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
25 INT158573 Negative_regulation of Jak3 3 0.43 8.2 3.99
26 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
27 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
28 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
29 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
30 INT121818 Binding of STAT3 25 0.47 11.16 3.67
31 INT122327 Regulation of Src 6 0.59 0.59 3.6
32 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
33 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29
34 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
35 INT145298 Gene_expression of Jak3 5 0.78 7.69 3.07
36 INT76611 Positive_regulation of Srms 5 0.59 3.21 3.04
37 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
38 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74
39 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
40 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
41 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
42 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
43 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
44 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54
45 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
46 INT113339 Binding of JAK2 6 0.40 5.31 2.4
47 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
48 INT71603 Regulation of Srms 7 0.24 0.93 2.34
49 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
50 INT17617 Gene_expression of ABL2 8 0.75 2.73 2.25
51 INT146945 Positive_regulation of Lyn 6 0.49 2.81 2.25
52 INT203839 Positive_regulation of Eif2ak2 18 0.32 4.36 2.22
53 INT115193 Positive_regulation of Phosphorylation of STAT3 30 0.64 11.37 2.2
54 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
55 INT122671 Positive_regulation of LCK 4 0.13 2.69 2.14
56 INT145297 Positive_regulation of Jak3 3 0.50 5.52 2.14
57 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
58 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
59 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
60 INT118291 Binding of TXK 19 0.10 11.77 1.94
61 INT101243 Regulation of STAT3 12 0.62 9.98 1.92
62 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
63 INT148788 Binding of Csk 2 0.12 2.14 1.89
64 INT100689 Negative_regulation of JAK1 8 0.57 5.36 1.87
65 INT49380 Localization of FYN 4 0.78 0.9 1.87
66 INT76612 Binding of Srms 3 0.42 1.1 1.87
67 INT189839 Gene_expression of Jak1 2 0.50 0.51 1.87
68 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
69 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
70 INT44723 Positive_regulation of ABL2 7 0.49 2.23 1.82
71 INT132837 Positive_regulation of Csk 5 0.45 1.75 1.79
72 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
73 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
74 INT165617 Localization of STAT3 28 0.78 9.04 1.72
75 INT212391 Gene_expression of Tnk1 1 0.07 1.61 1.71
76 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
77 INT278981 Negative_regulation of JAK3 5 0.46 2.12 1.69
78 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
79 INT263398 Positive_regulation of Abl1 1 0.60 1.44 1.66
80 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
81 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
82 INT206144 Phosphorylation of JAK1 6 0.57 1.77 1.64
83 INT148937 Positive_regulation of Csk 2 0.13 2.25 1.63
84 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
85 INT121677 Gene_expression of Srms 6 0.59 3.15 1.61
86 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
87 INT54901 Positive_regulation of Gene_expression of FYN 3 0.02 0.61 1.54
88 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
89 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
90 INT221560 Gene_expression of Fes 36 0.72 6.63 1.51
91 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
92 INT98455 Regulation of Src 4 0.20 1.76 1.48
93 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45
94 INT122672 Regulation of Positive_regulation of LCK 1 0.06 1.15 1.44
95 INT121820 Binding of STAT1 9 0.46 2.54 1.4
96 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
97 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
98 INT114715 Binding of SRC 8 0.36 4.26 1.32
99 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
100 INT120075 Gene_expression of Itk 11 0.43 6.39 1.27
101 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
102 INT319293 Phosphorylation of Ptk2b 9 0.80 3.14 1.24
103 INT91368 Negative_regulation of Phosphorylation of STAT3 14 0.59 9.22 1.2
104 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
105 INT155846 Transcription of JAK1 4 0.67 1.93 1.19
106 INT61948 Positive_regulation of FYN 4 0.45 2.49 1.19
107 INT87346 Binding of PTK2 6 0.37 4.03 1.18
108 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17
109 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
110 INT121814 Regulation of STAT1 3 0.43 0.83 1.15
111 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
112 INT130477 Negative_regulation of Fyn 3 0.29 1.59 1.14
113 INT249522 Positive_regulation of Binding of Src 1 0.22 0.68 1.12
114 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1
115 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1
116 INT102758 Negative_regulation of Abl1 2 0.51 1.13 1.1
117 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1
118 INT70209 Negative_regulation of FYN 3 0.08 1.07 1.06
119 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
120 INT274898 Positive_regulation of Positive_regulation of Lyn 1 0.35 1.51 1.05
121 INT98174 Positive_regulation of Gene_expression of ABL2 1 0.49 1.1 1.05
122 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
123 INT119519 Positive_regulation of Gene_expression of TXK 3 0.09 2.92 1.02
124 INT290411 Gene_expression of Ptk2b 10 0.65 3.72 1.01
125 INT130262 Gene_expression of Abl2 2 0.58 1.06 1
126 INT248588 Gene_expression of LCK 9 0.28 4.9 0.98
127 INT101240 Regulation of Phosphorylation of STAT3 5 0.57 3.04 0.98
128 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97
129 INT278975 Gene_expression of JAK3 3 0.52 1.03 0.97
130 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
131 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
132 INT317504 Protein_catabolism of Src 1 0.49 0.13 0.97
133 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
134 INT109470 Negative_regulation of ITK 3 0.24 2.13 0.96
135 INT226480 Positive_regulation of JAK3 4 0.45 0.96 0.95
136 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
137 INT146939 Negative_regulation of Lyn 3 0.53 2.97 0.95
138 INT46783 Negative_regulation of Abl2 2 0.15 0.2 0.95
139 INT236927 Positive_regulation of Ptk2b 9 0.67 3.41 0.94
140 INT100221 Negative_regulation of Phosphorylation of Src 2 0.24 0.74 0.93
141 INT169336 Binding of Jak2 2 0.42 1.31 0.93
142 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
143 INT263387 Binding of Abl1 8 0.42 0.86 0.91
144 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
145 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
146 INT149383 Binding of Lyn 1 0.36 1.14 0.91
147 INT267894 Gene_expression of ITK 13 0.57 9.71 0.9
148 INT128424 Transcription of STAT1 5 0.37 3.28 0.9
149 INT161313 Phosphorylation of ZAP70 2 0.55 0.23 0.88
150 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
151 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87
152 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
153 INT205906 Negative_regulation of Gene_expression of Jak1 1 0.32 0.47 0.87
154 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
155 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
156 INT339476 Regulation of Eif2ak2 1 0.28 0.57 0.86
157 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
158 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
159 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
160 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
161 INT146940 Gene_expression of Fyn 2 0.52 2.76 0.83
162 INT132835 Phosphorylation of Csk 2 0.36 0 0.83
163 INT326427 Gene_expression of Eif2ak2 2 0.36 1.32 0.83
164 INT161311 Positive_regulation of Negative_regulation of LCK 2 0.45 0.74 0.83
165 INT221543 Binding of Fes 1 0.45 1.79 0.83
166 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
167 INT146942 Gene_expression of Lck 1 0.46 1.3 0.83
168 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
169 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
170 INT169706 Positive_regulation of Gene_expression of Itk 2 0.32 2.08 0.81
171 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8
172 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
173 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
174 INT143912 Localization of Src 4 0.48 2.51 0.78
175 INT130263 Positive_regulation of Gene_expression of Abl2 1 0.45 0.61 0.78
176 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
177 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
178 INT249506 Regulation of Phosphorylation of Src 1 0.13 0.48 0.77
179 INT221557 Phosphorylation of Fes 1 0.76 2.49 0.76
180 INT170614 Phosphorylation of Srms 1 0.02 0.1 0.76
181 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75
182 INT241499 Binding of Abl1 23 0.47 8.86 0.75
183 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
184 INT145932 Gene_expression of Hck 5 0.77 2.69 0.73
185 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
186 INT122670 Negative_regulation of Positive_regulation of LCK 1 0.06 0.58 0.72
187 INT284453 Positive_regulation of Positive_regulation of Eif2ak2 2 0.32 1.23 0.71
188 INT186276 Phosphorylation of Jak1 4 0.58 0.65 0.68
189 INT184016 Negative_regulation of Jak1 4 0.32 0.68 0.68
190 INT128422 Positive_regulation of Positive_regulation of STAT1 5 0.35 4.24 0.67
191 INT46784 Binding of Abl2 1 0.09 0 0.66
192 INT329708 Transcription of LCK 1 0.04 1.54 0.63
193 INT148786 Negative_regulation of Csk 4 0.09 0.97 0.62
194 INT278714 Regulation of Phosphorylation of STAT1 1 0.21 0.81 0.62
195 INT142184 Regulation of TXK 10 0.11 8.25 0.59
196 INT132324 Localization of SYK 2 0.78 1.9 0.59
197 INT165618 Negative_regulation of Localization of STAT3 2 0.39 0.31 0.59
198 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
199 INT132836 Regulation of Csk 1 0.30 0.42 0.59
200 INT235996 Negative_regulation of Gene_expression of Src 3 0.09 1.29 0.58
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