GO:0004800

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Name thyroxine 5'-deiodinase activity
Categary Function
Go Slim No
Go Link GO:0004800
Unique Molecular Interactions 66
Total Molecular Interactions 89
Total Single Events 686
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thyroxine 5'-deiodinase activity. They are ordered first by their pain relevance and then by number of times they were reported for thyroxine 5'-deiodinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
2 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
3 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
4 INT63489 Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
5 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
6 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
7 INT353372 Dio1 Positive_regulation of Grin1 1 0.16 0 0.98
8 INT210984 Cfp Positive_regulation of Positive_regulation of Dio1 1 0.07 0.81 0.75
9 INT210980 Cysltr1 Positive_regulation of Positive_regulation of Dio1 1 0.00 0.81 0.75
10 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
11 INT5112 DIO2 Positive_regulation of Positive_regulation of Gal 1 0.27 0 0.53
12 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
13 INT151338 Binding of Dio1 and P9Ehs1 1 0.09 0.16 0.52
14 INT228850 Dio1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.06 0 0.44
15 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
16 INT50621 Positive_regulation of Dio1 Positive_regulation of Gene_expression of Fos 1 0.43 0 0.37
17 INT33977 DIO2 Regulation of PCDHB17 1 0.00 0.44 0.27
18 INT34784 DIO2 Regulation of Localization of GHRH 1 0.00 0 0.25
19 INT34785 DIO2 Positive_regulation of Localization of GHRH 1 0.01 0 0.25
20 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24
21 INT50620 Dio1 Positive_regulation of Gene_expression of Fos 1 0.43 0 0.22
22 INT266005 Binding of DIO3 and SGCG 1 0.00 0.86 0.22
23 INT244855 Lbx1 Negative_regulation of Dio1 1 0.03 0.09 0.16
24 INT266003 Binding of COL5A2 and DIO3 1 0.01 0.43 0.11
25 INT319786 Ccbp2 Positive_regulation of Negative_regulation of Dio1 1 0.09 0.94 0.05
26 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03
27 INT319787 Binding of Dio1 and Ccbp2 1 0.06 0.92 0.03
28 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
29 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
30 INT325900 Binding of Dio1 and Wbp5 1 0.00 0.25 0
31 INT215764 Dio1 Regulation of Ces1c 1 0.00 0.05 0
32 INT215768 Dio1 Regulation of Cdk4 1 0.01 0.05 0
33 INT325901 Binding of Dio1 and F2 1 0.01 0.63 0
34 INT269770 Binding of DIO2 and NOVA2 1 0.07 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thyroxine 5'-deiodinase activity. They are ordered first by their pain relevance and then by number of times they were reported in thyroxine 5'-deiodinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91
2 INT6749 Binding of Dio1 25 0.38 4.41 13.07
3 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
4 INT27507 Positive_regulation of Dio1 23 0.44 3.43 12.11
5 INT6748 Regulation of Dio1 15 0.45 2.63 11.18
6 INT31780 Binding of DIO2 17 0.36 10.07 10
7 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
8 INT52465 Negative_regulation of Dio1 17 0.58 4.45 7.76
9 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
10 INT95759 Gene_expression of DIO3 5 0.51 2.55 5.28
11 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
12 INT202577 Localization of DIO2 9 0.56 1.3 2.97
13 INT90981 Transcription of Dio1 2 0.42 1.44 2.85
14 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31
15 INT167699 Positive_regulation of Positive_regulation of Dio1 2 0.26 1.12 2.04
16 INT122895 Transcription of DIO2 3 0.52 0.91 1.73
17 INT143317 Regulation of Gene_expression of Dio1 4 0.26 2.9 1.4
18 INT147345 Localization of Dio1 7 0.50 1.72 1.38
19 INT143233 Positive_regulation of Binding of Dio1 1 0.21 0 1.36
20 INT103272 Positive_regulation of Gene_expression of Dio1 4 0.26 1.66 1.34
21 INT122894 Transcription of DIO3 1 0.52 0.71 1.19
22 INT55699 Regulation of Binding of DIO2 2 0.24 1.91 1.16
23 INT40540 Localization of DIO3 2 0.73 1.11 0.96
24 INT151336 Regulation of Binding of Dio1 2 0.30 0.2 0.9
25 INT63486 Negative_regulation of Positive_regulation of Dio1 1 0.19 0.33 0.79
26 INT335719 Positive_regulation of Gene_expression of DIO2 3 0.23 0.59 0.61
27 INT257949 Regulation of Gene_expression of DIO2 1 0.15 0.17 0.6
28 INT200875 Protein_catabolism of Dio1 1 0.03 0 0.57
29 INT257946 Regulation of Positive_regulation of DIO2 1 0.13 0.45 0.49
30 INT39018 Protein_catabolism of DIO2 1 0.02 0 0.49
31 INT349611 Positive_regulation of Localization of DIO2 1 0.26 0 0.46
32 INT40541 Negative_regulation of Positive_regulation of DIO2 2 0.41 0.86 0.4
33 INT319780 Negative_regulation of Gene_expression of Dio1 2 0.31 1.51 0.4
34 INT347801 Regulation of Regulation of Dio1 1 0.15 0.55 0.39
35 INT228849 Negative_regulation of Binding of Dio1 1 0.06 0 0.36
36 INT349614 Negative_regulation of Binding of DIO2 1 0.27 0.77 0.16
37 INT78367 Positive_regulation of Negative_regulation of Dio1 1 0.50 0.46 0.14
38 INT95761 Negative_regulation of DIO3 1 0.25 0.52 0.1
39 INT335654 Negative_regulation of Gene_expression of DIO2 1 0.17 0.72 0.1
40 INT39690 Positive_regulation of DIO3 2 0.02 0.48 0.06
41 INT319778 Regulation of Localization of Dio1 1 0.24 0.29 0
42 INT276140 Regulation of Negative_regulation of DIO2 1 0.34 0.07 0
43 INT319783 Positive_regulation of Localization of Dio1 1 0.26 0.24 0
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