GO:0004726

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Name non-membrane spanning protein tyrosine phosphatase activity
Categary Function
Go Slim No
Go Link GO:0004726
Unique Molecular Interactions 51
Total Molecular Interactions 67
Total Single Events 498
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for non-membrane spanning protein tyrosine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for non-membrane spanning protein tyrosine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
2 INT37153 Binding of Mpz and Ptpn2 1 0.12 0.68 1.08
3 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
4 INT144282 ACP1 Negative_regulation of Positive_regulation of PHOSPHO2 1 0.05 0.58 0.94
5 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
6 INT144284 ACP1 Negative_regulation of PHOSPHO2 1 0.05 0.58 0.93
7 INT144283 ACP1 Positive_regulation of ABCB1 1 0.63 0.6 0.81
8 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
9 INT232620 Ptpn4 Regulation of Cysltr1 1 0.02 0.58 0.68
10 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
11 INT227499 Binding of PTPN4 and ECA1 1 0.01 0.33 0.59
12 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46
13 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42
14 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
15 INT227496 PTPN4 Regulation of PMEL 1 0.00 0.45 0.33
16 INT106893 Ptpn2 Positive_regulation of Tac1 1 0.02 2.02 0.29
17 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19
18 INT338898 Binding of PECAM1 and PTPN11 1 0.04 0.38 0.19
19 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
20 INT221234 Gja3 Regulation of Binding of Ptpn2 1 0.08 0.58 0.18
21 INT349505 Ptpn2 Negative_regulation of Slc6a3 1 0.19 0.7 0.16
22 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16
23 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
24 INT106894 Ptpn2 Negative_regulation of Tac1 1 0.02 1.17 0.1
25 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
26 INT221232 Ptpn2 Positive_regulation of Gene_expression of Ros1 1 0.04 1.12 0.07
27 INT277432 Ptpn2 Positive_regulation of Gdnf 1 0.29 1.41 0.06
28 INT221251 PRKG1 Negative_regulation of Positive_regulation of Ptpn2 1 0.04 0.7 0.05
29 INT295337 Egf Positive_regulation of Ptpn11 1 0.15 0.08 0.05
30 INT277429 Ptpn2 Regulation of Gdnf 1 0.34 0.47 0.03
31 INT277427 Ptpn2 Positive_regulation of Gene_expression of Gdnf 1 0.32 0.47 0.03
32 INT295349 Binding of Ptpn11 and Grb7 1 0.13 0.11 0.03
33 INT277428 Positive_regulation of Ptpn2 Positive_regulation of Gdnf 1 0.29 0.47 0.03
34 INT285580 Binding of PTPN11 and S100A8 1 0.05 0.2 0
35 INT295338 Ptpn11 Regulation of Binding of Xpo1 1 0.02 0 0
36 INT295340 Binding of Ptpn11 and Fig4 1 0.04 0 0
37 INT279534 Binding of CFH and PTPN11 1 0.02 2.54 0
38 INT295359 Ptpn11 Regulation of Phosphorylation of Grb7 1 0.10 0 0
39 INT241300 Binding of IGHG3 and PTPN11 1 0.01 1.47 0
40 INT221247 Hspa9 Negative_regulation of Ptpn2 1 0.03 0.67 0
41 INT295345 Egf Regulation of Ptpn11 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for non-membrane spanning protein tyrosine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in non-membrane spanning protein tyrosine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48
2 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4
3 INT43903 Regulation of Ptpn2 21 0.41 15.51 4.08
4 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59
5 INT212100 Binding of PTPN4 7 0.32 1.37 2.93
6 INT268616 Positive_regulation of Gene_expression of Ptpn2 7 0.43 8.14 2.08
7 INT92667 Gene_expression of ACP1 4 0.01 2.49 1.81
8 INT212102 Gene_expression of PTPN4 16 0.58 0.2 1.39
9 INT164817 Negative_regulation of Regulation of Ptpn2 1 0.01 0 1.29
10 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22
11 INT212101 Regulation of PTPN4 2 0.25 0.19 1.22
12 INT221190 Phosphorylation of Ptpn2 9 0.48 7 1.15
13 INT43902 Binding of Ptpn2 6 0.29 3.59 0.93
14 INT221210 Negative_regulation of Gene_expression of Ptpn2 9 0.37 8.3 0.84
15 INT349490 Positive_regulation of Positive_regulation of Ptpn2 1 0.39 2.33 0.8
16 INT221218 Regulation of Negative_regulation of Ptpn2 3 0.30 2.69 0.79
17 INT144290 Phosphorylation of ACP1 1 0.59 0.39 0.77
18 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
19 INT119836 Positive_regulation of Gene_expression of PTPN11 5 0.67 3.44 0.69
20 INT221207 Localization of Ptpn2 5 0.74 5.76 0.59
21 INT112689 Protein_catabolism of Ptpn2 1 0.59 1.45 0.44
22 INT119826 Positive_regulation of PTPN11 2 0.45 2.67 0.43
23 INT241304 Regulation of Transcription of PTPN11 3 0.43 4.49 0.41
24 INT264073 Positive_regulation of Negative_regulation of Ptpn2 1 0.13 0.86 0.32
25 INT302668 Localization of PTPN4 8 0.69 0.07 0.28
26 INT354815 Transcription of Ptpn2 1 0.29 0.61 0.27
27 INT178592 Binding of ACP1 1 0.14 1.93 0.25
28 INT310814 Phosphorylation of Ptpn4 1 0.55 0.8 0.25
29 INT168356 Positive_regulation of PTPN4 2 0.44 0 0.23
30 INT310815 Gene_expression of Ptpn4 1 0.46 0.8 0.23
31 INT241302 Transcription of PTPN11 3 0.67 2.81 0.2
32 INT289228 Localization of Ptpn11 1 0.15 0.87 0.18
33 INT349489 Negative_regulation of Positive_regulation of Ptpn2 1 0.33 0.81 0.17
34 INT221205 Regulation of Phosphorylation of Ptpn2 1 0.26 0.93 0.14
35 INT36108 Positive_regulation of ACP1 2 0.41 0.82 0.13
36 INT184029 Binding of Ptpn11 2 0.19 0.18 0.12
37 INT310818 Positive_regulation of Gene_expression of Ptpn4 1 0.30 0.37 0.11
38 INT295368 Localization of Ptpn11 1 0.25 0 0.11
39 INT241305 Binding of PTPN11 9 0.46 6.08 0.1
40 INT267568 Negative_regulation of PTPN11 7 0.28 0.36 0.1
41 INT245585 Binding of Ptpn4 1 0.31 0.19 0.1
42 INT213470 Positive_regulation of Ptpn11 1 0.05 0.07 0.1
43 INT213468 Regulation of Ptpn11 1 0.05 0.08 0.09
44 INT331322 Protein_catabolism of PTPN11 1 0.06 0.96 0.08
45 INT241303 Localization of PTPN11 8 0.77 10.23 0.06
46 INT326329 Regulation of Localization of PTPN11 1 0.20 0.74 0.06
47 INT221208 Negative_regulation of Negative_regulation of Ptpn2 1 0.25 0.76 0.04
48 INT310813 Negative_regulation of Ptpn4 1 0.25 0.06 0.03
49 INT285583 Regulation of PTPN11 3 0.44 1.17 0
50 INT319957 Regulation of Gene_expression of PTPN4 1 0.39 0 0
51 INT225246 Phosphorylation of Ptpn11 1 0.28 0.9 0
52 INT36109 Localization of ACP1 1 0.62 0 0
53 INT332190 Regulation of Regulation of PTPN11 1 0.13 0.34 0
54 INT295391 Positive_regulation of Ptpn11 1 0.23 0 0
55 INT295371 Positive_regulation of Positive_regulation of Ptpn11 1 0.15 0 0
56 INT295379 Gene_expression of Ptpn11 1 0.20 0 0
57 INT241301 Positive_regulation of Localization of PTPN11 1 0.45 2.78 0
58 INT285584 Positive_regulation of Binding of PTPN11 1 0.06 0 0
59 INT347597 Negative_regulation of Gene_expression of PTPN11 1 0.42 0.44 0
60 INT295369 Regulation of Binding of Ptpn11 1 0.15 0 0
61 INT319959 Positive_regulation of Gene_expression of PTPN4 1 0.43 0 0
62 INT290423 Gene_expression of Ptpn11 1 0.39 0.15 0
63 INT290402 Regulation of Gene_expression of Ptpn11 1 0.26 0.15 0
64 INT225245 Negative_regulation of Phosphorylation of Ptpn11 1 0.19 0.26 0
65 INT306211 Phosphorylation of PTPN11 1 0.79 1.13 0
66 INT295393 Binding of Ptpn11 1 0.12 0 0
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