GO:0004767

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Name sphingomyelin phosphodiesterase activity
Categary Function
Go Slim No
Go Link GO:0004767
Unique Molecular Interactions 20
Total Molecular Interactions 24
Total Single Events 384
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sphingomyelin phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for sphingomyelin phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
2 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
3 INT8356 Binding of YY1 and Smpd1 1 0.32 0 0.43
4 INT210935 Il6 Positive_regulation of Smpd1 1 0.02 0.46 0.3
5 INT149940 Smpd1 Positive_regulation of spc 1 0.03 0.19 0.24
6 INT173358 Gnaq Positive_regulation of SMPD1 1 0.01 0.13 0.23
7 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22
8 INT302979 Binding of Gnb2l1 and Smpd2 1 0.07 0.71 0.09
9 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
10 INT302980 Mmp2 Positive_regulation of Smpd3 1 0.29 0.78 0.05
11 INT302982 Smpd1 Positive_regulation of Gene_expression of Smpd3 1 0.30 0.64 0.04
12 INT302981 Nqo1 Positive_regulation of Positive_regulation of Smpd2 1 0.00 0.45 0.04
13 INT333637 Smpd1 Positive_regulation of IRF3 1 0.09 0.62 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for sphingomyelin phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in sphingomyelin phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171033 Localization of SMPD1 15 0.16 11.92 5.16
2 INT171019 Gene_expression of SMPD1 26 0.27 12.08 5.08
3 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95
4 INT171013 Regulation of SMPD1 4 0.11 4.84 2.74
5 INT171032 Positive_regulation of SMPD1 9 0.12 8.94 2.52
6 INT86914 Positive_regulation of Smpd1 11 0.43 4.73 1.74
7 INT20233 Negative_regulation of SMPD1 8 0.51 4.19 1.4
8 INT62385 Localization of SMPD2 4 0.68 3.45 1.19
9 INT302938 Gene_expression of Smpd3 1 0.78 16.18 1.17
10 INT171038 Positive_regulation of Localization of SMPD1 2 0.08 1.8 0.99
11 INT302945 Positive_regulation of Smpd3 1 0.70 9.99 0.93
12 INT112760 Negative_regulation of Positive_regulation of Smpd1 2 0.38 1.45 0.84
13 INT302953 Positive_regulation of Smpd2 1 0.52 9.07 0.83
14 INT171030 Positive_regulation of Gene_expression of SMPD1 2 0.09 0.92 0.82
15 INT171024 Negative_regulation of Localization of SMPD1 1 0.07 1.29 0.72
16 INT103456 Positive_regulation of SMPD2 4 0.49 1.85 0.55
17 INT171043 Negative_regulation of Gene_expression of SMPD1 2 0.08 1.15 0.53
18 INT217525 Gene_expression of SMPD2 9 0.75 1.9 0.35
19 INT302947 Negative_regulation of Gene_expression of Smpd3 1 0.43 3.76 0.31
20 INT173329 Protein_catabolism of SMPD1 1 0.13 0 0.31
21 INT103453 Positive_regulation of Localization of SMPD2 1 0.03 0.54 0.27
22 INT103455 Negative_regulation of Positive_regulation of SMPD2 1 0.02 0.5 0.25
23 INT103454 Negative_regulation of Localization of SMPD2 1 0.02 0.5 0.25
24 INT302956 Localization of Smpd3 1 0.75 2.92 0.24
25 INT302967 Localization of Smpd2 1 0.56 1.29 0.24
26 INT84638 Regulation of Smpd1 3 0.37 2.36 0.22
27 INT302952 Negative_regulation of Smpd3 1 0.43 2.57 0.22
28 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21
29 INT309940 Localization of Smpd1 3 0.21 2.79 0.21
30 INT232104 Negative_regulation of Gene_expression of SMPD2 1 0.02 0.14 0.18
31 INT138436 Positive_regulation of Gene_expression of Smpd1 3 0.41 0.6 0.17
32 INT171035 Binding of SMPD1 1 0.06 1.57 0.17
33 INT147970 Positive_regulation of Positive_regulation of Smpd1 3 0.43 0.88 0.15
34 INT173347 Regulation of Gene_expression of SMPD1 1 0.07 0.48 0.14
35 INT147971 Positive_regulation of Negative_regulation of Smpd1 1 0.43 0 0.11
36 INT302942 Regulation of Smpd2 1 0.46 0.55 0.11
37 INT63795 Phosphorylation of Smpd1 1 0.00 0 0.11
38 INT302948 Negative_regulation of Binding of Smpd3 1 0.43 1.54 0.1
39 INT302940 Binding of Smpd3 1 0.37 1.53 0.1
40 INT20232 Negative_regulation of Negative_regulation of SMPD1 1 0.37 0.55 0.1
41 INT302949 Negative_regulation of Positive_regulation of Smpd2 1 0.32 0.75 0.09
42 INT302963 Protein_catabolism of Smpd1 1 0.39 0.86 0.08
43 INT302969 Positive_regulation of Positive_regulation of Smpd3 1 0.50 1.27 0.06
44 INT217524 Regulation of Gene_expression of SMPD2 1 0.44 0.53 0.06
45 INT217526 Positive_regulation of Gene_expression of SMPD2 1 0.49 0.53 0.06
46 INT232103 Binding of SMPD2 1 0.02 0.47 0.05
47 INT302955 Regulation of Positive_regulation of Smpd2 1 0.34 0.24 0.04
48 INT302965 Regulation of Positive_regulation of Smpd3 1 0.27 0.78 0.03
49 INT189969 Phosphorylation of SMPD2 1 0.25 0.44 0.03
50 INT302943 Regulation of Smpd3 1 0.45 1.35 0.03
51 INT232105 Negative_regulation of SMPD2 2 0.42 0.7 0
52 INT320839 Regulation of Gene_expression of Smpd1 1 0.37 0.61 0
53 INT302970 Gene_expression of Smpd2 1 0.58 0.97 0
54 INT232102 Transcription of SMPD2 1 0.04 0.07 0
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