GO:0004725

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Name protein tyrosine phosphatase activity
Categary Function
Go Slim No
Go Link GO:0004725
Unique Molecular Interactions 331
Total Molecular Interactions 435
Total Single Events 3351
Pain Genes Associated 49

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for protein tyrosine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
2 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
3 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29
4 INT203044 Binding of PDCD1 and DTHD1 1 0.02 3.19 1.87
5 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5
6 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
7 INT64259 Binding of Gtpbp4 and Ptprg 1 0.06 0 1.1
8 INT37153 Binding of Mpz and Ptpn2 1 0.12 0.68 1.08
9 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
10 INT348175 Binding of NIDDM1 and PTPN22 1 0.01 2.36 0.99
11 INT203040 Binding of PDCD1 and PDCD1LG2 3 0.40 4.86 0.98
12 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
13 INT111504 Pnoc Positive_regulation of Binding of Ptprg 1 0.01 0 0.96
14 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
15 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
16 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
17 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
18 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85
19 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
20 INT116558 Ptpn5 Positive_regulation of Nfkb1 1 0.46 2.01 0.83
21 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
22 INT73462 PTPLA Regulation of Gene_expression of SART1 1 0.00 0.79 0.82
23 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
24 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
25 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
26 INT72689 Binding of Oprd1 and Ptprg 1 0.00 0.38 0.71
27 INT111506 Negative_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71
28 INT111505 Positive_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71
29 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69
30 INT203046 Binding of PDCD1 and CD274 2 0.40 3.97 0.68
31 INT232620 Ptpn4 Regulation of Cysltr1 1 0.02 0.58 0.68
32 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
33 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67
34 INT274871 Positive_regulation of Cbr2 Positive_regulation of Positive_regulation of Dusp6 1 0.02 0.72 0.67
35 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
36 INT253935 Binding of PTPLA and Trpv1 1 0.14 1.25 0.65
37 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
38 INT329961 Binding of IL2RA and PTPN22 1 0.35 1.87 0.63
39 INT169285 PTPLA Positive_regulation of GRAP2 1 0.03 0.15 0.63
40 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63
41 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
42 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
43 INT5544 Ptpro Regulation of Syt17 1 0.05 0 0.6
44 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
45 INT169291 CNR1 Positive_regulation of Gene_expression of PTPLA 1 0.19 0.11 0.59
46 INT352463 Gse1 Regulation of Gene_expression of Dusp1 1 0.07 0 0.59
47 INT169298 TRPV1 Positive_regulation of Gene_expression of PTPLA 1 0.20 0.11 0.59
48 INT169292 Positive_regulation of CNR1 Positive_regulation of Gene_expression of PTPLA 1 0.19 0.11 0.59
49 INT203056 Binding of Cd274 and PDCD1LG2 1 0.13 1.61 0.57
50 INT203041 Binding of CD274 and PDCD1LG2 1 0.03 1.61 0.57
51 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
52 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
53 INT144932 DUSP5 Negative_regulation of TRPV1 1 0.00 0 0.48
54 INT83690 Binding of Oprm1 and Ptprg 1 0.00 0.08 0.48
55 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
56 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
57 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
58 INT111509 Pnoc Positive_regulation of Binding of Ptprg 1 0.00 0 0.47
59 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
60 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46
61 INT191691 Igh-Dex Positive_regulation of Dusp1 1 0.02 1.8 0.46
62 INT52383 Binding of Gs and Ptprg 1 0.00 0.48 0.44
63 INT72016 Positive_regulation of Binding of Gnai2 and Ptprg 1 0.02 0 0.44
64 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
65 INT77585 Binding of Htr1a and Ptprg 1 0.01 0 0.42
66 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
67 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42
68 INT77584 Negative_regulation of Binding of Htr1a and Ptprg 1 0.01 0 0.42
69 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
70 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
71 INT33380 Binding of PTPLA and NPL 1 0.23 0.27 0.41
72 INT72018 Binding of Gnai2 and Ptprg 1 0.01 0 0.41
73 INT66660 Pck1 Positive_regulation of Localization of Ptprg 1 0.07 0 0.4
74 INT129768 Binding of LYZ and PTPRC 1 0.34 0.87 0.37
75 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
76 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
77 INT71925 Binding of Ptprs and Positive_regulation of Racgap1 1 0.10 0 0.35
78 INT71924 Ptprs Positive_regulation of Racgap1 1 0.10 0 0.35
79 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
80 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
81 INT328043 Binding of PTPRC and Enox2 1 0.00 0.88 0.34
82 INT328044 Positive_regulation of Binding of PTPRC and Enox2 1 0.00 0.89 0.34
83 INT328045 Binding of PTPRC and Tag 1 0.00 0.88 0.34
84 INT352445 Gse1 Positive_regulation of Gene_expression of Dusp1 1 0.06 0.41 0.34
85 INT253147 Positive_regulation of Nr1h2 Negative_regulation of Positive_regulation of Ptpn1 1 0.17 0.61 0.33
86 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32
87 INT264504 Binding of CRYGD and PTPN22 1 0.04 0.42 0.31
88 INT203055 Binding of PDCD1 and Cd274 1 0.40 0.8 0.29
89 INT106893 Ptpn2 Positive_regulation of Tac1 1 0.02 2.02 0.29
90 INT218936 Dusp1 Negative_regulation of Ephb1 2 0.03 0.89 0.28
91 INT259936 CTLA4 Regulation of PTPN22 1 0.45 1.64 0.28
92 INT352458 Dusp1 Regulation of Gene_expression of Tnc 1 0.07 0 0.28
93 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
94 INT352443 Gse1 Regulation of Dusp1 1 0.03 0 0.27
95 INT333549 Binding of CTLA4 and PDCD1 1 0.36 1.2 0.27
96 INT352449 Dusp1 Regulation of Gene_expression of Slc1a3 1 0.05 0 0.27
97 INT352466 Calca Regulation of Gene_expression of Dusp1 1 0.04 0 0.27
98 INT116561 Ptpn5 Positive_regulation of Nfkb1 1 0.04 0.66 0.27
99 INT222986 PTPRC Positive_regulation of SMN1 1 0.01 0.46 0.26
100 INT222975 PTPRC Positive_regulation of VIM 1 0.05 0.46 0.26
101 INT259937 Binding of CSK and PTPN22 1 0.21 1.69 0.25
102 INT261976 Binding of PDCD1 and SUGT1 1 0.00 1.3 0.25
103 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
104 INT78296 Negative_regulation of Binding of Ptpra and Ldlr 1 0.22 0.25 0.24
105 INT60130 Binding of pcp and Ptprs 1 0.00 0 0.24
106 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
107 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
108 INT78291 Binding of Ptpra and Ldlr 1 0.20 0.25 0.24
109 INT165637 Ptpn6 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.57 0.23
110 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
111 INT106761 Tlr4 Positive_regulation of Dusp1 1 0.01 0.16 0.21
112 INT72019 Binding of Gnaq and Ptprg 1 0.01 0 0.21
113 INT71923 Ptprs Regulation of Racgap1 1 0.09 0 0.21
114 INT165636 Ptpn6 Regulation of Nfkb1 1 0.01 0.36 0.2
115 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
116 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
117 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
118 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19
119 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
120 INT334314 Tlr4 Positive_regulation of Gene_expression of Dusp1 1 0.01 0.37 0.19
121 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19
122 INT274832 Dusp6 Positive_regulation of Localization of Tlr4 1 0.00 0 0.19
123 INT338898 Binding of PECAM1 and PTPN11 1 0.04 0.38 0.19
124 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
125 INT221234 Gja3 Regulation of Binding of Ptpn2 1 0.08 0.58 0.18
126 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
127 INT253127 Il6 Regulation of Gene_expression of Ptpn1 1 0.24 1.31 0.17
128 INT96559 Binding of PTPRC and KRT20 2 0.33 1.99 0.16
129 INT330388 Binding of PTPRC and TLR2 1 0.00 1.19 0.16
130 INT172674 Ptpn6 Negative_regulation of Gene_expression of Plat 1 0.02 1.3 0.16
131 INT349505 Ptpn2 Negative_regulation of Slc6a3 1 0.19 0.7 0.16
132 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16
133 INT34451 Binding of Itpr3 and Ptprg 1 0.03 0 0.15
134 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
135 INT253154 TNF Positive_regulation of Ptpn1 1 0.73 0.91 0.15
136 INT273238 Grin1 Positive_regulation of Ptprs 1 0.07 0.51 0.14
137 INT153154 OPN1MW Regulation of PTPRF 1 0.03 0.51 0.14
138 INT222783 Binding of MR1 and PTPRC 1 0.00 0.46 0.14
139 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12
140 INT34443 Negative_regulation of Binding of Trh and Ptprg 1 0.20 0.08 0.12
141 INT212808 Rngtt Negative_regulation of Gene_expression of Ptger2 1 0.00 0.31 0.12
142 INT34445 Binding of Trh and Ptprg 1 0.23 0.08 0.12
143 INT352467 Dusp1 Negative_regulation of Mapk8 1 0.02 0.23 0.12
144 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
145 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
146 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
147 INT106894 Ptpn2 Negative_regulation of Tac1 1 0.02 1.17 0.1
148 INT212814 Rngtt Negative_regulation of Gene_expression of Tlr4 1 0.00 0.08 0.1
149 INT212807 Rngtt Negative_regulation of Nos2 1 0.03 0.08 0.1
150 INT212811 Rngtt Negative_regulation of Tlr4 1 0.00 0.08 0.1
151 INT338901 Binding of PECAM1 and PTPN6 1 0.03 0.18 0.1
152 INT267587 PTAFR Positive_regulation of Localization of PTPRC 1 0.00 2.04 0.09
153 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
154 INT253300 Itgam Positive_regulation of Gene_expression of Ptprc 1 0.19 0.11 0.09
155 INT20959 Binding of PTPRC and Pak1 1 0.01 0.76 0.09
156 INT343794 Binding of F8 and PTPRC 1 0.00 0.69 0.09
157 INT259938 Binding of CTLA4 and PTPN22 1 0.36 0.85 0.08
158 INT91097 Ptprg Positive_regulation of Npr1 1 0.00 0.62 0.08
159 INT316792 Binding of HLA-DRB1 and Ptpn22 1 0.07 0.33 0.08
160 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
161 INT103810 Binding of PTPRC and RPL26 1 0.09 1.01 0.08
162 INT267017 Bdnf Positive_regulation of Dusp6 1 0.13 0.1 0.07
163 INT34448 Trh Negative_regulation of Negative_regulation of Ptprg 1 0.23 0 0.07
164 INT159463 Ptprn2 Negative_regulation of HPSE 1 0.00 0 0.07
165 INT244130 Binding of CASP1 and RNGTT 1 0.07 0.24 0.07
166 INT244131 Binding of RNGTT and NLRP1 1 0.11 0.24 0.07
167 INT221232 Ptpn2 Positive_regulation of Gene_expression of Ros1 1 0.04 1.12 0.07
168 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07
169 INT231507 Binding of Ptprc and Tlr4 2 0.21 1.22 0.06
170 INT277432 Ptpn2 Positive_regulation of Gdnf 1 0.29 1.41 0.06
171 INT236363 Regulation of Binding of Ptprc and Tlr4 1 0.25 1.23 0.06
172 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
173 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05
174 INT179852 Binding of PTPRC and Ecm1 1 0.00 0 0.05
175 INT34447 Ptprg Positive_regulation of Itpr3 1 0.04 0 0.05
176 INT237351 Binding of Mtm1 and Gopc 1 0.19 0.17 0.05
177 INT341542 Binding of DUSP4 and MAPK8 1 0.04 0.28 0.05
178 INT221251 PRKG1 Negative_regulation of Positive_regulation of Ptpn2 1 0.04 0.7 0.05
179 INT295337 Egf Positive_regulation of Ptpn11 1 0.15 0.08 0.05
180 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
181 INT341533 DUSP4 Regulation of MAPK8 1 0.03 0.28 0.05
182 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04
183 INT265451 CSPG4 Positive_regulation of RNGTT 1 0.03 0.24 0.04
184 INT274833 Negative_regulation of Dusp6 Positive_regulation of Mapk1 1 0.01 0 0.04
185 INT227072 Binding of LTF and PTPRC 1 0.00 0.51 0.04
186 INT332323 Mdp1 Regulation of Pirt 1 0.00 0 0.04
187 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04
188 INT336639 PTPRC Positive_regulation of Ecm1 1 0.00 0.62 0.04
189 INT244129 Binding of RNGTT and NOD1 1 0.11 0 0.04
190 INT274830 Tlr4 Positive_regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03
191 INT253132 Il6 Positive_regulation of Gene_expression of Ptpn1 1 0.42 0.54 0.03
192 INT288199 Binding of Ptprc and Trav6-3 1 0.00 0.05 0.03
193 INT259935 CSK Positive_regulation of Negative_regulation of LCK 1 0.09 0.57 0.03
194 INT277429 Ptpn2 Regulation of Gdnf 1 0.34 0.47 0.03
195 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
196 INT259940 CSK Positive_regulation of Phosphorylation of LCK 1 0.09 0.51 0.03
197 INT277427 Ptpn2 Positive_regulation of Gene_expression of Gdnf 1 0.32 0.47 0.03
198 INT259939 Negative_regulation of Binding of CSK and PTPN22 1 0.19 0.62 0.03
199 INT329729 Binding of LCK and Fyn 1 0.00 0.21 0.03
200 INT337183 Binding of TLR3 and Positive_regulation of CD274 1 0.16 0.31 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein tyrosine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in protein tyrosine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT21185 Binding of Ptprg 213 0.47 13.49 157.75
2 INT72011 Positive_regulation of Binding of Ptprg 42 0.50 2.72 39.89
3 INT21186 Negative_regulation of Binding of Ptprg 28 0.44 1.78 27.04
4 INT75421 Regulation of Binding of Ptprg 13 0.44 0.96 12.64
5 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57
6 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
7 INT26248 Positive_regulation of Ptprg 12 0.40 1.42 9.48
8 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
9 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
10 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48
11 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4
12 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
13 INT106757 Gene_expression of Dusp1 9 0.66 10.45 7.26
14 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
15 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76
16 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
17 INT106756 Positive_regulation of Gene_expression of Dusp1 7 0.59 7.65 5.24
18 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21
19 INT245593 Gene_expression of PTPN3 32 0.38 10.68 5.09
20 INT203050 Binding of PDCD1 12 0.48 12.93 4.5
21 INT21188 Negative_regulation of Ptprg 9 0.37 0.62 4.16
22 INT43903 Regulation of Ptpn2 21 0.41 15.51 4.08
23 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
24 INT11261 Positive_regulation of PTPLA 3 0.50 4.4 3.74
25 INT28389 Negative_regulation of Ptpra 5 0.37 0.4 3.69
26 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59
27 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
28 INT15930 Positive_regulation of Ptprs 8 0.67 7.02 3.48
29 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45
30 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
31 INT167647 Binding of PTPN5 2 0.32 3.21 3.38
32 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
33 INT106760 Positive_regulation of Dusp1 16 0.59 8.5 3.35
34 INT37601 Negative_regulation of Ptprs 8 0.42 3.7 3.29
35 INT111099 Positive_regulation of Dusp1 11 0.68 7.62 3.18
36 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
37 INT192676 Binding of PTEN 14 0.46 10.58 3.06
38 INT202606 Regulation of PTPN5 1 0.26 3.92 3.04
39 INT21187 Regulation of Ptprg 7 0.39 0.38 2.93
40 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
41 INT246978 Binding of PTPLA 3 0.18 3.62 2.79
42 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74
43 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
44 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
45 INT203048 Gene_expression of PDCD1 13 0.78 8.5 2.62
46 INT187454 Binding of Ptprc 34 0.38 9.66 2.54
47 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
48 INT230758 Positive_regulation of Gene_expression of PTPRC 11 0.49 6.04 2.45
49 INT111098 Regulation of Dusp1 5 0.27 3.03 2.45
50 INT9721 Gene_expression of Ptpra 3 0.26 5.97 2.38
51 INT203049 Negative_regulation of PDCD1 6 0.43 7.15 2.36
52 INT231573 Binding of PTPN22 5 0.44 7.94 2.33
53 INT203047 Gene_expression of CD274 16 0.52 12.32 2.21
54 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
55 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
56 INT49433 Binding of PTPRM 2 0.02 0.26 2.15
57 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
58 INT122671 Positive_regulation of LCK 4 0.13 2.69 2.14
59 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
60 INT268616 Positive_regulation of Gene_expression of Ptpn2 7 0.43 8.14 2.08
61 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
62 INT317880 Regulation of Gene_expression of Dusp1 2 0.42 2.98 1.94
63 INT49432 Gene_expression of PTPRM 2 0.04 0.27 1.87
64 INT202602 Positive_regulation of PTPN5 4 0.29 3.34 1.83
65 INT244169 Localization of RNGTT 8 0.23 1.92 1.81
66 INT15556 Positive_regulation of Epm2a 3 0.44 1.53 1.69
67 INT38266 Localization of PTPRC 30 0.68 17.05 1.68
68 INT207100 Gene_expression of Ptpn1 13 0.73 8.13 1.68
69 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
70 INT206528 Negative_regulation of Gene_expression of Ptprc 8 0.34 3.91 1.61
71 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59
72 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
73 INT274884 Positive_regulation of Dusp6 1 0.07 2.08 1.52
74 INT207092 Localization of Dusp1 6 0.70 4.7 1.51
75 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
76 INT265567 Localization of PTPN5 1 0.49 1.39 1.47
77 INT128478 Positive_regulation of Ptprc 26 0.44 8.1 1.45
78 INT228249 Binding of Pten 7 0.48 3.26 1.45
79 INT122672 Regulation of Positive_regulation of LCK 1 0.06 1.15 1.44
80 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
81 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
82 INT178898 Gene_expression of PTPN5 4 0.38 3.06 1.4
83 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
84 INT271464 Transcription of Ptpro 1 0.02 0.95 1.4
85 INT274892 Gene_expression of Dusp6 1 0.08 1.81 1.4
86 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
87 INT65121 Negative_regulation of Ptpro 1 0.02 0.97 1.36
88 INT154497 Gene_expression of Ptprq 3 0.04 0.91 1.31
89 INT164817 Negative_regulation of Regulation of Ptpn2 1 0.01 0 1.29
90 INT316787 Binding of Ptpn22 1 0.29 3.61 1.29
91 INT90771 Positive_regulation of Ptprc 20 0.48 8.43 1.27
92 INT74254 Binding of PTPRC 16 0.36 8.37 1.27
93 INT37253 Negative_regulation of PTPRC 12 0.37 6.13 1.26
94 INT26372 Localization of Ptprg 2 0.10 0.09 1.24
95 INT245598 Positive_regulation of PTPN3 3 0.34 1.13 1.23
96 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22
97 INT206515 Regulation of Gene_expression of Ptprc 6 0.39 3.4 1.22
98 INT190014 Regulation of Pten 8 0.62 6.03 1.2
99 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
100 INT12435 Binding of Ptprs 1 0.06 0 1.17
101 INT221190 Phosphorylation of Ptpn2 9 0.48 7 1.15
102 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
103 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
104 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
105 INT178674 Positive_regulation of RNGTT 6 0.15 1.05 1.09
106 INT62237 Gene_expression of Ptprf 2 0.65 1.63 1.08
107 INT33884 Gene_expression of Ptprg 3 0.59 0.83 1.07
108 INT236138 Negative_regulation of Ptpn1 10 0.55 5.83 1.04
109 INT125960 Gene_expression of Ptprs 8 0.78 2.87 0.99
110 INT147464 Binding of Ptprc 13 0.36 15.18 0.98
111 INT248588 Gene_expression of LCK 9 0.28 4.9 0.98
112 INT253114 Positive_regulation of Ptpn1 9 0.44 5.48 0.96
113 INT9722 Negative_regulation of Gene_expression of Ptpra 1 0.15 0.8 0.96
114 INT43902 Binding of Ptpn2 6 0.29 3.59 0.93
115 INT274888 Negative_regulation of Dusp6 1 0.06 1.82 0.93
116 INT294150 Regulation of Gene_expression of PTPRC 6 0.32 3.3 0.88
117 INT221210 Negative_regulation of Gene_expression of Ptpn2 9 0.37 8.3 0.84
118 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
119 INT42766 Localization of Dusp1 1 0.10 0 0.84
120 INT161311 Positive_regulation of Negative_regulation of LCK 2 0.45 0.74 0.83
121 INT147183 Gene_expression of RNGTT 16 0.37 2.43 0.82
122 INT25800 Negative_regulation of Negative_regulation of Ptprg 2 0.06 0.22 0.82
123 INT349490 Positive_regulation of Positive_regulation of Ptpn2 1 0.39 2.33 0.8
124 INT245596 Positive_regulation of Gene_expression of PTPN3 5 0.25 0.92 0.79
125 INT221218 Regulation of Negative_regulation of Ptpn2 3 0.30 2.69 0.79
126 INT253103 Negative_regulation of Gene_expression of Ptpn1 1 0.55 2.56 0.79
127 INT193313 Gene_expression of PDCD1LG2 7 0.57 3.52 0.76
128 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
129 INT250144 Positive_regulation of CD274 11 0.47 5.77 0.72
130 INT122670 Negative_regulation of Positive_regulation of LCK 1 0.06 0.58 0.72
131 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
132 INT119836 Positive_regulation of Gene_expression of PTPN11 5 0.67 3.44 0.69
133 INT253934 Positive_regulation of Binding of PTPLA 1 0.16 0.51 0.69
134 INT226221 Binding of Dusp1 1 0.04 0.92 0.68
135 INT276199 Binding of Pten 2 0.30 0.4 0.67
136 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
137 INT209225 Regulation of Ptprs 3 0.12 1.84 0.63
138 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
139 INT274881 Regulation of Dusp6 1 0.04 0.9 0.63
140 INT329708 Transcription of LCK 1 0.04 1.54 0.63
141 INT276179 Regulation of Pten 1 0.46 0.81 0.63
142 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
143 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
144 INT261979 Positive_regulation of PDCD1 4 0.49 6.95 0.61
145 INT244157 Negative_regulation of RNGTT 2 0.12 0.17 0.61
146 INT274885 Negative_regulation of Gene_expression of Dusp6 1 0.04 0.89 0.6
147 INT221207 Localization of Ptpn2 5 0.74 5.76 0.59
148 INT109505 Regulation of Ptprc 3 0.32 2.45 0.58
149 INT161322 Localization of PTEN 9 0.73 5.65 0.57
150 INT203051 Positive_regulation of Gene_expression of PDCD1 2 0.50 2.08 0.57
151 INT169304 Phosphorylation of PTPLA 1 0.23 0.18 0.57
152 INT191677 Positive_regulation of Gene_expression of Dusp1 2 0.20 4.93 0.55
153 INT274880 Negative_regulation of Positive_regulation of Dusp6 1 0.04 0.89 0.52
154 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
155 INT143131 Regulation of Ptprc 4 0.27 2.56 0.5
156 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
157 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
158 INT163579 Gene_expression of Epm2a 2 0.06 1.15 0.49
159 INT253098 Positive_regulation of Gene_expression of Ptpn1 3 0.65 2.05 0.48
160 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
161 INT144943 Positive_regulation of DUSP5 1 0.00 0 0.47
162 INT267615 Positive_regulation of Localization of PTPRC 3 0.01 3.41 0.46
163 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
164 INT203052 Regulation of PDCD1 1 0.39 0.79 0.45
165 INT112689 Protein_catabolism of Ptpn2 1 0.59 1.45 0.44
166 INT21183 Negative_regulation of Regulation of Ptprg 1 0.37 0.08 0.44
167 INT203053 Localization of PDCD1 1 0.70 1.55 0.44
168 INT119826 Positive_regulation of PTPN11 2 0.45 2.67 0.43
169 INT244163 Positive_regulation of Localization of RNGTT 1 0.15 0.08 0.43
170 INT33885 Positive_regulation of Gene_expression of Ptprg 1 0.02 0 0.43
171 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
172 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
173 INT187463 Positive_regulation of Gene_expression of Ptprc 9 0.44 2.8 0.42
174 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
175 INT218920 Phosphorylation of Dusp1 5 0.44 1.13 0.41
176 INT241304 Regulation of Transcription of PTPN11 3 0.43 4.49 0.41
177 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
178 INT321429 Positive_regulation of Gene_expression of PTPN6 1 0.03 1.78 0.41
179 INT245599 Regulation of Gene_expression of PTPN3 1 0.22 0.57 0.41
180 INT203816 Localization of Pten 4 0.75 1.37 0.4
181 INT189030 Phosphorylation of PTPN3 3 0.31 1.17 0.39
182 INT55723 Regulation of Regulation of Ptprs 1 0.26 0 0.39
183 INT55722 Regulation of Ptprs 1 0.26 0 0.39
184 INT212803 Gene_expression of Rngtt 6 0.37 0.47 0.37
185 INT71922 Binding of Ptprs 2 0.11 0.29 0.37
186 INT168101 Positive_regulation of PTPRF 2 0.45 1.04 0.37
187 INT106758 Negative_regulation of Positive_regulation of Dusp1 1 0.18 0.3 0.37
188 INT158592 Negative_regulation of CSK 2 0.19 0.43 0.36
189 INT207088 Localization of Ptpn1 2 0.35 1.48 0.36
190 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
191 INT245591 Negative_regulation of Gene_expression of PTPN3 2 0.21 0.44 0.35
192 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
193 INT329707 Negative_regulation of Transcription of LCK 1 0.04 0.9 0.35
194 INT231497 Negative_regulation of Binding of Ptprc 2 0.34 0.99 0.33
195 INT111097 Negative_regulation of Dusp1 3 0.58 1.41 0.32
196 INT281469 Transcription of Pten 2 0.72 1.12 0.32
197 INT264073 Positive_regulation of Negative_regulation of Ptpn2 1 0.13 0.86 0.32
198 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
199 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
200 INT178400 Negative_regulation of Gene_expression of Dusp1 4 0.40 3.61 0.31
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