GO:0004721

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Name phosphoprotein phosphatase activity
Categary Function
Go Slim No
Go Link GO:0004721
Unique Molecular Interactions 225
Total Molecular Interactions 283
Total Single Events 1915
Pain Genes Associated 36

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphoprotein phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for phosphoprotein phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
2 INT100816 PPP1R14C Regulation of Ppp1cc 1 0.08 0 1.27
3 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12
4 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 0.24 0 1.11
5 INT37153 Binding of Mpz and Ptpn2 1 0.12 0.68 1.08
6 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
7 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
8 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
9 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
10 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
11 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69
12 INT232620 Ptpn4 Regulation of Cysltr1 1 0.02 0.58 0.68
13 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
14 INT274871 Positive_regulation of Cbr2 Positive_regulation of Positive_regulation of Dusp6 1 0.02 0.72 0.67
15 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
16 INT100806 Ppp1r14a Regulation of Ppp1cc 1 0.05 0 0.65
17 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63
18 INT218837 Ppp1cc Regulation of Ltp 1 0.13 1.19 0.62
19 INT218835 Ppp1cc Regulation of Cysltr1 1 0.01 1.19 0.62
20 INT218833 Binding of Ppp1cc and Regulation of Ltp 1 0.13 1.2 0.62
21 INT218836 Binding of Ppp1cc and Regulation of Cysltr1 1 0.01 1.2 0.62
22 INT218845 Ppp1cc Positive_regulation of Positive_regulation of Cysltr1 1 0.02 0.92 0.6
23 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
24 INT196809 Arpp21 Regulation of Ppp1cc 1 0.01 0 0.52
25 INT196826 Ppp1r1b Regulation of Ppp1cc 1 0.10 0 0.51
26 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
27 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
28 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
29 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
30 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
31 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46
32 INT191691 Igh-Dex Positive_regulation of Dusp1 1 0.02 1.8 0.46
33 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
34 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
35 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
36 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42
37 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
38 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
39 INT313455 Binding of Ppp2ca and Syp 1 0.45 0.68 0.4
40 INT196828 Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.4
41 INT196800 Trh Negative_regulation of Ppp1cc 1 0.01 0 0.39
42 INT196829 Ppp1r1b Negative_regulation of Phosphorylation of Ppp1cc 1 0.07 0 0.39
43 INT188427 IL6 Positive_regulation of Pdxp 1 0.00 0.84 0.38
44 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
45 INT218843 Binding of Ppp1cc and Ppp1r9a 1 0.17 0.52 0.36
46 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
47 INT71925 Binding of Ptprs and Positive_regulation of Racgap1 1 0.10 0 0.35
48 INT71924 Ptprs Positive_regulation of Racgap1 1 0.10 0 0.35
49 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
50 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
51 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
52 INT253147 Positive_regulation of Nr1h2 Negative_regulation of Positive_regulation of Ptpn1 1 0.17 0.61 0.33
53 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32
54 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31
55 INT235872 Phosphorylation of Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.31
56 INT218831 Ppp1cc Regulation of Gria2 1 0.27 0.86 0.3
57 INT235886 Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.3
58 INT196825 Prkaca Positive_regulation of Phosphorylation of Ppp2ca 1 0.20 0 0.29
59 INT196831 Positive_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.20 0 0.29
60 INT196814 Negative_regulation of Prkaca Positive_regulation of Ppp2ca 1 0.17 0 0.29
61 INT106893 Ptpn2 Positive_regulation of Tac1 1 0.02 2.02 0.29
62 INT218847 Ppp1cc Positive_regulation of Regulation of Ltp 1 0.22 0.46 0.29
63 INT313446 Syp Regulation of Ppp2ca 1 0.58 0.62 0.26
64 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
65 INT165637 Ptpn6 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.57 0.23
66 INT90280 Binding of Ppp1cc and Ppp2ca 1 0.34 0.22 0.22
67 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
68 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21
69 INT71923 Ptprs Regulation of Racgap1 1 0.09 0 0.21
70 INT165636 Ptpn6 Regulation of Nfkb1 1 0.01 0.36 0.2
71 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
72 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
73 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
74 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
75 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19
76 INT274832 Dusp6 Positive_regulation of Localization of Tlr4 1 0.00 0 0.19
77 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
78 INT221234 Gja3 Regulation of Binding of Ptpn2 1 0.08 0.58 0.18
79 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
80 INT253127 Il6 Regulation of Gene_expression of Ptpn1 1 0.24 1.31 0.17
81 INT313449 Siglec1 Regulation of Ppp2ca 1 0.03 0.61 0.17
82 INT172674 Ptpn6 Negative_regulation of Gene_expression of Plat 1 0.02 1.3 0.16
83 INT349505 Ptpn2 Negative_regulation of Slc6a3 1 0.19 0.7 0.16
84 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16
85 INT235883 Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
86 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
87 INT235879 Regulation of Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
88 INT253154 TNF Positive_regulation of Ptpn1 1 0.73 0.91 0.15
89 INT244052 Ppp1ca Regulation of Phosphorylation of Gabrg1 1 0.00 0.18 0.14
90 INT273238 Grin1 Positive_regulation of Ptprs 1 0.07 0.51 0.14
91 INT244051 Ppp1ca Regulation of Prkaca 1 0.00 0.18 0.14
92 INT86551 Ppm1f Positive_regulation of Camk1g 1 0.49 0 0.13
93 INT276037 Binding of Prkaca and Ppp1cc 1 0.08 0 0.12
94 INT276040 Binding of Camk2a and Ppp1cc 1 0.13 0 0.12
95 INT145215 Binding of C4orf6 and Ctdspl2 1 0.01 0 0.12
96 INT244032 Binding of Ppp1ca and Plcl1 1 0.00 0.16 0.12
97 INT145207 Binding of Sigmar1 and Ctdspl2 1 0.00 0 0.12
98 INT244033 Binding of Gabrg1 and Ppp1ca 1 0.00 0.16 0.12
99 INT171383 Ppp1cc Positive_regulation of Positive_regulation of Mapk1 1 0.18 0 0.11
100 INT196827 Phosphorylation of Prkaca Positive_regulation of Ppp2ca 1 0.18 0 0.11
101 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
102 INT171385 Ppp1cc Positive_regulation of Phosphorylation of Egfr 1 0.15 0 0.11
103 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
104 INT196819 Prkaca Positive_regulation of Binding of Ppp2ca 1 0.20 0 0.11
105 INT171387 Ppp1cc Positive_regulation of Phosphorylation of Src 1 0.07 0 0.11
106 INT171392 Ppp1cc Positive_regulation of Phosphorylation of Gpbar1 1 0.06 0 0.11
107 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
108 INT106894 Ptpn2 Negative_regulation of Tac1 1 0.02 1.17 0.1
109 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
110 INT253300 Itgam Positive_regulation of Gene_expression of Ptprc 1 0.19 0.11 0.09
111 INT313430 Syp Positive_regulation of Ppp2ca 1 0.66 0.08 0.09
112 INT276033 Binding of Ppp1cc and Ppp1r1b 1 0.06 0 0.09
113 INT313447 Ppp2ca Regulation of Phosphorylation of Syp 1 0.43 0 0.08
114 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
115 INT313469 Ppp2ca Regulation of Phosphorylation of Siglec1 1 0.06 0 0.08
116 INT196810 Binding of Prkaca and Ppp2ca 1 0.14 0 0.07
117 INT267017 Bdnf Positive_regulation of Dusp6 1 0.13 0.1 0.07
118 INT218834 Ppp1cc Regulation of Phosphorylation of Gria1 1 0.19 0.66 0.07
119 INT218829 Ppp1cc Regulation of Phosphorylation of Gria1 1 0.20 0.63 0.07
120 INT221232 Ptpn2 Positive_regulation of Gene_expression of Ros1 1 0.04 1.12 0.07
121 INT231507 Binding of Ptprc and Tlr4 2 0.21 1.22 0.06
122 INT277432 Ptpn2 Positive_regulation of Gdnf 1 0.29 1.41 0.06
123 INT236363 Regulation of Binding of Ptprc and Tlr4 1 0.25 1.23 0.06
124 INT313463 Ppp2ca Regulation of Syp 1 0.43 0.6 0.06
125 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
126 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05
127 INT332269 Cndp2 Negative_regulation of Tenc1 1 0.41 0.8 0.05
128 INT237351 Binding of Mtm1 and Gopc 1 0.19 0.17 0.05
129 INT221251 PRKG1 Negative_regulation of Positive_regulation of Ptpn2 1 0.04 0.7 0.05
130 INT295337 Egf Positive_regulation of Ptpn11 1 0.15 0.08 0.05
131 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
132 INT274833 Negative_regulation of Dusp6 Positive_regulation of Mapk1 1 0.01 0 0.04
133 INT343540 Binding of PPP1R12A and MLC1 1 0.09 0.15 0.04
134 INT313462 Syp Positive_regulation of Binding of Ppp2ca 1 0.47 0 0.04
135 INT332323 Mdp1 Regulation of Pirt 1 0.00 0 0.04
136 INT274830 Tlr4 Positive_regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03
137 INT253132 Il6 Positive_regulation of Gene_expression of Ptpn1 1 0.42 0.54 0.03
138 INT288199 Binding of Ptprc and Trav6-3 1 0.00 0.05 0.03
139 INT313464 Negative_regulation of Ppp2ca Positive_regulation of Phosphorylation of Mapk1 1 0.09 0 0.03
140 INT277429 Ptpn2 Regulation of Gdnf 1 0.34 0.47 0.03
141 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
142 INT313445 53T Regulation of Ppp2ca 1 0.00 0 0.03
143 INT277427 Ptpn2 Positive_regulation of Gene_expression of Gdnf 1 0.32 0.47 0.03
144 INT295349 Binding of Ptpn11 and Grb7 1 0.13 0.11 0.03
145 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
146 INT277428 Positive_regulation of Ptpn2 Positive_regulation of Gdnf 1 0.29 0.47 0.03
147 INT274829 Tlr4 Regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03
148 INT244026 Ppp1cc Regulation of Phosphorylation of Camk2a 1 0.03 0 0
149 INT354123 MIR124-1 Negative_regulation of Gene_expression of CTDSP1 1 0.01 0.15 0
150 INT314397 Binding of Ptpn6 and Slc17a7 1 0.05 0 0
151 INT295338 Ptpn11 Regulation of Binding of Xpo1 1 0.02 0 0
152 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
153 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0
154 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
155 INT332268 Binding of Cndp2 and Tenc1 1 0.05 0.17 0
156 INT314393 Ptpn6 Regulation of 1190002H23Rik 1 0.01 0 0
157 INT276044 Binding of Pde1b and Ppp1cc 1 0.12 0 0
158 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0
159 INT295340 Binding of Ptpn11 and Fig4 1 0.04 0 0
160 INT210548 SCARA3 Regulation of Tenc1 1 0.03 0 0
161 INT297212 Gene_expression of Ppp3ca Positive_regulation of Nfatc1 1 0.38 0.22 0
162 INT296211 Binding of Ptprc and Tg(CAG-EGFP)D4Nagy 1 0.01 0.13 0
163 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
164 INT276073 Camk2a Regulation of Ppp1cc 1 0.10 0 0
165 INT314402 Positive_regulation of Ptpn6 Regulation of 1190002H23Rik 1 0.02 0 0
166 INT196434 Binding of Ccne2 and Cdc25a 1 0.01 0.48 0
167 INT313457 Ppp2ca Regulation of Th 1 0.36 0 0
168 INT249825 Gopc Positive_regulation of Ppp4c 1 0.12 0.06 0
169 INT314403 Ptpn6 Positive_regulation of Gpsm2 1 0.12 0.07 0
170 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0
171 INT196836 Binding of Ppp1cc and Phospho1 1 0.00 0 0
172 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0
173 INT314398 Ptpn6 Regulation of Gene_expression of Ctbs 1 0.03 0 0
174 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
175 INT242674 Binding of Pde6b and Ppp3cb 1 0.00 0.6 0
176 INT313465 Syp Regulation of Regulation of Ppp2ca 1 0.26 0.56 0
177 INT348723 ED Positive_regulation of PTEN 1 0.04 1.3 0
178 INT313426 Positive_regulation of Ppp2ca Positive_regulation of Bax 1 0.46 0.36 0
179 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0
180 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
181 INT327448 Binding of REN and PPAP2B 1 0.01 0.26 0
182 INT313296 Binding of KEAP1 and PGAM5 1 0.11 0.15 0
183 INT351682 Fut1 Positive_regulation of PTEN 1 0.01 1.81 0
184 INT253144 Il6 Positive_regulation of Ptpn1 1 0.62 0.42 0
185 INT228285 Binding of Ptprc and Nt5e 1 0.06 0.25 0
186 INT351164 CAV1 Negative_regulation of Ppp1cc 1 0.11 1.5 0
187 INT223574 PTEN Negative_regulation of AKT1 1 0.06 0.56 0
188 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
189 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
190 INT295359 Ptpn11 Regulation of Phosphorylation of Grb7 1 0.10 0 0
191 INT245865 Binding of Cd34 and Ptprc 1 0.04 0 0
192 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0
193 INT314396 Binding of Ptpn6 and Slc17a6 1 0.05 0 0
194 INT276074 Binding of Car2 and Ppp1cc 1 0.09 0 0
195 INT217770 MIR181A1 Regulation of PPP3CB 1 0.00 0.7 0
196 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0
197 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0
198 INT244020 Ppp1cc Negative_regulation of Gabrg1 1 0.10 0 0
199 INT297215 Gene_expression of Ppp3ca Positive_regulation of Ppp3r1 1 0.36 0.22 0
200 INT221247 Hspa9 Negative_regulation of Ptpn2 1 0.03 0.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphoprotein phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in phosphoprotein phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87
2 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12
3 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
4 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
5 INT195203 Binding of Tenc1 14 0.32 13.97 8.28
6 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
7 INT72884 Positive_regulation of Tenc1 13 0.42 14.01 7.67
8 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48
9 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4
10 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
11 INT90275 Negative_regulation of Ppp1cc 29 0.58 1.91 7.11
12 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
13 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
14 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21
15 INT58079 Localization of Tenc1 13 0.68 5.9 4.75
16 INT196782 Positive_regulation of Ppp2ca 32 0.61 1.89 4.33
17 INT71868 Regulation of Tenc1 9 0.52 10.73 4.09
18 INT43903 Regulation of Ptpn2 21 0.41 15.51 4.08
19 INT90277 Negative_regulation of Ppp2ca 15 0.41 4.04 4.02
20 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
21 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59
22 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
23 INT15930 Positive_regulation of Ptprs 8 0.67 7.02 3.48
24 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
25 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
26 INT37601 Negative_regulation of Ptprs 8 0.42 3.7 3.29
27 INT196779 Phosphorylation of Ppp2ca 28 0.72 1.86 3.25
28 INT111099 Positive_regulation of Dusp1 11 0.68 7.62 3.18
29 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
30 INT192676 Binding of PTEN 14 0.46 10.58 3.06
31 INT90276 Gene_expression of Ppp1cc 10 0.73 0.83 2.87
32 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
33 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
34 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
35 INT90273 Positive_regulation of Ppp1cc 10 0.41 0.82 2.71
36 INT98457 Phosphorylation of Ppp1cc 11 0.33 0.12 2.57
37 INT187454 Binding of Ptprc 34 0.38 9.66 2.54
38 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
39 INT210527 Positive_regulation of Gene_expression of Tenc1 14 0.38 6.37 2.45
40 INT111098 Regulation of Dusp1 5 0.27 3.03 2.45
41 INT100805 Binding of Ppp1cc 7 0.47 1.77 2.23
42 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
43 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
44 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
45 INT102056 Protein_catabolism of Tenc1 14 0.84 6.29 2.14
46 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
47 INT90272 Gene_expression of Ppp2ca 18 0.68 4.69 2.08
48 INT268616 Positive_regulation of Gene_expression of Ptpn2 7 0.43 8.14 2.08
49 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
50 INT317880 Regulation of Gene_expression of Dusp1 2 0.42 2.98 1.94
51 INT207100 Gene_expression of Ptpn1 13 0.73 8.13 1.68
52 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
53 INT206528 Negative_regulation of Gene_expression of Ptprc 8 0.34 3.91 1.61
54 INT211853 Phosphorylation of Tenc1 2 0.61 2.53 1.59
55 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
56 INT274884 Positive_regulation of Dusp6 1 0.07 2.08 1.52
57 INT207092 Localization of Dusp1 6 0.70 4.7 1.51
58 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
59 INT128478 Positive_regulation of Ptprc 26 0.44 8.1 1.45
60 INT228249 Binding of Pten 7 0.48 3.26 1.45
61 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
62 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
63 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
64 INT274892 Gene_expression of Dusp6 1 0.08 1.81 1.4
65 INT144805 Regulation of Negative_regulation of Ppp2ca 1 0.28 0.24 1.38
66 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
67 INT164817 Negative_regulation of Regulation of Ptpn2 1 0.01 0 1.29
68 INT206515 Regulation of Gene_expression of Ptprc 6 0.39 3.4 1.22
69 INT190014 Regulation of Pten 8 0.62 6.03 1.2
70 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
71 INT196785 Regulation of Ppp2ca 5 0.54 2.1 1.17
72 INT221190 Phosphorylation of Ptpn2 9 0.48 7 1.15
73 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
74 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
75 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
76 INT62237 Gene_expression of Ptprf 2 0.65 1.63 1.08
77 INT236138 Negative_regulation of Ptpn1 10 0.55 5.83 1.04
78 INT280495 Regulation of PPAP2B 1 0.06 1.64 1
79 INT125960 Gene_expression of Ptprs 8 0.78 2.87 0.99
80 INT253114 Positive_regulation of Ptpn1 9 0.44 5.48 0.96
81 INT90278 Localization of Ppp2ca 4 0.66 1.12 0.94
82 INT43902 Binding of Ptpn2 6 0.29 3.59 0.93
83 INT274888 Negative_regulation of Dusp6 1 0.06 1.82 0.93
84 INT210534 Positive_regulation of Localization of Tenc1 4 0.59 1.39 0.92
85 INT196754 Binding of Ppp2ca 5 0.37 0.42 0.89
86 INT221210 Negative_regulation of Gene_expression of Ptpn2 9 0.37 8.3 0.84
87 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
88 INT349490 Positive_regulation of Positive_regulation of Ptpn2 1 0.39 2.33 0.8
89 INT221218 Regulation of Negative_regulation of Ptpn2 3 0.30 2.69 0.79
90 INT253103 Negative_regulation of Gene_expression of Ptpn1 1 0.55 2.56 0.79
91 INT196741 Positive_regulation of Negative_regulation of Ppp1cc 3 0.33 0.42 0.76
92 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
93 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
94 INT196753 Negative_regulation of Phosphorylation of Ppp2ca 3 0.37 0.52 0.7
95 INT196742 Positive_regulation of Positive_regulation of Ppp2ca 4 0.44 0.05 0.68
96 INT210523 Positive_regulation of Negative_regulation of Tenc1 2 0.43 2.42 0.68
97 INT226221 Binding of Dusp1 1 0.04 0.92 0.68
98 INT276199 Binding of Pten 2 0.30 0.4 0.67
99 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
100 INT196739 Regulation of Ppp1cc 5 0.19 0 0.63
101 INT209225 Regulation of Ptprs 3 0.12 1.84 0.63
102 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
103 INT274881 Regulation of Dusp6 1 0.04 0.9 0.63
104 INT276179 Regulation of Pten 1 0.46 0.81 0.63
105 INT195202 Negative_regulation of Gene_expression of Tenc1 7 0.24 3.76 0.62
106 INT296253 Negative_regulation of Gene_expression of Ppp2ca 3 0.41 1.71 0.62
107 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
108 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
109 INT196765 Positive_regulation of Gene_expression of Ppp2ca 4 0.44 1.05 0.6
110 INT100804 Regulation of Gene_expression of Ppp1cc 2 0.18 0 0.6
111 INT274885 Negative_regulation of Gene_expression of Dusp6 1 0.04 0.89 0.6
112 INT221207 Localization of Ptpn2 5 0.74 5.76 0.59
113 INT21087 Negative_regulation of Ppp3ca 2 0.32 0.31 0.58
114 INT161322 Localization of PTEN 9 0.73 5.65 0.57
115 INT100803 Regulation of Phosphorylation of Ppp1cc 1 0.10 0 0.57
116 INT191677 Positive_regulation of Gene_expression of Dusp1 2 0.20 4.93 0.55
117 INT274880 Negative_regulation of Positive_regulation of Dusp6 1 0.04 0.89 0.52
118 INT243952 Phosphorylation of Ppp1ca 3 0.11 0.33 0.51
119 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
120 INT143131 Regulation of Ptprc 4 0.27 2.56 0.5
121 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
122 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
123 INT110748 Transcription of Tenc1 5 0.30 3.06 0.48
124 INT253098 Positive_regulation of Gene_expression of Ptpn1 3 0.65 2.05 0.48
125 INT92962 Negative_regulation of Regulation of Tenc1 1 0.34 1.32 0.48
126 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
127 INT92960 Positive_regulation of Regulation of Tenc1 1 0.37 1.32 0.47
128 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
129 INT126428 Negative_regulation of Negative_regulation of Ppp1cc 1 0.42 0 0.45
130 INT112689 Protein_catabolism of Ptpn2 1 0.59 1.45 0.44
131 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
132 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
133 INT187463 Positive_regulation of Gene_expression of Ptprc 9 0.44 2.8 0.42
134 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
135 INT167616 Protein_catabolism of Ppp2cb 1 0.02 0.87 0.42
136 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
137 INT203816 Localization of Pten 4 0.75 1.37 0.4
138 INT264827 Negative_regulation of Ppp1ca 2 0.08 0.19 0.4
139 INT71922 Binding of Ptprs 2 0.11 0.29 0.37
140 INT207088 Localization of Ptpn1 2 0.35 1.48 0.36
141 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
142 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
143 INT231497 Negative_regulation of Binding of Ptprc 2 0.34 0.99 0.33
144 INT111097 Negative_regulation of Dusp1 3 0.58 1.41 0.32
145 INT281469 Transcription of Pten 2 0.72 1.12 0.32
146 INT264073 Positive_regulation of Negative_regulation of Ptpn2 1 0.13 0.86 0.32
147 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
148 INT188420 Positive_regulation of Pdxp 1 0.04 0.8 0.32
149 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
150 INT178400 Negative_regulation of Gene_expression of Dusp1 4 0.40 3.61 0.31
151 INT196732 Localization of Ppp1cc 2 0.30 0 0.31
152 INT86549 Positive_regulation of Ppm1f 1 0.66 0 0.31
153 INT34275 Positive_regulation of Ppp3ca 2 0.31 0.24 0.27
154 INT354815 Transcription of Ptpn2 1 0.29 0.61 0.27
155 INT274883 Positive_regulation of Gene_expression of Dusp6 1 0.07 0.39 0.27
156 INT264830 Regulation of Phosphorylation of Ppp1ca 1 0.05 0.06 0.27
157 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
158 INT227102 Gene_expression of Mtm1 2 0.77 9.58 0.26
159 INT187465 Localization of Ptprc 8 0.62 3.71 0.25
160 INT187460 Transcription of Ptprc 2 0.44 0.51 0.25
161 INT310814 Phosphorylation of Ptpn4 1 0.55 0.8 0.25
162 INT274876 Positive_regulation of Positive_regulation of Dusp6 1 0.04 0.49 0.25
163 INT209220 Regulation of Regulation of Ptprs 1 0.09 0.56 0.23
164 INT310815 Gene_expression of Ptpn4 1 0.46 0.8 0.23
165 INT196761 Regulation of Positive_regulation of Ppp2ca 2 0.40 0.05 0.22
166 INT1594 Binding of Ppp3ca 1 0.29 0 0.22
167 INT196763 Positive_regulation of Regulation of Ppp2ca 1 0.30 0 0.21
168 INT196787 Positive_regulation of Localization of Ppp1cc 1 0.20 0 0.21
169 INT196759 Negative_regulation of Negative_regulation of Ppp2ca 2 0.30 0.17 0.2
170 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
171 INT289228 Localization of Ptpn11 1 0.15 0.87 0.18
172 INT349489 Negative_regulation of Positive_regulation of Ptpn2 1 0.33 0.81 0.17
173 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
174 INT280906 Negative_regulation of Ptprc 2 0.15 2.26 0.16
175 INT196770 Negative_regulation of Positive_regulation of Ppp2ca 1 0.27 0 0.16
176 INT187456 Regulation of Binding of Ptprc 1 0.29 0.51 0.15
177 INT221451 Negative_regulation of Positive_regulation of Dusp1 2 0.35 1.17 0.14
178 INT96224 Positive_regulation of Ptprf 1 0.11 0.36 0.14
179 INT86546 Gene_expression of Ppm1f 1 0.64 0 0.14
180 INT196751 Negative_regulation of Phosphorylation of Ppp1cc 1 0.17 0 0.14
181 INT221205 Regulation of Phosphorylation of Ptpn2 1 0.26 0.93 0.14
182 INT237340 Positive_regulation of Mtm1 1 0.60 1.52 0.14
183 INT200943 Negative_regulation of PPP2CA 1 0.10 0.13 0.14
184 INT337099 Positive_regulation of Phosphorylation of Ppp1ca 1 0.08 0.13 0.13
185 INT69864 Binding of Mdp1 1 0.01 0 0.13
186 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
187 INT184029 Binding of Ptpn11 2 0.19 0.18 0.12
188 INT217824 Positive_regulation of PPP3CB 2 0.19 1.02 0.11
189 INT310818 Positive_regulation of Gene_expression of Ptpn4 1 0.30 0.37 0.11
190 INT313409 Positive_regulation of Phosphorylation of Ppp2ca 1 0.39 0.16 0.11
191 INT295368 Localization of Ptpn11 1 0.25 0 0.11
192 INT253100 Positive_regulation of Positive_regulation of Ptpn1 1 0.44 0.81 0.11
193 INT243967 Localization of Ppp1ca 1 0.01 0.15 0.11
194 INT313423 Positive_regulation of Localization of Ppp2ca 1 0.44 0.12 0.1
195 INT245585 Binding of Ptpn4 1 0.31 0.19 0.1
196 INT213470 Positive_regulation of Ptpn11 1 0.05 0.07 0.1
197 INT231491 Regulation of Positive_regulation of Ptprc 1 0.35 0.18 0.1
198 INT195204 Regulation of Gene_expression of Tenc1 3 0.25 2.37 0.09
199 INT231493 Positive_regulation of Binding of Ptprc 1 0.39 0.19 0.09
200 INT213468 Regulation of Ptpn11 1 0.05 0.08 0.09
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