GO:0004784

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Name superoxide dismutase activity
Categary Function
Go Slim No
Go Link GO:0004784
Unique Molecular Interactions 183
Total Molecular Interactions 232
Total Single Events 3403
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for superoxide dismutase activity. They are ordered first by their pain relevance and then by number of times they were reported for superoxide dismutase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84
2 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
3 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2
4 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
5 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
6 INT48751 Binding of Nqo1 and Npy 1 0.28 0 0.82
7 INT144449 Plscr1 Positive_regulation of Gene_expression of Nqo1 1 0.15 0.18 0.8
8 INT144451 Napa Positive_regulation of Gene_expression of Nqo1 1 0.07 0.18 0.8
9 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
10 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
11 INT274625 OPN1MW Positive_regulation of SOD1 1 0.19 0.29 0.5
12 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
13 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
14 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
15 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
16 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
17 INT235971 Positive_regulation of Binding of Nqo1 and NMO-IgG 1 0.00 1.86 0.32
18 INT351391 Binding of Sod2 and Gtf3a 1 0.00 0.18 0.27
19 INT235959 Nqo1 Positive_regulation of Localization of Aqp4 1 0.02 1.39 0.26
20 INT206763 Binding of CSF2 and Nqo1 1 0.00 1.7 0.25
21 INT235967 Binding of Ighm and Nqo1 1 0.00 1.45 0.23
22 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22
23 INT305508 Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
24 INT305511 Negative_regulation of Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
25 INT199191 Negative_regulation of Sod2 Positive_regulation of Ros1 1 0.08 0 0.19
26 INT28562 SOD1 Negative_regulation of Pacs1 1 0.03 2.63 0.19
27 INT79511 Negative_regulation of NOS1 Regulation of Negative_regulation of Nqo1 1 0.05 0.08 0.19
28 INT251492 Binding of HSPD1 and SOD1 1 0.02 1.45 0.18
29 INT250949 Binding of KIR3DL2 and SOD1 1 0.24 0.55 0.18
30 INT319173 TXN Positive_regulation of Gene_expression of SOD2 1 0.23 0.1 0.18
31 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17
32 INT252575 Rpe Negative_regulation of SOD1 1 0.03 2.39 0.14
33 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
34 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14
35 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12
36 INT266900 Gene_expression of Sod2 Negative_regulation of Gene_expression of Sod1 1 0.11 0.41 0.11
37 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08
38 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08
39 INT346695 Negative_regulation of SOD1 Positive_regulation of Negative_regulation of Hist3h2a 1 0.00 0.41 0.08
40 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08
41 INT31986 NTS Positive_regulation of Binding of SOD1 1 0.16 0 0.08
42 INT201736 Nfkb1 Positive_regulation of Transcription of Sod2 1 0.01 0.93 0.08
43 INT302131 Negative_regulation of SOD2 Regulation of BAK1 1 0.09 1.22 0.07
44 INT302128 SOD2 Regulation of BAK1 1 0.09 1.22 0.07
45 INT297735 Cbr1 Positive_regulation of Sod2 1 0.11 1.28 0.07
46 INT220724 Binding of IGFALS and SOD1 1 0.06 2.1 0.06
47 INT243119 Binding of amd and Sod2 1 0.29 3.25 0.06
48 INT262233 Nr1i2 Negative_regulation of SOD1 1 0.03 0.23 0.05
49 INT341375 Sod2 Regulation of Bcl2 1 0.08 1.96 0.05
50 INT262230 SOD1 Regulation of Nr1i2 1 0.02 0.3 0.05
51 INT240888 Sod1 Regulation of Gene_expression of Ins1 1 0.08 0.18 0.04
52 INT266902 Nfe2l2 Positive_regulation of Sod2 1 0.16 0.19 0.04
53 INT235969 Binding of Ighg1 and Nqo1 1 0.01 2.63 0.04
54 INT302981 Nqo1 Positive_regulation of Positive_regulation of Smpd2 1 0.00 0.45 0.04
55 INT266897 Nfe2l2 Positive_regulation of Sod1 1 0.11 0.19 0.04
56 INT347416 Tlr4 Negative_regulation of SOD1 1 0.00 0.36 0.04
57 INT266898 Gtf3a Positive_regulation of Sod2 1 0.00 0 0.04
58 INT302974 Nqo1 Positive_regulation of Jag2 1 0.00 0.45 0.04
59 INT240905 Gene_expression of Sod1 Negative_regulation of Phosphorylation of Creb1 1 0.32 0.1 0.03
60 INT240881 Gene_expression of Sod1 Positive_regulation of Phosphorylation of Foxo1 1 0.38 0.07 0.03
61 INT292416 SOD1 Regulation of Cat 1 0.01 0.45 0.03
62 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
63 INT235968 NMO-IgG Positive_regulation of Nqo1 1 0.00 2.11 0.03
64 INT240875 Gene_expression of Sod1 Negative_regulation of Gene_expression of Pck1 1 0.33 0.27 0.03
65 INT240876 Gene_expression of Sod1 Negative_regulation of Pck1 1 0.33 0.27 0.03
66 INT341376 Sod2 Regulation of Bax 1 0.09 0.99 0.03
67 INT239181 Gene_expression of Gh Negative_regulation of Sod1 1 0.24 0.33 0
68 INT329340 UCN2 Positive_regulation of SOD1 1 0.02 1.12 0
69 INT47720 Gpr143 Regulation of Nqo1 1 0.01 0 0
70 INT333853 Binding of SOD1 and Gtf3a 1 0.00 0 0
71 INT240887 Binding of Sod1 and Gopc 1 0.10 0.08 0
72 INT204320 SOD1 Positive_regulation of Protein_catabolism of ROS1 1 0.06 0.05 0
73 INT333854 Binding of SOD1 and Creb1 1 0.02 0 0
74 INT291716 Binding of SOD1 and Rxra 1 0.21 0 0
75 INT232575 SNRNP70 Regulation of SOD1 1 0.12 0.65 0
76 INT229418 Mpo Positive_regulation of Sod1 1 0.20 0.71 0
77 INT240882 Sod1 Positive_regulation of Phosphorylation of Creb1 1 0.31 0.1 0
78 INT229826 Fos Positive_regulation of Sod1 1 0.42 0.38 0
79 INT302672 Gene_expression of Zmat3 Positive_regulation of Sod1 1 0.05 0.05 0
80 INT234164 Binding of Sod1 and Dynll1 1 0.06 1.27 0
81 INT240896 Gene_expression of Sod1 Negative_regulation of Ros1 1 0.12 0.69 0
82 INT347418 Tlr4 Positive_regulation of SOD1 1 0.01 0 0
83 INT229810 Fos Positive_regulation of Sod3 1 0.40 0.38 0
84 INT186247 CGA Regulation of Gene_expression of SOD1 1 0.01 0.35 0
85 INT240874 Sod1 Negative_regulation of Ros1 1 0.11 0.09 0
86 INT347417 Positive_regulation of Tlr4 Positive_regulation of SOD1 1 0.01 0 0
87 INT191413 Tert Positive_regulation of Nqo1 1 0.02 0.84 0
88 INT302671 Zmat3 Positive_regulation of Gene_expression of Sod1 1 0.04 0.3 0
89 INT147067 Binding of Aqp4 and Nqo1 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for superoxide dismutase activity. They are ordered first by their pain relevance and then by number of times they were reported in superoxide dismutase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
2 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
3 INT10384 Positive_regulation of Nqo1 62 0.70 14.27 11.08
4 INT41627 Gene_expression of Nqo1 33 0.65 4.58 10.48
5 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7
6 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
7 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64
8 INT103824 Positive_regulation of SOD2 26 0.70 17.42 7.17
9 INT39282 Negative_regulation of SOD2 27 0.59 16.89 7.03
10 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
11 INT140170 Binding of Nqo1 24 0.38 36.16 6.79
12 INT73382 Regulation of Nqo1 13 0.58 1.58 6.16
13 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65
14 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
15 INT35599 Negative_regulation of Nqo1 25 0.54 4.6 4.42
16 INT84703 Negative_regulation of Nqo1 8 0.38 7.1 4.05
17 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92
18 INT141658 Positive_regulation of Gene_expression of Sod2 51 0.69 35.6 3.71
19 INT99453 Gene_expression of SOD2 25 0.77 13.28 3.6
20 INT69943 Regulation of Gene_expression of Nqo1 3 0.26 0.98 3.56
21 INT18744 Localization of Nqo1 7 0.69 1.06 3.19
22 INT89229 Positive_regulation of Gene_expression of Nqo1 2 0.06 0.1 2.81
23 INT91899 Binding of Sod1 17 0.47 11.56 2.63
24 INT31989 Binding of SOD1 43 0.47 19.38 2.55
25 INT206760 Localization of Nqo1 8 0.09 15.76 2.4
26 INT48750 Binding of Nqo1 5 0.29 0.1 2.31
27 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
28 INT109334 Regulation of SOD2 13 0.60 7.48 2.14
29 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99
30 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
31 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
32 INT122300 Negative_regulation of Positive_regulation of Nqo1 2 0.59 1.07 1.84
33 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
34 INT47714 Regulation of Nqo1 12 0.24 11.12 1.71
35 INT27293 Regulation of SOD1 21 0.53 15.73 1.55
36 INT124299 Negative_regulation of Gene_expression of Sod2 15 0.53 13.8 1.51
37 INT178615 Binding of SOD2 12 0.48 6.93 1.51
38 INT91900 Localization of Sod1 12 0.77 6.62 1.51
39 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
40 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
41 INT117100 Positive_regulation of Gene_expression of Sod1 5 0.60 1.18 1.2
42 INT134061 Transcription of Sod2 5 0.68 3.46 1.19
43 INT130437 Phosphorylation of Nqo1 3 0.25 0.97 1.14
44 INT159543 Localization of SOD1 29 0.75 8.62 1.06
45 INT129398 Negative_regulation of Gene_expression of SOD1 22 0.43 7.11 1.02
46 INT130438 Negative_regulation of Phosphorylation of Nqo1 1 0.01 0.47 0.91
47 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9
48 INT135836 Negative_regulation of Sod1 5 0.25 1.62 0.82
49 INT103823 Positive_regulation of Gene_expression of SOD2 10 0.68 4.69 0.79
50 INT125270 Regulation of Binding of Nqo1 1 0.01 0.1 0.74
51 INT129630 Regulation of Sod1 6 0.44 4.94 0.73
52 INT49137 Negative_regulation of Positive_regulation of Nqo1 1 0.14 0.33 0.73
53 INT28561 Regulation of Gene_expression of SOD1 9 0.61 2.83 0.71
54 INT327776 Negative_regulation of Gene_expression of Nqo1 2 0.02 2.39 0.69
55 INT266894 Positive_regulation of Positive_regulation of Sod2 5 0.41 3.26 0.67
56 INT112173 Regulation of Transcription of SOD2 3 0.60 2.25 0.67
57 INT108857 Transcription of SOD2 5 0.70 3.51 0.66
58 INT270033 Regulation of Gene_expression of Sod2 5 0.45 2.34 0.63
59 INT56207 Positive_regulation of Positive_regulation of Nqo1 7 0.47 1.08 0.62
60 INT130184 Positive_regulation of Regulation of Nqo1 1 0.14 0 0.6
61 INT111960 Binding of Sod2 4 0.37 2.03 0.59
62 INT122410 Transcription of Nqo1 4 0.68 1.42 0.58
63 INT108856 Regulation of Gene_expression of SOD2 3 0.44 0.79 0.58
64 INT79725 Regulation of Sod2 8 0.61 4.95 0.54
65 INT162429 Negative_regulation of Gene_expression of Sod1 6 0.48 2.46 0.53
66 INT130436 Positive_regulation of Phosphorylation of Nqo1 1 0.01 0.2 0.44
67 INT84062 Binding of Sod3 3 0.25 1.73 0.4
68 INT124298 Localization of Sod2 8 0.74 3.5 0.37
69 INT187472 Regulation of Gene_expression of Sod1 5 0.53 2.68 0.37
70 INT159542 Localization of SOD2 5 0.80 1.91 0.36
71 INT134800 Negative_regulation of Sod3 1 0.37 0.29 0.36
72 INT144475 Protein_catabolism of Sod2 1 0.17 0.58 0.33
73 INT129632 Negative_regulation of Transcription of Sod1 1 0.43 0.69 0.28
74 INT129631 Transcription of Sod1 1 0.52 0.69 0.28
75 INT319179 Positive_regulation of Positive_regulation of SOD2 1 0.68 0.51 0.27
76 INT129399 Transcription of SOD1 6 0.66 3.08 0.25
77 INT109333 Negative_regulation of Gene_expression of SOD2 2 0.42 0.71 0.24
78 INT260399 Positive_regulation of Sod3 1 0.19 1.4 0.24
79 INT238310 Localization of Sod3 1 0.48 0.14 0.24
80 INT108715 Gene_expression of Sod3 3 0.47 1.95 0.22
81 INT122414 Positive_regulation of Transcription of Nqo1 1 0.44 0.15 0.22
82 INT220727 Regulation of Binding of SOD1 1 0.42 1.46 0.21
83 INT238309 Negative_regulation of Gene_expression of Sod1 3 0.38 1.09 0.2
84 INT116432 Positive_regulation of Positive_regulation of SOD1 3 0.40 3.88 0.2
85 INT334150 Positive_regulation of Gene_expression of Nqo1 1 0.01 0.41 0.2
86 INT174127 Positive_regulation of Positive_regulation of Sod1 2 0.45 4.9 0.19
87 INT240279 Negative_regulation of Positive_regulation of SOD1 5 0.43 2.45 0.18
88 INT79510 Regulation of Negative_regulation of Nqo1 1 0.32 0.08 0.18
89 INT319180 Regulation of Transcription of SOD1 1 0.21 0.3 0.17
90 INT319182 Positive_regulation of Negative_regulation of SOD2 1 0.46 0.95 0.17
91 INT108717 Negative_regulation of Gene_expression of Sod3 2 0.25 0.8 0.16
92 INT232580 Protein_catabolism of SOD2 2 0.97 1.22 0.16
93 INT238306 Regulation of Gene_expression of Sod1 1 0.39 0.46 0.16
94 INT124301 Negative_regulation of Localization of Sod2 1 0.38 1.25 0.16
95 INT142420 Negative_regulation of Gene_expression of Nqo1 2 0.41 0.26 0.15
96 INT204370 Negative_regulation of Binding of SOD1 4 0.41 0.82 0.13
97 INT314356 Positive_regulation of Localization of SOD1 1 0.04 0.82 0.13
98 INT229429 Localization of Sod1 2 0.65 0.8 0.12
99 INT270029 Negative_regulation of Phosphorylation of Sod2 1 0.26 1.3 0.12
100 INT270035 Phosphorylation of Sod2 1 0.50 1.29 0.12
101 INT266895 Positive_regulation of Negative_regulation of Sod2 2 0.46 1.36 0.11
102 INT319178 Regulation of Negative_regulation of SOD2 1 0.27 0.53 0.11
103 INT204330 Protein_catabolism of SOD1 8 0.84 4.75 0.1
104 INT268725 Positive_regulation of Negative_regulation of SOD1 3 0.35 2.41 0.1
105 INT177582 Regulation of Sod1 2 0.24 0.39 0.1
106 INT203330 Negative_regulation of Binding of Sod1 1 0.28 1.03 0.1
107 INT108716 Positive_regulation of Gene_expression of Sod3 1 0.41 0.43 0.1
108 INT252574 Negative_regulation of Regulation of SOD1 1 0.06 1.11 0.09
109 INT309388 Regulation of Positive_regulation of Sod2 1 0.41 0.26 0.08
110 INT342172 Regulation of Regulation of SOD1 1 0.02 0.75 0.08
111 INT333947 Regulation of Regulation of SOD2 1 0.42 0.14 0.07
112 INT260401 Negative_regulation of Positive_regulation of Sod3 1 0.11 0.82 0.05
113 INT199177 Positive_regulation of Localization of Sod2 2 0.37 0.06 0.03
114 INT297729 Regulation of Regulation of Sod2 1 0.37 0.05 0.03
115 INT272876 Negative_regulation of Localization of Sod1 1 0.18 0.57 0.03
116 INT239155 Positive_regulation of Transcription of Sod2 1 0.62 1.75 0.03
117 INT240277 Negative_regulation of Protein_catabolism of SOD1 1 0.42 1.23 0.03
118 INT250969 Regulation of Positive_regulation of SOD1 2 0.44 0.38 0
119 INT174131 Regulation of Negative_regulation of Sod1 1 0.43 0.52 0
120 INT333949 Positive_regulation of Localization of SOD2 1 0.46 0.32 0
121 INT108855 Positive_regulation of Transcription of SOD2 1 0.47 0.07 0
122 INT253184 Binding of Sod1 1 0.33 0.06 0
123 INT268728 Negative_regulation of Negative_regulation of SOD1 1 0.24 0 0
124 INT174130 Positive_regulation of Binding of Sod1 1 0.48 0.72 0
125 INT330964 Negative_regulation of Transcription of SOD2 1 0.15 1.22 0
126 INT118577 Positive_regulation of Binding of SOD1 1 0.28 0.16 0
127 INT279975 Regulation of Gene_expression of Nqo1 1 0.02 0.1 0
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